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Q6FPH0

- Q6FPH0_CANGA

UniProt

Q6FPH0 - Q6FPH0_CANGA

Protein
Submitted name:

Strain CBS138 chromosome J complete sequence

Gene

CAGL0J03894g

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei11 – 111NADP; via amide nitrogen and carbonyl oxygenImported
    Binding sitei19 – 191NADP; via carbonyl oxygenImported
    Binding sitei98 – 981NADP; via amide nitrogenImported

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi24 – 252NADPImported
    Nucleotide bindingi56 – 583NADPImported
    Nucleotide bindingi78 – 792NADPImported
    Nucleotide bindingi123 – 1297NADPImported

    GO - Molecular functioni

    1. dihydrofolate reductase activity Source: InterPro
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. glycine biosynthetic process Source: InterPro
    2. nucleotide biosynthetic process Source: InterPro

    Keywords - Ligandi

    NADPImported, Nucleotide-bindingImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Strain CBS138 chromosome J complete sequenceImported
    Gene namesi
    Ordered Locus Names:CAGL0J03894gImported
    OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)Imported
    Taxonomic identifieri284593 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
    ProteomesiUP000002428: Chromosome J

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3CSEX-ray1.60A/B1-217[»]
    3EEJX-ray2.11A/B1-217[»]
    3EEKX-ray2.03A/B1-217[»]
    3EELX-ray1.95A/B1-217[»]
    3EEMX-ray2.11A/B1-217[»]
    3QLXX-ray2.24A/B1-217[»]
    3QLYX-ray2.52A/B1-217[»]
    3QLZX-ray1.94A/B1-217[»]
    3RO9X-ray2.60A/B3-217[»]
    3ROAX-ray2.30A/B3-217[»]
    4H98X-ray2.90A/B4-217[»]
    4HOGX-ray2.00A/B1-217[»]
    ProteinModelPortaliQ6FPH0.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ6FPH0.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the dihydrofolate reductase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000040235.
    KOiK00287.
    OMAiKEMKYFR.
    OrthoDBiEOG7Q8D07.

    Family and domain databases

    Gene3Di3.40.430.10. 1 hit.
    InterProiIPR012259. DHFR.
    IPR024072. DHFR-like_dom.
    IPR017925. DHFR_CS.
    IPR001796. DHFR_dom.
    [Graphical view]
    PfamiPF00186. DHFR_1. 1 hit.
    [Graphical view]
    PRINTSiPR00070. DHFR.
    SUPFAMiSSF53597. SSF53597. 2 hits.
    PROSITEiPS00075. DHFR_1. 1 hit.
    PS51330. DHFR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6FPH0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKVPVVGIV AALLPEMGIG FQGNLPWRLA KEMKYFREVT TLTNDNSKQN    50
    VVIMGRKTWE SIPQKFRPLP KRINVVVSRS FDGELRKVED GIYHSNSLRN 100
    CLTALQSSLA NENKIERIYI IGGGEIYRQS MDLADHWLIT KIMPLPETTI 150
    PQMDTFLQKQ ELEQRFYDNS DKLVDFLPSS IQLEGRLTSQ EWNGELVKGL 200
    PVQEKGYQFY FTLYTKK 217
    Length:217
    Mass (Da):25,050
    Last modified:July 19, 2004 - v1
    Checksum:iAF1E7DC86BB5BE80
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380956 Genomic DNA. Translation: CAG60823.1.
    RefSeqiXP_447874.1. XM_447874.1.

    Genome annotation databases

    GeneIDi2889661.
    KEGGicgr:CAGL0J03894g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380956 Genomic DNA. Translation: CAG60823.1 .
    RefSeqi XP_447874.1. XM_447874.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3CSE X-ray 1.60 A/B 1-217 [» ]
    3EEJ X-ray 2.11 A/B 1-217 [» ]
    3EEK X-ray 2.03 A/B 1-217 [» ]
    3EEL X-ray 1.95 A/B 1-217 [» ]
    3EEM X-ray 2.11 A/B 1-217 [» ]
    3QLX X-ray 2.24 A/B 1-217 [» ]
    3QLY X-ray 2.52 A/B 1-217 [» ]
    3QLZ X-ray 1.94 A/B 1-217 [» ]
    3RO9 X-ray 2.60 A/B 3-217 [» ]
    3ROA X-ray 2.30 A/B 3-217 [» ]
    4H98 X-ray 2.90 A/B 4-217 [» ]
    4HOG X-ray 2.00 A/B 1-217 [» ]
    ProteinModelPortali Q6FPH0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2889661.
    KEGGi cgr:CAGL0J03894g.

    Phylogenomic databases

    HOGENOMi HOG000040235.
    KOi K00287.
    OMAi KEMKYFR.
    OrthoDBi EOG7Q8D07.

    Miscellaneous databases

    EvolutionaryTracei Q6FPH0.

    Family and domain databases

    Gene3Di 3.40.430.10. 1 hit.
    InterProi IPR012259. DHFR.
    IPR024072. DHFR-like_dom.
    IPR017925. DHFR_CS.
    IPR001796. DHFR_dom.
    [Graphical view ]
    Pfami PF00186. DHFR_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00070. DHFR.
    SUPFAMi SSF53597. SSF53597. 2 hits.
    PROSITEi PS00075. DHFR_1. 1 hit.
    PS51330. DHFR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome evolution in yeasts."
      Genolevures
      Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
      , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
      Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65Imported.
    2. "Structure-guided development of efficacious antifungal agents targeting Candida glabrata dihydrofolate reductase."
      Liu J., Bolstad D.B., Smith A.E., Priestley N.D., Wright D.L., Anderson A.C.
      Chem. Biol. 15:990-996(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH NADP.
    3. "Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors."
      Liu J., Bolstad D.B., Smith A.E., Priestley N.D., Wright D.L., Anderson A.C.
      Chem. Biol. Drug Des. 73:62-74(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) IN COMPLEX WITH NADP.
    4. "Crystal structures of Candida albicans dihydrofolate reductase bound to propargyl-linked antifolates reveal the flexibility of active site loop residues critical for ligand potency and selectivity."
      Paulsen J.L., Bendel S.D., Anderson A.C.
      Chem. Biol. Drug Des. 78:505-512(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.94 ANGSTROMS) IN COMPLEX WITH NADP.
    5. "Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species."
      Paulsen J.L., Viswanathan K., Wright D.L., Anderson A.C.
      Bioorg. Med. Chem. Lett. 23:1279-1284(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 3-217 IN COMPLEX WITH NADP.
    6. "Propargyl-linked antifolates are dual inhibitors of Candida albicans and Candida glabrata."
      G-Dayanandan N., Paulsen J.L., Viswanathan K., Keshipeddy S., Lombardo M.N., Zhou W., Lamb K.M., Sochia A.E., Alverson J.B., Priestley N.D., Wright D.L., Anderson A.C.
      J. Med. Chem. 57:2643-2656(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH NADP.

    Entry informationi

    Entry nameiQ6FPH0_CANGA
    AccessioniPrimary (citable) accession number: Q6FPH0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 19, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3