Reviewed, UniProtKB/Swiss-Prot Q6FML4 (MCES_CANGA)

Names and origin

Protein names

Recommended name:
    mRNA cap guanine-N7 methyltransferase
    EC=2.1.1.56
Alternative name(s):
    mRNA (guanine-N(7)-)-methyltransferase
    mRNA cap methyltransferase

Gene names

Name:	ABD1
Ordered Locus Names:	CAGL0K07051g

Organism

Candida glabrata (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

5478 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	417 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Responsible for methylating the 5'-cap structure of mRNAs By similarity.
Catalytic activity	S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m(7)G(5')pppR-RNA.
Subcellular location	NucleusBy similarity.
Sequence similarities	Belongs to the mRNA cap methyltransferase family.

Ontologies

Keywords
Biological process	mRNA capping mRNA processing
Cellular component	Nucleus
Ligand	RNA-binding S-adenosyl-L-methionine
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	RNA binding Inferred from electronic annotation. Source: UniProtKB-KW mRNA (guanine-N7-)-methyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 417	417	mRNA cap guanine-N7 methyltransferase		PRO_0000303906

Sequences

	Sequence		Length	Mass (Da)
	Q6FML4-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 244715F6DABFBFE8	FASTA	417	48,079
	10 20 30 40 50 60 MSVKPEKPVW MSQEDYDRQY GTVGDGENKT AIVEKTTITT QSSSNVVVGE ASKTSSDIGA 70 80 90 100 110 120 NKIQKRKRHD DFALEEKKRR ERERRLREEQ LKEHEIKLTA EKITNVNNLV REHYNERTYI 130 140 150 160 170 180 ANRTKRNQSP IIKLRNFNNA IKFMLIDKFT HTGDVVLELG CGKGGDLRKY GAAGISQFIG 190 200 210 220 230 240 IDISNASIQE AHKRYQSMKN LDFQAILITG DCFGESLGVA VEPFPECRFP CDVVSTQFCL 250 260 270 280 290 300 HYAFETEEKA RRALLNVSKS LKVGGRFFGT IPDSEFLRYK LNKIGKDVQE PKWGNQIYSI 310 320 330 340 350 360 KFSNNDYHEN GNEFPSPYGQ MYTFWLEDAI DNVPEYVVPF ETLRSLADEY GMELILQMPF 370 380 390 400 410 NQFFVQEIPK WVNRFSPKMR EGLTRSDGKY GVEGIEKEPA AYLYTVFAFK KVREHVE

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / IFO 0622 / NRRL Y-65.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR380957 Genomic DNA. Translation: CAG61491.1.
RefSeq	XP_448530.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2890389.
KEGG	cgr:CAGL0K07051g.
Phylogenomic databases
HOGENOM	Q6FML4.
Family and domain databases
InterPro	IPR016899. mRNA_G-N7_MeTrfase. IPR004971. Pox_MCEL. [Graphical view]
Pfam	PF03291. Pox_MCEL. 1 hit. [Graphical view]
PIRSF	PIRSF028762. ABD1. 1 hit.
BLOCKS	Search...
ProtoNet	Search...

Entry information

Entry name

MCES_CANGA

Accession

Primary (citable) accession number: Q6FML4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 11, 2007
Last sequence update:	July 19, 2004
Last modified:	November 4, 2008
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)