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Q6FPK7 (ACEA_CANGA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate lyase
Short name=ICL
Short name=Isocitrase
Short name=Isocitratase
EC=4.1.3.1
Gene names
Name:ICL1
Ordered Locus Names:CAGL0J03058g
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier284593 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces ›

Protein attributes

Sequence length553 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate = succinate + glyoxylate.

Pathway

Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.

Subunit structure

Homotetramer By similarity.

Subcellular location

Peroxisome Potential.

Sequence similarities

Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.

Ontologies

Keywords
   Biological processGlyoxylate bypass
Tricarboxylic acid cycle
   Cellular componentPeroxisome
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglyoxylate cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentperoxisome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionisocitrate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 553553Isocitrate lyase
PRO_0000068785

Regions

Motif551 – 5533Microbody targeting signal Potential

Sites

Active site2161 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6FPK7 [UniParc].

Last modified February 10, 2009. Version 2.
Checksum: D97EB314A3306D9C

FASTA55362,177
        10         20         30         40         50         60 
MPVPNSEANE FQALQARIDA DAKEIEQWWS EPRWNKTKRT YSAREIAIRR GTFPPLTYPS 

        70         80         90        100        110        120 
SVMAKKVYKV LEKHHKEGTV SRTFGALDPV QVSQMAKFLD TIYVSGWQCS STASTSNEPG 

       130        140        150        160        170        180 
PDLADYPMDT VPNKVEHLFK AQQFHDRKQW ENRAKATSQE ELDAMGPAID YMTPIIADAD 

       190        200        210        220        230        240 
AGHGGLTAVF KLTKMFIERG AAGIHMEDQT STNKKCGHMA GRCVIPVQEH INRLVTIRMC 

       250        260        270        280        290        300 
ADIMHSELVI VARTDSEAAT LISSTIDTRD HYFVVGATNP DIEPFAEYMD RAIMAGVSGD 

       310        320        330        340        350        360 
ELQKLEAAWI EKAGLKLFHE AFADEVNKSS VSNKQEIIKK FNDKVGPLTE TSHREAKKLA 

       370        380        390        400        410        420 
KELLGKDIFF DWDLPRVREG LYRYRGGTQC SVMRARAFAP YADLVWMESN YPDFEQAREF 

       430        440        450        460        470        480 
AEGVKAKYPD QWLAYNLSPS FNWPKAMSVD EQATFIERLG QLGYIWQFIT LAGLHTTALA 

       490        500        510        520        530        540 
IHKFSEDFAR EGMKAYAQNV QQIEMDEGVD VLKHQKWSGA EYIDGLLKLA QGGVSATAAM 

       550 
GQGVTEDQFK SNL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR380956 Genomic DNA. Translation: CAG60786.2.
RefSeqXP_447837.2. XM_447837.2.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2889724.
KEGGcgr:CAGL0J03058g.

Phylogenomic databases

HOGENOMHOG000238475.
KOK01637.
OMAMVTQMAK.
OrthoDBEOG4P5PJP.

Enzyme and pathway databases

UniPathwayUPA00703; UER00719.

Family and domain databases

Gene3D3.20.20.60. 2 hits.
InterProIPR006254. Isocitrate_lyase.
IPR000918. Isocitrate_lyase/Pmutase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase.
[Graphical view]
PANTHERPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamPF00463. ICL. 1 hit.
[Graphical view]
PIRSFPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMSSF51621. Pyrv/PenolPyrv_Kinase_cat. 1 hit.
TIGRFAMsTIGR01346. isocit_lyase. 1 hit.
PROSITEPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACEA_CANGA
AccessionPrimary (citable) accession number: Q6FPK7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: February 10, 2009
Last modified: May 1, 2013
This is version 60 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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