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Q6FRZ7 (ERG6_CANGA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sterol 24-C-methyltransferase

EC=2.1.1.41
Alternative name(s):
Delta(24)-sterol C-methyltransferase
Gene names
Name:ERG6
Ordered Locus Names:CAGL0H04653g
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier284593 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces

Protein attributes

Sequence length372 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol By similarity.

Catalytic activity

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

Pathway

Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 1/5.

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 372372Sterol 24-C-methyltransferase
PRO_0000124790

Sequences

Sequence LengthMass (Da)Tools
Q6FRZ7 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 4B0180321C688B80

FASTA37242,440
        10         20         30         40         50         60 
MSESELRQRQ AEFTKELHGE GAESRTGLTA LLSKNRNAQR EAVSKYLRHW DGKTDKEAED 

        70         80         90        100        110        120 
RRLEDYNEAT HSYYNVVTDF YEYGWGSSFH FSRFYKGENF QAAMARHEQY LAYMAGIKKG 

       130        140        150        160        170        180 
DLVLDVGCGV GGPARTIARF TGCNIIGLNN NDYQIQKAKY YAKKYNLQDH MDFVKGDFMN 

       190        200        210        220        230        240 
MEFEPNSFDK VYAIEATCHA PKLEGVYGEI YKVLKPGGTF AVYEWVMTEN YDENNEEHRK 

       250        260        270        280        290        300 
IAYEIELGDG IPKMFTVDVA KQALKNVGFE VEVSKDLADE DDEIPWYYPL TGEWKYVQSL 

       310        320        330        340        350        360 
SDIATFFRTS YFGRKFTNCM VSIMEKVGVA PQGSVEVTAA LENAAVGLVE GGRKKLFTPM 

       370 
FLFVAKKPED AK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY942653 Genomic DNA. Translation: AAX73200.1.
CR380954 Genomic DNA. Translation: CAG59930.1.
RefSeqXP_446997.1. XM_446997.1.

3D structure databases

ProteinModelPortalQ6FRZ7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2888522.
KEGGcgr:CAGL0H04653g.

Phylogenomic databases

HOGENOMHOG000171097.
KOK00559.
OMAFHFCRFS.
OrthoDBEOG7DVDMW.

Enzyme and pathway databases

UniPathwayUPA00768; UER00760.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR025810. ERG6.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view]
PfamPF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view]
SUPFAMSSF53335. SSF53335. 2 hits.
PROSITEPS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameERG6_CANGA
AccessionPrimary (citable) accession number: Q6FRZ7
Secondary accession number(s): Q56J90
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 19, 2004
Last modified: June 11, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways