Putative lipase ATG15 - Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Putative lipase ATG15
EC=3.1.1.3

Alternative name(s):
Autophagy-related protein 15

Gene names

Name:	ATG15
Ordered Locus Names:	CAGL0J03542g

Organism

Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

284593 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces

Protein attributes

Sequence length	504 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	May be involved in lysis of subvacuolar cytoplasm to vacuole targeted bodies, intravacuolar autophagic bodies and of intravacuolar multivesicular body (MVB) vesicles By similarity.
Catalytic activity	Triacylglycerol + H₂O = diacylglycerol + a carboxylate.
Subcellular location	Endoplasmic reticulum membrane; Single-pass type II membrane protein By similarity. Golgi apparatus membrane; Single-pass type II membrane protein By similarity. Endosome › multivesicular body membrane; Single-pass type II membrane protein By similarity. Prevacuolar compartment membrane; Single-pass type II membrane protein By similarity. Note: From ER, targeted to vacuolar lumen at the MVB vesicles via the Golgi and the prevacuolar compartment (PVC) By similarity.
Sequence similarities	Belongs to the AB hydrolase superfamily. Lipase family.

Ontologies

Keywords
Biological process	Autophagy Lipid degradation
Cellular component	Endoplasmic reticulum Endosome Golgi apparatus Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW lipid catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW multivesicular body membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	triglyceride lipase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 504

504

Putative lipase ATG15

PRO_0000090366

Regions

Topological domain

1

Cytoplasmic Potential

Transmembrane

2 – 22

21

Helical; Signal-anchor for type II membrane protein; Potential

Topological domain

23 – 504

482

Lumenal Potential

Sites

Active site

313

1

Charge relay system By similarity

Amino acid modifications

Glycosylation

183

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q6FPI6 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 1AFC76CEF0B16FEB
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FASTA

504

56,503

        10         20         30         40         50         60 
MLGRQVTMLL KVIVAVAVLF VWHRSRDSSR GDGSNGDGLS DSSGNGFRLE HIWAYDPEDV 

        70         80         90        100        110        120 
VSSCVDVSEE MRVSADEYVS MESGSEFVES WWAKTGARPF SHVFDLRSRS MDIQRLQDRD 

       130        140        150        160        170        180 
PVSMEKYIDF SLENPELART IELEWETAKI QVPDVRNRNT VLALALMSSN AYVRTPYTGD 

       190        200        210        220        230        240 
WRNLSSSWGH TGEEKFGWDK DGLRGHIFVN KITKVVVIAI KGTSSQGLFG SGEEDTITND 

       250        260        270        280        290        300 
KINDNLLFSC CCARISYLWT TVCDCYMKSY TCDENCVEAE LKRKDRYYAA TLKLYKQVTE 

       310        320        330        340        350        360 
MYPDSAIWLT GHSLGGALAA LLGRTYGVPA VTFEAPGELL PAKRLHLPLP PGLPDYEEAI 

       370        380        390        400        410        420 
WHFGHNADPI FMGTCNGASS SCSIGGYAME TACHSGQYCM YDVVNDKGWR VNLLNHRIHR 

       430        440        450        460        470        480 
VIDEVILEYG RPAKCQRAPT CIDCYNWKFV NKRRNRREES SSSIASSSQL TSSHSESETL 

       490        500 
TSTDAPEKTC IGRNWLGICT DYGV

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References

[1]

"Genome evolution in yeasts."
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.

Souciet J.-L.
Nature 430:35-44(2004) [PubMed: 15229592] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR380956 Genomic DNA. Translation: CAG60807.1.
RefSeq	XP_447858.1. XM_447858.1.
3D structure databases
ProteinModelPortal	Q6FPI6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2889699.
GenomeReviews	Gene locus CAGL0J03542g in contig CR380956_GR.
KEGG	cgr:CAGL0J03542g.
Phylogenomic databases
eggNOG	fuNOG04745.
HOGENOM	HBG398588.
OMA	AMETSCH.
OrthoDB	EOG4F7RV2.
Family and domain databases
InterPro	IPR002921. Lipase_3. [Graphical view]
Pfam	PF01764. Lipase_3. 1 hit. [Graphical view]
PROSITE	PS00120. LIPASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG15_CANGA

Accession

Primary (citable) accession number: Q6FPI6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2005
Last sequence update:	July 19, 2004
Last modified:	December 14, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families