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Q6FRV2 (GSHR_CANGA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione reductase

Short name=GR
Short name=GRase
EC=1.8.1.7
Gene names
Name:GLR1
Ordered Locus Names:CAGL0H05665g
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier284593 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces

Protein attributes

Sequence length476 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Maintains high levels of reduced glutathione in the cytosol By similarity.

Catalytic activity

2 glutathione + NADP+ = glutathione disulfide + NADPH.

Cofactor

Binds 1 FAD per subunit By similarity.

Subcellular location

Cytoplasm By similarity.

Miscellaneous

The active site is a redox-active disulfide bond By similarity.

Sequence similarities

Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainRedox-active center
   LigandFAD
Flavoprotein
NADP
   Molecular functionOxidoreductase
   PTMDisulfide bond
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcell redox homeostasis

Inferred from electronic annotation. Source: InterPro

glutathione metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionNADP binding

Inferred from electronic annotation. Source: InterPro

flavin adenine dinucleotide binding

Inferred from electronic annotation. Source: InterPro

glutathione-disulfide reductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 476476Glutathione reductase
PRO_0000067966

Regions

Nucleotide binding46 – 549FAD By similarity

Sites

Active site4651Proton acceptor By similarity

Amino acid modifications

Disulfide bond54 ↔ 59Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6FRV2 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: BA4793D0F077D14D

FASTA47652,499
        10         20         30         40         50         60 
MIVKRLFRTM APVAKHFDYL VIGGGSGGVA SSRRAASYGA KTLLIEGKAL GGTCVNVGCV 

        70         80         90        100        110        120 
PKKVMWYASD LATRLTHAHE YGLAQNVPLS KESITFNWPE FKKKRDAYIH RLNGIYENNL 

       130        140        150        160        170        180 
KKEGVEVVFG WAKFNKDGNV EVTKHDNTTE VYSADRILVA TGGKPVYPEK VPGFELGTDS 

       190        200        210        220        230        240 
DGFFRLEEQP KKVVVVGAGY IGIELAGVFH GLGSDSHLVI RGKTVLRKFD EIIQNTVTDY 

       250        260        270        280        290        300 
YVEEGINVHK ETNVDKVEKD EKTGKLSVHL TNGQVLEDVD ELIWTMGRRS LLGIGLENVG 

       310        320        330        340        350        360 
VKLNDKEQII TDEYQNTNVP NIYSLGDVSG RVELTPVAIA AGRKLSNRLF GPEQYRNDKL 

       370        380        390        400        410        420 
DYTNVPSVVF SHPEAGSIGL TEDEAIKQYG KDNIKVYTSK FTAMYYAMLE HKSPTRYKII 

       430        440        450        460        470 
CEGPNEKVVG LHIVGDSSAE ILQGFGVAIK MGATKADFDN CVAIHPTSAE ELVTMR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR380954 Genomic DNA. Translation: CAG59975.1.
RefSeqXP_447042.1. XM_447042.1.

3D structure databases

ProteinModelPortalQ6FRV2.
SMRQ6FRV2. Positions 15-476.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2888553.
KEGGcgr:CAGL0H05665g.

Phylogenomic databases

HOGENOMHOG000276712.
KOK00383.
OMAGTNSDGF.
OrthoDBEOG79W9F2.

Family and domain databases

Gene3D3.30.390.30. 1 hit.
InterProIPR016156. FAD/NAD-linked_Rdtase_dimer.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR006322. Glutathione_Rdtase_euk/bac.
IPR004099. Pyr_nucl-diS_OxRdtase_dimer.
IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD.
IPR012999. Pyr_OxRdtase_I_AS.
IPR001327. Pyr_OxRdtase_NAD-bd_dom.
[Graphical view]
PfamPF00070. Pyr_redox. 1 hit.
PF07992. Pyr_redox_2. 1 hit.
PF02852. Pyr_redox_dim. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
SUPFAMSSF55424. SSF55424. 1 hit.
TIGRFAMsTIGR01421. gluta_reduc_1. 1 hit.
PROSITEPS00076. PYRIDINE_REDOX_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSHR_CANGA
AccessionPrimary (citable) accession number: Q6FRV2
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families