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Reviewed, UniProtKB/Swiss-Prot Q6FRB7 (IPYR_CANGA)

Last modified January 19, 2010. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Inorganic pyrophosphatase
    EC=3.6.1.1
Alternative name(s):
    Pyrophosphate phospho-hydrolase
      Short name=PPase
Gene names
Name: IPP1
Ordered Locus Names: CAGL0H09878g
OrganismCandida glabrata (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier5478 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces

Protein attributes

Sequence length287 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Diphosphate + H2O = 2 phosphate.

Cofactor

Binds 4 magnesium ions per subunit. Other metal ions can support activity, but at a lower rate. Two magnesium ions are required for the activation of the enzyme and are present before substrate binds, two additional magnesium ions form complexes with substrate and product By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the PPase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMagnesium
Metal-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processphosphate metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functioninorganic diphosphatase activity

Inferred from electronic annotation. Source: EC

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 287287Inorganic pyrophosphatase
PRO_0000137581

Sites

Metal binding1161Magnesium 1 By similarity
Metal binding1211Magnesium 1 By similarity
Metal binding1211Magnesium 2 By similarity
Metal binding1531Magnesium 1 By similarity
Binding site791Inorganic pyrophosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6FRB7-1 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: E4BEC0B55E442AAA

FASTA28732,313
        10         20         30         40         50         60 
MVYTTRQIGA KNTLDYKVFI EEDGKPVSPF HDIPLYADKE ENIFNMVVEI PRWTNAKLEI 

        70         80         90        100        110        120 
TKEETLNPII QDTKKGKLRY VRNCFPHHGY IHNYGAFPQT WEDPNQTHPE TKAVGDNDPV 

       130        140        150        160        170        180 
DVLEIGETIG YTGQVKQVKV LGIMALLDEG ETDWKVIAID INDPLAPKLN DIEDVEKYFP 

       190        200        210        220        230        240 
GLLRATNEWF RIYKIPDGKP ENQFAFSGEA KNKKYALDII KETNESWKQL IAGKSTDSKD 

       250        260        270        280 
IALENTKVTD SPYYSASAAS AIPAAAPQAD APIDKSVDKW FFISGSA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR380954 Genomic DNA. Translation: CAG60160.1.
RefSeqXP_447227.1.

3D structure databases

SMRQ6FRB7. Positions 3-286.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6FRB7.

Genome annotation databases

GeneID2888731.
GenomeReviewsGene locus CAGL0H09878g in contig CR380954_GR.
KEGGcgr:CAGL0H09878g.

Phylogenomic databases

eggNOGfuNOG04419.
HOGENOMHBG434750.
OMAWFFISGS.
OrthoDBEOG93JDNG.
PhylomeDBQ6FRB7.

Enzyme and pathway databases

BRENDA3.6.1.1. 189220.

Family and domain databases

InterProIPR008162. Pyrophosphatase.
[Graphical view]
Gene3DG3DSA:3.90.80.10. Pyrophosphatase. 1 hit.
PANTHERPTHR10286. Pyrophosphatase. 1 hit.
PfamPF00719. Pyrophosphatase. 1 hit.
[Graphical view]
PROSITEPS00387. PPASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIPYR_CANGA
AccessionPrimary (citable) accession number: Q6FRB7
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 19, 2004
Last modified: January 19, 2010
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents