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Protein

Serine/threonine-protein kinase BUR1

Gene

BUR1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei89 – 891ATPPROSITE-ProRule annotation
Active sitei207 – 2071Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 749ATPPROSITE-ProRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase BUR1 (EC:2.7.11.22, EC:2.7.11.23)
Gene namesi
Name:BUR1
Ordered Locus Names:CAGL0I08349g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428 Componenti: Chromosome I

Organism-specific databases

EuPathDBiFungiDB:CAGL0I08349g.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 667667Serine/threonine-protein kinase BUR1PRO_0000085680Add
BLAST

Proteomic databases

PRIDEiQ6FQ83.

Structurei

3D structure databases

ProteinModelPortaliQ6FQ83.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 378319Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ6FQ83.
KOiK15562.
OMAiDERTWEL.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FQ83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQENSNVPA LKRTESKYKI GRVKSLPTVQ IDEKTGDSYI ELAPRSEGKI
60 70 80 90 100
YGCTTFQGNY KEEEKLGQGT FGEVYKGLHL QTQRKVAMKR IIVNQENDLF
110 120 130 140 150
PITAQREITI LKRLNHKNII KLLEMVYDFP PESNNKDYAQ FNQNNSANPP
160 170 180 190 200
AVPKKFFYMI LPYMVADLSG ILHNPRIELK MADIKNMMKQ ILEGVNFIHC
210 220 230 240 250
SKFMHRDIKT ANLLIDHNGV LKLADFGLAR QYYGSPPNIK FPGSAGSGAK
260 270 280 290 300
YTSVVVTRWY RAPELVLGDK YYTTAVDIWG VGCVFAEFFE KKPILQGKTD
310 320 330 340 350
IDQGHVIFKL MGTPDERTWE LAKYLPGAEL TKTEYKSTID ERFGKHLTPT
360 370 380 390 400
GLSFLKGLLA LDPYKRLTAM SAMKHPFFQE EPLAADRLTL PCEESHEADI
410 420 430 440 450
KRYKEELHEA MSQKGPSAPP GHIKEATPSP AKFEKKSGIK REQPYQSNQK
460 470 480 490 500
NDQYPIKRQK FNQNPSVPHP QPKANRYGGS SLPSGPKYGR YEGNNHSGSL
510 520 530 540 550
RNRITPSNMG THSNPRAENM GSKPYQSEGR YSSNEDRKNG YNRGYSSSVN
560 570 580 590 600
SRYNNRAAFN ETEDQSITTT TLNRYRHKGY HDNNQSQTRL QGHSSLPGKP
610 620 630 640 650
TSKYNSTQTN IPYRRTEIPN PNEYNASKLG SQDTKKNDYP KHSETQKQQN
660
NEEKKIHSEQ KDIADLY
Length:667
Mass (Da):75,961
Last modified:July 19, 2004 - v1
Checksum:i2D5D6197E6CAC4F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380955 Genomic DNA. Translation: CAG60548.1.
RefSeqiXP_447611.1. XM_447611.1.

Genome annotation databases

GeneIDi2889404.
KEGGicgr:CAGL0I08349g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380955 Genomic DNA. Translation: CAG60548.1.
RefSeqiXP_447611.1. XM_447611.1.

3D structure databases

ProteinModelPortaliQ6FQ83.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6FQ83.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2889404.
KEGGicgr:CAGL0I08349g.

Organism-specific databases

EuPathDBiFungiDB:CAGL0I08349g.

Phylogenomic databases

InParanoidiQ6FQ83.
KOiK15562.
OMAiDERTWEL.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBUR1_CANGA
AccessioniPrimary (citable) accession number: Q6FQ83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 19, 2004
Last modified: April 29, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.