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Q6FU50

- LHS1_CANGA

UniProt

Q6FU50 - LHS1_CANGA

Protein

Heat shock protein 70 homolog LHS1

Gene

LHS1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Chaperone required for protein translocation and folding in the endoplasmic reticulum.By similarity

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    GO - Molecular functioni

    1. ATPase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone, Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heat shock protein 70 homolog LHS1 (EC:3.6.1.3)
    Gene namesi
    Name:LHS1
    Ordered Locus Names:CAGL0F06369g
    OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
    Taxonomic identifieri284593 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
    ProteomesiUP000002428: Chromosome F

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum lumen Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Chaini16 – 889874Heat shock protein 70 homolog LHS1PRO_0000013555Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi366 – 3661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi462 – 4621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi502 – 5021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi716 – 7161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi752 – 7521N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ6FU50.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi886 – 8894Prevents secretion from ERSequence Analysis

    Sequence similaritiesi

    Belongs to the heat shock protein 70 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOGENOMiHOG000111144.
    KOiK09486.
    OMAiIDYGQQF.
    OrthoDBiEOG7DC2CX.

    Family and domain databases

    Gene3Di2.60.34.10. 1 hit.
    InterProiIPR018181. Heat_shock_70_CS.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view]
    PfamiPF00012. HSP70. 1 hit.
    [Graphical view]
    PRINTSiPR00301. HEATSHOCK70.
    PROSITEiPS01036. HSP70_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6FU50-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLSILFLFA IAVQAAFLGI DYGQQSIKAM VVSPKAMMEI VLTPEAKRKD    50
    TSGICIRNVN GVLERHYGNS IGSLVTRFPQ NTAMHLRSLL GKSMNDKDTI 100
    ESYLRENPGA NLTSTTRNTI AITIDGVEYP VEQLVAMNLQ EIIDRANQHI 150
    KETDTTGIDF VEQVGIAIPE QFNQAQRQAL LDALALTSVK DEAVLVSDGL 200
    SVAIDYALKR PDLEINVPQY YIVFDVGTSA AKATLFSLTQ PEDLSSPIKI 250
    EIGAFDSEAT VGGSKFIAAI ADIVEDKFLE KNTKITRKSL VENPRARAKI 300
    IQAAEKAKLV LSANNEAIIS IESLVDDIDF RTTIARSEFQ DIFEDNKHTV 350
    VKAIKGAIGN QLWDDNISLE DISGVILSGG SSRVPMVQEE IAKLVGEEKI 400
    LKNVNADETV INGATLKGLK YFGSFKTKPL DITERSLFDY SVEMSGESSS 450
    KTVFEKGTKF PNESSILYKA PKKFGKELKF DLFESDTRIL SNIVDTTVSS 500
    KNWTSACKKG QLYLNVTFDL DSNRVFKIKD ITVLCDSDGN AKEEEFEFID 550
    VINDVTKATD VMPLSNAEIR QLSNAITSWN RKDRERKRVQ ESLNVLEAEL 600
    YDCRSFIEEF EEKLGEEEFE TLKSFTAFVK EKLEYLEDNS ADMSKKDIEK 650
    LVRETRSQRD TLSRFYNSLD AALGSKDFQK LVDTASKSIK KYKEIESKNL 700
    ADLENKAEKF NVIGLNVTEK YNSILSKMSF SSIRRSSEEN IKTLAGLIDE 750
    VNESIKSKAI DDESLENLIK TKLAFEELIN TLDLENRQWT YQHQLVMKEL 800
    KKMYNKKMKA IKKQEKQNEN EENGDDEGDD EDETKTKKYL KEATSSGDSS 850
    TIKEEDSTGS NEAGNKGDEE DEEEEEDDSS AGNVFDDEL 889
    Length:889
    Mass (Da):99,634
    Last modified:July 19, 2004 - v1
    Checksum:i58CD2D752B2DD11F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380952 Genomic DNA. Translation: CAG59168.1.
    RefSeqiXP_446244.1. XM_446244.1.

    Genome annotation databases

    GeneIDi2887859.
    KEGGicgr:CAGL0F06369g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380952 Genomic DNA. Translation: CAG59168.1 .
    RefSeqi XP_446244.1. XM_446244.1.

    3D structure databases

    ProteinModelPortali Q6FU50.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2887859.
    KEGGi cgr:CAGL0F06369g.

    Phylogenomic databases

    HOGENOMi HOG000111144.
    KOi K09486.
    OMAi IDYGQQF.
    OrthoDBi EOG7DC2CX.

    Family and domain databases

    Gene3Di 2.60.34.10. 1 hit.
    InterProi IPR018181. Heat_shock_70_CS.
    IPR029047. HSP70_peptide-bd.
    IPR013126. Hsp_70_fam.
    [Graphical view ]
    Pfami PF00012. HSP70. 1 hit.
    [Graphical view ]
    PRINTSi PR00301. HEATSHOCK70.
    PROSITEi PS01036. HSP70_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiLHS1_CANGA
    AccessioniPrimary (citable) accession number: Q6FU50
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3