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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

CAGL0J00847g

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SDH2), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (CAGL0J00847g), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (CAGL0E03850g)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
Ordered Locus Names:CAGL0J00847gImported
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)Imported
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome J

Organism-specific databases

CGDiCAL0133218. CAGL0J00847g.
EuPathDBiFungiDB:CAGL0J00847g.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MembraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_447749.1.

Structurei

3D structure databases

ProteinModelPortaliQ6FPU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 520FAD_binding_2InterPro annotationAdd BLAST396
Domaini575 – 710Succ_DH_flav_CInterPro annotationAdd BLAST136

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG2403. Eukaryota.
COG1053. LUCA.
HOGENOMiHOG000160475.
InParanoidiQ6FPU5.
KOiK00234.
OMAiGDSPWEH.
OrthoDBiEOG092C17LB.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
InterProiView protein in InterPro
IPR003953. FAD-binding_2.
IPR036188. FAD/NAD-bd_sf.
IPR003952. FRD_SDH_FAD_BS.
IPR037099. Fum_R/Succ_DH_flav-like_C_sf.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat_sf.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
PfamiView protein in Pfam
PF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiView protein in PROSITE
PS00504. FRD_SDH_FAD_BINDING. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FPU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METDFSENQS ETTKCEAAQC CPLYAALVPY PSLPAGSRAR ARARVLCGSE
60 70 80 90 100
TYIRDMLRYV VGLGGETIHR SGEQEISKNP NTSTHKKMLR TGLRLRQLST
110 120 130 140 150
SCVRRHAAPA GLGAGKYNVI DHEYDCLVVG AGGAGLRAAF GLAEAGFKTA
160 170 180 190 200
CISKLFPTRS HTVAAQGGIN AALGNMHKDN WKWHMYDTVK GSDWLGDQDA
210 220 230 240 250
IHYMTREAPK SIIELEHYGM PFSRTEEGRI YQRAFGGQSK EFGKGGQAYR
260 270 280 290 300
TCAVADRTGH AMLHTLYGQA LNHDCHFFIE FFAMDLLTHN GEVVGIIAYN
310 320 330 340 350
QEDGTIHRFR AHKTVLATGG YGRAYFSCTS AHTCTGDGNA MVSRAGFPLQ
360 370 380 390 400
DLEFVQFHPS GIYGSGCLIT EGARGEGGFL LNSEGERFME RYAPTAKDLA
410 420 430 440 450
SRDVVSRAMT MEIREGRGVG KHKDHIFLQL SHLPPAVLKE RLPGISETAA
460 470 480 490 500
IFAGVDVTKQ PIPVLPTVHY NMGGIPTKWT GECLTIDENG EDKVIPGLMA
510 520 530 540 550
CGEAACVSVH GANRLGANSL LDLVVFGRAV ANTVADTLQP GTPHKPLPAD
560 570 580 590 600
LGKESLASLD AIRNASGDKT TAQIRLNMQK TMQKDVSVFR MQETLDEGVK
610 620 630 640 650
NITAVDKTFK DVHVTDKSMI WNSDLVETME LRNLLTCATQ TAVSAAERKE
660 670 680 690 700
SRGAHAREDY PSRDDENWRK HTLSWQQHTG DPVSIKYRKV IATTLDEAEC
710
PPVPPAVRSY
Length:710
Mass (Da):77,652
Last modified:July 19, 2004 - v1
Checksum:iCFE2B930028238D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380956 Genomic DNA. Translation: CAG60696.1.
RefSeqiXP_447749.1. XM_447749.1.

Genome annotation databases

EnsemblFungiiCAG60696; CAG60696; CAGL0J00847g.
GeneIDi2889870.
KEGGicgr:CAGL0J00847g.

Similar proteinsi

Entry informationi

Entry nameiQ6FPU5_CANGA
AccessioniPrimary (citable) accession number: Q6FPU5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 22, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported