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Q6FPW3 (G3P1_CANGA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Glyceraldehyde-3-phosphate dehydrogenase 1
Short name=GAPDH 1
EC=1.2.1.12
Gene names
Name:GPD1
Ordered Locus Names:CAGL0J00451g
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier284593 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces

Protein attributes

Sequence length332 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processglycolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionNAD binding

Inferred from electronic annotation. Source: InterPro

NADP binding

Inferred from electronic annotation. Source: InterPro

glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 332332Glyceraldehyde-3-phosphate dehydrogenase 1
PRO_0000145542

Regions

Nucleotide binding11 – 122NAD By similarity
Region149 – 1513Glyceraldehyde 3-phosphate binding By similarity
Region209 – 2102Glyceraldehyde 3-phosphate binding By similarity

Sites

Active site1501Nucleophile By similarity
Binding site331NAD By similarity
Binding site781NAD; via carbonyl oxygen By similarity
Binding site1801Glyceraldehyde 3-phosphate By similarity
Binding site2321Glyceraldehyde 3-phosphate By similarity
Binding site3141NAD By similarity
Site1771Activates thiol group during catalysis By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6FPW3 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: E301E384BDDBDAB0

FASTA33235,919
        10         20         30         40         50         60 
MVRVAINGFG RIGRIVLRIA MKRDGIDVVA INDPFITNDY AAYMFKYDST HGRYDGEVTH 

        70         80         90        100        110        120 
DDKDLIIDGK AIKCYQERDP ADLPWGDNDI DIVIEATGVF TAKDLAEKHI TAGAKKVVIT 

       130        140        150        160        170        180 
GPSATAPMFV KGVNDDKYTS DVTVISNASC TTNCLAPLAK VLQDNFGIEE ALMSTVHSQT 

       190        200        210        220        230        240 
ATQKTVDGPS KKDWRGGRTA SANIIPSSTG AAKAVTKVLP ELEGKLTGMA FRVPTVDVSV 

       250        260        270        280        290        300 
VDLTVRFAKD VTYDEIKAAI KKASEGEMKG ILAYTEDAVV STDFLGDTHS SIFDASAGIQ 

       310        320        330 
LSPRFVKLVS WYDNEYGFSA RVVDMVELVS KA

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR380956 Genomic DNA. Translation: CAG60678.1.
RefSeqXP_447731.1. XM_447731.1.

3D structure databases

ProteinModelPortalQ6FPW3.
SMRQ6FPW3. Positions 1-330.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2889895.
GenomeReviewsGene locus CAGL0J00451g in contig CR380956_GR.
KEGGcgr:CAGL0J00451g.

Phylogenomic databases

eggNOGfuNOG04196.
HOGENOMHBG571736.
OMAVGKVLPS.
OrthoDBEOG4578GC.

Family and domain databases

InterProIPR020831. GlycerAld/Erythrose_P_DH.
IPR020830. GlycerAld_3-P_DH_AS.
IPR020829. GlycerAld_3-P_DH_cat.
IPR020828. GlycerAld_3-P_DH_NAD(P)-bd.
IPR006424. Glyceraldehyde-3-P_DH_1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KOK00134.
PANTHERPTHR10836. GAP_DH. 1 hit.
PfamPF02800. Gp_dh_C. 1 hit.
PF00044. Gp_dh_N. 1 hit.
[Graphical view]
PIRSFPIRSF000149. GAP_DH. 1 hit.
PRINTSPR00078. G3PDHDRGNASE.
SMARTSM00846. Gp_dh_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01534. GAPDH-I. 1 hit.
PROSITEPS00071. GAPDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameG3P1_CANGA
AccessionPrimary (citable) accession number: Q6FPW3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 19, 2004
Last modified: December 14, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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