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Protein

DNA polymerase epsilon subunit B

Gene

DPB2

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

DNA polymerase II participates in chromosomal DNA replication.

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase epsilon subunit B (EC:2.7.7.7)
Alternative name(s):
DNA polymerase II subunit 2
Gene namesi
Name:DPB2
Ordered Locus Names:CAGL0G09801g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome G

Organism-specific databases

CGDiCAL0137567. CAGL0G09801g.
EuPathDBiFungiDB:CAGL0G09801g.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 719719DNA polymerase epsilon subunit BPRO_0000071567Add
BLAST

Interactioni

Subunit structurei

Heterotetramer. Consists of four subunits: POL2, DPB2, DPB3 and DPB4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi284593.XP_446786.1.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi277 – 2837Poly-Asn

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3818. Eukaryota.
ENOG410XP7N. LUCA.
HOGENOMiHOG000246706.
InParanoidiQ6FSK8.
KOiK02325.
OrthoDBiEOG7XH6ZR.

Family and domain databases

InterProiIPR007185. DNA_pol_alpha/epsilon_bsu.
[Graphical view]
PfamiPF04042. DNA_pol_E_B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FSK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTSGKVLPT KIQPPLLRPM AYRVLSKKYG LSIKSDGLAA LSDFIGSTFG
60 70 80 90 100
MDWKRNPDTI KFLEVFATVW KQQERGLFVD STGVKDVINE LKEREKATLQ
110 120 130 140 150
ESQNMASIPP KTKTYNNGGG KTTTIDRFLT KRPSPSDNDE GPLDQSIDDI
160 170 180 190 200
PVSQATQIDE EELPMAQEIS DQISSPARDQ TPEEEFDNRI LNWRDYFRII
210 220 230 240 250
NTTDQKKFSY NPVKRQIFYQ PPKDQLKSVL KIPNAQAKTD LFRTRYFLTR
260 270 280 290 300
DRLLRNESFQ SSHDTFNPLS SMIQLKNNIN NNNQDDTPTG LSITQIKNLL
310 320 330 340 350
GRDGQNFLIL GVLKMNPKGQ WSLEDASGSI DIDISQTLPS PGLFYIPGAI
360 370 380 390 400
VLAEGIYYTV GHTFAVTSMT FPPGERRDKT LDHIGNLDLL GIHGTEKSSY
410 420 430 440 450
IPRLDNEIKI RLHLLEQDLT HQKFVLLGGD LFLDDQHVMD GLKKVFTKLD
460 470 480 490 500
QEAPTVIVLF GSFSSFPVHA AMSSKNISST TEYKNNFDSL AEMLSQFENI
510 520 530 540 550
INHTHVVLIP GPHDPWVSLC SLGANGSLPQ SSIPTHFSKR MNKICKNITW
560 570 580 590 600
ASNPTRIAYL SQEIVLFRDN FLELCKRHQI LFPVVESKRA EDLAELEEQM
610 620 630 640 650
ANNSIDDTTI LVDRIISEKQ QLPAKVLESR KVVKTLLDQG HLSPFVDSIR
660 670 680 690 700
PISWDMDHTL TLYPIPSTLI LADMSSAAYD LTYNGCKTIN PGKFIHKRQA
710
RYIQFQPYLK SVSQEEVFF
Length:719
Mass (Da):81,472
Last modified:July 19, 2004 - v1
Checksum:i89EC061E3976F157
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380953 Genomic DNA. Translation: CAG59713.1.
RefSeqiXP_446786.1. XM_446786.1.

Genome annotation databases

EnsemblFungiiCAG59713; CAG59713; CAGL0G09801g.
GeneIDi2888291.
KEGGicgr:CAGL0G09801g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380953 Genomic DNA. Translation: CAG59713.1.
RefSeqiXP_446786.1. XM_446786.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284593.XP_446786.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG59713; CAG59713; CAGL0G09801g.
GeneIDi2888291.
KEGGicgr:CAGL0G09801g.

Organism-specific databases

CGDiCAL0137567. CAGL0G09801g.
EuPathDBiFungiDB:CAGL0G09801g.

Phylogenomic databases

eggNOGiKOG3818. Eukaryota.
ENOG410XP7N. LUCA.
HOGENOMiHOG000246706.
InParanoidiQ6FSK8.
KOiK02325.
OrthoDBiEOG7XH6ZR.

Family and domain databases

InterProiIPR007185. DNA_pol_alpha/epsilon_bsu.
[Graphical view]
PfamiPF04042. DNA_pol_E_B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDPB2_CANGA
AccessioniPrimary (citable) accession number: Q6FSK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: July 19, 2004
Last modified: January 20, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.