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Q6FRW1 (G6PI_CANGA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glucose-6-phosphate isomerase

Short name=GPI
EC=5.3.1.9
Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI
Gene names
Name:PGI1
Ordered Locus Names:CAGL0H05445g
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier284593 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP-Rule MF_00473

Pathway

Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP-Rule MF_00473

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00473.

Sequence similarities

Belongs to the GPI family.

Ontologies

Keywords
   Biological processGluconeogenesis
Glycolysis
   Cellular componentCytoplasm
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processgluconeogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

glycolysis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytosol

Inferred from direct assay PubMed 21085892. Source: CGD

   Molecular_functionglucose-6-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Glucose-6-phosphate isomerase HAMAP-Rule MF_00473
PRO_0000180573

Sites

Active site3681Proton donor By similarity
Active site3991 By similarity
Active site5211 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6FRW1 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: D6237C5392EFF0CA

FASTA55561,310
        10         20         30         40         50         60 
MASSNTYSNF KLATELPAWS KLQKLYDAQG KSLNVKEEFQ KDSARYNKYA KTLTNYDGSK 

        70         80         90        100        110        120 
ILFDFSKNLI NDEILATLIE LAKEAKVTDL RDAMFAGEHI NFTEDRAVYH VALRNRANKP 

       130        140        150        160        170        180 
MKVDGVDVAP EVDAVLQHMK EFSEQVRSGE WKGYTGKKIT DVVNIGIGGS DLGPVMVTEA 

       190        200        210        220        230        240 
LKHYAGVLDV HFVSNIDGTH IAEVLKVVDP ETTLFLVASK TFTTAETITN ANTAKNWFLS 

       250        260        270        280        290        300 
KTGNDQSNIA KHFAALSTNE TEVAKFGIDT KNMFGFENWV GGRYSVWSAI GLSVALYIGF 

       310        320        330        340        350        360 
DNFEAFLKGA EAVDKHFVET PLEDNIPLLG GLLSVWYNNF FGAQTHLVAP FDQYLHRFPA 

       370        380        390        400        410        420 
YLQQLSMESN GKSVTRGNVF STYSTGSILF GEPATNAQHS FFQLVHQGTK LIPSDFILAA 

       430        440        450        460        470        480 
QSHNPIENNL HQKMLASNFF AQAEALMVGK DEAQVKSEGA TGGLVPHKIF SGNRPTTSIL 

       490        500        510        520        530        540 
AQKITPAALG SLIAYYEHVT FTEGAIWNIN SFDQWGVELG KVLAKVIGKE LDNTEKITAH 

       550 
DASTNGLINQ FKEWL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR380954 Genomic DNA. Translation: CAG59966.1.
RefSeqXP_447033.1. XM_447033.1.

3D structure databases

ProteinModelPortalQ6FRW1.
SMRQ6FRW1. Positions 13-554.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ6FRW1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2888511.
KEGGcgr:CAGL0H05445g.

Phylogenomic databases

HOGENOMHOG000261371.
KOK01810.
OMALKMHFVS.
OrthoDBEOG7N0CDV.

Enzyme and pathway databases

UniPathwayUPA00109; UER00181.

Family and domain databases

Gene3D1.10.1390.10. 1 hit.
HAMAPMF_00473. G6P_isomerase.
InterProIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERPTHR11469. PTHR11469. 1 hit.
PfamPF00342. PGI. 1 hit.
[Graphical view]
PRINTSPR00662. G6PISOMERASE.
PROSITEPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG6PI_CANGA
AccessionPrimary (citable) accession number: Q6FRW1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 19, 2004
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways