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Q6FQ83

- BUR1_CANGA

UniProt

Q6FQ83 - BUR1_CANGA

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Protein
Serine/threonine-protein kinase BUR1
Gene
BUR1, CAGL0I08349g
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei89 – 891ATP By similarity
Active sitei207 – 2071Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi66 – 749ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
  3. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase BUR1 (EC:2.7.11.22, EC:2.7.11.23)
    Gene namesi
    Name:BUR1
    Ordered Locus Names:CAGL0I08349g
    OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
    Taxonomic identifieri284593 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
    ProteomesiUP000002428: Chromosome I

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 667667Serine/threonine-protein kinase BUR1
    PRO_0000085680Add
    BLAST

    Proteomic databases

    PRIDEiQ6FQ83.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6FQ83.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini60 – 378319Protein kinase
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    KOiK15562.
    OMAiSHANLIN.
    OrthoDBiEOG7K3TWD.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6FQ83-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQENSNVPA LKRTESKYKI GRVKSLPTVQ IDEKTGDSYI ELAPRSEGKI    50
    YGCTTFQGNY KEEEKLGQGT FGEVYKGLHL QTQRKVAMKR IIVNQENDLF 100
    PITAQREITI LKRLNHKNII KLLEMVYDFP PESNNKDYAQ FNQNNSANPP 150
    AVPKKFFYMI LPYMVADLSG ILHNPRIELK MADIKNMMKQ ILEGVNFIHC 200
    SKFMHRDIKT ANLLIDHNGV LKLADFGLAR QYYGSPPNIK FPGSAGSGAK 250
    YTSVVVTRWY RAPELVLGDK YYTTAVDIWG VGCVFAEFFE KKPILQGKTD 300
    IDQGHVIFKL MGTPDERTWE LAKYLPGAEL TKTEYKSTID ERFGKHLTPT 350
    GLSFLKGLLA LDPYKRLTAM SAMKHPFFQE EPLAADRLTL PCEESHEADI 400
    KRYKEELHEA MSQKGPSAPP GHIKEATPSP AKFEKKSGIK REQPYQSNQK 450
    NDQYPIKRQK FNQNPSVPHP QPKANRYGGS SLPSGPKYGR YEGNNHSGSL 500
    RNRITPSNMG THSNPRAENM GSKPYQSEGR YSSNEDRKNG YNRGYSSSVN 550
    SRYNNRAAFN ETEDQSITTT TLNRYRHKGY HDNNQSQTRL QGHSSLPGKP 600
    TSKYNSTQTN IPYRRTEIPN PNEYNASKLG SQDTKKNDYP KHSETQKQQN 650
    NEEKKIHSEQ KDIADLY 667
    Length:667
    Mass (Da):75,961
    Last modified:July 19, 2004 - v1
    Checksum:i2D5D6197E6CAC4F6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380955 Genomic DNA. Translation: CAG60548.1.
    RefSeqiXP_447611.1. XM_447611.1.

    Genome annotation databases

    GeneIDi2889404.
    KEGGicgr:CAGL0I08349g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380955 Genomic DNA. Translation: CAG60548.1 .
    RefSeqi XP_447611.1. XM_447611.1.

    3D structure databases

    ProteinModelPortali Q6FQ83.
    ModBasei Search...

    Proteomic databases

    PRIDEi Q6FQ83.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2889404.
    KEGGi cgr:CAGL0I08349g.

    Phylogenomic databases

    KOi K15562.
    OMAi SHANLIN.
    OrthoDBi EOG7K3TWD.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiBUR1_CANGA
    AccessioniPrimary (citable) accession number: Q6FQ83
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: July 19, 2004
    Last modified: May 14, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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