UniProtKB - Q6FR76 (UBC2_CANGA)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Ubiquitin-conjugating enzyme E2 2
Gene
UBC2
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Functioni
Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation.PROSITE-ProRule annotation
Catalytic activityi
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotationView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 88 | Glycyl thioester intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- single-stranded DNA binding Source: EnsemblFungi
- single-stranded DNA-dependent ATPase activity Source: EnsemblFungi
- ubiquitin conjugating enzyme activity Source: EnsemblFungi
GO - Biological processi
- cellular response to hyperoxia Source: EnsemblFungi
- chromatin assembly Source: EnsemblFungi
- chromatin silencing at telomere Source: EnsemblFungi
- cytoplasm protein quality control by the ubiquitin-proteasome system Source: EnsemblFungi
- DNA-templated transcription, termination Source: EnsemblFungi
- double-strand break repair via homologous recombination Source: EnsemblFungi
- error-free postreplication DNA repair Source: EnsemblFungi
- error-free translesion synthesis Source: EnsemblFungi
- error-prone translesion synthesis Source: EnsemblFungi
- histone H2B conserved C-terminal lysine ubiquitination Source: EnsemblFungi
- histone monoubiquitination Source: EnsemblFungi
- meiotic DNA double-strand break formation Source: EnsemblFungi
- mitotic G1 DNA damage checkpoint Source: EnsemblFungi
- negative regulation of chromatin silencing at silent mating-type cassette Source: EnsemblFungi
- negative regulation of chromatin silencing at telomere Source: EnsemblFungi
- negative regulation of SREBP signaling pathway Source: EnsemblFungi
- proteasome localization to nuclear periphery Source: EnsemblFungi
- protein K63-linked ubiquitination Source: EnsemblFungi
- regulation of dipeptide transport Source: EnsemblFungi
- regulation of histone H3-K4 methylation Source: EnsemblFungi
- sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
- telomere maintenance via recombination Source: EnsemblFungi
- transcription by RNA polymerase II Source: EnsemblFungi
- ubiquitin-dependent ERAD pathway Source: EnsemblFungi
- ubiquitin-dependent protein catabolic process via the N-end rule pathway Source: EnsemblFungi
Keywordsi
Molecular function | Chromatin regulator, Transferase |
Biological process | DNA damage, DNA repair, Sporulation, Transcription, Transcription regulation, Ubl conjugation pathway |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin-conjugating enzyme E2 2 (EC:2.3.2.23)Alternative name(s): E2 ubiquitin-conjugating enzyme 2 Ubiquitin carrier protein UBC2 Ubiquitin-protein ligase UBC2 |
Gene namesi | Name:UBC2 Ordered Locus Names:CAGL0I00352g |
Organismi | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) |
Taxonomic identifieri | 284593 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › Nakaseomyces/Candida clade › |
Proteomesi |
|
Organism-specific databases
CGDi | CAL0130017 CAGL0I00352g |
EuPathDBi | FungiDB:CAGL0I00352g |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000082529 | 1 – 167 | Ubiquitin-conjugating enzyme E2 2Add BLAST | 167 |
Structurei
3D structure databases
ProteinModelPortali | Q6FR76 |
SMRi | Q6FR76 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG0419 Eukaryota COG5078 LUCA |
InParanoidi | Q6FR76 |
KOi | K10573 |
OMAi | RENMKEY |
OrthoDBi | EOG092C50OL |
Family and domain databases
CDDi | cd00195 UBCc, 1 hit |
Gene3Di | 3.10.110.101 hit |
InterProi | View protein in InterPro IPR000608 UBQ-conjugat_E2 IPR023313 UBQ-conjugating_AS IPR016135 UBQ-conjugating_enzyme/RWD |
Pfami | View protein in Pfam PF00179 UQ_con, 1 hit |
SUPFAMi | SSF54495 SSF54495, 1 hit |
PROSITEi | View protein in PROSITE PS00183 UBIQUITIN_CONJUGAT_1, 1 hit PS50127 UBIQUITIN_CONJUGAT_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6FR76-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTPARRRLM RDFKRMKEDS PPGVSASPLP DNVMVWNAMI IGPADTPYED
60 70 80 90 100
GTFRLLLEFD EDYPNKPPHV KFLSEMFHPN VYANGEICLD ILQNRWTPTY
110 120 130 140 150
DVASILTSIQ SLFNDPNPAS PANVEAATLF KDHKSQYIKR VKETVEKSWE
160
DNMDDMDDSD EDDEDDE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CR380955 Genomic DNA Translation: CAG60205.1 |
RefSeqi | XP_447268.1, XM_447268.1 |
Genome annotation databases
EnsemblFungii | CAG60205; CAG60205; CAGL0I00352g |
GeneIDi | 2889314 |
KEGGi | cgr:CAGL0I00352g |
Similar proteinsi
Entry informationi
Entry namei | UBC2_CANGA | |
Accessioni | Q6FR76Primary (citable) accession number: Q6FR76 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2006 |
Last sequence update: | July 19, 2004 | |
Last modified: | April 25, 2018 | |
This is version 106 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |