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Q6FRZ7

- ERG6_CANGA

UniProt

Q6FRZ7 - ERG6_CANGA

Protein

Sterol 24-C-methyltransferase

Gene

ERG6

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + 5-alpha-cholesta-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol.

    Pathwayi

    GO - Molecular functioni

    1. sterol 24-C-methyltransferase activity Source: CGD

    GO - Biological processi

    1. ergosterol biosynthetic process Source: CGD

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    UniPathwayiUPA00768; UER00760.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sterol 24-C-methyltransferase (EC:2.1.1.41)
    Alternative name(s):
    Delta(24)-sterol C-methyltransferase
    Gene namesi
    Name:ERG6
    Ordered Locus Names:CAGL0H04653g
    OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
    Taxonomic identifieri284593 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
    ProteomesiUP000002428: Chromosome H

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 372372Sterol 24-C-methyltransferasePRO_0000124790Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6FRZ7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.PROSITE-ProRule annotation

    Phylogenomic databases

    HOGENOMiHOG000171097.
    KOiK00559.
    OMAiFHFCRFS.
    OrthoDBiEOG7DVDMW.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR025810. ERG6.
    IPR013216. Methyltransf_11.
    IPR029063. SAM-dependent_MTases-like.
    IPR013705. Sterol_MeTrfase_C.
    [Graphical view]
    PfamiPF08241. Methyltransf_11. 1 hit.
    PF08498. Sterol_MT_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 2 hits.
    PROSITEiPS51685. SAM_MT_ERG6_SMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6FRZ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSESELRQRQ AEFTKELHGE GAESRTGLTA LLSKNRNAQR EAVSKYLRHW    50
    DGKTDKEAED RRLEDYNEAT HSYYNVVTDF YEYGWGSSFH FSRFYKGENF 100
    QAAMARHEQY LAYMAGIKKG DLVLDVGCGV GGPARTIARF TGCNIIGLNN 150
    NDYQIQKAKY YAKKYNLQDH MDFVKGDFMN MEFEPNSFDK VYAIEATCHA 200
    PKLEGVYGEI YKVLKPGGTF AVYEWVMTEN YDENNEEHRK IAYEIELGDG 250
    IPKMFTVDVA KQALKNVGFE VEVSKDLADE DDEIPWYYPL TGEWKYVQSL 300
    SDIATFFRTS YFGRKFTNCM VSIMEKVGVA PQGSVEVTAA LENAAVGLVE 350
    GGRKKLFTPM FLFVAKKPED AK 372
    Length:372
    Mass (Da):42,440
    Last modified:July 19, 2004 - v1
    Checksum:i4B0180321C688B80
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY942653 Genomic DNA. Translation: AAX73200.1.
    CR380954 Genomic DNA. Translation: CAG59930.1.
    RefSeqiXP_446997.1. XM_446997.1.

    Genome annotation databases

    GeneIDi2888522.
    KEGGicgr:CAGL0H04653g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY942653 Genomic DNA. Translation: AAX73200.1 .
    CR380954 Genomic DNA. Translation: CAG59930.1 .
    RefSeqi XP_446997.1. XM_446997.1.

    3D structure databases

    ProteinModelPortali Q6FRZ7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2888522.
    KEGGi cgr:CAGL0H04653g.

    Phylogenomic databases

    HOGENOMi HOG000171097.
    KOi K00559.
    OMAi FHFCRFS.
    OrthoDBi EOG7DVDMW.

    Enzyme and pathway databases

    UniPathwayi UPA00768 ; UER00760 .

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR025810. ERG6.
    IPR013216. Methyltransf_11.
    IPR029063. SAM-dependent_MTases-like.
    IPR013705. Sterol_MeTrfase_C.
    [Graphical view ]
    Pfami PF08241. Methyltransf_11. 1 hit.
    PF08498. Sterol_MT_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 2 hits.
    PROSITEi PS51685. SAM_MT_ERG6_SMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Polyene resistance in Candida glabrata."
      Vandeputte P., Bouchara J.-P.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: IHEM 21231.
    2. "Genome evolution in yeasts."
      Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
      , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
      Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.

    Entry informationi

    Entry nameiERG6_CANGA
    AccessioniPrimary (citable) accession number: Q6FRZ7
    Secondary accession number(s): Q56J90
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3