Reviewed, UniProtKB/Swiss-Prot Q6FU50 (LHS1_CANGA)

Names and origin

Protein names

Recommended name:
    Heat shock protein 70 homolog LHS1
    EC=3.6.1.3

Gene names

Name:	LHS1
Ordered Locus Names:	CAGL0F06369g

Organism

Candida glabrata (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

5478 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces

Protein attributes

Sequence length	889 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Chaperone required for protein translocation and folding in the endoplasmic reticulum By similarity.
Catalytic activity	ATP + H2O = ADP + phosphate.
Subcellular location	Endoplasmic reticulum lumen By similarity.
Sequence similarities	Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Signal
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-KW endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, uncoupled Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	Potential
	Chain	16 – 889	874	Heat shock protein 70 homolog LHS1		PRO_0000013555
Regions
	Motif	886 – 889	4	Prevents secretion from ER Potential
Amino acid modifications
	Glycosylation	111	1	N-linked (GlcNAc...) Potential
	Glycosylation	366	1	N-linked (GlcNAc...) Potential
	Glycosylation	462	1	N-linked (GlcNAc...) Potential
	Glycosylation	502	1	N-linked (GlcNAc...) Potential
	Glycosylation	515	1	N-linked (GlcNAc...) Potential
	Glycosylation	716	1	N-linked (GlcNAc...) Potential
	Glycosylation	752	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6FU50-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 58CD2D752B2DD11F	FASTA	889	99,634
	10 20 30 40 50 60 MKLSILFLFA IAVQAAFLGI DYGQQSIKAM VVSPKAMMEI VLTPEAKRKD TSGICIRNVN 70 80 90 100 110 120 GVLERHYGNS IGSLVTRFPQ NTAMHLRSLL GKSMNDKDTI ESYLRENPGA NLTSTTRNTI 130 140 150 160 170 180 AITIDGVEYP VEQLVAMNLQ EIIDRANQHI KETDTTGIDF VEQVGIAIPE QFNQAQRQAL 190 200 210 220 230 240 LDALALTSVK DEAVLVSDGL SVAIDYALKR PDLEINVPQY YIVFDVGTSA AKATLFSLTQ 250 260 270 280 290 300 PEDLSSPIKI EIGAFDSEAT VGGSKFIAAI ADIVEDKFLE KNTKITRKSL VENPRARAKI 310 320 330 340 350 360 IQAAEKAKLV LSANNEAIIS IESLVDDIDF RTTIARSEFQ DIFEDNKHTV VKAIKGAIGN 370 380 390 400 410 420 QLWDDNISLE DISGVILSGG SSRVPMVQEE IAKLVGEEKI LKNVNADETV INGATLKGLK 430 440 450 460 470 480 YFGSFKTKPL DITERSLFDY SVEMSGESSS KTVFEKGTKF PNESSILYKA PKKFGKELKF 490 500 510 520 530 540 DLFESDTRIL SNIVDTTVSS KNWTSACKKG QLYLNVTFDL DSNRVFKIKD ITVLCDSDGN 550 560 570 580 590 600 AKEEEFEFID VINDVTKATD VMPLSNAEIR QLSNAITSWN RKDRERKRVQ ESLNVLEAEL 610 620 630 640 650 660 YDCRSFIEEF EEKLGEEEFE TLKSFTAFVK EKLEYLEDNS ADMSKKDIEK LVRETRSQRD 670 680 690 700 710 720 TLSRFYNSLD AALGSKDFQK LVDTASKSIK KYKEIESKNL ADLENKAEKF NVIGLNVTEK 730 740 750 760 770 780 YNSILSKMSF SSIRRSSEEN IKTLAGLIDE VNESIKSKAI DDESLENLIK TKLAFEELIN 790 800 810 820 830 840 TLDLENRQWT YQHQLVMKEL KKMYNKKMKA IKKQEKQNEN EENGDDEGDD EDETKTKKYL 850 860 870 880 KEATSSGDSS TIKEEDSTGS NEAGNKGDEE DEEEEEDDSS AGNVFDDEL

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / IFO 0622 / NRRL Y-65.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR380952 Genomic DNA. Translation: CAG59168.1.
RefSeq	XP_446244.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2887859.
KEGG	cgr:CAGL0F06369g.
Phylogenomic databases
HOGENOM	Q6FU50.
OMA	Q6FU50. KSVNTDE.
Family and domain databases
InterPro	IPR018181. Heat_shock_70_CS. IPR001023. Hsp70. IPR013126. Hsp_70. [Graphical view]
PANTHER	PTHR19375. Hsp70. 1 hit.
Pfam	PF00012. HSP70. 1 hit. [Graphical view]
PRINTS	PR00301. HEATSHOCK70.
PROSITE	PS00297. HSP70_1. False negative. PS00329. HSP70_2. False negative. PS01036. HSP70_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LHS1_CANGA

Accession

Primary (citable) accession number: Q6FU50

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	July 19, 2004
Last modified:	June 16, 2009
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)