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Protein

Glutathione reductase

Gene

GLR1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Maintains high levels of reduced glutathione in the cytosol.By similarity

Miscellaneous

The active site is a redox-active disulfide bond.By similarity

Catalytic activityi

2 glutathione + NADP+ = glutathione disulfide + NADPH.

Cofactori

FADBy similarityNote: Binds 1 FAD per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei465Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi46 – 54FADBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione reductase (EC:1.8.1.7)
Short name:
GR
Short name:
GRase
Gene namesi
Name:GLR1
Ordered Locus Names:CAGL0H05665g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome H

Organism-specific databases

CGDiCAL0131774 GLR1
EuPathDBiFungiDB:CAGL0H05665g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000679661 – 476Glutathione reductaseAdd BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 59Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiQ6FRV2

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_447042.1

Structurei

3D structure databases

ProteinModelPortaliQ6FRV2
SMRiQ6FRV2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG0405 Eukaryota
COG1249 LUCA
HOGENOMiHOG000276712
InParanoidiQ6FRV2
KOiK00383
OMAiGLECACF
OrthoDBiEOG092C2ILO

Family and domain databases

Gene3Di3.30.390.30, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR016156 FAD/NAD-linked_Rdtase_dimer_sf
IPR006322 Glutathione_Rdtase_euk/bac
IPR001100 Pyr_nuc-diS_OxRdtase
IPR004099 Pyr_nucl-diS_OxRdtase_dimer
IPR012999 Pyr_OxRdtase_I_AS
PANTHERiPTHR42737 PTHR42737, 1 hit
PfamiView protein in Pfam
PF07992 Pyr_redox_2, 1 hit
PF02852 Pyr_redox_dim, 1 hit
PIRSFiPIRSF000350 Mercury_reductase_MerA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
SSF55424 SSF55424, 1 hit
TIGRFAMsiTIGR01421 gluta_reduc_1, 1 hit
PROSITEiView protein in PROSITE
PS00076 PYRIDINE_REDOX_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q6FRV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVKRLFRTM APVAKHFDYL VIGGGSGGVA SSRRAASYGA KTLLIEGKAL
60 70 80 90 100
GGTCVNVGCV PKKVMWYASD LATRLTHAHE YGLAQNVPLS KESITFNWPE
110 120 130 140 150
FKKKRDAYIH RLNGIYENNL KKEGVEVVFG WAKFNKDGNV EVTKHDNTTE
160 170 180 190 200
VYSADRILVA TGGKPVYPEK VPGFELGTDS DGFFRLEEQP KKVVVVGAGY
210 220 230 240 250
IGIELAGVFH GLGSDSHLVI RGKTVLRKFD EIIQNTVTDY YVEEGINVHK
260 270 280 290 300
ETNVDKVEKD EKTGKLSVHL TNGQVLEDVD ELIWTMGRRS LLGIGLENVG
310 320 330 340 350
VKLNDKEQII TDEYQNTNVP NIYSLGDVSG RVELTPVAIA AGRKLSNRLF
360 370 380 390 400
GPEQYRNDKL DYTNVPSVVF SHPEAGSIGL TEDEAIKQYG KDNIKVYTSK
410 420 430 440 450
FTAMYYAMLE HKSPTRYKII CEGPNEKVVG LHIVGDSSAE ILQGFGVAIK
460 470
MGATKADFDN CVAIHPTSAE ELVTMR
Length:476
Mass (Da):52,499
Last modified:July 19, 2004 - v1
Checksum:iBA4793D0F077D14D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380954 Genomic DNA Translation: CAG59975.1
RefSeqiXP_447042.1, XM_447042.1

Genome annotation databases

EnsemblFungiiCAG59975; CAG59975; CAGL0H05665g
GeneIDi2888553
KEGGicgr:CAGL0H05665g

Similar proteinsi

Entry informationi

Entry nameiGSHR_CANGA
AccessioniPrimary (citable) accession number: Q6FRV2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 19, 2004
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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