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Q6FUF3 (GUAA_CANGA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
GMP synthase [glutamine-hydrolyzing]
EC=6.3.5.2
Alternative name(s):
GMP synthetase
Glutamine amidotransferase
Gene names
Name:GUA1
Ordered Locus Names:CAGL0F03927g
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier284593 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces

Protein attributes

Sequence length525 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.

Pathway

Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Contains 1 glutamine amidotransferase type-1 domain.

Contains 1 GMPS ATP-PPase (ATP pyrophosphatase) domain.

Ontologies

Keywords
   Biological processGMP biosynthesis
Purine biosynthesis
   Cellular componentCytoplasm
   DomainGlutamine amidotransferase
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processGMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

glutamine metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

GMP synthase (glutamine-hydrolyzing) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 525525GMP synthase [glutamine-hydrolyzing]
PRO_0000286147

Regions

Domain13 – 202190Glutamine amidotransferase type-1
Domain203 – 400198GMPS ATP-PPase
Nucleotide binding231 – 2377ATP By similarity

Sites

Active site891For GATase activity By similarity
Active site1761For GATase activity By similarity
Active site1781For GATase activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6FUF3 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 370FEA87F8749EB0

FASTA52558,584
        10         20         30         40         50         60 
MSSIEQVNEV FDTILVLDFG SQYSHLITRR LREFNIYAEM LPCTQKIADL HFKPKGVIMS 

        70         80         90        100        110        120 
GGPYSVYAED APHVDHAIFD LGVPILGICY GMQELAWING KQVARGEKRE YGPATLNVLD 

       130        140        150        160        170        180 
KEDALFKNVD HSTVWMSHGD KLHGLPTGFK VIATSDNSPY CGIVHESKQI YGIQFHPEVT 

       190        200        210        220        230        240 
HSSNGKTLLK NFAVDLCHAK QNWTMKNFIG TEVQRIRDLV GPTAEVIGAV SGGVDSTVAS 

       250        260        270        280        290        300 
KLMTEAIGDR FHAILVDNGV LRLNEAATVK KTLVDGLGIN LTVVDAADEF LDNLKGVTDP 

       310        320        330        340        350        360 
EKKRKIIGNT FIHVFEREAE KIKPKDGKAI EFLLQGTLYP DVIESISFKG PSQTIKTHHN 

       370        380        390        400        410        420 
VGGLLENMKL KLIEPLRELF KDEVRELGEL LGISHELVWR HPFPGPGIAI RVLGEVTREQ 

       430        440        450        460        470        480 
VEIARKADHI YIEEIRKAGL YDKISQAFAC LLPVKSVGVM GDQRTYEQVI ALRAIETTDF 

       490        500        510        520 
MTADWYPFEH SFLRKVASRI VNEVDGVARV TYDITSKPPA TVEWE

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR380952 Genomic DNA. Translation: CAG59065.1.
RefSeqXP_446141.1. XM_446141.1.

3D structure databases

HSSPHSSP built from PDB template 1GPM based on UniProtKB P04079.
ProteinModelPortalQ6FUF3.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2887636.
GenomeReviewsGene locus CAGL0F03927g in contig CR380952_GR.
KEGGcgr:CAGL0F03927g.

Phylogenomic databases

eggNOGfuNOG07551.
HOGENOMHBG391775.
OMAACEIRID.
OrthoDBEOG4WWVST.

Family and domain databases

InterProIPR017926. GATASE_1.
IPR001674. GMP_synth_C.
IPR004739. GMP_synth_N.
IPR022955. GMP_synthase.
IPR022310. NAD/GMP_synthase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KOK01951.
PfamPF00117. GATase. 1 hit.
PF00958. GMP_synt_C. 1 hit.
PF02540. NAD_synthase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00884. GuaA_Cterm. 1 hit.
TIGR00888. GuaA_Nterm. 1 hit.
PROSITEPS51273. GATASE_TYPE_1. 1 hit.
PS51553. GMPS_ATP_PPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGUAA_CANGA
AccessionPrimary (citable) accession number: Q6FUF3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: July 19, 2004
Last modified: January 25, 2012
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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