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Q6FPN5

- HIS4_CANGA

UniProt

Q6FPN5 - HIS4_CANGA

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Protein

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Gene

HIS6

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.

Pathwayi

GO - Molecular functioni

  1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00031; UER00009.

Names & Taxonomyi

Protein namesi
Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (EC:5.3.1.16)
Alternative name(s):
5-proFAR isomerase
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Gene namesi
Name:HIS6
Ordered Locus Names:CAGL0J02398g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428: Chromosome J

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2612611-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerasePRO_0000141957Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6FPN5.
SMRiQ6FPN5. Positions 2-260.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HisA/HisF family.Curated

Phylogenomic databases

HOGENOMiHOG000172261.
InParanoidiQ6FPN5.
KOiK01814.
OMAiFVAMNKW.
OrthoDBiEOG7ZWDC9.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR011858. HisA_euk.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PANTHERiPTHR21169. PTHR21169. 1 hit.
PfamiPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02129. hisA_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FPN5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTKFVGCIDL HDGQVKQIVG GTLKDNDDSL ETNFVSKYPP SYYAQLYLEN
60 70 80 90 100
RIEGCHVIKL GPNNDAAAME ALNAAPGFLQ VGGGINDENC LQWLEKASKI
110 120 130 140 150
IVTSWLFTKE GTFLMDRLQL LSNKCGPDRI VVDLSCRRTP DSKWVVAMNK
160 170 180 190 200
WQTLTTLELN KETFTELSKY TDEFLIHAAD VEGLCKGIET DLVTKLYEWT
210 220 230 240 250
KDINKEVKIV YAGGAKSISD LELVDKLSNG TVDLTYGSSL DIFGGKLVRF
260
QDCCEWNSKH N
Length:261
Mass (Da):29,191
Last modified:July 19, 2004 - v1
Checksum:iB1A088D2BC57D326
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380956 Genomic DNA. Translation: CAG60758.1.
RefSeqiXP_447809.1. XM_447809.1.

Genome annotation databases

GeneIDi2889762.
KEGGicgr:CAGL0J02398g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380956 Genomic DNA. Translation: CAG60758.1 .
RefSeqi XP_447809.1. XM_447809.1.

3D structure databases

ProteinModelPortali Q6FPN5.
SMRi Q6FPN5. Positions 2-260.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2889762.
KEGGi cgr:CAGL0J02398g.

Phylogenomic databases

HOGENOMi HOG000172261.
InParanoidi Q6FPN5.
KOi K01814.
OMAi FVAMNKW.
OrthoDBi EOG7ZWDC9.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00009 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR011858. HisA_euk.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
PANTHERi PTHR21169. PTHR21169. 1 hit.
Pfami PF00977. His_biosynth. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02129. hisA_euk. 1 hit.
ProtoNeti Search...

Entry informationi

Entry nameiHIS4_CANGA
AccessioniPrimary (citable) accession number: Q6FPN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: July 19, 2004
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3