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Protein

Serine/threonine-protein phosphatase 4 catalytic subunit

Gene

PPH3

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Forms the histone H2A phosphatase complex in association with the regulatory subunits PSY2 and PSY4, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi52Manganese 1By similarity1
Metal bindingi54Manganese 1By similarity1
Metal bindingi80Manganese 1By similarity1
Metal bindingi80Manganese 2By similarity1
Metal bindingi112Manganese 2By similarity1
Active sitei113Proton donorBy similarity1
Metal bindingi162Manganese 2By similarity1
Metal bindingi236Manganese 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase
LigandManganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit (EC:3.1.3.16)
Short name:
PP4C
Gene namesi
Name:PPH3
Ordered Locus Names:CAGL0K10208g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome K

Organism-specific databases

CGDiCAL0134435 CAGL0K10208g
EuPathDBiFungiDB:CAGL0K10208g

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002236501 – 309Serine/threonine-protein phosphatase 4 catalytic subunitAdd BLAST309

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei309Leucine methyl esterBy similarity1

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Catalytic subunit of the histone H2A phosphatase complex (HTP-C) containing PPH3, PSY2 and PSY4.By similarity

Protein-protein interaction databases

STRINGi284593.XP_448663.1

Structurei

3D structure databases

ProteinModelPortaliQ6FM81
SMRiQ6FM81
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0371 Eukaryota
COG0639 LUCA
HOGENOMiHOG000172696
InParanoidiQ6FM81
KOiK15423
OMAiNRIFCTH
OrthoDBiEOG092C2R40

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
IPR006186 Ser/Thr-sp_prot-phosphatase
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PRINTSiPR00114 STPHPHTASE
SMARTiView protein in SMART
SM00156 PP2Ac, 1 hit
PROSITEiView protein in PROSITE
PS00125 SER_THR_PHOSPHATASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q6FM81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVDLDEILV SLKEGRHIPE ETVYALCMDS QELLMNESNV ARVDTPVTIC
60 70 80 90 100
GDIHGQLHDL LTLFEKSGGV EKTRYVFLGD FVDRGFYSLE SFLLLLVYKL
110 120 130 140 150
RYPDRITLIR GNHETRQITK VYGFYDEVMR KYGNSNVWRY CCEVFDYLSL
160 170 180 190 200
GAIINDSIFC VHGGLSPDIT TLNEIRAIDR KQEVPHEGGM CDLLWSDPDE
210 220 230 240 250
VDTWSMSPRG AGFLFGKGEV DEFLHVNNVD LIARAHQLVM EGYKEMFDGG
260 270 280 290 300
LVTVWSAPNY CYRCGNVAAV LKIEDNLERK YTIFEAVQAQ NGVGNTIIPT

KKAQMDYFL
Length:309
Mass (Da):35,186
Last modified:July 19, 2004 - v1
Checksum:i18E0E819D03D0EBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380957 Genomic DNA Translation: CAG61626.1
RefSeqiXP_448663.1, XM_448663.1

Genome annotation databases

EnsemblFungiiCAG61626; CAG61626; CAGL0K10208g
GeneIDi2890113
KEGGicgr:CAGL0K10208g

Similar proteinsi

Entry informationi

Entry nameiPP4C_CANGA
AccessioniPrimary (citable) accession number: Q6FM81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: July 19, 2004
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health