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Q6FMI5

- LYS2_CANGA

UniProt

Q6FMI5 - LYS2_CANGA

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Protein
L-aminoadipate-semialdehyde dehydrogenase large subunit
Gene
LYS2, CAGL0K07788g
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH By similarity.

Catalytic activityi

(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H.

Cofactori

Binds 1 phosphopantetheine covalently Reviewed prediction.

Pathwayi

GO - Molecular functioni

  1. L-aminoadipate-semialdehyde dehydrogenase activity Source: UniProtKB-EC
  2. phosphopantetheine binding Source: InterPro

GO - Biological processi

  1. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00033; UER00032.

Names & Taxonomyi

Protein namesi
Recommended name:
L-aminoadipate-semialdehyde dehydrogenase large subunit (EC:1.2.1.31)
Alternative name(s):
Alpha-aminoadipate reductase
Short name:
Alpha-AR
Gene namesi
Name:LYS2
Ordered Locus Names:CAGL0K07788g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
ProteomesiUP000002428: Chromosome K

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13741374L-aminoadipate-semialdehyde dehydrogenase large subunit
PRO_0000193150Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei865 – 8651O-(pantetheine 4'-phosphoryl)serine Reviewed prediction

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6FMI5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini833 – 90270Acyl carrier
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000191209.
KOiK00143.
OMAiDRFTMLS.
OrthoDBiEOG74TX6Z.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR010071. AA_adenyl_domain.
IPR009081. Acyl_carrier_prot-like.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR014397. L-NH2adipate-semiAld_DH_lsu.
IPR013120. Male_sterile_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR006162. PPantetheine_attach_site.
IPR010080. Thioester_reductase-like_dom.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
PF07993. NAD_binding_4. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view]
PIRSFiPIRSF001617. Alpha-AR. 1 hit.
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR01733. AA-adenyl-dom. 1 hit.
TIGR03443. alpha_am_amid. 1 hit.
TIGR01746. Thioester-redct. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00455. AMP_BINDING. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FMI5-1 [UniParc]FASTAAdd to Basket

« Hide

MSWKERLDNP TLSVWPHDYL RPHAEPFVEQ GTYSISIPQL SGDYATLLAA     50
WTALLYRVTG DDDIVLYVRD NKVLRFTITP ELTFTQLQNK INEQLAELAN 100
VEGTNFDALS ESLQKESGLE RPPQLFRIAC VTEDLQLDRY THSPLDIGLQ 150
LHESSSDVSI VFNKLLFSQD RITILADQLT LFLTSVLQNA KQVFTKVSLI 200
TDSSTSILPD PKANLDWCGF VGCIHDIFQD NAEKFPERTC VVETPPINST 250
KTRTFTYKDI NEASNIVAHY LINTGIKRGD VVMIYSSRGV DLMVCVMGVL 300
KAGATFSVID PAYPPARQTI YLGVAKPKGL IVIRAAGQLD QLVEDYITKE 350
LDLVSRIPSI AIQDNGTVEG GSLPSESGDV LASYTELKST RTGVVVGPDS 400
NPTLSFTSGS EGIPKGVLGR HFSLAYYFSW MAKQFNLSEN DKFTMLSGIA 450
HDPIQRDMFT PLFLGAQLYV PTQDDIGTPG RLAEWMGKYG CTVTHLTPAM 500
GQLLTAQAVT PFPKLHHAFF VGDILTKRDC LRLQTLAENC CIVNMYGTTE 550
TQRAVSYFEV TSRSQDPHFL KKLKDVMPAG RGMKNVQLLV VNRNDRTQVC 600
GVGEIGEIYV RAGGLAEGYR GLPDLNKEKF VNNWFVEEGH WNYLDKDLEA 650
PWKEFWQGPR DRLYRTGDLG RYLPNGDCEC CGRADDQVKI RGFRIELGEI 700
DTNISQHPLV RENITLVRNN LEGEKCLVTY MVPRFDKPEL ENFKIEVPSN 750
ISDDPVVCGL IGYSPFTKDL KAFLKKRLAS YAIPSLIIVL PKLPLNPNGK 800
VDKPKLQFPT VKQLELVAKN SSIDINDSEF NQQEREIRDL WLECLPTKPT 850
SISPEDSFFD LGGHSILATK MIFTVKKQLN VELPLGTIFK YPTIKAFAAE 900
VSRLKSTDKI EEETTALTAD YASDAASLID TLPKSYPAAR ALGSPSEMAG 950
PTTVNIFVTG VTGFLGSFIL SDILNRTVTG VNFKIFAHVR AADETSGLDR 1000
IRKAGTVYGT WKEEYANSLQ VVIGDLSKKN FGLTDDKWSH LSETIDIIIH 1050
NGALVHWVYP YSKLRNANVV STINIMNLAS EGKPKLFNFV SSTSVLDTNH 1100
YFELSDKLQQ SGKEGIPESD DLMGSSLGLT SGYGQSKWAA EHIIRAAGKR 1150
GLRGSIIRPG YVTGASYNGS SNTDDFLLRF LKSAVQLGKI PDINNTVNMV 1200
PVDQVARVVV AASINPPCGD DLCVVHVNAH PRIIFKDYLY ELKNYGYDVE 1250
IENYEQWKKT LEEAVIERSE DNALFPLLHM VLGDLEDSTK APELDDKNAI 1300
TSLRADIEWT NEDRTKGMGA TPEQIGIYIS FLESVGFLPH PKHFGDKALP 1350
NIKISEQQKE LVASGAGARS SSAA 1374
Length:1,374
Mass (Da):152,537
Last modified:July 19, 2004 - v1
Checksum:iFF8BF53926B4B184
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380957 Genomic DNA. Translation: CAG61522.1.
RefSeqiXP_448559.1. XM_448559.1.

Genome annotation databases

GeneIDi2890361.
KEGGicgr:CAGL0K07788g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380957 Genomic DNA. Translation: CAG61522.1 .
RefSeqi XP_448559.1. XM_448559.1.

3D structure databases

ProteinModelPortali Q6FMI5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2890361.
KEGGi cgr:CAGL0K07788g.

Phylogenomic databases

HOGENOMi HOG000191209.
KOi K00143.
OMAi DRFTMLS.
OrthoDBi EOG74TX6Z.

Enzyme and pathway databases

UniPathwayi UPA00033 ; UER00032 .

Family and domain databases

Gene3Di 1.10.1200.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR010071. AA_adenyl_domain.
IPR009081. Acyl_carrier_prot-like.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR014397. L-NH2adipate-semiAld_DH_lsu.
IPR013120. Male_sterile_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR006162. PPantetheine_attach_site.
IPR010080. Thioester_reductase-like_dom.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
PF07993. NAD_binding_4. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view ]
PIRSFi PIRSF001617. Alpha-AR. 1 hit.
SUPFAMi SSF47336. SSF47336. 1 hit.
TIGRFAMsi TIGR01733. AA-adenyl-dom. 1 hit.
TIGR03443. alpha_am_amid. 1 hit.
TIGR01746. Thioester-redct. 1 hit.
PROSITEi PS50075. ACP_DOMAIN. 1 hit.
PS00455. AMP_BINDING. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiLYS2_CANGA
AccessioniPrimary (citable) accession number: Q6FMI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 19, 2004
Last modified: February 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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