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Protein

Acyl-CoA desaturase

Gene

CAGL0I00418g

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Stearyl-CoA desaturase that utilizes O2 and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.UniRule annotation

Catalytic activityi

Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.UniRule annotation

Cofactori

Fe2+UniRule annotationNote: Expected to bind 2 Fe2+ ions per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotation
Biological processElectron transportUniRule annotation, Fatty acid biosynthesisUniRule annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transport
LigandHemeUniRule annotationSAAS annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA desaturaseUniRule annotation (EC:1.14.19.1UniRule annotation)
Gene namesi
Ordered Locus Names:CAGL0I00418gImported
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)Imported
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome I

Organism-specific databases

CGDiCAL0132290. CAGL0I00418g.
EuPathDBiFungiDB:CAGL0I00418g.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei88 – 107HelicalSequence analysisAdd BLAST20
Transmembranei119 – 138HelicalSequence analysisAdd BLAST20
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_447271.1.

Structurei

3D structure databases

ProteinModelPortaliQ6FR73.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini386 – 464Cytochrome b5 heme-bindingInterPro annotationAdd BLAST79

Sequence similaritiesi

Belongs to the fatty acid desaturase type 1 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0537. Eukaryota.
KOG1600. Eukaryota.
COG1398. LUCA.
COG5274. LUCA.
InParanoidiQ6FR73.
KOiK00507.
OMAiFNGGVYF.
OrthoDBiEOG092C2CE8.

Family and domain databases

CDDicd03505. Delta9-FADS-like. 1 hit.
Gene3Di3.10.120.10. 1 hit.
InterProiView protein in InterPro
IPR009160. Acyl-CoA_deSatase_haem/ster-bd.
IPR015876. Acyl-CoA_DS.
IPR001199. Cyt_B5-like_heme/steroid-bd.
IPR036400. Cyt_B5-like_heme/steroid_sf.
IPR018506. Cyt_B5_heme-BS.
IPR005804. FA_desaturase_dom.
IPR001522. FADS-1_CS.
PANTHERiPTHR11351. PTHR11351. 1 hit.
PfamiView protein in Pfam
PF00173. Cyt-b5. 1 hit.
PF00487. FA_desaturase. 1 hit.
PIRSFiPIRSF000345. OLE1. 1 hit.
PRINTSiPR00075. FACDDSATRASE.
SMARTiView protein in SMART
SM01117. Cyt-b5. 1 hit.
SUPFAMiSSF55856. SSF55856. 1 hit.
PROSITEiView protein in PROSITE
PS00191. CYTOCHROME_B5_1. 1 hit.
PS50255. CYTOCHROME_B5_2. 1 hit.
PS00476. FATTY_ACID_DESATUR_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FR73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRVETRNVT TEFQKDGLDE VDLVQANILA AGLDKKTVRV VNGLGKLMGS
60 70 80 90 100
KEMVQVEFNK DKPTSKISAS TPHISEQPWT LNNWHEHLNW LNLVLVCGLP
110 120 130 140 150
MIGWYFVVSG KAKLTWQMAL FATFYYALGG ISITAGYHRL WSHRAYSARL
160 170 180 190 200
PLKIFFAFFG AASVQGSIKW WGHSHRIHHR YTDTLRDPYD ARQGLWYSHM
210 220 230 240 250
GWMLLKPNPK YKARADISDL TDDWVVRFQH KHYIPMMLLS GFVLPCLLGG
260 270 280 290 300
YLLNDYLGGL IYGGFIRIFV IQQATFCINS MAHYLGTQPF DDRRTPRDNW
310 320 330 340 350
ITAIVTFGEG YHNFHHEFPS DYRNAIKWYQ YDPTKVFIYL TSLFGLSYDL
360 370 380 390 400
KTFSQNIIQQ ALIQQRQKKI DRDSKSVNWG PKLADLPAWT KEEFLEKNRE
410 420 430 440 450
NDGLVIVGGI VHDVSGYITE HPGGEKLLKN ALGKDATKAF SGGVYRHSNA
460 470 480 490
AHNTLATMRV AVMKDNKETA MRFAQKRGER AERVERAHMN
Length:490
Mass (Da):56,218
Last modified:July 19, 2004 - v1
Checksum:iC688CBD152F6C297
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380955 Genomic DNA. Translation: CAG60208.1.
RefSeqiXP_447271.1. XM_447271.1.

Genome annotation databases

EnsemblFungiiCAG60208; CAG60208; CAGL0I00418g.
GeneIDi2889318.
KEGGicgr:CAGL0I00418g.

Similar proteinsi

Entry informationi

Entry nameiQ6FR73_CANGA
AccessioniPrimary (citable) accession number: Q6FR73
Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2004
Last sequence update: July 19, 2004
Last modified: October 25, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported