Q6FPF3 (ACH1_CANGA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetyl-CoA hydrolase
EC=3.1.2.1

Alternative name(s):
Acetyl-CoA deacylase
Short name=Acetyl-CoA acylase

Gene names

Name:	ACH1
Ordered Locus Names:	CAGL0J04268g

Organism

Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

284593 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces › Candida glabrata

Protein attributes

Sequence length	526 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation By similarity.
Catalytic activity	Acetyl-CoA + H2O = CoA + acetate.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the acetyl-CoA hydrolase/transferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	acetyl-CoA metabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	acetyl-CoA hydrolase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 526	526	Acetyl-CoA hydrolase		PRO_0000215518

Sequences

	Sequence		Length	Mass (Da)
	Q6FPF3 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: D36573740EBAD8FF	FASTA	526	58,578
	10 20 30 40 50 60 MTVSKLLKER VRYAPYLAKV KTPEELIPLF KNGQYLGWSG FTGVGTPKAV PDALIKHVED 70 80 90 100 110 120 NNLQGKLRFN LFVGASAGPE ENKWAEHDMI IRRAPHQVGK PIAKAINNGK IQFFDKHLSM 130 140 150 160 170 180 FPQDLTYGYY TRDRTDGKIL DYMIIEATAI KEDGSIVPGP SVGGSPEFIS VSDKVIIEVN 190 200 210 220 230 240 TATPSFEGVH DIDMPVNPPH RVPYPYTKVD QKIGVDSIPV DPERVIAIVE SKTRDQVGPN 250 260 270 280 290 300 TPSDDMSKAI AGNLIEFFRN EVKHGRLPEN LLPLQSGIGN IANAVIEGLT DANFKHLNVW 310 320 330 340 350 360 TEVLQDSFLD LFENGSLDYA TATSIRLTEP GFERVFKNWD FYKSRLCLRS QVVSNNPELI 370 380 390 400 410 420 RRLGVIAMNT PVEADIYAHA NSTNVNGSRM LNGLGGSADF LRNAKLSIMH CPAARPTKVD 430 440 450 460 470 480 PTGISSIVPM VSHVDQTEHD LDVLVTDQGL ADLRGLSPRE RAREIINKCA HPDYKPLLQD 490 500 510 520 YLDRAEHYAT KHGCLHEPHM LKNAFKFHTN LAEKGTMKVE SWDPVE

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR380956 Genomic DNA. Translation: CAG60840.1.
RefSeq	XP_447891.1. XM_447891.1.
3D structure databases
ProteinModelPortal	Q6FPF3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2889653.
KEGG	cgr:CAGL0J04268g.
Phylogenomic databases
HOGENOM	HOG000172597.
KO	K01067.
OMA	EVSNHPE.
OrthoDB	EOG4DBXNW.
Family and domain databases
InterPro	IPR026888. AcetylCoA_hyd_C. IPR003702. ActCoA_hydro. IPR017821. Succinate_CoA_transferase. [Graphical view]
PANTHER	PTHR21432. PTHR21432. 1 hit. PTHR21432:SF10. PTHR21432:SF10. 1 hit.
Pfam	PF13336. AcetylCoA_hyd_C. 1 hit. PF02550. AcetylCoA_hydro. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACH1_CANGA

Accession

Primary (citable) accession number: Q6FPF3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 4, 2005
Last sequence update:	July 19, 2004
Last modified:	May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program