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Protein

Pheromone-processing carboxypeptidase KEX1

Gene

KEX1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).By similarity

Catalytic activityi

Preferential release of a C-terminal arginine or lysine residue.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei181PROSITE-ProRule annotation1
Active sitei376PROSITE-ProRule annotation1
Active sitei441PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Protease

Keywords - Biological processi

Apoptosis

Protein family/group databases

ESTHERicanga-q6ftm9. Carboxypeptidase_S10.
MEROPSiS10.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-processing carboxypeptidase KEX1 (EC:3.4.16.6)
Alternative name(s):
Carboxypeptidase D
Gene namesi
Name:KEX1
Ordered Locus Names:CAGL0G01232g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome G

Organism-specific databases

CGDiCAL0130288. CAGL0G01232g.
EuPathDBiFungiDB:CAGL0G01232g.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 599LumenalSequence analysisAdd BLAST580
Transmembranei600 – 620HelicalSequence analysisAdd BLAST21
Topological domaini621 – 730CytoplasmicSequence analysisAdd BLAST110

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000041191020 – 730Pheromone-processing carboxypeptidase KEX1Add BLAST711

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi60N-linked (GlcNAc...)Sequence analysis1
Glycosylationi497N-linked (GlcNAc...)Sequence analysis1
Glycosylationi507N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_446415.1.

Structurei

3D structure databases

ProteinModelPortaliQ6FTM9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi536 – 559Poly-AspAdd BLAST24

Sequence similaritiesi

Belongs to the peptidase S10 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
HOGENOMiHOG000113220.
InParanoidiQ6FTM9.
KOiK01288.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6FTM9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHATVLPIL LWLATLAYGF DRKEFLVDGN ELPGFTKLKN TKHWTVPKMY
60 70 80 90 100
AGHLPATRDN DTQYFFWKFE NKKTKKNDET PLIIWLNGGP GCSSMAGALM
110 120 130 140 150
EIGPFRLNKK AEVIKNDGSW HMRGSVLFLD QPVGTGFSYS KEDNEVSELD
160 170 180 190 200
EVADNFMVFL QNYYATFPDD KDRELILAGE SYAGQFIPYF TKAIIKFNEQ
210 220 230 240 250
QRDENSKINI KVMFIGNGWL DPKRQYLSYV PFSLEKGIIK KEDPAFKDIL
260 270 280 290 300
KQHETCQNYI NSDHTGHSEL SYPPCEAVLG KIISQDKTQC INVYKFDEYD
310 320 330 340 350
SYPSCGLEWP VDTKFTKQFL TDKKVLAALH ANDERSWIEC RPDVKLENIK
360 370 380 390 400
AKPAIELIPS LLESGIELIL FNGNKDLICN TLGIDNVLKH LQWEGETGFT
410 420 430 440 450
DEVQIFDWVY RDDLKSDKEK VAGTVKYERQ LTLITIEDGS HMVSYDKALI
460 470 480 490 500
SRGILDMYYD DVLLVHRDGK DTLISSKDGD IDGYLEDDKS QDENKDNESE
510 520 530 540 550
DESEDENDSD DESDGKEGDK QENKPDDSDD ESDEEDDDED EDDEDDDDDD
560 570 580 590 600
DDDDGDDEDK KGDQNSHPSH GDMNGGLDND LETGGEYYQD EDEEGSNFKA
610 620 630 640 650
FFLILSLVSA FIIVAAFYIS DYIKSRRHPI LVDGDGRSRL NKSVTWASDI
660 670 680 690 700
ENGSFDIEDD DPEFGTEGME DNMELEDVFS IDEEDEEQLE GVVPESTRKS
710 720 730
KKGSKKKGKY FSVPNDDSAE DIELQDIERH
Length:730
Mass (Da):83,259
Last modified:July 19, 2004 - v1
Checksum:i4033FFE7B7965132
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380953 Genomic DNA. Translation: CAG59342.1.
RefSeqiXP_446415.1. XM_446415.1.

Genome annotation databases

EnsemblFungiiCAG59342; CAG59342; CAGL0G01232g.
GeneIDi2888423.
KEGGicgr:CAGL0G01232g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380953 Genomic DNA. Translation: CAG59342.1.
RefSeqiXP_446415.1. XM_446415.1.

3D structure databases

ProteinModelPortaliQ6FTM9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284593.XP_446415.1.

Protein family/group databases

ESTHERicanga-q6ftm9. Carboxypeptidase_S10.
MEROPSiS10.007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG59342; CAG59342; CAGL0G01232g.
GeneIDi2888423.
KEGGicgr:CAGL0G01232g.

Organism-specific databases

CGDiCAL0130288. CAGL0G01232g.
EuPathDBiFungiDB:CAGL0G01232g.

Phylogenomic databases

eggNOGiKOG1282. Eukaryota.
COG2939. LUCA.
HOGENOMiHOG000113220.
InParanoidiQ6FTM9.
KOiK01288.
OrthoDBiEOG092C255X.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001563. Peptidase_S10.
IPR018202. Ser_caboxypep_ser_AS.
[Graphical view]
PANTHERiPTHR11802. PTHR11802. 1 hit.
PfamiPF00450. Peptidase_S10. 1 hit.
[Graphical view]
PRINTSiPR00724. CRBOXYPTASEC.
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS00131. CARBOXYPEPT_SER_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKEX1_CANGA
AccessioniPrimary (citable) accession number: Q6FTM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 19, 2004
Last modified: September 7, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.