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Protein

GMP synthase [glutamine-hydrolyzing]

Gene

GUA1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.

Pathwayi: GMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes GMP from XMP (L-Gln route).
Proteins known to be involved in this subpathway in this organism are:
  1. GMP synthase [glutamine-hydrolyzing] (GUA1)
This subpathway is part of the pathway GMP biosynthesis, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes GMP from XMP (L-Gln route), the pathway GMP biosynthesis and in Purine metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891For GATase activityBy similarity
Active sitei176 – 1761For GATase activityBy similarity
Active sitei178 – 1781For GATase activityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi231 – 2377ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00189; UER00296.

Protein family/group databases

MEROPSiC26.957.

Names & Taxonomyi

Protein namesi
Recommended name:
GMP synthase [glutamine-hydrolyzing] (EC:6.3.5.2)
Alternative name(s):
GMP synthetase
Glutamine amidotransferase
Gene namesi
Name:GUA1
Ordered Locus Names:CAGL0F03927g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome F

Organism-specific databases

CGDiCAL0129288. CAGL0F03927g.
EuPathDBiFungiDB:CAGL0F03927g.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525GMP synthase [glutamine-hydrolyzing]PRO_0000286147Add
BLAST

Proteomic databases

PRIDEiQ6FUF3.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi284593.XP_446141.1.

Structurei

3D structure databases

ProteinModelPortaliQ6FUF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 202190Glutamine amidotransferase type-1Add
BLAST
Domaini203 – 400198GMPS ATP-PPaseAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiKOG1622. Eukaryota.
COG0518. LUCA.
COG0519. LUCA.
HOGENOMiHOG000223964.
InParanoidiQ6FUF3.
KOiK01951.
OMAiMSHGDSV.
OrthoDBiEOG7J70QG.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.40.50.880. 1 hit.
HAMAPiMF_00344. GMP_synthase.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR025777. GMPS_ATP_PPase_dom.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00884. guaA_Cterm. 1 hit.
TIGR00888. guaA_Nterm. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FUF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSIEQVNEV FDTILVLDFG SQYSHLITRR LREFNIYAEM LPCTQKIADL
60 70 80 90 100
HFKPKGVIMS GGPYSVYAED APHVDHAIFD LGVPILGICY GMQELAWING
110 120 130 140 150
KQVARGEKRE YGPATLNVLD KEDALFKNVD HSTVWMSHGD KLHGLPTGFK
160 170 180 190 200
VIATSDNSPY CGIVHESKQI YGIQFHPEVT HSSNGKTLLK NFAVDLCHAK
210 220 230 240 250
QNWTMKNFIG TEVQRIRDLV GPTAEVIGAV SGGVDSTVAS KLMTEAIGDR
260 270 280 290 300
FHAILVDNGV LRLNEAATVK KTLVDGLGIN LTVVDAADEF LDNLKGVTDP
310 320 330 340 350
EKKRKIIGNT FIHVFEREAE KIKPKDGKAI EFLLQGTLYP DVIESISFKG
360 370 380 390 400
PSQTIKTHHN VGGLLENMKL KLIEPLRELF KDEVRELGEL LGISHELVWR
410 420 430 440 450
HPFPGPGIAI RVLGEVTREQ VEIARKADHI YIEEIRKAGL YDKISQAFAC
460 470 480 490 500
LLPVKSVGVM GDQRTYEQVI ALRAIETTDF MTADWYPFEH SFLRKVASRI
510 520
VNEVDGVARV TYDITSKPPA TVEWE
Length:525
Mass (Da):58,584
Last modified:July 19, 2004 - v1
Checksum:i370FEA87F8749EB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380952 Genomic DNA. Translation: CAG59065.1.
RefSeqiXP_446141.1. XM_446141.1.

Genome annotation databases

EnsemblFungiiCAG59065; CAG59065; CAGL0F03927g.
GeneIDi2887636.
KEGGicgr:CAGL0F03927g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380952 Genomic DNA. Translation: CAG59065.1.
RefSeqiXP_446141.1. XM_446141.1.

3D structure databases

ProteinModelPortaliQ6FUF3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284593.XP_446141.1.

Protein family/group databases

MEROPSiC26.957.

Proteomic databases

PRIDEiQ6FUF3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG59065; CAG59065; CAGL0F03927g.
GeneIDi2887636.
KEGGicgr:CAGL0F03927g.

Organism-specific databases

CGDiCAL0129288. CAGL0F03927g.
EuPathDBiFungiDB:CAGL0F03927g.

Phylogenomic databases

eggNOGiKOG1622. Eukaryota.
COG0518. LUCA.
COG0519. LUCA.
HOGENOMiHOG000223964.
InParanoidiQ6FUF3.
KOiK01951.
OMAiMSHGDSV.
OrthoDBiEOG7J70QG.

Enzyme and pathway databases

UniPathwayiUPA00189; UER00296.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.40.50.880. 1 hit.
HAMAPiMF_00344. GMP_synthase.
InterProiIPR029062. Class_I_gatase-like.
IPR017926. GATASE.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR025777. GMPS_ATP_PPase_dom.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
TIGRFAMsiTIGR00884. guaA_Cterm. 1 hit.
TIGR00888. guaA_Nterm. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGUAA_CANGA
AccessioniPrimary (citable) accession number: Q6FUF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 19, 2004
Last modified: June 8, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.