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Q6FTW5

- GCN5_CANGA

UniProt

Q6FTW5 - GCN5_CANGA

Protein

Histone acetyltransferase GCN5

Gene

GCN5

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei280 – 2801Important for catalytic activityBy similarity

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone acetyltransferase GCN5 (EC:2.3.1.48)
    Gene namesi
    Name:GCN5
    Ordered Locus Names:CAGL0F08283g
    OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
    Taxonomic identifieri284593 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
    ProteomesiUP000002428: Chromosome F

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 546546Histone acetyltransferase GCN5PRO_0000211196Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6FTW5.
    SMRiQ6FTW5. Positions 206-369, 436-545.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini207 – 362156N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST
    Domaini451 – 52171BromoPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi37 – 208172Glu-richAdd
    BLAST
    Compositional biasi45 – 11571Asp-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 bromo domain.PROSITE-ProRule annotation
    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Bromodomain

    Phylogenomic databases

    HOGENOMiHOG000192257.
    KOiK06062.
    OMAiAKSENND.
    OrthoDBiEOG7XM37B.

    Family and domain databases

    Gene3Di1.20.920.10. 1 hit.
    3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR000182. GNAT_dom.
    [Graphical view]
    PfamiPF13508. Acetyltransf_7. 1 hit.
    PF00439. Bromodomain. 1 hit.
    [Graphical view]
    PRINTSiPR00503. BROMODOMAIN.
    SMARTiSM00297. BROMO. 1 hit.
    [Graphical view]
    SUPFAMiSSF47370. SSF47370. 1 hit.
    SSF55729. SSF55729. 1 hit.
    PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6FTW5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTRRRLHHP EVEQVSKRQK VDKAESKNKK HADVAAERGE QSTEDHEDES    50
    QDKKDKKVVG DNRDEDEEVS PNGQEAAEDN DDRKDKDAKE KDTETNDEGT 100
    EKSHTDVNDD DDDVDESKEE DAAAAVDITK EKKDEQESDN KTEEKKVQEN 150
    EEEEEEDENK NDEDVEELGS TEPVDDEKKG LVKFEFDGVE YKFKERASVI 200
    EENEGKIEFR VVSNDNTREN MMVLTGLKNI FQKQLPKMPK EYIARLVYDR 250
    SHLSMAVIRK PLTVVGGITY KPFNKRQFAE IVFCAISSTE QVRGYGAHLM 300
    NHLKDYVRNT SDIRYFLTYA DNYAIGYFKK QGFTKDITLD KKVWMGYIKD 350
    YEGGTLMQCS MLPRIRYLDA AKILLLQEAA LRRKIRTISK SHVVHPGLEC 400
    FNDIENIKPI DPMSIPGLKE AGWTPEMDEL AQRPKRGPHY AAIQNILVEL 450
    QNHAAAWPFL RPVNKEEVPD YYEFIKEPMD LSTMELKLEN NKYEKMEEFI 500
    YDARLVCNNC RLYNGENTSY YKYANRLEKF FNNKVKEIPE YSHLID 546
    Length:546
    Mass (Da):63,512
    Last modified:July 19, 2004 - v1
    Checksum:i977FDACF889D0189
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380952 Genomic DNA. Translation: CAG59253.1.
    RefSeqiXP_446329.1. XM_446329.1.

    Genome annotation databases

    GeneIDi2887572.
    KEGGicgr:CAGL0F08283g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380952 Genomic DNA. Translation: CAG59253.1 .
    RefSeqi XP_446329.1. XM_446329.1.

    3D structure databases

    ProteinModelPortali Q6FTW5.
    SMRi Q6FTW5. Positions 206-369, 436-545.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2887572.
    KEGGi cgr:CAGL0F08283g.

    Phylogenomic databases

    HOGENOMi HOG000192257.
    KOi K06062.
    OMAi AKSENND.
    OrthoDBi EOG7XM37B.

    Family and domain databases

    Gene3Di 1.20.920.10. 1 hit.
    3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR001487. Bromodomain.
    IPR018359. Bromodomain_CS.
    IPR000182. GNAT_dom.
    [Graphical view ]
    Pfami PF13508. Acetyltransf_7. 1 hit.
    PF00439. Bromodomain. 1 hit.
    [Graphical view ]
    PRINTSi PR00503. BROMODOMAIN.
    SMARTi SM00297. BROMO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47370. SSF47370. 1 hit.
    SSF55729. SSF55729. 1 hit.
    PROSITEi PS00633. BROMODOMAIN_1. 1 hit.
    PS50014. BROMODOMAIN_2. 1 hit.
    PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiGCN5_CANGA
    AccessioniPrimary (citable) accession number: Q6FTW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3