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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei181 – 1811PROSITE-ProRule annotation
Active sitei376 – 3761PROSITE-ProRule annotation
Active sitei441 – 4411PROSITE-ProRule annotation

GO - Molecular functioni

  1. serine-type carboxypeptidase activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
Ordered Locus Names:CAGL0G01232g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428: Chromosome G

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 599580LumenalSequence AnalysisAdd
BLAST
Transmembranei600 – 62021HelicalSequence AnalysisAdd
BLAST
Topological domaini621 – 730110CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 730711Pheromone-processing carboxypeptidase KEX1PRO_0000411910Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
Glycosylationi497 – 4971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi507 – 5071N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ6FTM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi536 – 55924Poly-AspAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000113220.
InParanoidiQ6FTM9.
KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6FTM9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLHATVLPIL LWLATLAYGF DRKEFLVDGN ELPGFTKLKN TKHWTVPKMY
60 70 80 90 100
AGHLPATRDN DTQYFFWKFE NKKTKKNDET PLIIWLNGGP GCSSMAGALM
110 120 130 140 150
EIGPFRLNKK AEVIKNDGSW HMRGSVLFLD QPVGTGFSYS KEDNEVSELD
160 170 180 190 200
EVADNFMVFL QNYYATFPDD KDRELILAGE SYAGQFIPYF TKAIIKFNEQ
210 220 230 240 250
QRDENSKINI KVMFIGNGWL DPKRQYLSYV PFSLEKGIIK KEDPAFKDIL
260 270 280 290 300
KQHETCQNYI NSDHTGHSEL SYPPCEAVLG KIISQDKTQC INVYKFDEYD
310 320 330 340 350
SYPSCGLEWP VDTKFTKQFL TDKKVLAALH ANDERSWIEC RPDVKLENIK
360 370 380 390 400
AKPAIELIPS LLESGIELIL FNGNKDLICN TLGIDNVLKH LQWEGETGFT
410 420 430 440 450
DEVQIFDWVY RDDLKSDKEK VAGTVKYERQ LTLITIEDGS HMVSYDKALI
460 470 480 490 500
SRGILDMYYD DVLLVHRDGK DTLISSKDGD IDGYLEDDKS QDENKDNESE
510 520 530 540 550
DESEDENDSD DESDGKEGDK QENKPDDSDD ESDEEDDDED EDDEDDDDDD
560 570 580 590 600
DDDDGDDEDK KGDQNSHPSH GDMNGGLDND LETGGEYYQD EDEEGSNFKA
610 620 630 640 650
FFLILSLVSA FIIVAAFYIS DYIKSRRHPI LVDGDGRSRL NKSVTWASDI
660 670 680 690 700
ENGSFDIEDD DPEFGTEGME DNMELEDVFS IDEEDEEQLE GVVPESTRKS
710 720 730
KKGSKKKGKY FSVPNDDSAE DIELQDIERH
Length:730
Mass (Da):83,259
Last modified:July 19, 2004 - v1
Checksum:i4033FFE7B7965132
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380953 Genomic DNA. Translation: CAG59342.1.
RefSeqiXP_446415.1. XM_446415.1.

Genome annotation databases

GeneIDi2888423.
KEGGicgr:CAGL0G01232g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380953 Genomic DNA. Translation: CAG59342.1.
RefSeqiXP_446415.1. XM_446415.1.

3D structure databases

ProteinModelPortaliQ6FTM9.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS10.007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2888423.
KEGGicgr:CAGL0G01232g.

Phylogenomic databases

HOGENOMiHOG000113220.
InParanoidiQ6FTM9.
KOiK01288.
OrthoDBiEOG7TJ3SJ.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Peptidase_S10_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_CANGA
AccessioniPrimary (citable) accession number: Q6FTM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 19, 2004
Last modified: January 7, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.