Q6FP78 (ADE_CANGA) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 55.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Adenine deaminase Short name=ADE EC=3.5.4.2 Alternative name(s): Adenine aminohydrolase Short name=AAH | ||||
| Gene names |
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| Organism | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome] | ||||
| Taxonomic identifier | 284593 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces |
Protein attributes
| Sequence length | 347 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism By similarity. |
| Catalytic activity | Adenine + H2O = hypoxanthine + NH3. |
| Cofactor | Binds 1 zinc ion per subunit By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide metabolism |
| Cellular component | Cytoplasm Nucleus |
| Ligand | Metal-binding Zinc |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | adenine deaminase activity Inferred from electronic annotation. Source: EC metal ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 347 | 347 | Adenine deaminase | PRO_0000256233 | |||||
Sites | |||||||||
| Active site | 207 | 1 | Proton donor By similarity | ||||||
| Metal binding | 16 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 18 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 204 | 1 | Zinc; catalytic By similarity | ||||||
| Metal binding | 285 | 1 | Zinc; catalytic By similarity | ||||||
| Binding site | 286 | 1 | Substrate By similarity | ||||||
| Site | 228 | 1 | Important for catalytic activity By similarity | ||||||
Sequences
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References
| [1] | "Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. Souciet J.-L.Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CR380956 Genomic DNA. Translation: CAG60917.1. |
| RefSeq | XP_447966.1. XM_447966.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 2AMX based on UniProtKB Q7RMV2. |
| ProteinModelPortal | Q6FP78. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 2889775. |
| GenomeReviews | Gene locus CAGL0J05984g in contig CR380956_GR. |
| KEGG | cgr:CAGL0J05984g. |
Phylogenomic databases | |
| eggNOG | fuNOG04795. |
| HOGENOM | HBG630382. |
| OMA | CLLRHLP. |
| OrthoDB | EOG4P5PJR. |
Family and domain databases | |
| InterPro | IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase_dom. IPR006330. A_deaminase. [Graphical view] |
| KO | K01488. |
| PANTHER | PTHR11409:SF21. PTHR11409:SF21. 1 hit. |
| Pfam | PF00962. A_deaminase. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01430. Aden_deam. 1 hit. |
| PROSITE | PS00485. A_DEAMINASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ADE_CANGA | ||||||||
| Accession | Primary (citable) accession number: Q6FP78 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Fungal Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

Clusters with