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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei181PROSITE-ProRule annotation1
Active sitei376PROSITE-ProRule annotation1
Active sitei441PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCarboxypeptidase, Hydrolase, Protease
Biological processApoptosis

Protein family/group databases

ESTHERicanga-q6ftm9 Carboxypeptidase_S10
MEROPSiS10.007

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
Ordered Locus Names:CAGL0G01232g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome G

Organism-specific databases

CGDiCAL0130288 CAGL0G01232g
EuPathDBiFungiDB:CAGL0G01232g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 599LumenalSequence analysisAdd BLAST580
Transmembranei600 – 620HelicalSequence analysisAdd BLAST21
Topological domaini621 – 730CytoplasmicSequence analysisAdd BLAST110

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000041191020 – 730Pheromone-processing carboxypeptidase KEX1Add BLAST711

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi60N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi497N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi507N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ6FTM9

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_446415.1

Structurei

3D structure databases

ProteinModelPortaliQ6FTM9
SMRiQ6FTM9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi536 – 559Poly-AspAdd BLAST24

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1282 Eukaryota
COG2939 LUCA
HOGENOMiHOG000113220
InParanoidiQ6FTM9
KOiK01288
OrthoDBiEOG092C255X

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR001563 Peptidase_S10
IPR018202 Ser_caboxypep_ser_AS
PANTHERiPTHR11802 PTHR11802, 1 hit
PfamiView protein in Pfam
PF00450 Peptidase_S10, 1 hit
PRINTSiPR00724 CRBOXYPTASEC
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00131 CARBOXYPEPT_SER_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6FTM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHATVLPIL LWLATLAYGF DRKEFLVDGN ELPGFTKLKN TKHWTVPKMY
60 70 80 90 100
AGHLPATRDN DTQYFFWKFE NKKTKKNDET PLIIWLNGGP GCSSMAGALM
110 120 130 140 150
EIGPFRLNKK AEVIKNDGSW HMRGSVLFLD QPVGTGFSYS KEDNEVSELD
160 170 180 190 200
EVADNFMVFL QNYYATFPDD KDRELILAGE SYAGQFIPYF TKAIIKFNEQ
210 220 230 240 250
QRDENSKINI KVMFIGNGWL DPKRQYLSYV PFSLEKGIIK KEDPAFKDIL
260 270 280 290 300
KQHETCQNYI NSDHTGHSEL SYPPCEAVLG KIISQDKTQC INVYKFDEYD
310 320 330 340 350
SYPSCGLEWP VDTKFTKQFL TDKKVLAALH ANDERSWIEC RPDVKLENIK
360 370 380 390 400
AKPAIELIPS LLESGIELIL FNGNKDLICN TLGIDNVLKH LQWEGETGFT
410 420 430 440 450
DEVQIFDWVY RDDLKSDKEK VAGTVKYERQ LTLITIEDGS HMVSYDKALI
460 470 480 490 500
SRGILDMYYD DVLLVHRDGK DTLISSKDGD IDGYLEDDKS QDENKDNESE
510 520 530 540 550
DESEDENDSD DESDGKEGDK QENKPDDSDD ESDEEDDDED EDDEDDDDDD
560 570 580 590 600
DDDDGDDEDK KGDQNSHPSH GDMNGGLDND LETGGEYYQD EDEEGSNFKA
610 620 630 640 650
FFLILSLVSA FIIVAAFYIS DYIKSRRHPI LVDGDGRSRL NKSVTWASDI
660 670 680 690 700
ENGSFDIEDD DPEFGTEGME DNMELEDVFS IDEEDEEQLE GVVPESTRKS
710 720 730
KKGSKKKGKY FSVPNDDSAE DIELQDIERH
Length:730
Mass (Da):83,259
Last modified:July 19, 2004 - v1
Checksum:i4033FFE7B7965132
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380953 Genomic DNA Translation: CAG59342.1
RefSeqiXP_446415.1, XM_446415.1

Genome annotation databases

EnsemblFungiiCAG59342; CAG59342; CAGL0G01232g
GeneIDi2888423
KEGGicgr:CAGL0G01232g

Similar proteinsi

Entry informationi

Entry nameiKEX1_CANGA
AccessioniPrimary (citable) accession number: Q6FTM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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