Q6FUI7 (CYM1_CANGA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mitochondrial presequence protease
EC=3.4.24.-

Gene names

Name:	CYM1
Ordered Locus Names:	CAGL0F03157g

Organism

Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

284593 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces › Candida glabrata

Protein attributes

Sequence length	990 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides By similarity.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the peptidase M16 family. PreP subfamily.

Ontologies

Keywords
Cellular component	Mitochondrion
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Metalloprotease Protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrion Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 990	990	Mitochondrial presequence protease		PRO_0000249944
Sites
	Active site	87	1	Proton acceptor By similarity
	Metal binding	84	1	Zinc; catalytic By similarity
	Metal binding	88	1	Zinc; catalytic By similarity
	Metal binding	185	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6FUI7 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: F5AAC8E63BD08EF8	FASTA	990	111,695
	10 20 30 40 50 60 MLRFQRFAST YNQRAVLRKY PVGGIIHGFQ VRRAVPVPEL KLTAVDLIHE QTGAEHLHID 70 80 90 100 110 120 RDDKNNVFSI AFRTLPPDAT GVPHILEHTT LCGSEKYPVR DPFFKMLNKS LANFMNAMTG 130 140 150 160 170 180 PDYTFFPFAT TNARDFVNLR DVYLNSTLRP LLKEQDFYQE GWRLEHSEVT NPKSDIIFKG 190 200 210 220 230 240 VVFNEMKGQV SNADYHFWSQ FQQNIYPSLN NSGGDPQKIT DLHYQDLVDF HHANYHPSNA 250 260 270 280 290 300 RTFTYGSFPL EDTLKKVNEE FRAYGKRIIN KKLPKPLELI ETKELTLEGQ IDPMLPAEKQ 310 320 330 340 350 360 TKTSLTWKCG EPTDLYETFL LKILGNLLLD GHDSIMYKGL IESGLGHDFS VNTGVESMTA 370 380 390 400 410 420 ANFLTVGIQG SQNVEEFKSK VFDLFKEFIE NDVDSNKVDA IIHQLELSKK DQKADFGLQI 430 440 450 460 470 480 LYSILPGWTN GIDPIEGLEF DELIGRLKSD FKENGTKIFK NILDKYIIDQ PYFHFTMKGS 490 500 510 520 530 540 EEFSSKLAAE ESTKLDKKLK ELDETDRKAI FERGLLLEAA QNHKEDLSCL PTLGVADISR 550 560 570 580 590 600 KVDTYDLNTN ANITVRNTAT NGISYIRGKK LINDMIPLEL YPFLSLFAAS LTHLGTKTTP 610 620 630 640 650 660 YGAIDNEIKL HTGGISTNIS VNADPTTLQP NLYFDMSGFS LNEKSDYIFN FLKTILMETD 670 680 690 700 710 720 FSTHKDKLKV LINSIASSNT SHIADSGHTV ARSFASGHLS TVAAIQEHIS GVEHYKLISR 730 740 750 760 770 780 LCSIMNDDKL FQSEVIDKLV MLQRIIVNSQ NMEFFASVDC QAQENKIRKE VDYFVSTLPN 790 800 810 820 830 840 TSSDISGAIQ TACVPRYSDS QVLNLIKFPF QVHYTAQAYN GVSYTHKDGA ALQVLANMLT 850 860 870 880 890 900 FKHLHKEIRE KGGAYGGGAT FSALSGIFSY YSYRDPNPLA SIQTFEKSAS YVLNDAKWTQ 910 920 930 940 950 960 SDLDESKLSI FQQVDAPISP KSEGSTFFNL GVTDEMRQVR REQLLDTSLL DIHRVAERYI 970 980 990 LPNKSIATVV GPGIDGETVS PKWHIEDIKV

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR380952 Genomic DNA. Translation: CAG59031.1.
RefSeq	XP_446107.1. XM_446107.1.
3D structure databases
ProteinModelPortal	Q6FUI7.
ModBase	Search...
Protein family/group databases
MEROPS	M16.013.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2887720.
KEGG	cgr:CAGL0F03157g.
Phylogenomic databases
HOGENOM	HOG000008829.
KO	K06972.
OMA	MKGAMSS.
OrthoDB	EOG4QRMC5.
Family and domain databases
Gene3D	3.30.830.10. 1 hit.
InterPro	IPR011249. Metalloenz_LuxS/M16. IPR011237. Pept_M16_dom. IPR011765. Pept_M16_N. IPR007863. Peptidase_M16_C. IPR013578. Peptidase_M16C_assoc. [Graphical view]
Pfam	PF08367. M16C_assoc. 1 hit. PF00675. Peptidase_M16. 1 hit. PF05193. Peptidase_M16_C. 2 hits. [Graphical view]
SUPFAM	SSF63411. Metalloenz_metal-bd. 4 hits.
PROSITE	PS00143. INSULINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CYM1_CANGA

Accession

Primary (citable) accession number: Q6FUI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	July 19, 2004
Last modified:	May 29, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program