Reviewed, UniProtKB/Swiss-Prot Q6FRY2 (MPG12_CANGA)

Names and origin

Protein names

Recommended name:
    Mannose-1-phosphate guanyltransferase 2
    EC=2.7.7.13
Alternative name(s):
    ATP-mannose-1-phosphate guanylyltransferase 2
    GDP-mannose pyrophosphorylase 2

Gene names

Name:	MPG1
Ordered Locus Names:	CAGL0H04983g

Organism

Candida glabrata (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

5478 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint By similarity.
Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Protein modification; protein glycosylation.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Biological process	Cell cycle
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	Mannose-1-phosphate guanyltransferase 2		PRO_0000248401

Sequences

	Sequence		Length	Mass (Da)
	Q6FRY2-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: FCF021E334A6872B	FASTA	361	39,611
	10 20 30 40 50 60 MKGLILVGGY GTRLRPLTLS VPKPLVEFCN RPMILHQIEA LAEAGVTDIV LAVNYRPEVM 70 80 90 100 110 120 VDTLKKYEKE YGVNITFSVE TEPLGTAGPL KLAEKILKKD NSPFFVLNSD VICEYPFKEL 130 140 150 160 170 180 AEFHKSHGGK GTIVATKVDE PSKYGVIVHD LGTPNLIDRF VEKPKEFVGN RINAGLYILN 190 200 210 220 230 240 PEVIDLIEMK PTSIETETFP KLVNEKSLYT FDLEGFWMDV GQPKDFLAGT GLYLQSLSRR 250 260 270 280 290 300 HPEKLSTGSN IVSNAIIDPT AKISPDAKIG PDVVIGPNCV IGSGVRIVRS VLLKNCVVKE 310 320 330 340 350 360 NSLIKDTIVG WDSTIGRWCR LEGCAVLGHD VAVKDEVYVN GAKVLPHKSI SANVPSEAII M

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / IFO 0622 / NRRL Y-65.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR380954 Genomic DNA. Translation: CAG59945.1.
RefSeq	XP_447012.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2888449.
KEGG	cgr:CAGL0H04983g.
Phylogenomic databases
HOGENOM	Q6FRY2.
OMA	Q6FRY2. HETAVIG.
Enzyme and pathway databases
BRENDA	2.7.7.13. 189220.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00132. Hexapep. 4 hits. PF00483. NTP_transferase. 1 hit. [Graphical view]
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MPG12_CANGA

Accession

Primary (citable) accession number: Q6FRY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	July 19, 2004
Last modified:	June 16, 2009
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)