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Q6FPH0

- Q6FPH0_CANGA

UniProt

Q6FPH0 - Q6FPH0_CANGA

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Protein
Submitted name:

Strain CBS138 chromosome J complete sequence

Gene

CAGL0J03894g

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111NADP; via amide nitrogen and carbonyl oxygenImported
Binding sitei19 – 191NADP; via carbonyl oxygenImported
Binding sitei98 – 981NADP; via amide nitrogenImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 252NADPImported
Nucleotide bindingi56 – 583NADPImported
Nucleotide bindingi78 – 792NADPImported
Nucleotide bindingi123 – 1297NADPImported

GO - Molecular functioni

  1. dihydrofolate reductase activity Source: InterPro
  2. NADP binding Source: InterPro

GO - Biological processi

  1. glycine biosynthetic process Source: InterPro
  2. nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Ligandi

NADPImported, Nucleotide-bindingImported

Names & Taxonomyi

Protein namesi
Submitted name:
Strain CBS138 chromosome J complete sequenceImported
Gene namesi
Ordered Locus Names:CAGL0J03894gImported
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)Imported
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428: Chromosome J

Interactioni

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3CSEX-ray1.60A/B1-217[»]
3EEJX-ray2.11A/B1-217[»]
3EEKX-ray2.03A/B1-217[»]
3EELX-ray1.95A/B1-217[»]
3EEMX-ray2.11A/B1-217[»]
3QLXX-ray2.24A/B1-217[»]
3QLYX-ray2.52A/B1-217[»]
3QLZX-ray1.94A/B1-217[»]
3RO9X-ray2.60A/B3-217[»]
3ROAX-ray2.30A/B3-217[»]
4H98X-ray2.90A/B4-217[»]
4HOGX-ray2.00A/B1-217[»]
ProteinModelPortaliQ6FPH0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6FPH0.

Family & Domainsi

Sequence similaritiesi

Belongs to the dihydrofolate reductase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000040235.
InParanoidiQ6FPH0.
KOiK00287.
OMAiKEMKYFR.
OrthoDBiEOG7Q8D07.

Family and domain databases

Gene3Di3.40.430.10. 1 hit.
InterProiIPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view]
PfamiPF00186. DHFR_1. 1 hit.
[Graphical view]
PRINTSiPR00070. DHFR.
SUPFAMiSSF53597. SSF53597. 2 hits.
PROSITEiPS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FPH0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKVPVVGIV AALLPEMGIG FQGNLPWRLA KEMKYFREVT TLTNDNSKQN
60 70 80 90 100
VVIMGRKTWE SIPQKFRPLP KRINVVVSRS FDGELRKVED GIYHSNSLRN
110 120 130 140 150
CLTALQSSLA NENKIERIYI IGGGEIYRQS MDLADHWLIT KIMPLPETTI
160 170 180 190 200
PQMDTFLQKQ ELEQRFYDNS DKLVDFLPSS IQLEGRLTSQ EWNGELVKGL
210
PVQEKGYQFY FTLYTKK
Length:217
Mass (Da):25,050
Last modified:July 19, 2004 - v1
Checksum:iAF1E7DC86BB5BE80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380956 Genomic DNA. Translation: CAG60823.1.
RefSeqiXP_447874.1. XM_447874.1.

Genome annotation databases

GeneIDi2889661.
KEGGicgr:CAGL0J03894g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380956 Genomic DNA. Translation: CAG60823.1 .
RefSeqi XP_447874.1. XM_447874.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3CSE X-ray 1.60 A/B 1-217 [» ]
3EEJ X-ray 2.11 A/B 1-217 [» ]
3EEK X-ray 2.03 A/B 1-217 [» ]
3EEL X-ray 1.95 A/B 1-217 [» ]
3EEM X-ray 2.11 A/B 1-217 [» ]
3QLX X-ray 2.24 A/B 1-217 [» ]
3QLY X-ray 2.52 A/B 1-217 [» ]
3QLZ X-ray 1.94 A/B 1-217 [» ]
3RO9 X-ray 2.60 A/B 3-217 [» ]
3ROA X-ray 2.30 A/B 3-217 [» ]
4H98 X-ray 2.90 A/B 4-217 [» ]
4HOG X-ray 2.00 A/B 1-217 [» ]
ProteinModelPortali Q6FPH0.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q6FPH0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2889661.
KEGGi cgr:CAGL0J03894g.

Phylogenomic databases

HOGENOMi HOG000040235.
InParanoidi Q6FPH0.
KOi K00287.
OMAi KEMKYFR.
OrthoDBi EOG7Q8D07.

Miscellaneous databases

EvolutionaryTracei Q6FPH0.

Family and domain databases

Gene3Di 3.40.430.10. 1 hit.
InterProi IPR012259. DHFR.
IPR024072. DHFR-like_dom.
IPR017925. DHFR_CS.
IPR001796. DHFR_dom.
[Graphical view ]
Pfami PF00186. DHFR_1. 1 hit.
[Graphical view ]
PRINTSi PR00070. DHFR.
SUPFAMi SSF53597. SSF53597. 2 hits.
PROSITEi PS00075. DHFR_1. 1 hit.
PS51330. DHFR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome evolution in yeasts."
    Genolevures
    Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.
    , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L.
    Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65Imported.
  2. "Structure-guided development of efficacious antifungal agents targeting Candida glabrata dihydrofolate reductase."
    Liu J., Bolstad D.B., Smith A.E., Priestley N.D., Wright D.L., Anderson A.C.
    Chem. Biol. 15:990-996(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH NADP.
  3. "Probing the active site of Candida glabrata dihydrofolate reductase with high resolution crystal structures and the synthesis of new inhibitors."
    Liu J., Bolstad D.B., Smith A.E., Priestley N.D., Wright D.L., Anderson A.C.
    Chem. Biol. Drug Des. 73:62-74(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) IN COMPLEX WITH NADP.
  4. "Crystal structures of Candida albicans dihydrofolate reductase bound to propargyl-linked antifolates reveal the flexibility of active site loop residues critical for ligand potency and selectivity."
    Paulsen J.L., Bendel S.D., Anderson A.C.
    Chem. Biol. Drug Des. 78:505-512(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.94 ANGSTROMS) IN COMPLEX WITH NADP.
  5. "Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species."
    Paulsen J.L., Viswanathan K., Wright D.L., Anderson A.C.
    Bioorg. Med. Chem. Lett. 23:1279-1284(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 3-217 IN COMPLEX WITH NADP.
  6. "Propargyl-linked antifolates are dual inhibitors of Candida albicans and Candida glabrata."
    G-Dayanandan N., Paulsen J.L., Viswanathan K., Keshipeddy S., Lombardo M.N., Zhou W., Lamb K.M., Sochia A.E., Alverson J.B., Priestley N.D., Wright D.L., Anderson A.C.
    J. Med. Chem. 57:2643-2656(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH NADP.

Entry informationi

Entry nameiQ6FPH0_CANGA
AccessioniPrimary (citable) accession number: Q6FPH0
Entry historyi
Integrated into UniProtKB/TrEMBL: July 19, 2004
Last sequence update: July 19, 2004
Last modified: November 26, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3