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Protein

Histone acetyltransferase GCN5

Gene

GCN5

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation. Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei280Proton donor/acceptorBy similarity1
Sitei280Important for catalytic activityBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Acyltransferase, Chromatin regulator, Transferase
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase GCN5 (EC:2.3.1.48)
Gene namesi
Name:GCN5
Ordered Locus Names:CAGL0F08283g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome F

Organism-specific databases

CGDiCAL0131206 GCN5
EuPathDBiFungiDB:CAGL0F08283g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002111961 – 546Histone acetyltransferase GCN5Add BLAST546

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi284593.XP_446329.1

Structurei

3D structure databases

ProteinModelPortaliQ6FTW5
SMRiQ6FTW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini207 – 362N-acetyltransferasePROSITE-ProRule annotationAdd BLAST156
Domaini451 – 521BromoPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni284 – 286Acetyl-CoA bindingBy similarity3
Regioni291 – 297Acetyl-CoA bindingBy similarity7
Regioni323 – 326Acetyl-CoA bindingBy similarity4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi37 – 208Glu-richAdd BLAST172
Compositional biasi45 – 115Asp-richAdd BLAST71

Sequence similaritiesi

Keywords - Domaini

Bromodomain

Phylogenomic databases

eggNOGiKOG1472 Eukaryota
COG5076 LUCA
HOGENOMiHOG000192257
InParanoidiQ6FTW5
KOiK06062
OMAiIQSRIQI
OrthoDBiEOG092C0SVC

Family and domain databases

Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR016181 Acyl_CoA_acyltransferase
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR037800 GCN5
IPR000182 GNAT_dom
PANTHERiPTHR22880:SF124 PTHR22880:SF124, 1 hit
PfamiView protein in Pfam
PF00583 Acetyltransf_1, 1 hit
PF00439 Bromodomain, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
SSF55729 SSF55729, 1 hit
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS51186 GNAT, 1 hit

Sequencei

Sequence statusi: Complete.

Q6FTW5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTRRRLHHP EVEQVSKRQK VDKAESKNKK HADVAAERGE QSTEDHEDES
60 70 80 90 100
QDKKDKKVVG DNRDEDEEVS PNGQEAAEDN DDRKDKDAKE KDTETNDEGT
110 120 130 140 150
EKSHTDVNDD DDDVDESKEE DAAAAVDITK EKKDEQESDN KTEEKKVQEN
160 170 180 190 200
EEEEEEDENK NDEDVEELGS TEPVDDEKKG LVKFEFDGVE YKFKERASVI
210 220 230 240 250
EENEGKIEFR VVSNDNTREN MMVLTGLKNI FQKQLPKMPK EYIARLVYDR
260 270 280 290 300
SHLSMAVIRK PLTVVGGITY KPFNKRQFAE IVFCAISSTE QVRGYGAHLM
310 320 330 340 350
NHLKDYVRNT SDIRYFLTYA DNYAIGYFKK QGFTKDITLD KKVWMGYIKD
360 370 380 390 400
YEGGTLMQCS MLPRIRYLDA AKILLLQEAA LRRKIRTISK SHVVHPGLEC
410 420 430 440 450
FNDIENIKPI DPMSIPGLKE AGWTPEMDEL AQRPKRGPHY AAIQNILVEL
460 470 480 490 500
QNHAAAWPFL RPVNKEEVPD YYEFIKEPMD LSTMELKLEN NKYEKMEEFI
510 520 530 540
YDARLVCNNC RLYNGENTSY YKYANRLEKF FNNKVKEIPE YSHLID
Length:546
Mass (Da):63,512
Last modified:July 19, 2004 - v1
Checksum:i977FDACF889D0189
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380952 Genomic DNA Translation: CAG59253.1
RefSeqiXP_446329.1, XM_446329.1

Genome annotation databases

EnsemblFungiiCAG59253; CAG59253; CAGL0F08283g
GeneIDi2887572
KEGGicgr:CAGL0F08283g

Similar proteinsi

Entry informationi

Entry nameiGCN5_CANGA
AccessioniPrimary (citable) accession number: Q6FTW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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