Reviewed, UniProtKB/Swiss-Prot Q6FRZ9 (ATM_CANGA)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase TEL1
    EC=2.7.11.1
Alternative name(s):
    DNA-damage checkpoint kinase TEL1
    Telomere length regulation protein 1
    ATM homolog

Gene names

Name:	TEL1
Ordered Locus Names:	CAGL0H04609g

Organism

Candida glabrata (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

5478 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	2763 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subunit structure	Associates with DNA double-strand breaks By similarity.
Subcellular location	NucleusBy similarity. TelomereBy similarity. Note= Localizes to nuclear DNA repair foci with other DNA repair proteins in response to DNA double strand breaks By similarity.
Sequence similarities	Belongs to the PI3/PI4-kinase family. ATM subfamily. Contains 1 FAT domain. Contains 1 FATC domain. Contains 1 PI3K/PI4K domain.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Chromosomal protein Nucleus Telomere
Molecular function	Chromatin regulator Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chromosome, telomeric region Inferred from electronic annotation. Source: UniProtKB-KW nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 2763	2763	Serine/threonine-protein kinase TEL1		PRO_0000227699
Regions
	Domain	1715 – 2294	580	FAT
	Domain	2429 – 2763	335	PI3K/PI4K
	Domain	2731 – 2763	33	FATC

Sequences

	Sequence		Length	Mass (Da)
	Q6FRZ9-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 3CF36DFF08660AD7	FASTA	2,763	319,038
	10 20 30 40 50 60 MENYQIRTLQ DQLTSSKLRD RNAGLQELQS ILKDNPGFIA NEQINGLLNT LLSLLENEAG 70 80 90 100 110 120 KYIDSIEDDT DSRQRKENIS ISRFSNITYT LRLFIETVIE KFKLSHLKLT ISAVKDLFYN 130 140 150 160 170 180 DARIIVPVIN DVTYCILAIV KSEIFGNKIG PSQWLDVAEY TLWLIKITSS NRSNIRALTN 190 200 210 220 230 240 SLDTFYVLLI KGSISLSKVA KEALVIITNL IVFEKGETAT TNVLLSISSN LVARLHCQHY 250 260 270 280 290 300 YDTTSLIIEC WKLYTRIGKT NNFNLLNDIS KIDIFGGGLL QNQIPIMPGQ EIMGSRISHS 310 320 330 340 350 360 VVLSTLQDYI PMKVKEMLDV DHSLTIGIYD DLNNSNMDLT YNTFAKTHCK DLAWLRLFGL 370 380 390 400 410 420 YDTLCLYYRL SNQERENNAT QILKKIKYEG SLQSNLNQCN SLLDYSQSLL ESGDPLIQLL 430 440 450 460 470 480 GCKLFFLLNL DHPIACNTEL IDRLCINTNN ISLTSWHLAC IFTNISYDLW NFDETLYLKV 490 500 510 520 530 540 LKYITPLLST SEVNIMACLI FNKLLHSLTR EPIDELSSLV NSIIASPDSV LPIEISSVTC 550 560 570 580 590 600 EAWQHIFVFA INNLKVDNSL LLDSFSKWIN HNITQTIHIE HLKLIFEFFL WSLDVVVGST 610 620 630 640 650 660 SHNKQHNTYN LLNLKTSDSA LAIWYFYENQ RKFLTQTIQT SSQASVNTKS MVCPITSTNI 670 680 690 700 710 720 KIQWLLNIID NYFTTSKNHS LKYTFAISLI YFINFIEKSG KVYTYLNQEL NQRLNSILIE 730 740 750 760 770 780 LDFLSFDKWE EGKQFIEIIC NQETFFNRLH NDVVFKDNIL LSLINLFEKE YSHFLNADNG 790 800 810 820 830 840 STAKTGNDIY LNQRSILRFR TDIKLMTQFF TCVDSNVPGK IGIYLDRLLL YSMGPNESLV 850 860 870 880 890 900 LDELLSWVTN PSNNQYYEVH SLEKLCQFLA KSLLNSKYQL SDFSMIRLGL FLTSTIELWV 910 920 930 940 950 960 NVKYNILNSD CNDFLIWITN NLVQNNFGET GTFVVLIRLF ISVLKHNSTV NSSCAIKTQD 970 980 990 1000 1010 1020 LYSMLIFCMR NVAYSTLGNI VDELKAYMSK KSHKNRKTIL DDLVELFEPM PESVEKAASS 1030 1040 1050 1060 1070 1080 CFVLFGLLDC NDTNFVYTLD IFSNYGNIPH ISFFLKKAVK NYVNNYYQGN KIQLLNVHIL 1090 1100 1110 1120 1130 1140 EVIRQWTKRN DTDRQLYFNS VIGSLFGFGS IQEFERQYNR EICALIFSRS DSESLERNFF 1150 1160 1170 1180 1190 1200 SDRNTSKCEM LRRSLYLLIP LSYYDNGVGD MVFNKLKDSF RGQLESVLSS NFIIVMRYAL 1210 1220 1230 1240 1250 1260 KLCDCSDYTS VLNEMQRPNQ SSSLLELFMD SEMKNAINRM NIYITVHSVI KIFKNCGRSR 1270 1280 1290 1300 1310 1320 QTLLLDLRTL ILWIISDIQK SESSWEQNNH LRQLQLLVFL YEDTFLQSVL HIELMNWLSY 1330 1340 1350 1360 1370 1380 LLKIENIEAD VFLLLNCLLS LIKPNSLDKP DSLTLFFLNV LHFYVRNKEC LKIGDEDMNM 1390 1400 1410 1420 1430 1440 LSNNLSTVNS IALKLLTNGQ VTDLIYNQVG DLTSQMYFAE EVELFALLMT FAPPMPDYVS 1450 1460 1470 1480 1490 1500 HKMNKKFIEY VYKSNNLIDI DNFSLWFSDY STQYSSLILE LEENSSFCEK DGFGIDDMEI 1510 1520 1530 1540 1550 1560 VYDFSDSAVS AMYSVLFRSL ISIKPTIGFK SFALSNIICH LISINILKDK DLLSKFLRAT 1570 1580 1590 1600 1610 1620 KMKIAFSAKE IDETIIEHFG KSNCGCVISE HYLESEFFDT NIPYKDWLVK LCMFFISQIS 1630 1640 1650 1660 1670 1680 LNSKEIQWFI PLCYESMDFC KQNVCIFFLA AFSFDHRRMS STWKHIFSRL NDLTMASDCL 1690 1700 1710 1720 1730 1740 AKLTLLLSFI RLIRSGALQG RKEYSNLYQK IEFKGVIDAA LKIKDSKFAL QLFEEAYMCE 1750 1760 1770 1780 1790 1800 NGDYDVALLT SIYEQLDDVD MLYALPTPIS LNGFIKNANR LSPHSLKALQ LNGAYFDANF 1810 1820 1830 1840 1850 1860 NHLVDNGSHQ LVNTLTGMGF NALADIADLR TSCDNPADAY LRCLQLDKWD LPKPKAIDCK 1870 1880 1890 1900 1910 1920 IVSFYNTAYD LRNTNIEFVD LLQNAEIQLY KAKANFSSKL EWFETIREYV KTKRAIISLK 1930 1940 1950 1960 1970 1980 TDTDISRFKI DHVINPDRYL ENALISDIKI NWQFRYLMLK IYVEREKFAN EAMKCIPILE 1990 2000 2010 2020 2030 2040 LIHQTELSVD FHIQQTSLSR ILSMEAAMKR FHIADTNLVE QLSRHVSYVT ALALREFGET 2050 2060 2070 2080 2090 2100 KAPLTILSKL LSDKSYKLNY NTFVSDDEVR AQLIWDSYQA KVKSGIQIFE NDVEHWDVSI 2110 2120 2130 2140 2150 2160 NNIRSAPDTI YKVANFLNLE ISRLNGSDQL KEKQKSYRRT RQELKDIESV VKSSNLSNEE 2170 2180 2190 2200 2210 2220 LLVGQKHYHN LKTHMENDRL AIENICLTRK KLIKRALDYY VQILILTNNY DYDVLDRFCG 2230 2240 2250 2260 2270 2280 LWFENDDDDD INTDLTSKLS QIPTWKFLPW VNQFTSKLSL LKSKFQKQLW YIMKRLLYKL 2290 2300 2310 2320 2330 2340 PFETGYAVIN LQLYEKYSDK LDEKISEKIK AANLIFDQLQ NSQISVKEGE YLRTIQEFCY 2350 2360 2370 2380 2390 2400 ATLEIAELKV KGKNAQISLE TLNIGRYWIT ELPKKNLPLP TVTRTINSSQ YTLDSSRNIV 2410 2420 2430 2440 2450 2460 KVIGNITITS TGLSLPKVMT LLLSDGSRHK VVIKYGSDDL RQDAIMEQVF QQVNKIFGKD 2470 2480 2490 2500 2510 2520 VEMRRSDLHM RTYNVVPLGP KAGLIEFVNN SLSLHSILTD IHKDDNYSWL EARRSMKDVQ 2530 2540 2550 2560 2570 2580 SKSDKERILT YLDITKKISP KFRNFFFNSF IDANGWICAK RKYTKGVATS SMVGYILGLG 2590 2600 2610 2620 2630 2640 DRHLNNILID TTTGEPIHID LGIAFDQGRL LKIPELVPFR LTRDIIDGFG ITGVEGIFRR 2650 2660 2670 2680 2690 2700 TCEQVLNVLS RDSEKVMCVL NILKWDPLYS WAVSPFKKHK YMYDDNLEGH MTTATNNSKV 2710 2720 2730 2740 2750 2760 IERKLTPKLD SDENQQSYRA LKGVQEKLDR NGLTIEATVE KLIQEAVDES NLALIFNGWS PFY

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / IFO 0622 / NRRL Y-65.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR380954 Genomic DNA. Translation: CAG59928.1.
RefSeq	XP_446995.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2888643.
KEGG	cgr:CAGL0H04609g.
Phylogenomic databases
HOGENOM	Q6FRZ9.
Family and domain databases
InterPro	IPR015519. Ataxia_Telang_Mut. IPR003152. FATC. IPR000403. PI3/4_kinase_cat. IPR014009. PIK_FAT. [Graphical view]
Gene3D	G3DSA:1.10.1070.11. PI3/4_kinase_cat. 1 hit.
PANTHER	PTHR11139:SF3. Ataxia_Telang_Mut. 1 hit.
Pfam	PF02260. FATC. 1 hit. PF00454. PI3_PI4_kinase. 1 hit. [Graphical view]
SMART	SM00146. PI3Kc. 1 hit. [Graphical view]
PROSITE	PS51189. FAT. 1 hit. PS51190. FATC. 1 hit. PS00915. PI3_4_KINASE_1. 1 hit. PS00916. PI3_4_KINASE_2. 1 hit. PS50290. PI3_4_KINASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATM_CANGA

Accession

Primary (citable) accession number: Q6FRZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 21, 2006
Last sequence update:	July 19, 2004
Last modified:	November 4, 2008
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)