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Q6FPK7

- ACEA_CANGA

UniProt

Q6FPK7 - ACEA_CANGA

Protein

Isocitrate lyase

Gene

ICL1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate = succinate + glyoxylate.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei216 – 2161PROSITE-ProRule annotation

    GO - Molecular functioni

    1. isocitrate lyase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-UniPathway
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Glyoxylate bypass, Tricarboxylic acid cycle

    Enzyme and pathway databases

    UniPathwayiUPA00703; UER00719.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate lyase (EC:4.1.3.1)
    Short name:
    ICL
    Short name:
    Isocitrase
    Short name:
    Isocitratase
    Gene namesi
    Name:ICL1
    Ordered Locus Names:CAGL0J03058g
    OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
    Taxonomic identifieri284593 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
    ProteomesiUP000002428: Chromosome J

    Subcellular locationi

    Peroxisome Curated

    GO - Cellular componenti

    1. peroxisome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 553553Isocitrate lyasePRO_0000068785Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi551 – 5533Microbody targeting signalSequence Analysis

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000238475.
    KOiK01637.
    OMAiNDLFANA.
    OrthoDBiEOG73Z331.

    Family and domain databases

    Gene3Di3.20.20.60. 2 hits.
    InterProiIPR006254. Isocitrate_lyase.
    IPR018523. Isocitrate_lyase_ph_CS.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
    PfamiPF00463. ICL. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
    PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6FPK7-1 [UniParc]FASTAAdd to Basket

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    MPVPNSEANE FQALQARIDA DAKEIEQWWS EPRWNKTKRT YSAREIAIRR    50
    GTFPPLTYPS SVMAKKVYKV LEKHHKEGTV SRTFGALDPV QVSQMAKFLD 100
    TIYVSGWQCS STASTSNEPG PDLADYPMDT VPNKVEHLFK AQQFHDRKQW 150
    ENRAKATSQE ELDAMGPAID YMTPIIADAD AGHGGLTAVF KLTKMFIERG 200
    AAGIHMEDQT STNKKCGHMA GRCVIPVQEH INRLVTIRMC ADIMHSELVI 250
    VARTDSEAAT LISSTIDTRD HYFVVGATNP DIEPFAEYMD RAIMAGVSGD 300
    ELQKLEAAWI EKAGLKLFHE AFADEVNKSS VSNKQEIIKK FNDKVGPLTE 350
    TSHREAKKLA KELLGKDIFF DWDLPRVREG LYRYRGGTQC SVMRARAFAP 400
    YADLVWMESN YPDFEQAREF AEGVKAKYPD QWLAYNLSPS FNWPKAMSVD 450
    EQATFIERLG QLGYIWQFIT LAGLHTTALA IHKFSEDFAR EGMKAYAQNV 500
    QQIEMDEGVD VLKHQKWSGA EYIDGLLKLA QGGVSATAAM GQGVTEDQFK 550
    SNL 553
    Length:553
    Mass (Da):62,177
    Last modified:February 10, 2009 - v2
    Checksum:iD97EB314A3306D9C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380956 Genomic DNA. Translation: CAG60786.2.
    RefSeqiXP_447837.2. XM_447837.2.

    Genome annotation databases

    GeneIDi2889724.
    KEGGicgr:CAGL0J03058g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380956 Genomic DNA. Translation: CAG60786.2 .
    RefSeqi XP_447837.2. XM_447837.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2889724.
    KEGGi cgr:CAGL0J03058g.

    Phylogenomic databases

    HOGENOMi HOG000238475.
    KOi K01637.
    OMAi NDLFANA.
    OrthoDBi EOG73Z331.

    Enzyme and pathway databases

    UniPathwayi UPA00703 ; UER00719 .

    Family and domain databases

    Gene3Di 3.20.20.60. 2 hits.
    InterProi IPR006254. Isocitrate_lyase.
    IPR018523. Isocitrate_lyase_ph_CS.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    PANTHERi PTHR21631:SF3. PTHR21631:SF3. 1 hit.
    Pfami PF00463. ICL. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001362. Isocit_lyase. 1 hit.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    TIGRFAMsi TIGR01346. isocit_lyase. 1 hit.
    PROSITEi PS00161. ISOCITRATE_LYASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiACEA_CANGA
    AccessioniPrimary (citable) accession number: Q6FPK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3