Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Isocitrate lyase

Gene

ICL1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate = succinate + glyoxylate.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei216 – 2161PROSITE-ProRule annotation

GO - Molecular functioni

  1. isocitrate lyase activity Source: UniProtKB-EC

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-UniPathway
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glyoxylate bypass, Tricarboxylic acid cycle

Enzyme and pathway databases

UniPathwayiUPA00703; UER00719.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate lyase (EC:4.1.3.1)
Short name:
ICL
Short name:
Isocitrase
Short name:
Isocitratase
Gene namesi
Name:ICL1
Ordered Locus Names:CAGL0J03058g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428: Chromosome J

Subcellular locationi

Peroxisome Curated

GO - Cellular componenti

  1. peroxisome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 553553Isocitrate lyasePRO_0000068785Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi551 – 5533Microbody targeting signalSequence Analysis

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000238475.
InParanoidiQ6FPK7.
KOiK01637.
OMAiDAIHKEY.
OrthoDBiEOG73Z331.

Family and domain databases

Gene3Di3.20.20.60. 2 hits.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 1 hit.
[Graphical view]
PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FPK7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVPNSEANE FQALQARIDA DAKEIEQWWS EPRWNKTKRT YSAREIAIRR
60 70 80 90 100
GTFPPLTYPS SVMAKKVYKV LEKHHKEGTV SRTFGALDPV QVSQMAKFLD
110 120 130 140 150
TIYVSGWQCS STASTSNEPG PDLADYPMDT VPNKVEHLFK AQQFHDRKQW
160 170 180 190 200
ENRAKATSQE ELDAMGPAID YMTPIIADAD AGHGGLTAVF KLTKMFIERG
210 220 230 240 250
AAGIHMEDQT STNKKCGHMA GRCVIPVQEH INRLVTIRMC ADIMHSELVI
260 270 280 290 300
VARTDSEAAT LISSTIDTRD HYFVVGATNP DIEPFAEYMD RAIMAGVSGD
310 320 330 340 350
ELQKLEAAWI EKAGLKLFHE AFADEVNKSS VSNKQEIIKK FNDKVGPLTE
360 370 380 390 400
TSHREAKKLA KELLGKDIFF DWDLPRVREG LYRYRGGTQC SVMRARAFAP
410 420 430 440 450
YADLVWMESN YPDFEQAREF AEGVKAKYPD QWLAYNLSPS FNWPKAMSVD
460 470 480 490 500
EQATFIERLG QLGYIWQFIT LAGLHTTALA IHKFSEDFAR EGMKAYAQNV
510 520 530 540 550
QQIEMDEGVD VLKHQKWSGA EYIDGLLKLA QGGVSATAAM GQGVTEDQFK

SNL
Length:553
Mass (Da):62,177
Last modified:February 10, 2009 - v2
Checksum:iD97EB314A3306D9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380956 Genomic DNA. Translation: CAG60786.2.
RefSeqiXP_447837.2. XM_447837.2.

Genome annotation databases

GeneIDi2889724.
KEGGicgr:CAGL0J03058g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380956 Genomic DNA. Translation: CAG60786.2.
RefSeqiXP_447837.2. XM_447837.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2889724.
KEGGicgr:CAGL0J03058g.

Phylogenomic databases

HOGENOMiHOG000238475.
InParanoidiQ6FPK7.
KOiK01637.
OMAiDAIHKEY.
OrthoDBiEOG73Z331.

Enzyme and pathway databases

UniPathwayiUPA00703; UER00719.

Family and domain databases

Gene3Di3.20.20.60. 2 hits.
InterProiIPR006254. Isocitrate_lyase.
IPR018523. Isocitrate_lyase_ph_CS.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PANTHERiPTHR21631:SF3. PTHR21631:SF3. 1 hit.
PfamiPF00463. ICL. 1 hit.
[Graphical view]
PIRSFiPIRSF001362. Isocit_lyase. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR01346. isocit_lyase. 1 hit.
PROSITEiPS00161. ISOCITRATE_LYASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACEA_CANGA
AccessioniPrimary (citable) accession number: Q6FPK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: February 10, 2009
Last modified: January 7, 2015
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.