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Q6FMI5

- LYS2_CANGA

UniProt

Q6FMI5 - LYS2_CANGA

Protein

L-aminoadipate-semialdehyde dehydrogenase large subunit

Gene

LYS2

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH.By similarity

    Catalytic activityi

    (S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H.

    Cofactori

    Binds 1 phosphopantetheine covalently.Curated

    Pathwayi

    GO - Molecular functioni

    1. L-aminoadipate-semialdehyde dehydrogenase activity Source: UniProtKB-EC
    2. phosphopantetheine binding Source: InterPro

    GO - Biological processi

    1. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Amino-acid biosynthesis, Lysine biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00033; UER00032.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    L-aminoadipate-semialdehyde dehydrogenase large subunit (EC:1.2.1.31)
    Alternative name(s):
    Alpha-aminoadipate reductase
    Short name:
    Alpha-AR
    Gene namesi
    Name:LYS2
    Ordered Locus Names:CAGL0K07788g
    OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
    Taxonomic identifieri284593 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
    ProteomesiUP000002428: Chromosome K

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13741374L-aminoadipate-semialdehyde dehydrogenase large subunitPRO_0000193150Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei865 – 8651O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation

    Keywords - PTMi

    Phosphopantetheine, Phosphoprotein

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6FMI5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini833 – 90270Acyl carrierPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 acyl carrier domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOGENOMiHOG000191209.
    KOiK00143.
    OMAiDRFTMLS.
    OrthoDBiEOG74TX6Z.

    Family and domain databases

    Gene3Di1.10.1200.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR010071. AA_adenyl_domain.
    IPR009081. Acyl_carrier_prot-like.
    IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    IPR014397. L-NH2adipate-semiAld_DH_lsu.
    IPR013120. Male_sterile_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    IPR006162. PPantetheine_attach_site.
    IPR010080. Thioester_reductase-like_dom.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    PF07993. NAD_binding_4. 1 hit.
    PF00550. PP-binding. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001617. Alpha-AR. 1 hit.
    SUPFAMiSSF47336. SSF47336. 1 hit.
    TIGRFAMsiTIGR01733. AA-adenyl-dom. 1 hit.
    TIGR03443. alpha_am_amid. 1 hit.
    TIGR01746. Thioester-redct. 1 hit.
    PROSITEiPS50075. ACP_DOMAIN. 1 hit.
    PS00455. AMP_BINDING. 1 hit.
    PS00012. PHOSPHOPANTETHEINE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6FMI5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWKERLDNP TLSVWPHDYL RPHAEPFVEQ GTYSISIPQL SGDYATLLAA     50
    WTALLYRVTG DDDIVLYVRD NKVLRFTITP ELTFTQLQNK INEQLAELAN 100
    VEGTNFDALS ESLQKESGLE RPPQLFRIAC VTEDLQLDRY THSPLDIGLQ 150
    LHESSSDVSI VFNKLLFSQD RITILADQLT LFLTSVLQNA KQVFTKVSLI 200
    TDSSTSILPD PKANLDWCGF VGCIHDIFQD NAEKFPERTC VVETPPINST 250
    KTRTFTYKDI NEASNIVAHY LINTGIKRGD VVMIYSSRGV DLMVCVMGVL 300
    KAGATFSVID PAYPPARQTI YLGVAKPKGL IVIRAAGQLD QLVEDYITKE 350
    LDLVSRIPSI AIQDNGTVEG GSLPSESGDV LASYTELKST RTGVVVGPDS 400
    NPTLSFTSGS EGIPKGVLGR HFSLAYYFSW MAKQFNLSEN DKFTMLSGIA 450
    HDPIQRDMFT PLFLGAQLYV PTQDDIGTPG RLAEWMGKYG CTVTHLTPAM 500
    GQLLTAQAVT PFPKLHHAFF VGDILTKRDC LRLQTLAENC CIVNMYGTTE 550
    TQRAVSYFEV TSRSQDPHFL KKLKDVMPAG RGMKNVQLLV VNRNDRTQVC 600
    GVGEIGEIYV RAGGLAEGYR GLPDLNKEKF VNNWFVEEGH WNYLDKDLEA 650
    PWKEFWQGPR DRLYRTGDLG RYLPNGDCEC CGRADDQVKI RGFRIELGEI 700
    DTNISQHPLV RENITLVRNN LEGEKCLVTY MVPRFDKPEL ENFKIEVPSN 750
    ISDDPVVCGL IGYSPFTKDL KAFLKKRLAS YAIPSLIIVL PKLPLNPNGK 800
    VDKPKLQFPT VKQLELVAKN SSIDINDSEF NQQEREIRDL WLECLPTKPT 850
    SISPEDSFFD LGGHSILATK MIFTVKKQLN VELPLGTIFK YPTIKAFAAE 900
    VSRLKSTDKI EEETTALTAD YASDAASLID TLPKSYPAAR ALGSPSEMAG 950
    PTTVNIFVTG VTGFLGSFIL SDILNRTVTG VNFKIFAHVR AADETSGLDR 1000
    IRKAGTVYGT WKEEYANSLQ VVIGDLSKKN FGLTDDKWSH LSETIDIIIH 1050
    NGALVHWVYP YSKLRNANVV STINIMNLAS EGKPKLFNFV SSTSVLDTNH 1100
    YFELSDKLQQ SGKEGIPESD DLMGSSLGLT SGYGQSKWAA EHIIRAAGKR 1150
    GLRGSIIRPG YVTGASYNGS SNTDDFLLRF LKSAVQLGKI PDINNTVNMV 1200
    PVDQVARVVV AASINPPCGD DLCVVHVNAH PRIIFKDYLY ELKNYGYDVE 1250
    IENYEQWKKT LEEAVIERSE DNALFPLLHM VLGDLEDSTK APELDDKNAI 1300
    TSLRADIEWT NEDRTKGMGA TPEQIGIYIS FLESVGFLPH PKHFGDKALP 1350
    NIKISEQQKE LVASGAGARS SSAA 1374
    Length:1,374
    Mass (Da):152,537
    Last modified:July 19, 2004 - v1
    Checksum:iFF8BF53926B4B184
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380957 Genomic DNA. Translation: CAG61522.1.
    RefSeqiXP_448559.1. XM_448559.1.

    Genome annotation databases

    GeneIDi2890361.
    KEGGicgr:CAGL0K07788g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380957 Genomic DNA. Translation: CAG61522.1 .
    RefSeqi XP_448559.1. XM_448559.1.

    3D structure databases

    ProteinModelPortali Q6FMI5.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2890361.
    KEGGi cgr:CAGL0K07788g.

    Phylogenomic databases

    HOGENOMi HOG000191209.
    KOi K00143.
    OMAi DRFTMLS.
    OrthoDBi EOG74TX6Z.

    Enzyme and pathway databases

    UniPathwayi UPA00033 ; UER00032 .

    Family and domain databases

    Gene3Di 1.10.1200.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR010071. AA_adenyl_domain.
    IPR009081. Acyl_carrier_prot-like.
    IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    IPR014397. L-NH2adipate-semiAld_DH_lsu.
    IPR013120. Male_sterile_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    IPR006162. PPantetheine_attach_site.
    IPR010080. Thioester_reductase-like_dom.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    PF07993. NAD_binding_4. 1 hit.
    PF00550. PP-binding. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001617. Alpha-AR. 1 hit.
    SUPFAMi SSF47336. SSF47336. 1 hit.
    TIGRFAMsi TIGR01733. AA-adenyl-dom. 1 hit.
    TIGR03443. alpha_am_amid. 1 hit.
    TIGR01746. Thioester-redct. 1 hit.
    PROSITEi PS50075. ACP_DOMAIN. 1 hit.
    PS00455. AMP_BINDING. 1 hit.
    PS00012. PHOSPHOPANTETHEINE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiLYS2_CANGA
    AccessioniPrimary (citable) accession number: Q6FMI5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3