Q6FRW1 (G6PI_CANGA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	PGI1
Ordered Locus Names:	CAGL0H05445g

Organism

Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

284593 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces

Protein attributes

Sequence length	555 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate.
Pathway	Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 555	555	Glucose-6-phosphate isomerase		PRO_0000180573
Sites
	Active site	368	1	Proton donor By similarity
	Active site	399	1	By similarity
	Active site	521	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6FRW1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: D6237C5392EFF0CA	FASTA	555	61,310
	10 20 30 40 50 60 MASSNTYSNF KLATELPAWS KLQKLYDAQG KSLNVKEEFQ KDSARYNKYA KTLTNYDGSK 70 80 90 100 110 120 ILFDFSKNLI NDEILATLIE LAKEAKVTDL RDAMFAGEHI NFTEDRAVYH VALRNRANKP 130 140 150 160 170 180 MKVDGVDVAP EVDAVLQHMK EFSEQVRSGE WKGYTGKKIT DVVNIGIGGS DLGPVMVTEA 190 200 210 220 230 240 LKHYAGVLDV HFVSNIDGTH IAEVLKVVDP ETTLFLVASK TFTTAETITN ANTAKNWFLS 250 260 270 280 290 300 KTGNDQSNIA KHFAALSTNE TEVAKFGIDT KNMFGFENWV GGRYSVWSAI GLSVALYIGF 310 320 330 340 350 360 DNFEAFLKGA EAVDKHFVET PLEDNIPLLG GLLSVWYNNF FGAQTHLVAP FDQYLHRFPA 370 380 390 400 410 420 YLQQLSMESN GKSVTRGNVF STYSTGSILF GEPATNAQHS FFQLVHQGTK LIPSDFILAA 430 440 450 460 470 480 QSHNPIENNL HQKMLASNFF AQAEALMVGK DEAQVKSEGA TGGLVPHKIF SGNRPTTSIL 490 500 510 520 530 540 AQKITPAALG SLIAYYEHVT FTEGAIWNIN SFDQWGVELG KVLAKVIGKE LDNTEKITAH 550 DASTNGLINQ FKEWL

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR380954 Genomic DNA. Translation: CAG59966.1.
RefSeq	XP_447033.1. XM_447033.1.
3D structure databases
ProteinModelPortal	Q6FRW1.
SMR	Q6FRW1. Positions 13-554.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2888511.
GenomeReviews	Gene locus CAGL0H05445g in contig CR380954_GR.
KEGG	cgr:CAGL0H05445g.
Phylogenomic databases
eggNOG	fuNOG04321.
HOGENOM	HBG352954.
OMA	AVHIGFE.
OrthoDB	EOG43NBN0.
Family and domain databases
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_CANGA

Accession

Primary (citable) accession number: Q6FRW1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	July 19, 2004
Last modified:	December 14, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program