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Q6FU50 (LHS1_CANGA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heat shock protein 70 homolog LHS1

EC=3.6.1.3
Gene names
Name:LHS1
Ordered Locus Names:CAGL0F06369g
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier284593 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces

Protein attributes

Sequence length889 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Chaperone required for protein translocation and folding in the endoplasmic reticulum By similarity.

Catalytic activity

ATP + H2O = ADP + phosphate.

Subcellular location

Endoplasmic reticulum lumen By similarity.

Sequence similarities

Belongs to the heat shock protein 70 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainSignal
   LigandATP-binding
Nucleotide-binding
   Molecular functionChaperone
Hydrolase
   PTMGlycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum lumen

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

ATPase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Chain16 – 889874Heat shock protein 70 homolog LHS1
PRO_0000013555

Regions

Motif886 – 8894Prevents secretion from ER Potential

Amino acid modifications

Glycosylation1111N-linked (GlcNAc...) Potential
Glycosylation3661N-linked (GlcNAc...) Potential
Glycosylation4621N-linked (GlcNAc...) Potential
Glycosylation5021N-linked (GlcNAc...) Potential
Glycosylation5151N-linked (GlcNAc...) Potential
Glycosylation7161N-linked (GlcNAc...) Potential
Glycosylation7521N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6FU50 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 58CD2D752B2DD11F

FASTA88999,634
        10         20         30         40         50         60 
MKLSILFLFA IAVQAAFLGI DYGQQSIKAM VVSPKAMMEI VLTPEAKRKD TSGICIRNVN 

        70         80         90        100        110        120 
GVLERHYGNS IGSLVTRFPQ NTAMHLRSLL GKSMNDKDTI ESYLRENPGA NLTSTTRNTI 

       130        140        150        160        170        180 
AITIDGVEYP VEQLVAMNLQ EIIDRANQHI KETDTTGIDF VEQVGIAIPE QFNQAQRQAL 

       190        200        210        220        230        240 
LDALALTSVK DEAVLVSDGL SVAIDYALKR PDLEINVPQY YIVFDVGTSA AKATLFSLTQ 

       250        260        270        280        290        300 
PEDLSSPIKI EIGAFDSEAT VGGSKFIAAI ADIVEDKFLE KNTKITRKSL VENPRARAKI 

       310        320        330        340        350        360 
IQAAEKAKLV LSANNEAIIS IESLVDDIDF RTTIARSEFQ DIFEDNKHTV VKAIKGAIGN 

       370        380        390        400        410        420 
QLWDDNISLE DISGVILSGG SSRVPMVQEE IAKLVGEEKI LKNVNADETV INGATLKGLK 

       430        440        450        460        470        480 
YFGSFKTKPL DITERSLFDY SVEMSGESSS KTVFEKGTKF PNESSILYKA PKKFGKELKF 

       490        500        510        520        530        540 
DLFESDTRIL SNIVDTTVSS KNWTSACKKG QLYLNVTFDL DSNRVFKIKD ITVLCDSDGN 

       550        560        570        580        590        600 
AKEEEFEFID VINDVTKATD VMPLSNAEIR QLSNAITSWN RKDRERKRVQ ESLNVLEAEL 

       610        620        630        640        650        660 
YDCRSFIEEF EEKLGEEEFE TLKSFTAFVK EKLEYLEDNS ADMSKKDIEK LVRETRSQRD 

       670        680        690        700        710        720 
TLSRFYNSLD AALGSKDFQK LVDTASKSIK KYKEIESKNL ADLENKAEKF NVIGLNVTEK 

       730        740        750        760        770        780 
YNSILSKMSF SSIRRSSEEN IKTLAGLIDE VNESIKSKAI DDESLENLIK TKLAFEELIN 

       790        800        810        820        830        840 
TLDLENRQWT YQHQLVMKEL KKMYNKKMKA IKKQEKQNEN EENGDDEGDD EDETKTKKYL 

       850        860        870        880 
KEATSSGDSS TIKEEDSTGS NEAGNKGDEE DEEEEEDDSS AGNVFDDEL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR380952 Genomic DNA. Translation: CAG59168.1.
RefSeqXP_446244.1. XM_446244.1.

3D structure databases

ProteinModelPortalQ6FU50.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2887859.
KEGGcgr:CAGL0F06369g.

Phylogenomic databases

HOGENOMHOG000111144.
KOK09486.
OMAIDYGQQF.
OrthoDBEOG7DC2CX.

Family and domain databases

InterProIPR018181. Heat_shock_70_CS.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSPR00301. HEATSHOCK70.
PROSITEPS01036. HSP70_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLHS1_CANGA
AccessionPrimary (citable) accession number: Q6FU50
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 19, 2004
Last modified: April 16, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families