Reviewed, UniProtKB/Swiss-Prot Q6FN96 (GPD1_CANGA)

Names and origin

Protein names

Recommended name:
    Glycerol-3-phosphate dehydrogenase [NAD+] 1
    EC=1.1.1.8

Gene names

Name:	GPD1
Ordered Locus Names:	CAGL0K01683g

Organism

Candida glabrata (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

5478 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces

Protein attributes

Sequence length	400 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.
Sequence similarities	Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro glycerol-3-phosphate catabolic process Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	glycerol-3-phosphate dehydrogenase complex Inferred from electronic annotation. Source: InterPro
Molecular function	NAD or NADH binding Inferred from electronic annotation. Source: InterPro glycerol-3-phosphate dehydrogenase (NAD+) activity Inferred from electronic annotation. Source: EC protein homodimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 400	400	Glycerol-3-phosphate dehydrogenase [NAD+] 1		PRO_0000138086
Regions
	Nucleotide binding	50 – 55	6	NAD By similarity
	Region	319 – 320	2	Substrate binding By similarity
Sites
	Active site	254	1	Proton acceptor By similarity
	Binding site	138	1	NAD By similarity
	Binding site	161	1	NAD; via amide nitrogen By similarity
	Binding site	161	1	Substrate By similarity
	Binding site	194	1	NAD; via amide nitrogen By similarity
	Binding site	319	1	NAD By similarity
	Binding site	348	1	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6FN96-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: DE850B128571D8E5	FASTA	400	43,988
	10 20 30 40 50 60 MSNSAAGRLN QTSHILNESI KNDDISLRRS QPSTTSLQAL EHPFKVTVIG SGNWGTTIAK 70 80 90 100 110 120 VVAENTALNP HLFVSRVDMW VFEEKIDGKN LTEIINEQHE NVKYLPDIKL PENLVANPNL 130 140 150 160 170 180 IDSVKGADIL IFNIPHQFLP RIVSNLKNHV GPHVRAISCL KGFEVGKKGV QLLSSYVTDE 190 200 210 220 230 240 LGIQCGALSG ANLAPEVAKE HWSETTVAYH IPKDFRGEGK DVDHKLLKAL FHRPYFHVNV 250 260 270 280 290 300 IEDVAGISIA GALKNVVALG CGFVEGLGWG NNAAAAIQRV GLGEIIKFGQ MFFPESRVQT 310 320 330 340 350 360 YYQESAGVAD LITTCSGGRN VRVAKHMAKT GKSALDAEKE LLNGQSAQGI ITCKEVHEWL 370 380 390 400 ETCEMTHEFP LFEAVYQIVY NNVPMKNLPD MIEELECIAD

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / IFO 0622 / NRRL Y-65.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR380957 Genomic DNA. Translation: CAG61259.1.
RefSeq	XP_448298.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2890024.
KEGG	cgr:CAGL0K01683g.
Phylogenomic databases
HOGENOM	Q6FN96.
OMA	Q6FN96. THESAGV.
Enzyme and pathway databases
BRENDA	1.1.1.8. 189220.
Family and domain databases
InterPro	IPR013328. DH_multihelical. IPR016040. NAD(P)-bd_dom. IPR006168. NAD-dep_Gly3P_DH. IPR017751. NAD-dep_Gly3P_DH_euk. IPR011128. NAD-dep_Gly3P_DH_N. IPR006109. NAD_Gly3P_DH_C. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PANTHER	PTHR11728. NAD_Gly3P_DH. 1 hit.
Pfam	PF07479. NAD_Gly3P_dh_C. 1 hit. PF01210. NAD_Gly3P_dh_N. 1 hit. [Graphical view]
PIRSF	PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTS	PR00077. GPDHDRGNASE.
ProDom	PD001278. NAD_Gly3P_C. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR03376. glycerol3P_DH. 1 hit.
PROSITE	PS00957. NAD_G3PDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPD1_CANGA

Accession

Primary (citable) accession number: Q6FN96

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 10, 2006
Last sequence update:	July 19, 2004
Last modified:	June 16, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)