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Protein

Serine/threonine-protein phosphatase 4 catalytic subunit

Gene

PPH3

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Forms the histone H2A phosphatase complex in association with the regulatory subunits PSY2 and PSY4, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi52 – 521Manganese 1By similarity
Metal bindingi54 – 541Manganese 1By similarity
Metal bindingi80 – 801Manganese 1By similarity
Metal bindingi80 – 801Manganese 2By similarity
Metal bindingi112 – 1121Manganese 2By similarity
Active sitei113 – 1131Proton donorBy similarity
Metal bindingi162 – 1621Manganese 2By similarity
Metal bindingi236 – 2361Manganese 2By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit (EC:3.1.3.16)
Short name:
PP4C
Gene namesi
Name:PPH3
Ordered Locus Names:CAGL0K10208g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428 Componenti: Chromosome K

Organism-specific databases

EuPathDBiFungiDB:CAGL0K10208g.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Serine/threonine-protein phosphatase 4 catalytic subunitPRO_0000223650Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei309 – 3091Leucine methyl esterBy similarity

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Catalytic subunit of the histone H2A phosphatase complex (HTP-C) containing PPH3, PSY2 and PSY4.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6FM81.
SMRiQ6FM81. Positions 3-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000172696.
InParanoidiQ6FM81.
KOiK15423.
OMAiHIPEETV.
OrthoDBiEOG7FFN29.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FM81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVDLDEILV SLKEGRHIPE ETVYALCMDS QELLMNESNV ARVDTPVTIC
60 70 80 90 100
GDIHGQLHDL LTLFEKSGGV EKTRYVFLGD FVDRGFYSLE SFLLLLVYKL
110 120 130 140 150
RYPDRITLIR GNHETRQITK VYGFYDEVMR KYGNSNVWRY CCEVFDYLSL
160 170 180 190 200
GAIINDSIFC VHGGLSPDIT TLNEIRAIDR KQEVPHEGGM CDLLWSDPDE
210 220 230 240 250
VDTWSMSPRG AGFLFGKGEV DEFLHVNNVD LIARAHQLVM EGYKEMFDGG
260 270 280 290 300
LVTVWSAPNY CYRCGNVAAV LKIEDNLERK YTIFEAVQAQ NGVGNTIIPT

KKAQMDYFL
Length:309
Mass (Da):35,186
Last modified:July 19, 2004 - v1
Checksum:i18E0E819D03D0EBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380957 Genomic DNA. Translation: CAG61626.1.
RefSeqiXP_448663.1. XM_448663.1.

Genome annotation databases

GeneIDi2890113.
KEGGicgr:CAGL0K10208g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380957 Genomic DNA. Translation: CAG61626.1.
RefSeqiXP_448663.1. XM_448663.1.

3D structure databases

ProteinModelPortaliQ6FM81.
SMRiQ6FM81. Positions 3-308.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2890113.
KEGGicgr:CAGL0K10208g.

Organism-specific databases

EuPathDBiFungiDB:CAGL0K10208g.

Phylogenomic databases

HOGENOMiHOG000172696.
InParanoidiQ6FM81.
KOiK15423.
OMAiHIPEETV.
OrthoDBiEOG7FFN29.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP4C_CANGA
AccessioniPrimary (citable) accession number: Q6FM81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: July 19, 2004
Last modified: April 29, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.