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Q6FU50

- LHS1_CANGA

UniProt

Q6FU50 - LHS1_CANGA

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Protein
Heat shock protein 70 homolog LHS1
Gene
LHS1, CAGL0F06369g
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Chaperone required for protein translocation and folding in the endoplasmic reticulum By similarity.

Catalytic activityi

ATP + H2O = ADP + phosphate.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 70 homolog LHS1 (EC:3.6.1.3)
Gene namesi
Name:LHS1
Ordered Locus Names:CAGL0F06369g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
ProteomesiUP000002428: Chromosome F

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum lumen Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515 Reviewed prediction
Add
BLAST
Chaini16 – 889874Heat shock protein 70 homolog LHS1
PRO_0000013555Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi111 – 1111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi366 – 3661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi462 – 4621N-linked (GlcNAc...) Reviewed prediction
Glycosylationi502 – 5021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi515 – 5151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi716 – 7161N-linked (GlcNAc...) Reviewed prediction
Glycosylationi752 – 7521N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ6FU50.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi886 – 8894Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000111144.
KOiK09486.
OMAiIDYGQQF.
OrthoDBiEOG7DC2CX.

Family and domain databases

Gene3Di2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
PROSITEiPS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6FU50-1 [UniParc]FASTAAdd to Basket

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MKLSILFLFA IAVQAAFLGI DYGQQSIKAM VVSPKAMMEI VLTPEAKRKD    50
TSGICIRNVN GVLERHYGNS IGSLVTRFPQ NTAMHLRSLL GKSMNDKDTI 100
ESYLRENPGA NLTSTTRNTI AITIDGVEYP VEQLVAMNLQ EIIDRANQHI 150
KETDTTGIDF VEQVGIAIPE QFNQAQRQAL LDALALTSVK DEAVLVSDGL 200
SVAIDYALKR PDLEINVPQY YIVFDVGTSA AKATLFSLTQ PEDLSSPIKI 250
EIGAFDSEAT VGGSKFIAAI ADIVEDKFLE KNTKITRKSL VENPRARAKI 300
IQAAEKAKLV LSANNEAIIS IESLVDDIDF RTTIARSEFQ DIFEDNKHTV 350
VKAIKGAIGN QLWDDNISLE DISGVILSGG SSRVPMVQEE IAKLVGEEKI 400
LKNVNADETV INGATLKGLK YFGSFKTKPL DITERSLFDY SVEMSGESSS 450
KTVFEKGTKF PNESSILYKA PKKFGKELKF DLFESDTRIL SNIVDTTVSS 500
KNWTSACKKG QLYLNVTFDL DSNRVFKIKD ITVLCDSDGN AKEEEFEFID 550
VINDVTKATD VMPLSNAEIR QLSNAITSWN RKDRERKRVQ ESLNVLEAEL 600
YDCRSFIEEF EEKLGEEEFE TLKSFTAFVK EKLEYLEDNS ADMSKKDIEK 650
LVRETRSQRD TLSRFYNSLD AALGSKDFQK LVDTASKSIK KYKEIESKNL 700
ADLENKAEKF NVIGLNVTEK YNSILSKMSF SSIRRSSEEN IKTLAGLIDE 750
VNESIKSKAI DDESLENLIK TKLAFEELIN TLDLENRQWT YQHQLVMKEL 800
KKMYNKKMKA IKKQEKQNEN EENGDDEGDD EDETKTKKYL KEATSSGDSS 850
TIKEEDSTGS NEAGNKGDEE DEEEEEDDSS AGNVFDDEL 889
Length:889
Mass (Da):99,634
Last modified:July 19, 2004 - v1
Checksum:i58CD2D752B2DD11F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380952 Genomic DNA. Translation: CAG59168.1.
RefSeqiXP_446244.1. XM_446244.1.

Genome annotation databases

GeneIDi2887859.
KEGGicgr:CAGL0F06369g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380952 Genomic DNA. Translation: CAG59168.1 .
RefSeqi XP_446244.1. XM_446244.1.

3D structure databases

ProteinModelPortali Q6FU50.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2887859.
KEGGi cgr:CAGL0F06369g.

Phylogenomic databases

HOGENOMi HOG000111144.
KOi K09486.
OMAi IDYGQQF.
OrthoDBi EOG7DC2CX.

Family and domain databases

Gene3Di 2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
PROSITEi PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiLHS1_CANGA
AccessioniPrimary (citable) accession number: Q6FU50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 19, 2004
Last modified: June 11, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3