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Q6FRZ7

- ERG6_CANGA

UniProt

Q6FRZ7 - ERG6_CANGA

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Protein

Sterol 24-C-methyltransferase

Gene

ERG6

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.By similarity

Catalytic activityi

S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

Pathwayi

GO - Molecular functioni

  1. sterol 24-C-methyltransferase activity Source: CGD

GO - Biological processi

  1. ergosterol biosynthetic process Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00768; UER00760.

Names & Taxonomyi

Protein namesi
Recommended name:
Sterol 24-C-methyltransferase (EC:2.1.1.41)
Alternative name(s):
Delta(24)-sterol C-methyltransferase
Gene namesi
Name:ERG6
Ordered Locus Names:CAGL0H04653g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428: Chromosome H

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Sterol 24-C-methyltransferasePRO_0000124790Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6FRZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000171097.
InParanoidiQ6FRZ7.
KOiK00559.
OMAiFHFCRFS.
OrthoDBiEOG7DVDMW.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025810. ERG6.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FRZ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSESELRQRQ AEFTKELHGE GAESRTGLTA LLSKNRNAQR EAVSKYLRHW
60 70 80 90 100
DGKTDKEAED RRLEDYNEAT HSYYNVVTDF YEYGWGSSFH FSRFYKGENF
110 120 130 140 150
QAAMARHEQY LAYMAGIKKG DLVLDVGCGV GGPARTIARF TGCNIIGLNN
160 170 180 190 200
NDYQIQKAKY YAKKYNLQDH MDFVKGDFMN MEFEPNSFDK VYAIEATCHA
210 220 230 240 250
PKLEGVYGEI YKVLKPGGTF AVYEWVMTEN YDENNEEHRK IAYEIELGDG
260 270 280 290 300
IPKMFTVDVA KQALKNVGFE VEVSKDLADE DDEIPWYYPL TGEWKYVQSL
310 320 330 340 350
SDIATFFRTS YFGRKFTNCM VSIMEKVGVA PQGSVEVTAA LENAAVGLVE
360 370
GGRKKLFTPM FLFVAKKPED AK
Length:372
Mass (Da):42,440
Last modified:July 19, 2004 - v1
Checksum:i4B0180321C688B80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY942653 Genomic DNA. Translation: AAX73200.1.
CR380954 Genomic DNA. Translation: CAG59930.1.
RefSeqiXP_446997.1. XM_446997.1.

Genome annotation databases

GeneIDi2888522.
KEGGicgr:CAGL0H04653g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY942653 Genomic DNA. Translation: AAX73200.1 .
CR380954 Genomic DNA. Translation: CAG59930.1 .
RefSeqi XP_446997.1. XM_446997.1.

3D structure databases

ProteinModelPortali Q6FRZ7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2888522.
KEGGi cgr:CAGL0H04653g.

Phylogenomic databases

HOGENOMi HOG000171097.
InParanoidi Q6FRZ7.
KOi K00559.
OMAi FHFCRFS.
OrthoDBi EOG7DVDMW.

Enzyme and pathway databases

UniPathwayi UPA00768 ; UER00760 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR025810. ERG6.
IPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases-like.
IPR013705. Sterol_MeTrfase_C.
[Graphical view ]
Pfami PF08241. Methyltransf_11. 1 hit.
PF08498. Sterol_MT_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 2 hits.
PROSITEi PS51685. SAM_MT_ERG6_SMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Polyene resistance in Candida glabrata."
    Vandeputte P., Bouchara J.-P.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: IHEM 21231.
  2. "Genome evolution in yeasts."
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.

Entry informationi

Entry nameiERG6_CANGA
AccessioniPrimary (citable) accession number: Q6FRZ7
Secondary accession number(s): Q56J90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 19, 2004
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3