Reviewed, UniProtKB/Swiss-Prot Q6FP78 (ADA_CANGA)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	AAH1
Ordered Locus Names:	CAGL0J05984g

Organism

Candida glabrata (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

5478 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces

Protein attributes

Sequence length	347 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3.
Subcellular location	Cytoplasm By similarity. Nucleus By similarity.
Sequence similarities	Belongs to the adenosine and AMP deaminases family.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Cellular component	Cytoplasm Nucleus
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 347	347	Adenosine deaminase		PRO_0000256233
Sites
	Active site	204	1	Potential
	Active site	252	1	Potential
	Active site	285	1	Potential
	Active site	286	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6FP78-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: F48170A9E08B8C9F	FASTA	347	39,697
	10 20 30 40 50 60 MVPESFLLEL PKCEHHLHLE GTLEPDLLFP LAKRNNIQLP DHFPQTPEEL AVRYTQFKDL 70 80 90 100 110 120 QDFLDYYYIG TNVLLKEEDF FDLAWAYFTK VSKQGLVHAE LFYDPQSHTT RGVSLETVTR 130 140 150 160 170 180 GFERACKKAH EELGITSKLI MCLLRHLPPQ DCLQTIEEAE QLIKSGVIHG LGLDSAEKPF 190 200 210 220 230 240 PPSLFVECYE RAAKINPELR LTAHAGEEGT HQFVSDALDL LNVTRIDHGV NSKQSEELMA 250 260 270 280 290 300 RLAEQQTLLT VCPLSNVKLQ VVQSVKEIPL QLFLDKNIAF SLNSDDPAYF GGYILDNYYQ 310 320 330 340 VNKDFPDWDF KVWERIAKNG INGSWCEQKR KEELLAKVDA VVAKYTN

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / IFO 0622 / NRRL Y-65.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR380956 Genomic DNA. Translation: CAG60917.1.
RefSeq	XP_447966.1.
3D structure databases
HSSP	HSSP built from PDB template 2AMX based on UniProtKB Q7RMV2.
SMR	Q6FP78. Positions 8-339.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6FP78.
Genome annotation databases
GeneID	2889775.
GenomeReviews	Gene locus CAGL0J05984g in contig CR380956_GR.
KEGG	cgr:CAGL0J05984g.
Phylogenomic databases
eggNOG	fuNOG04795.
HOGENOM	HBG630382.
OMA	KLIMCLL.
OrthoDB	EOG9B2VDF.
PhylomeDB	Q6FP78.
Enzyme and pathway databases
BRENDA	3.5.4.4. 189220.
Family and domain databases
InterPro	IPR006650. A/AMP_deam_AS. IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADA_CANGA

Accession

Primary (citable) accession number: Q6FP78

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2006
Last sequence update:	July 19, 2004
Last modified:	February 9, 2010
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)