Reviewed, UniProtKB/Swiss-Prot Q6FRZ7 (ERG6_CANGA)

Names and origin

Protein names

Recommended name:
    Sterol 24-C-methyltransferase
    EC=2.1.1.41
Alternative name(s):
    Delta(24)-sterol C-methyltransferase

Gene names

Name:	ERG6
Ordered Locus Names:	CAGL0H04653g

Organism

Candida glabrata (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

5478 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces

Protein attributes

Sequence length	372 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol By similarity.
Catalytic activity	S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.
Pathway	Steroid metabolism; ergosterol biosynthesis; ergosterol from zymosterol: step 1/5.
Sequence similarities	Belongs to the methyltransferase superfamily. ERG6 family.

Ontologies

Keywords
Biological process	Lipid synthesis Steroid biosynthesis Sterol biosynthesis
Ligand	S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	sterol biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sterol 24-C-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 372	372	Sterol 24-C-methyltransferase		PRO_0000124790

Sequences

	Sequence		Length	Mass (Da)
	Q6FRZ7-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 4B0180321C688B80	FASTA	372	42,440
	10 20 30 40 50 60 MSESELRQRQ AEFTKELHGE GAESRTGLTA LLSKNRNAQR EAVSKYLRHW DGKTDKEAED 70 80 90 100 110 120 RRLEDYNEAT HSYYNVVTDF YEYGWGSSFH FSRFYKGENF QAAMARHEQY LAYMAGIKKG 130 140 150 160 170 180 DLVLDVGCGV GGPARTIARF TGCNIIGLNN NDYQIQKAKY YAKKYNLQDH MDFVKGDFMN 190 200 210 220 230 240 MEFEPNSFDK VYAIEATCHA PKLEGVYGEI YKVLKPGGTF AVYEWVMTEN YDENNEEHRK 250 260 270 280 290 300 IAYEIELGDG IPKMFTVDVA KQALKNVGFE VEVSKDLADE DDEIPWYYPL TGEWKYVQSL 310 320 330 340 350 360 SDIATFFRTS YFGRKFTNCM VSIMEKVGVA PQGSVEVTAA LENAAVGLVE GGRKKLFTPM 370 FLFVAKKPED AK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Polyene resistance in Candida glabrata." Vandeputte P., Bouchara J.-P. Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: IHEM 21231.
[2]	"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / IFO 0622 / NRRL Y-65.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY942653 Genomic DNA. Translation: AAX73200.1. CR380954 Genomic DNA. Translation: CAG59930.1.
RefSeq	XP_446997.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2888522.
KEGG	cgr:CAGL0H04653g.
Phylogenomic databases
HOGENOM	Q6FRZ7.
OMA	Q6FRZ7. FVKGDFM.
Enzyme and pathway databases
BRENDA	2.1.1.41. 189220.
Family and domain databases
InterPro	IPR013216. Methyltransf_11. IPR013705. Sterol_MeTrfase_C. [Graphical view]
Pfam	PF08241. Methyltransf_11. 1 hit. PF08498. Sterol_MT_C. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ERG6_CANGA

Accession

Primary (citable) accession number: Q6FRZ7
Secondary accession number(s): Q56J90

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	July 19, 2004
Last modified:	May 5, 2009
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)