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Protein

Sterol 24-C-methyltransferase

Gene

ERG6

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.By similarity

Catalytic activityi

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

Pathway: ergosterol biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes ergosterol from zymosterol.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Sterol 24-C-methyltransferase (ERG6)
  2. no protein annotated in this organism
  3. C-5 sterol desaturase (ERG3)
  4. no protein annotated in this organism
  5. no protein annotated in this organism
This subpathway is part of the pathway ergosterol biosynthesis, which is itself part of Steroid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ergosterol from zymosterol, the pathway ergosterol biosynthesis and in Steroid metabolism.

GO - Molecular functioni

  • sterol 24-C-methyltransferase activity Source: CGD

GO - Biological processi

  • ergosterol biosynthetic process Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00768; UER00760.

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol 24-C-methyltransferase (EC:2.1.1.41)
Alternative name(s):
Delta(24)-sterol C-methyltransferase
Gene namesi
Name:ERG6
Ordered Locus Names:CAGL0H04653g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428 Componenti: Chromosome H

Organism-specific databases

EuPathDBiFungiDB:CAGL0H04653g.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Sterol 24-C-methyltransferasePRO_0000124790Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_446997.1.

Structurei

3D structure databases

ProteinModelPortaliQ6FRZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000171097.
InParanoidiQ6FRZ7.
KOiK00559.
OMAiFHFCRFS.
OrthoDBiEOG7DVDMW.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013216. Methyltransf_11.
IPR030384. MeTrfase_SMT.
IPR029063. SAM-dependent_MTases.
IPR013705. Sterol_MeTrfase_C.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FRZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESELRQRQ AEFTKELHGE GAESRTGLTA LLSKNRNAQR EAVSKYLRHW
60 70 80 90 100
DGKTDKEAED RRLEDYNEAT HSYYNVVTDF YEYGWGSSFH FSRFYKGENF
110 120 130 140 150
QAAMARHEQY LAYMAGIKKG DLVLDVGCGV GGPARTIARF TGCNIIGLNN
160 170 180 190 200
NDYQIQKAKY YAKKYNLQDH MDFVKGDFMN MEFEPNSFDK VYAIEATCHA
210 220 230 240 250
PKLEGVYGEI YKVLKPGGTF AVYEWVMTEN YDENNEEHRK IAYEIELGDG
260 270 280 290 300
IPKMFTVDVA KQALKNVGFE VEVSKDLADE DDEIPWYYPL TGEWKYVQSL
310 320 330 340 350
SDIATFFRTS YFGRKFTNCM VSIMEKVGVA PQGSVEVTAA LENAAVGLVE
360 370
GGRKKLFTPM FLFVAKKPED AK
Length:372
Mass (Da):42,440
Last modified:July 19, 2004 - v1
Checksum:i4B0180321C688B80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY942653 Genomic DNA. Translation: AAX73200.1.
CR380954 Genomic DNA. Translation: CAG59930.1.
RefSeqiXP_446997.1. XM_446997.1.

Genome annotation databases

GeneIDi2888522.
KEGGicgr:CAGL0H04653g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY942653 Genomic DNA. Translation: AAX73200.1.
CR380954 Genomic DNA. Translation: CAG59930.1.
RefSeqiXP_446997.1. XM_446997.1.

3D structure databases

ProteinModelPortaliQ6FRZ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284593.XP_446997.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2888522.
KEGGicgr:CAGL0H04653g.

Organism-specific databases

EuPathDBiFungiDB:CAGL0H04653g.

Phylogenomic databases

HOGENOMiHOG000171097.
InParanoidiQ6FRZ7.
KOiK00559.
OMAiFHFCRFS.
OrthoDBiEOG7DVDMW.

Enzyme and pathway databases

UniPathwayiUPA00768; UER00760.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013216. Methyltransf_11.
IPR030384. MeTrfase_SMT.
IPR029063. SAM-dependent_MTases.
IPR013705. Sterol_MeTrfase_C.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Polyene resistance in Candida glabrata."
    Vandeputte P., Bouchara J.-P.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: IHEM 21231.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.

Entry informationi

Entry nameiERG6_CANGA
AccessioniPrimary (citable) accession number: Q6FRZ7
Secondary accession number(s): Q56J90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 19, 2004
Last modified: June 24, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.