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Q6FU50

- LHS1_CANGA

UniProt

Q6FU50 - LHS1_CANGA

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Protein

Heat shock protein 70 homolog LHS1

Gene

LHS1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Chaperone required for protein translocation and folding in the endoplasmic reticulum.By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

GO - Molecular functioni

  1. ATPase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 70 homolog LHS1 (EC:3.6.1.3)
Gene namesi
Name:LHS1
Ordered Locus Names:CAGL0F06369g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428: Chromosome F

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence AnalysisAdd
BLAST
Chaini16 – 889874Heat shock protein 70 homolog LHS1PRO_0000013555Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi366 – 3661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi462 – 4621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi502 – 5021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi515 – 5151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi716 – 7161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi752 – 7521N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ6FU50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi886 – 8894Prevents secretion from ERSequence Analysis

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000111144.
InParanoidiQ6FU50.
KOiK09486.
OMAiIDYGQQF.
OrthoDBiEOG7DC2CX.

Family and domain databases

Gene3Di2.60.34.10. 1 hit.
InterProiIPR018181. Heat_shock_70_CS.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view]
PfamiPF00012. HSP70. 1 hit.
[Graphical view]
PRINTSiPR00301. HEATSHOCK70.
PROSITEiPS01036. HSP70_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6FU50-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLSILFLFA IAVQAAFLGI DYGQQSIKAM VVSPKAMMEI VLTPEAKRKD
60 70 80 90 100
TSGICIRNVN GVLERHYGNS IGSLVTRFPQ NTAMHLRSLL GKSMNDKDTI
110 120 130 140 150
ESYLRENPGA NLTSTTRNTI AITIDGVEYP VEQLVAMNLQ EIIDRANQHI
160 170 180 190 200
KETDTTGIDF VEQVGIAIPE QFNQAQRQAL LDALALTSVK DEAVLVSDGL
210 220 230 240 250
SVAIDYALKR PDLEINVPQY YIVFDVGTSA AKATLFSLTQ PEDLSSPIKI
260 270 280 290 300
EIGAFDSEAT VGGSKFIAAI ADIVEDKFLE KNTKITRKSL VENPRARAKI
310 320 330 340 350
IQAAEKAKLV LSANNEAIIS IESLVDDIDF RTTIARSEFQ DIFEDNKHTV
360 370 380 390 400
VKAIKGAIGN QLWDDNISLE DISGVILSGG SSRVPMVQEE IAKLVGEEKI
410 420 430 440 450
LKNVNADETV INGATLKGLK YFGSFKTKPL DITERSLFDY SVEMSGESSS
460 470 480 490 500
KTVFEKGTKF PNESSILYKA PKKFGKELKF DLFESDTRIL SNIVDTTVSS
510 520 530 540 550
KNWTSACKKG QLYLNVTFDL DSNRVFKIKD ITVLCDSDGN AKEEEFEFID
560 570 580 590 600
VINDVTKATD VMPLSNAEIR QLSNAITSWN RKDRERKRVQ ESLNVLEAEL
610 620 630 640 650
YDCRSFIEEF EEKLGEEEFE TLKSFTAFVK EKLEYLEDNS ADMSKKDIEK
660 670 680 690 700
LVRETRSQRD TLSRFYNSLD AALGSKDFQK LVDTASKSIK KYKEIESKNL
710 720 730 740 750
ADLENKAEKF NVIGLNVTEK YNSILSKMSF SSIRRSSEEN IKTLAGLIDE
760 770 780 790 800
VNESIKSKAI DDESLENLIK TKLAFEELIN TLDLENRQWT YQHQLVMKEL
810 820 830 840 850
KKMYNKKMKA IKKQEKQNEN EENGDDEGDD EDETKTKKYL KEATSSGDSS
860 870 880
TIKEEDSTGS NEAGNKGDEE DEEEEEDDSS AGNVFDDEL
Length:889
Mass (Da):99,634
Last modified:July 19, 2004 - v1
Checksum:i58CD2D752B2DD11F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380952 Genomic DNA. Translation: CAG59168.1.
RefSeqiXP_446244.1. XM_446244.1.

Genome annotation databases

GeneIDi2887859.
KEGGicgr:CAGL0F06369g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380952 Genomic DNA. Translation: CAG59168.1 .
RefSeqi XP_446244.1. XM_446244.1.

3D structure databases

ProteinModelPortali Q6FU50.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2887859.
KEGGi cgr:CAGL0F06369g.

Phylogenomic databases

HOGENOMi HOG000111144.
InParanoidi Q6FU50.
KOi K09486.
OMAi IDYGQQF.
OrthoDBi EOG7DC2CX.

Family and domain databases

Gene3Di 2.60.34.10. 1 hit.
InterProi IPR018181. Heat_shock_70_CS.
IPR029047. HSP70_peptide-bd.
IPR013126. Hsp_70_fam.
[Graphical view ]
Pfami PF00012. HSP70. 1 hit.
[Graphical view ]
PRINTSi PR00301. HEATSHOCK70.
PROSITEi PS01036. HSP70_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiLHS1_CANGA
AccessioniPrimary (citable) accession number: Q6FU50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 19, 2004
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3