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Protein

Glucose-6-phosphate isomerase

Gene

PGI1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei368 – 3681Proton donorBy similarity
Active sitei399 – 3991By similarity
Active sitei521 – 5211By similarity

GO - Molecular functioni

  1. glucose-6-phosphate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-KW
  2. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:PGI1
Ordered Locus Names:CAGL0H05445g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428: Chromosome H

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Glucose-6-phosphate isomerasePRO_0000180573Add
BLAST

Proteomic databases

PRIDEiQ6FRW1.

Structurei

3D structure databases

ProteinModelPortaliQ6FRW1.
SMRiQ6FRW1. Positions 13-554.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

HOGENOMiHOG000261371.
InParanoidiQ6FRW1.
KOiK01810.
OMAiCETQAML.
OrthoDBiEOG7N0CDV.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FRW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSNTYSNF KLATELPAWS KLQKLYDAQG KSLNVKEEFQ KDSARYNKYA
60 70 80 90 100
KTLTNYDGSK ILFDFSKNLI NDEILATLIE LAKEAKVTDL RDAMFAGEHI
110 120 130 140 150
NFTEDRAVYH VALRNRANKP MKVDGVDVAP EVDAVLQHMK EFSEQVRSGE
160 170 180 190 200
WKGYTGKKIT DVVNIGIGGS DLGPVMVTEA LKHYAGVLDV HFVSNIDGTH
210 220 230 240 250
IAEVLKVVDP ETTLFLVASK TFTTAETITN ANTAKNWFLS KTGNDQSNIA
260 270 280 290 300
KHFAALSTNE TEVAKFGIDT KNMFGFENWV GGRYSVWSAI GLSVALYIGF
310 320 330 340 350
DNFEAFLKGA EAVDKHFVET PLEDNIPLLG GLLSVWYNNF FGAQTHLVAP
360 370 380 390 400
FDQYLHRFPA YLQQLSMESN GKSVTRGNVF STYSTGSILF GEPATNAQHS
410 420 430 440 450
FFQLVHQGTK LIPSDFILAA QSHNPIENNL HQKMLASNFF AQAEALMVGK
460 470 480 490 500
DEAQVKSEGA TGGLVPHKIF SGNRPTTSIL AQKITPAALG SLIAYYEHVT
510 520 530 540 550
FTEGAIWNIN SFDQWGVELG KVLAKVIGKE LDNTEKITAH DASTNGLINQ

FKEWL
Length:555
Mass (Da):61,310
Last modified:July 19, 2004 - v1
Checksum:iD6237C5392EFF0CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380954 Genomic DNA. Translation: CAG59966.1.
RefSeqiXP_447033.1. XM_447033.1.

Genome annotation databases

GeneIDi2888511.
KEGGicgr:CAGL0H05445g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380954 Genomic DNA. Translation: CAG59966.1.
RefSeqiXP_447033.1. XM_447033.1.

3D structure databases

ProteinModelPortaliQ6FRW1.
SMRiQ6FRW1. Positions 13-554.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6FRW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2888511.
KEGGicgr:CAGL0H05445g.

Phylogenomic databases

HOGENOMiHOG000261371.
InParanoidiQ6FRW1.
KOiK01810.
OMAiCETQAML.
OrthoDBiEOG7N0CDV.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG6PI_CANGA
AccessioniPrimary (citable) accession number: Q6FRW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 19, 2004
Last modified: January 7, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.