UBC2

Functionⁱ

Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation.PROSITE-ProRule annotation

Catalytic activityⁱ

S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PROSITE-ProRule annotation

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.PROSITE-ProRule annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	88	Glycyl thioester intermediatePROSITE-ProRule annotation		1

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
single-stranded DNA binding Source: EnsemblFungi
single-stranded DNA-dependent ATPase activity Source: EnsemblFungi
ubiquitin conjugating enzyme activity Source: EnsemblFungi

Complete GO annotation...

GO - Biological processⁱ

cellular response to hyperoxia Source: EnsemblFungi
chromatin assembly Source: EnsemblFungi
chromatin silencing at telomere Source: EnsemblFungi
DNA-templated transcription, termination Source: EnsemblFungi
double-strand break repair via homologous recombination Source: EnsemblFungi
error-free postreplication DNA repair Source: EnsemblFungi
error-free translesion synthesis Source: EnsemblFungi
error-prone translesion synthesis Source: EnsemblFungi
histone H2B conserved C-terminal lysine ubiquitination Source: EnsemblFungi
histone monoubiquitination Source: EnsemblFungi
meiotic DNA double-strand break formation Source: EnsemblFungi
mitotic G1 DNA damage checkpoint Source: EnsemblFungi
negative regulation of chromatin silencing at silent mating-type cassette Source: EnsemblFungi
negative regulation of chromatin silencing at telomere Source: EnsemblFungi
negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolic process in response to increased oxygen levels Source: EnsemblFungi
negative regulation of transcription by transcription factor catabolism Source: EnsemblFungi
proteasome localization to nuclear periphery Source: EnsemblFungi
protein K63-linked ubiquitination Source: EnsemblFungi
protein polyubiquitination involved in nucleus-associated proteasomal ubiquitin-dependent protein catabolic process Source: EnsemblFungi
regulation of dipeptide transport Source: EnsemblFungi
regulation of histone H3-K4 methylation Source: EnsemblFungi
sporulation resulting in formation of a cellular spore Source: UniProtKB-KW
telomere maintenance via recombination Source: EnsemblFungi
transcription from RNA polymerase II promoter Source: EnsemblFungi
ubiquitin-dependent catabolism of misfolded proteins by cytoplasm-associated proteasome Source: EnsemblFungi
ubiquitin-dependent ERAD pathway Source: EnsemblFungi
ubiquitin-dependent protein catabolic process via the N-end rule pathway Source: EnsemblFungi

Complete GO annotation...

Keywordsⁱ

Molecular function	Chromatin regulator, Transferase
Biological process	DNA damage, DNA repair, Sporulation, Transcription, Transcription regulation, Ubl conjugation pathway
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayⁱ	UPA00143.

UniPathwayⁱ

UPA00143.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ubiquitin-conjugating enzyme E2 2 (EC:2.3.2.23) Alternative name(s): E2 ubiquitin-conjugating enzyme 2 Ubiquitin carrier protein UBC2 Ubiquitin-protein ligase UBC2
Gene namesⁱ	Name:UBC2 Ordered Locus Names:CAGL0I00352g
Organismⁱ	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifierⁱ	284593 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › Nakaseomyces/Candida clade › Candida glabrata
Proteomesⁱ	UP000002428 Componentⁱ: Chromosome I

Organism-specific databases

Candida Genome Database More...CGDⁱ	CAL0130017. CAGL0I00352g.
EuPathDBⁱ	FungiDB:CAGL0I00352g.

Subcellular locationⁱ

GO - Cellular componentⁱ

chromosome, telomeric region Source: GOC
cytosol Source: EnsemblFungi
HULC complex Source: EnsemblFungi
MUB1-RAD6-UBR2 ubiquitin ligase complex Source: EnsemblFungi
nuclear chromatin Source: EnsemblFungi
proteasome complex Source: EnsemblFungi
Rad6-Rad18 complex Source: EnsemblFungi

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000082529	1 – 167	Ubiquitin-conjugating enzyme E2 2Add BLAST		167

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	284593.XP_447268.1.

STRINGⁱ

284593.XP_447268.1.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6FR76.
SMRⁱ	Q6FR76.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG0419. Eukaryota. COG5078. LUCA.
InParanoidⁱ	Q6FR76.
KEGG Orthology (KO) More...KOⁱ	K10573.
OMAⁱ	RENMKEY.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C50OL.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00195. UBCc. 1 hit.
Gene3Dⁱ	3.10.110.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000608. UBQ-conjugat_E2. IPR023313. UBQ-conjugating_AS. IPR016135. UBQ-conjugating_enzyme/RWD.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00179. UQ_con. 1 hit.
SUPFAMⁱ	SSF54495. SSF54495. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6FR76-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSTPARRRLM RDFKRMKEDS PPGVSASPLP DNVMVWNAMI IGPADTPYED 
        60         70         80         90        100
GTFRLLLEFD EDYPNKPPHV KFLSEMFHPN VYANGEICLD ILQNRWTPTY 
       110        120        130        140        150
DVASILTSIQ SLFNDPNPAS PANVEAATLF KDHKSQYIKR VKETVEKSWE 
       160 
DNMDDMDDSD EDDEDDE

Length:167

Mass (Da):19,189

Last modified:July 19, 2004 - v1

Checksum:ⁱA9EF7E08327079AE

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CR380955 Genomic DNA. Translation: CAG60205.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_447268.1. XM_447268.1.

Genome annotation databases

EnsemblFungiⁱ	CAG60205; CAG60205; CAGL0I00352g.
GeneIDⁱ	2889314.
KEGGⁱ	cgr:CAGL0I00352g.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CR380955 Genomic DNA. Translation: CAG60205.1.
NCBI Reference Sequences More...RefSeqⁱ	XP_447268.1. XM_447268.1.

3D structure databases

ProteinModelPortalⁱ	Q6FR76.
SMRⁱ	Q6FR76.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	284593.XP_447268.1.

STRINGⁱ

284593.XP_447268.1.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	CAG60205; CAG60205; CAGL0I00352g.
GeneIDⁱ	2889314.
KEGGⁱ	cgr:CAGL0I00352g.

Organism-specific databases

Candida Genome Database More...CGDⁱ	CAL0130017. CAGL0I00352g.
EuPathDBⁱ	FungiDB:CAGL0I00352g.

Phylogenomic databases

eggNOGⁱ	KOG0419. Eukaryota. COG5078. LUCA.
InParanoidⁱ	Q6FR76.
KEGG Orthology (KO) More...KOⁱ	K10573.
OMAⁱ	RENMKEY.
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C50OL.

Enzyme and pathway databases

UniPathwayⁱ	UPA00143.

UniPathwayⁱ

UPA00143.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00195. UBCc. 1 hit.
Gene3Dⁱ	3.10.110.10. 1 hit.
InterProⁱ	View protein in InterPro IPR000608. UBQ-conjugat_E2. IPR023313. UBQ-conjugating_AS. IPR016135. UBQ-conjugating_enzyme/RWD.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00179. UQ_con. 1 hit.
SUPFAMⁱ	SSF54495. SSF54495. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	UBC2_CANGA
Accessionⁱ	Q6FR76Primary (citable) accession number: Q6FR76
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
	Last sequence update:	July 19, 2004
	Last modified:	June 7, 2017
	This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

PATHWAY comments
Index of metabolic and biosynthesis pathways
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6FR76 (UBC2_CANGA)

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Ubiquitin-conjugating enzyme E2 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ