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Q6FPF3

- ACH1_CANGA

UniProt

Q6FPF3 - ACH1_CANGA

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Protein

Acetyl-CoA hydrolase

Gene

ACH1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation.By similarity

Catalytic activityi

Acetyl-CoA + H2O = CoA + acetate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei302 – 30215-glutamyl coenzyme A thioester intermediateBy similarity
Binding sitei392 – 3921Coenzyme ABy similarity
Binding sitei396 – 3961Coenzyme A; via amide nitrogenBy similarity

GO - Molecular functioni

  1. acetyl-CoA hydrolase activity Source: UniProtKB-EC

GO - Biological processi

  1. acetyl-CoA metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-CoA hydrolase (EC:3.1.2.1)
Alternative name(s):
Acetyl-CoA deacylase
Short name:
Acetyl-CoA acylase
Gene namesi
Name:ACH1
Ordered Locus Names:CAGL0J04268g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428: Chromosome J

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Acetyl-CoA hydrolasePRO_0000215518Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6FPF3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni277 – 2815Coenzyme A bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000172597.
InParanoidiQ6FPF3.
KOiK01067.
OMAiYIPTRRP.
OrthoDBiEOG7TQV8M.

Family and domain databases

InterProiIPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view]
PfamiPF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FPF3-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MTVSKLLKER VRYAPYLAKV KTPEELIPLF KNGQYLGWSG FTGVGTPKAV
60 70 80 90 100
PDALIKHVED NNLQGKLRFN LFVGASAGPE ENKWAEHDMI IRRAPHQVGK
110 120 130 140 150
PIAKAINNGK IQFFDKHLSM FPQDLTYGYY TRDRTDGKIL DYMIIEATAI
160 170 180 190 200
KEDGSIVPGP SVGGSPEFIS VSDKVIIEVN TATPSFEGVH DIDMPVNPPH
210 220 230 240 250
RVPYPYTKVD QKIGVDSIPV DPERVIAIVE SKTRDQVGPN TPSDDMSKAI
260 270 280 290 300
AGNLIEFFRN EVKHGRLPEN LLPLQSGIGN IANAVIEGLT DANFKHLNVW
310 320 330 340 350
TEVLQDSFLD LFENGSLDYA TATSIRLTEP GFERVFKNWD FYKSRLCLRS
360 370 380 390 400
QVVSNNPELI RRLGVIAMNT PVEADIYAHA NSTNVNGSRM LNGLGGSADF
410 420 430 440 450
LRNAKLSIMH CPAARPTKVD PTGISSIVPM VSHVDQTEHD LDVLVTDQGL
460 470 480 490 500
ADLRGLSPRE RAREIINKCA HPDYKPLLQD YLDRAEHYAT KHGCLHEPHM
510 520
LKNAFKFHTN LAEKGTMKVE SWDPVE
Length:526
Mass (Da):58,578
Last modified:July 19, 2004 - v1
Checksum:iD36573740EBAD8FF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380956 Genomic DNA. Translation: CAG60840.1.
RefSeqiXP_447891.1. XM_447891.1.

Genome annotation databases

GeneIDi2889653.
KEGGicgr:CAGL0J04268g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380956 Genomic DNA. Translation: CAG60840.1 .
RefSeqi XP_447891.1. XM_447891.1.

3D structure databases

ProteinModelPortali Q6FPF3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2889653.
KEGGi cgr:CAGL0J04268g.

Phylogenomic databases

HOGENOMi HOG000172597.
InParanoidi Q6FPF3.
KOi K01067.
OMAi YIPTRRP.
OrthoDBi EOG7TQV8M.

Family and domain databases

InterProi IPR026888. AcetylCoA_hyd_C.
IPR003702. ActCoA_hydro.
[Graphical view ]
Pfami PF13336. AcetylCoA_hyd_C. 1 hit.
PF02550. AcetylCoA_hydro. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiACH1_CANGA
AccessioniPrimary (citable) accession number: Q6FPF3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: July 19, 2004
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3