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Reviewed, UniProtKB/Swiss-Prot Q6FRY2 (MPG12_CANGA)

Last modified February 9, 2010. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Mannose-1-phosphate guanyltransferase 2
    EC=2.7.7.13
Alternative name(s):
    ATP-mannose-1-phosphate guanylyltransferase 2
    GDP-mannose pyrophosphorylase 2
Gene names
Name: MPG1
Ordered Locus Names: CAGL0H04983g
OrganismCandida glabrata (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier5478 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint By similarity.

Catalytic activity

GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.

Pathway

Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
   Biological processCell cycle
   Cellular componentCytoplasm
   LigandGTP-binding
Nucleotide-binding
   Molecular functionNucleotidyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processbiosynthetic process

Inferred from electronic annotation. Source: InterPro

cell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionGTP binding

Inferred from electronic annotation. Source: UniProtKB-KW

mannose-1-phosphate guanylyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 361361Mannose-1-phosphate guanyltransferase 2
PRO_0000248401

Sequences

Sequence LengthMass (Da)Tools
Q6FRY2-1 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: FCF021E334A6872B

FASTA36139,611
        10         20         30         40         50         60 
MKGLILVGGY GTRLRPLTLS VPKPLVEFCN RPMILHQIEA LAEAGVTDIV LAVNYRPEVM 

        70         80         90        100        110        120 
VDTLKKYEKE YGVNITFSVE TEPLGTAGPL KLAEKILKKD NSPFFVLNSD VICEYPFKEL 

       130        140        150        160        170        180 
AEFHKSHGGK GTIVATKVDE PSKYGVIVHD LGTPNLIDRF VEKPKEFVGN RINAGLYILN 

       190        200        210        220        230        240 
PEVIDLIEMK PTSIETETFP KLVNEKSLYT FDLEGFWMDV GQPKDFLAGT GLYLQSLSRR 

       250        260        270        280        290        300 
HPEKLSTGSN IVSNAIIDPT AKISPDAKIG PDVVIGPNCV IGSGVRIVRS VLLKNCVVKE 

       310        320        330        340        350        360 
NSLIKDTIVG WDSTIGRWCR LEGCAVLGHD VAVKDEVYVN GAKVLPHKSI SANVPSEAII 


M 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR380954 Genomic DNA. Translation: CAG59945.1.
RefSeqXP_447012.1.

3D structure databases

HSSPHSSP built from PDB template 1J2Z based on UniProtKB O25927.
SMRQ6FRY2. Positions 1-335.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6FRY2.

Genome annotation databases

GeneID2888449.
GenomeReviewsGene locus CAGL0H04983g in contig CR380954_GR.
KEGGcgr:CAGL0H04983g.

Phylogenomic databases

eggNOGfuNOG07401.
HOGENOMHBG688195.
OMAHETAVIG.
OrthoDBEOG9V70ZQ.
PhylomeDBQ6FRY2.

Enzyme and pathway databases

BRENDA2.7.7.13. 189220.

Family and domain databases

InterProIPR005835. NTP_transferase.
IPR011004. Trimer_LpxA-like.
[Graphical view]
PfamPF00483. NTP_transferase. 1 hit.
[Graphical view]
PROSITEPS00101. HEXAPEP_TRANSFERASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPG12_CANGA
AccessionPrimary (citable) accession number: Q6FRY2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 19, 2004
Last modified: February 9, 2010
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents