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Q6FM81

- PP4C_CANGA

UniProt

Q6FM81 - PP4C_CANGA

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Protein
Serine/threonine-protein phosphatase 4 catalytic subunit
Gene
PPH3, CAGL0K10208g
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Forms the histone H2A phosphatase complex in association with the regulatory subunits PSY2 and PSY4, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint By similarity.

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi52 – 521Manganese 1 By similarity
Metal bindingi54 – 541Manganese 1 By similarity
Metal bindingi80 – 801Manganese 1 By similarity
Metal bindingi80 – 801Manganese 2 By similarity
Metal bindingi112 – 1121Manganese 2 By similarity
Active sitei113 – 1131Proton donor By similarity
Metal bindingi162 – 1621Manganese 2 By similarity
Metal bindingi236 – 2361Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. calcium ion homeostasis Source: CGD
  2. cellular heat acclimation Source: CGD
  3. cellular response to drug Source: CGD
  4. fungal-type cell wall organization Source: CGD
  5. pathogenesis Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit (EC:3.1.3.16)
Short name:
PP4C
Gene namesi
Name:PPH3
Ordered Locus Names:CAGL0K10208g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
ProteomesiUP000002428: Chromosome K

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Serine/threonine-protein phosphatase 4 catalytic subunit
PRO_0000223650Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei309 – 3091Leucine methyl ester By similarity

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Catalytic subunit of the histone H2A phosphatase complex (HTP-C) containing PPH3, PSY2 and PSY4 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6FM81.
SMRiQ6FM81. Positions 3-308.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000172696.
KOiK15423.
OMAiINDSIFC.
OrthoDBiEOG7FFN29.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FM81-1 [UniParc]FASTAAdd to Basket

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MLVDLDEILV SLKEGRHIPE ETVYALCMDS QELLMNESNV ARVDTPVTIC    50
GDIHGQLHDL LTLFEKSGGV EKTRYVFLGD FVDRGFYSLE SFLLLLVYKL 100
RYPDRITLIR GNHETRQITK VYGFYDEVMR KYGNSNVWRY CCEVFDYLSL 150
GAIINDSIFC VHGGLSPDIT TLNEIRAIDR KQEVPHEGGM CDLLWSDPDE 200
VDTWSMSPRG AGFLFGKGEV DEFLHVNNVD LIARAHQLVM EGYKEMFDGG 250
LVTVWSAPNY CYRCGNVAAV LKIEDNLERK YTIFEAVQAQ NGVGNTIIPT 300
KKAQMDYFL 309
Length:309
Mass (Da):35,186
Last modified:July 19, 2004 - v1
Checksum:i18E0E819D03D0EBD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380957 Genomic DNA. Translation: CAG61626.1.
RefSeqiXP_448663.1. XM_448663.1.

Genome annotation databases

GeneIDi