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Q6FQ44 (GLYM_CANGA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serine hydroxymethyltransferase, mitochondrial
Short name=SHMT
EC=2.1.2.1
Alternative name(s):
Glycine hydroxymethyltransferase
Serine methylase
Gene names
Name:SHM1
Ordered Locus Names:CAGL0I09284g
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier284593 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces ›

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Interconversion of serine and glycine.

Catalytic activity

5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.

Cofactor

Pyridoxal phosphate By similarity.

Pathway

One-carbon metabolism; tetrahydrofolate interconversion.

Subunit structure

Homotetramer By similarity.

Subcellular location

Mitochondrion.

Miscellaneous

In eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one.

Sequence similarities

Belongs to the SHMT family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandPyridoxal phosphate
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processL-serine metabolic process

Inferred from electronic annotation. Source: InterPro

glycine metabolic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentmitochondrion

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionglycine hydroxymethyltransferase activity

Inferred from electronic annotation. Source: EC

pyridoxal phosphate binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 485Serine hydroxymethyltransferase, mitochondrialPRO_0000032566

Amino acid modifications

Modified residue2591N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6FQ44 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 996413A030E4F95A

FASTA48553,510
        10         20         30         40         50         60 
MMLLRAARVP VLGRRFLSQQ QLISKHVQEV DPEMFRILSD ERSRQKHSVT LIPSENFTSK 

        70         80         90        100        110        120 
AVMDLLGSEM QNKYSEGYPG ERYYGGNQFI DKAESLCQAR ALDLYGLDPE KWGVNVQALS 

       130        140        150        160        170        180 
GAPANLYAYS AVMEVGDRLM GLDLPHGGHL SHGYQLPSGT KISYISKYFN TMPYHVNTET 

       190        200        210        220        230        240 
GIIDYDTLAM TSKLFRPKVI VAGTSAYSRK LDYARFRKIA DGCGAYLLSD MAHISGLVAA 

       250        260        270        280        290        300 
NVIDSPFEHS DIVTTTTHKS LRGPRGAMIF YRKGIKKVNK KTGKETPFTF DKTINFSVFP 

       310        320        330        340        350        360 
GHQGGPHNHT ISALAVALKQ AKTPEFVEYQ KQVVSNAKAF GDELLKRGFE LVSGGTDNHL 

       370        380        390        400        410        420 
LLLNLSNMGI DGARLEAILE KINIAANKNT IPGDKSALFP SGLRVGTPAM TTRGFQEQDF 

       430        440        450        460        470        480 
KKVAEYIDNA VKLSIALKSQ ESADAKDVRS KLNSFKQLCD QSEPVQKLAE EVSSWVGTFP 


VPGEL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR380955 Genomic DNA. Translation: CAG60587.1.
RefSeqXP_447650.1. XM_447650.1.

3D structure databases

ProteinModelPortalQ6FQ44.
SMRQ6FQ44. Positions 17-483.
ModBaseSearch...

Proteomic databases

PRIDEQ6FQ44.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2889124.
KEGGcgr:CAGL0I09284g.

Phylogenomic databases

KOK00600.
OMAGFNENDV.
OrthoDBEOG4V1B88.

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR001085. Ser_HO-MeTrfase.
IPR019798. Ser_HO-MeTrfase_PLP_BS.
[Graphical view]
PANTHERPTHR11680. PTHR11680. 1 hit.
PfamPF00464. SHMT. 1 hit.
[Graphical view]
PIRSFPIRSF000412. SHMT. 1 hit.
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00096. SHMT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLYM_CANGA
AccessionPrimary (citable) accession number: Q6FQ44
Entry history
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 19, 2004
Last modified: May 1, 2013
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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