Reviewed, UniProtKB/Swiss-Prot Q6FPL6 (JHD1_CANGA)

Names and origin

Protein names

Recommended name:
    JmjC domain-containing histone demethylation protein 1
    EC=1.14.11.27
Alternative name(s):
    [Histone-H3]-lysine-36 demethylase 1

Gene names

Name:	JHD1
Ordered Locus Names:	CAGL0J02860g

Organism

Candida glabrata (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

5478 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	403 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code By similarity.
Catalytic activity	Protein N(6),N(6)-dimethyl-L-lysine + 2-oxoglutarate + O(2) = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO(2). Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O(2) = protein L-lysine + succinate + formaldehyde + CO(2).
Cofactor	Binds 1 Fe(2+) ion per subunit By similarity.
Subcellular location	NucleusBy similarity.
Domain	The JmjC domain mediates the demethylation activity By similarity.
Sequence similarities	Belongs to the JHDM1 histone demethylase family. Contains 1 JmjC domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	Iron Metal-binding
Molecular function	Chromatin regulator Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	histone demethylase activity (H3-K36 specific) Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 403	403	JmjC domain-containing histone demethylation protein 1		PRO_0000226794
Regions
	Domain	141 – 328	188	JmjC
Sites
	Metal binding	224	1	Iron; catalytic By similarity
	Metal binding	226	1	Iron; catalytic By similarity
	Metal binding	296	1	Iron; catalytic By similarity
	Binding site	221	1	Substrate By similarity
	Binding site	241	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6FPL6-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: F327A0D7EB1217BD	FASTA	403	47,030
	10 20 30 40 50 60 MAVKIEQALG EKRSLNDNDE VPRKKRYNFR KKVELDYSAL NEGEDKKSKF FHPHIALFEK 70 80 90 100 110 120 EFEKCLSNVT EDMSMTCSEY CKRFDDIDFP LKISDPENSG MVVSTNNKTT RDLTVDDITQ 130 140 150 160 170 180 AVGDDYFVNV MDVQSQENER WSLREWCNYF NKPAEEKDRI RNVISLEVSH VEDLQYDRPD 190 200 210 220 230 240 IVDDKDLVDI VWNNVENLDT ENDPRPKVTK YCLMSVKNAF TDYHLDFAGT SVYYNLAFGK 250 260 270 280 290 300 KKFILYPPTP ENIENYIEWS TSTYQNMLFL GEKLTGGVAM ELNGGDLFMI PSGYIHVVYT 310 320 330 340 350 360 PEDSLIFGGN YLTFRDISQQ LKIVDVEKQT GVTKRYTFPM FDEVMGRTCE WLCQNQKKGK 370 380 390 400 QMQVKKETVN DLISYMKSGK TKYKPTNFIN KKQMLQELSN LYL

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / IFO 0622 / NRRL Y-65.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR380956 Genomic DNA. Translation: CAG60777.1.
RefSeq	XP_447828.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2889738.
KEGG	cgr:CAGL0J02860g.
Phylogenomic databases
HOGENOM	Q6FPL6.
Family and domain databases
InterPro	IPR003347. TF_JmjC_AAH. [Graphical view]
SMART	SM00558. JmjC. 1 hit. [Graphical view]
PROSITE	PS51184. JMJC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

JHD1_CANGA

Accession

Primary (citable) accession number: Q6FPL6

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 7, 2006
Last sequence update:	July 19, 2004
Last modified:	November 4, 2008
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)