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Q6FQ83 (BUR1_CANGA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase BUR1

EC=2.7.11.22
EC=2.7.11.23
Gene names
Name:BUR1
Ordered Locus Names:CAGL0I08349g
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier284593 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces

Protein attributes

Sequence length667 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 667667Serine/threonine-protein kinase BUR1
PRO_0000085680

Regions

Domain60 – 378319Protein kinase
Nucleotide binding66 – 749ATP By similarity

Sites

Active site2071Proton acceptor By similarity
Binding site891ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6FQ83 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 2D5D6197E6CAC4F6

FASTA66775,961
        10         20         30         40         50         60 
MSQENSNVPA LKRTESKYKI GRVKSLPTVQ IDEKTGDSYI ELAPRSEGKI YGCTTFQGNY 

        70         80         90        100        110        120 
KEEEKLGQGT FGEVYKGLHL QTQRKVAMKR IIVNQENDLF PITAQREITI LKRLNHKNII 

       130        140        150        160        170        180 
KLLEMVYDFP PESNNKDYAQ FNQNNSANPP AVPKKFFYMI LPYMVADLSG ILHNPRIELK 

       190        200        210        220        230        240 
MADIKNMMKQ ILEGVNFIHC SKFMHRDIKT ANLLIDHNGV LKLADFGLAR QYYGSPPNIK 

       250        260        270        280        290        300 
FPGSAGSGAK YTSVVVTRWY RAPELVLGDK YYTTAVDIWG VGCVFAEFFE KKPILQGKTD 

       310        320        330        340        350        360 
IDQGHVIFKL MGTPDERTWE LAKYLPGAEL TKTEYKSTID ERFGKHLTPT GLSFLKGLLA 

       370        380        390        400        410        420 
LDPYKRLTAM SAMKHPFFQE EPLAADRLTL PCEESHEADI KRYKEELHEA MSQKGPSAPP 

       430        440        450        460        470        480 
GHIKEATPSP AKFEKKSGIK REQPYQSNQK NDQYPIKRQK FNQNPSVPHP QPKANRYGGS 

       490        500        510        520        530        540 
SLPSGPKYGR YEGNNHSGSL RNRITPSNMG THSNPRAENM GSKPYQSEGR YSSNEDRKNG 

       550        560        570        580        590        600 
YNRGYSSSVN SRYNNRAAFN ETEDQSITTT TLNRYRHKGY HDNNQSQTRL QGHSSLPGKP 

       610        620        630        640        650        660 
TSKYNSTQTN IPYRRTEIPN PNEYNASKLG SQDTKKNDYP KHSETQKQQN NEEKKIHSEQ 


KDIADLY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR380955 Genomic DNA. Translation: CAG60548.1.
RefSeqXP_447611.1. XM_447611.1.

3D structure databases

ProteinModelPortalQ6FQ83.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ6FQ83.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2889404.
KEGGcgr:CAGL0I08349g.

Phylogenomic databases

KOK15562.
OMASHANLIN.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBUR1_CANGA
AccessionPrimary (citable) accession number: Q6FQ83
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families