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Q6FMI5

- LYS2_CANGA

UniProt

Q6FMI5 - LYS2_CANGA

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Protein

L-aminoadipate-semialdehyde dehydrogenase large subunit

Gene

LYS2

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH.By similarity

Catalytic activityi

(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H.

Cofactori

pantetheine 4'-phosphateCuratedNote: Binds 1 phosphopantetheine covalently.Curated

Pathwayi

GO - Molecular functioni

  1. L-aminoadipate-semialdehyde dehydrogenase activity Source: UniProtKB-EC
  2. phosphopantetheine binding Source: InterPro

GO - Biological processi

  1. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Lysine biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00033; UER00032.

Names & Taxonomyi

Protein namesi
Recommended name:
L-aminoadipate-semialdehyde dehydrogenase large subunit (EC:1.2.1.31)
Alternative name(s):
Alpha-aminoadipate reductase
Short name:
Alpha-AR
Gene namesi
Name:LYS2
Ordered Locus Names:CAGL0K07788g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428: Chromosome K

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13741374L-aminoadipate-semialdehyde dehydrogenase large subunitPRO_0000193150Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei865 – 8651O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6FMI5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini833 – 90270Acyl carrierPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 acyl carrier domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000191209.
InParanoidiQ6FMI5.
KOiK00143.
OMAiDRFTMLS.
OrthoDBiEOG74TX6Z.

Family and domain databases

Gene3Di1.10.1200.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR010071. AA_adenyl_domain.
IPR009081. Acyl_carrier_prot-like.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR014397. L-NH2adipate-semiAld_DH_lsu.
IPR013120. Male_sterile_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR006162. PPantetheine_attach_site.
IPR010080. Thioester_reductase-like_dom.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
PF07993. NAD_binding_4. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view]
PIRSFiPIRSF001617. Alpha-AR. 1 hit.
SUPFAMiSSF47336. SSF47336. 1 hit.
TIGRFAMsiTIGR01733. AA-adenyl-dom. 1 hit.
TIGR03443. alpha_am_amid. 1 hit.
TIGR01746. Thioester-redct. 1 hit.
PROSITEiPS50075. ACP_DOMAIN. 1 hit.
PS00455. AMP_BINDING. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FMI5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSWKERLDNP TLSVWPHDYL RPHAEPFVEQ GTYSISIPQL SGDYATLLAA
60 70 80 90 100
WTALLYRVTG DDDIVLYVRD NKVLRFTITP ELTFTQLQNK INEQLAELAN
110 120 130 140 150
VEGTNFDALS ESLQKESGLE RPPQLFRIAC VTEDLQLDRY THSPLDIGLQ
160 170 180 190 200
LHESSSDVSI VFNKLLFSQD RITILADQLT LFLTSVLQNA KQVFTKVSLI
210 220 230 240 250
TDSSTSILPD PKANLDWCGF VGCIHDIFQD NAEKFPERTC VVETPPINST
260 270 280 290 300
KTRTFTYKDI NEASNIVAHY LINTGIKRGD VVMIYSSRGV DLMVCVMGVL
310 320 330 340 350
KAGATFSVID PAYPPARQTI YLGVAKPKGL IVIRAAGQLD QLVEDYITKE
360 370 380 390 400
LDLVSRIPSI AIQDNGTVEG GSLPSESGDV LASYTELKST RTGVVVGPDS
410 420 430 440 450
NPTLSFTSGS EGIPKGVLGR HFSLAYYFSW MAKQFNLSEN DKFTMLSGIA
460 470 480 490 500
HDPIQRDMFT PLFLGAQLYV PTQDDIGTPG RLAEWMGKYG CTVTHLTPAM
510 520 530 540 550
GQLLTAQAVT PFPKLHHAFF VGDILTKRDC LRLQTLAENC CIVNMYGTTE
560 570 580 590 600
TQRAVSYFEV TSRSQDPHFL KKLKDVMPAG RGMKNVQLLV VNRNDRTQVC
610 620 630 640 650
GVGEIGEIYV RAGGLAEGYR GLPDLNKEKF VNNWFVEEGH WNYLDKDLEA
660 670 680 690 700
PWKEFWQGPR DRLYRTGDLG RYLPNGDCEC CGRADDQVKI RGFRIELGEI
710 720 730 740 750
DTNISQHPLV RENITLVRNN LEGEKCLVTY MVPRFDKPEL ENFKIEVPSN
760 770 780 790 800
ISDDPVVCGL IGYSPFTKDL KAFLKKRLAS YAIPSLIIVL PKLPLNPNGK
810 820 830 840 850
VDKPKLQFPT VKQLELVAKN SSIDINDSEF NQQEREIRDL WLECLPTKPT
860 870 880 890 900
SISPEDSFFD LGGHSILATK MIFTVKKQLN VELPLGTIFK YPTIKAFAAE
910 920 930 940 950
VSRLKSTDKI EEETTALTAD YASDAASLID TLPKSYPAAR ALGSPSEMAG
960 970 980 990 1000
PTTVNIFVTG VTGFLGSFIL SDILNRTVTG VNFKIFAHVR AADETSGLDR
1010 1020 1030 1040 1050
IRKAGTVYGT WKEEYANSLQ VVIGDLSKKN FGLTDDKWSH LSETIDIIIH
1060 1070 1080 1090 1100
NGALVHWVYP YSKLRNANVV STINIMNLAS EGKPKLFNFV SSTSVLDTNH
1110 1120 1130 1140 1150
YFELSDKLQQ SGKEGIPESD DLMGSSLGLT SGYGQSKWAA EHIIRAAGKR
1160 1170 1180 1190 1200
GLRGSIIRPG YVTGASYNGS SNTDDFLLRF LKSAVQLGKI PDINNTVNMV
1210 1220 1230 1240 1250
PVDQVARVVV AASINPPCGD DLCVVHVNAH PRIIFKDYLY ELKNYGYDVE
1260 1270 1280 1290 1300
IENYEQWKKT LEEAVIERSE DNALFPLLHM VLGDLEDSTK APELDDKNAI
1310 1320 1330 1340 1350
TSLRADIEWT NEDRTKGMGA TPEQIGIYIS FLESVGFLPH PKHFGDKALP
1360 1370
NIKISEQQKE LVASGAGARS SSAA
Length:1,374
Mass (Da):152,537
Last modified:July 19, 2004 - v1
Checksum:iFF8BF53926B4B184
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380957 Genomic DNA. Translation: CAG61522.1.
RefSeqiXP_448559.1. XM_448559.1.

Genome annotation databases

GeneIDi2890361.
KEGGicgr:CAGL0K07788g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380957 Genomic DNA. Translation: CAG61522.1 .
RefSeqi XP_448559.1. XM_448559.1.

3D structure databases

ProteinModelPortali Q6FMI5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2890361.
KEGGi cgr:CAGL0K07788g.

Phylogenomic databases

HOGENOMi HOG000191209.
InParanoidi Q6FMI5.
KOi K00143.
OMAi DRFTMLS.
OrthoDBi EOG74TX6Z.

Enzyme and pathway databases

UniPathwayi UPA00033 ; UER00032 .

Family and domain databases

Gene3Di 1.10.1200.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR010071. AA_adenyl_domain.
IPR009081. Acyl_carrier_prot-like.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR014397. L-NH2adipate-semiAld_DH_lsu.
IPR013120. Male_sterile_NAD-bd.
IPR016040. NAD(P)-bd_dom.
IPR006162. PPantetheine_attach_site.
IPR010080. Thioester_reductase-like_dom.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
PF07993. NAD_binding_4. 1 hit.
PF00550. PP-binding. 1 hit.
[Graphical view ]
PIRSFi PIRSF001617. Alpha-AR. 1 hit.
SUPFAMi SSF47336. SSF47336. 1 hit.
TIGRFAMsi TIGR01733. AA-adenyl-dom. 1 hit.
TIGR03443. alpha_am_amid. 1 hit.
TIGR01746. Thioester-redct. 1 hit.
PROSITEi PS50075. ACP_DOMAIN. 1 hit.
PS00455. AMP_BINDING. 1 hit.
PS00012. PHOSPHOPANTETHEINE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiLYS2_CANGA
AccessioniPrimary (citable) accession number: Q6FMI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 19, 2004
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3