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Q6FTW5

- GCN5_CANGA

UniProt

Q6FTW5 - GCN5_CANGA

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Protein

Histone acetyltransferase GCN5

Gene
GCN5, CAGL0F08283g
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation By similarity.

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei280 – 2801Important for catalytic activity By similarity

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase GCN5 (EC:2.3.1.48)
Gene namesi
Name:GCN5
Ordered Locus Names:CAGL0F08283g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
ProteomesiUP000002428: Chromosome F

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 546546Histone acetyltransferase GCN5PRO_0000211196Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6FTW5.
SMRiQ6FTW5. Positions 206-369, 436-545.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini207 – 362156N-acetyltransferaseAdd
BLAST
Domaini451 – 52171BromoAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi37 – 208172Glu-richAdd
BLAST
Compositional biasi45 – 11571Asp-richAdd
BLAST

Sequence similaritiesi

Contains 1 bromo domain.

Keywords - Domaini

Bromodomain

Phylogenomic databases

HOGENOMiHOG000192257.
KOiK06062.
OMAiAKSENND.
OrthoDBiEOG7XM37B.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF13508. Acetyltransf_7. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 1 hit.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FTW5-1 [UniParc]FASTAAdd to Basket

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MVTRRRLHHP EVEQVSKRQK VDKAESKNKK HADVAAERGE QSTEDHEDES    50
QDKKDKKVVG DNRDEDEEVS PNGQEAAEDN DDRKDKDAKE KDTETNDEGT 100
EKSHTDVNDD DDDVDESKEE DAAAAVDITK EKKDEQESDN KTEEKKVQEN 150
EEEEEEDENK NDEDVEELGS TEPVDDEKKG LVKFEFDGVE YKFKERASVI 200
EENEGKIEFR VVSNDNTREN MMVLTGLKNI FQKQLPKMPK EYIARLVYDR 250
SHLSMAVIRK PLTVVGGITY KPFNKRQFAE IVFCAISSTE QVRGYGAHLM 300
NHLKDYVRNT SDIRYFLTYA DNYAIGYFKK QGFTKDITLD KKVWMGYIKD 350
YEGGTLMQCS MLPRIRYLDA AKILLLQEAA LRRKIRTISK SHVVHPGLEC 400
FNDIENIKPI DPMSIPGLKE AGWTPEMDEL AQRPKRGPHY AAIQNILVEL 450
QNHAAAWPFL RPVNKEEVPD YYEFIKEPMD LSTMELKLEN NKYEKMEEFI 500
YDARLVCNNC RLYNGENTSY YKYANRLEKF FNNKVKEIPE YSHLID 546
Length:546
Mass (Da):63,512
Last modified:July 19, 2004 - v1
Checksum:i977FDACF889D0189
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380952 Genomic DNA. Translation: CAG59253.1.
RefSeqiXP_446329.1. XM_446329.1.

Genome annotation databases

GeneIDi2887572.
KEGGicgr:CAGL0F08283g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380952 Genomic DNA. Translation: CAG59253.1 .
RefSeqi XP_446329.1. XM_446329.1.

3D structure databases

ProteinModelPortali Q6FTW5.
SMRi Q6FTW5. Positions 206-369, 436-545.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2887572.
KEGGi cgr:CAGL0F08283g.

Phylogenomic databases

HOGENOMi HOG000192257.
KOi K06062.
OMAi AKSENND.
OrthoDBi EOG7XM37B.

Family and domain databases

Gene3Di 1.20.920.10. 1 hit.
3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR000182. GNAT_dom.
[Graphical view ]
Pfami PF13508. Acetyltransf_7. 1 hit.
PF00439. Bromodomain. 1 hit.
[Graphical view ]
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00297. BROMO. 1 hit.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 1 hit.
SSF55729. SSF55729. 1 hit.
PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiGCN5_CANGA
AccessioniPrimary (citable) accession number: Q6FTW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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