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Protein

Ceramide very long chain fatty acid hydroxylase

Gene

SCS7

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Ceramide hydroxylase involved in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids. Hydroxylates the very long chain fatty acid of ceramides at C2 and C3.UniRule annotation

Cofactori

Fe cationUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processFatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandIronUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ceramide very long chain fatty acid hydroxylaseUniRule annotation (EC:1.-.-.-UniRule annotation)
Gene namesi
Name:SCS7Imported
Ordered Locus Names:CAGL0F03399gImported
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)Imported
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome F

Organism-specific databases

CGDiCAL0131212. SCS7.
EuPathDBiFungiDB:CAGL0F03399g.

Subcellular locationi

  • Endoplasmic reticulum membrane UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei193 – 213HelicalSequence analysisAdd BLAST21
Transmembranei220 – 242HelicalSequence analysisAdd BLAST23
Transmembranei254 – 270HelicalSequence analysisAdd BLAST17
Transmembranei277 – 295HelicalSequence analysisAdd BLAST19
Transmembranei301 – 325HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Endoplasmic reticulumUniRule annotation, Membrane

PTM / Processingi

Proteomic databases

PRIDEiQ6FUH7.

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_446117.1.

Structurei

3D structure databases

ProteinModelPortaliQ6FUH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 68Cytochrome b5 heme-bindingInterPro annotationAdd BLAST58

Sequence similaritiesi

Belongs to the sterol desaturase family. SCS7 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0537. Eukaryota.
KOG0539. Eukaryota.
COG3000. LUCA.
COG5274. LUCA.
HOGENOMiHOG000023981.
InParanoidiQ6FUH7.
KOiK19703.
OMAiHHFRIQT.
OrthoDBiEOG092C3MYJ.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiView protein in InterPro
IPR001199. Cyt_B5-like_heme/steroid-bd.
IPR006694. Fatty_acid_hydroxylase.
IPR014430. Scs7.
PfamiView protein in Pfam
PF00173. Cyt-b5. 1 hit.
PF04116. FA_hydroxylase. 1 hit.
PIRSFiPIRSF005149. IPC-B_HD. 1 hit.
SMARTiView protein in SMART
SM01117. Cyt-b5. 1 hit.
SUPFAMiSSF55856. SSF55856. 1 hit.
PROSITEiView protein in PROSITE
PS50255. CYTOCHROME_B5_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FUH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVAADSSKT LELFPQSVLA KHNSKDDCWV STHERKIYDV SKYLKDHPEE
60 70 80 90 100
ADAVHKALDG KHGTDISQME LTTLKFVTDD YLVGYLATSD EEKKLLTNKS
110 120 130 140 150
HKVEVKLNAD NTFDSTTFVK DLPTEDKLSI TTDYERDYKK HKFLDLNKPL
160 170 180 190 200
LKQILFGNFT KDFYLDQIHR PRHYGKGSAP LFGNFLEAFT KTAWWVVPTV
210 220 230 240 250
WGPVVLYFIT TALMNMNNPL ALFLFGLGIF VWTLIEYCLH RFLFHFDEWL
260 270 280 290 300
PEHSMFFMIH FLLHGCHHYL PMDAYRLVVP PALFVVLCAP IYKLVFAALP
310 320 330 340 350
YYWACAGFAG GMLGYICYDL CHYFLHHSKM PPFMRKLKKY HLEHHYKNYQ
360 370 380
LGFGVTSWFW DKVFGTYLGP DAPLSKMKYE
Length:380
Mass (Da):44,314
Last modified:July 19, 2004 - v1
Checksum:iF362590098AFF0A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380952 Genomic DNA. Translation: CAG59041.1.
RefSeqiXP_446117.1. XM_446117.1.

Genome annotation databases

EnsemblFungiiCAG59041; CAG59041; CAGL0F03399g.
GeneIDi2887589.
KEGGicgr:CAGL0F03399g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380952 Genomic DNA. Translation: CAG59041.1.
RefSeqiXP_446117.1. XM_446117.1.

3D structure databases

ProteinModelPortaliQ6FUH7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284593.XP_446117.1.

Proteomic databases

PRIDEiQ6FUH7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG59041; CAG59041; CAGL0F03399g.
GeneIDi2887589.
KEGGicgr:CAGL0F03399g.

Organism-specific databases

CGDiCAL0131212. SCS7.
EuPathDBiFungiDB:CAGL0F03399g.

Phylogenomic databases

eggNOGiKOG0537. Eukaryota.
KOG0539. Eukaryota.
COG3000. LUCA.
COG5274. LUCA.
HOGENOMiHOG000023981.
InParanoidiQ6FUH7.
KOiK19703.
OMAiHHFRIQT.
OrthoDBiEOG092C3MYJ.

Family and domain databases

Gene3Di3.10.120.10. 1 hit.
InterProiView protein in InterPro
IPR001199. Cyt_B5-like_heme/steroid-bd.
IPR006694. Fatty_acid_hydroxylase.
IPR014430. Scs7.
PfamiView protein in Pfam
PF00173. Cyt-b5. 1 hit.
PF04116. FA_hydroxylase. 1 hit.
PIRSFiPIRSF005149. IPC-B_HD. 1 hit.
SMARTiView protein in SMART
SM01117. Cyt-b5. 1 hit.
SUPFAMiSSF55856. SSF55856. 1 hit.
PROSITEiView protein in PROSITE
PS50255. CYTOCHROME_B5_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6FUH7_CANGA
AccessioniPrimary (citable) accession number: Q6FUH7
Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2004
Last sequence update: July 19, 2004
Last modified: June 7, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.