Q6FML4 (MCES_CANGA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
mRNA cap guanine-N7 methyltransferase
EC=2.1.1.56

Alternative name(s):
mRNA (guanine-N(7)-)-methyltransferase
mRNA cap methyltransferase

Gene names

Name:	ABD1
Ordered Locus Names:	CAGL0K07051g

Organism

Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

284593 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces

Protein attributes

Sequence length	417 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Responsible for methylating the 5'-cap structure of mRNAs By similarity.
Catalytic activity	S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the methyltransferase superfamily. mRNA cap methyltransferase family.

Ontologies

Keywords
Biological process	mRNA capping mRNA processing
Cellular component	Nucleus
Ligand	RNA-binding S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mRNA capping Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW mRNA (guanine-N7-)-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 417	417	mRNA cap guanine-N7 methyltransferase		PRO_0000303906

Sequences

	Sequence		Length	Mass (Da)
	Q6FML4 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 244715F6DABFBFE8	FASTA	417	48,079
	10 20 30 40 50 60 MSVKPEKPVW MSQEDYDRQY GTVGDGENKT AIVEKTTITT QSSSNVVVGE ASKTSSDIGA 70 80 90 100 110 120 NKIQKRKRHD DFALEEKKRR ERERRLREEQ LKEHEIKLTA EKITNVNNLV REHYNERTYI 130 140 150 160 170 180 ANRTKRNQSP IIKLRNFNNA IKFMLIDKFT HTGDVVLELG CGKGGDLRKY GAAGISQFIG 190 200 210 220 230 240 IDISNASIQE AHKRYQSMKN LDFQAILITG DCFGESLGVA VEPFPECRFP CDVVSTQFCL 250 260 270 280 290 300 HYAFETEEKA RRALLNVSKS LKVGGRFFGT IPDSEFLRYK LNKIGKDVQE PKWGNQIYSI 310 320 330 340 350 360 KFSNNDYHEN GNEFPSPYGQ MYTFWLEDAI DNVPEYVVPF ETLRSLADEY GMELILQMPF 370 380 390 400 410 NQFFVQEIPK WVNRFSPKMR EGLTRSDGKY GVEGIEKEPA AYLYTVFAFK KVREHVE

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR380957 Genomic DNA. Translation: CAG61491.1.
RefSeq	XP_448530.1. XM_448530.1.
3D structure databases
HSSP	HSSP built from PDB template 1RI5 based on UniProtKB Q8SR66.
ProteinModelPortal	Q6FML4.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2890389.
GenomeReviews	Gene locus CAGL0K07051g in contig CR380957_GR.
KEGG	cgr:CAGL0K07051g.
Phylogenomic databases
eggNOG	fuNOG05085.
HOGENOM	HBG377892.
OMA	WLEDAID.
OrthoDB	EOG4CZFR2.
Family and domain databases
InterPro	IPR016899. mRNA_G-N7_MeTrfase. IPR004971. Pox_MCEL. [Graphical view]
KO	K00565.
Pfam	PF03291. Pox_MCEL. 1 hit. [Graphical view]
PIRSF	PIRSF028762. ABD1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MCES_CANGA

Accession

Primary (citable) accession number: Q6FML4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	July 19, 2004
Last modified:	December 14, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program