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Protein

Solute carrier family 25 member 38 homolog

Gene

CAGL0H10538g

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial carrier required for the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 25 member 38 homologUniRule annotation
Gene namesi
Ordered Locus Names:CAGL0H10538g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome H

Organism-specific databases

CGDiCAL0131438. CAGL0H10538g.
EuPathDBiFungiDB:CAGL0H10538g.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 33Helical; Name=1UniRule annotationAdd BLAST26
Transmembranei56 – 82Helical; Name=2UniRule annotationAdd BLAST27
Transmembranei111 – 136Helical; Name=3UniRule annotationAdd BLAST26
Transmembranei164 – 187Helical; Name=4UniRule annotationAdd BLAST24
Transmembranei215 – 241Helical; Name=5UniRule annotationAdd BLAST27
Transmembranei270 – 288Helical; Name=6UniRule annotationAdd BLAST19

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003789321 – 297Solute carrier family 25 member 38 homologAdd BLAST297

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_447256.1.

Structurei

3D structure databases

ProteinModelPortaliQ6FR88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati5 – 81Solcar 1Add BLAST77
Repeati105 – 189Solcar 2Add BLAST85
Repeati211 – 295Solcar 3Add BLAST85

Sequence similaritiesi

Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily. [View classification]UniRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0766. Eukaryota.
ENOG410XRMK. LUCA.
HOGENOMiHOG000006978.
InParanoidiQ6FR88.
KOiK15118.
OMAiTVYEQMM.
OrthoDBiEOG092C3NVU.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
HAMAPiMF_03064. SLC25A38. 1 hit.
InterProiView protein in InterPro
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
IPR030847. SLC25A38.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q6FR88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSTGHLIG GFAGGLSSAV ALQPLDLLKT RFQQTKGGTL WQTVKSLDTP
60 70 80 90 100
WQLWRGTLPS AIRTSVGSAL YLSSLNLMRT ALAKRKQFDT ADSVVTGKSS
110 120 130 140 150
NLPQLSMYEN LVTGAFARGT VGYITMPITI IKVRYESTLY NYKSIAEAAK
160 170 180 190 200
SIAAQEGIRG FFRGFGPTCL RDAPYSGLYV LLYEKLKHTL PTILPKSLLQ
210 220 230 240 250
LDSEGRYTAY TSTAINSTSA ILSASMATTV TAPFDTIKTR MQLEPTKFKT
260 270 280 290
FWSTLTTIVT QEHPIKIFSG LSMRLTRKAL SAGIAWGIYE ELIKHFM
Length:297
Mass (Da):32,592
Last modified:July 19, 2004 - v1
Checksum:iC3E7DB744251EC4C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380954 Genomic DNA. Translation: CAG60189.1.
RefSeqiXP_447256.1. XM_447256.1.

Genome annotation databases

EnsemblFungiiCAG60189; CAG60189; CAGL0H10538g.
KEGGicgr:CAGL0H10538g.

Similar proteinsi

Entry informationi

Entry nameiS2538_CANGA
AccessioniPrimary (citable) accession number: Q6FR88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: July 19, 2004
Last modified: August 30, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families