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Q6FM81

- PP4C_CANGA

UniProt

Q6FM81 - PP4C_CANGA

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Protein

Serine/threonine-protein phosphatase 4 catalytic subunit

Gene

PPH3

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Forms the histone H2A phosphatase complex in association with the regulatory subunits PSY2 and PSY4, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi52 – 521Manganese 1By similarity
Metal bindingi54 – 541Manganese 1By similarity
Metal bindingi80 – 801Manganese 1By similarity
Metal bindingi80 – 801Manganese 2By similarity
Metal bindingi112 – 1121Manganese 2By similarity
Active sitei113 – 1131Proton donorBy similarity
Metal bindingi162 – 1621Manganese 2By similarity
Metal bindingi236 – 2361Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW

GO - Biological processi

  1. calcium ion homeostasis Source: CGD
  2. cellular heat acclimation Source: CGD
  3. cellular response to drug Source: CGD
  4. fungal-type cell wall organization Source: CGD
  5. pathogenesis Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit (EC:3.1.3.16)
Short name:
PP4C
Gene namesi
Name:PPH3
Ordered Locus Names:CAGL0K10208g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428: Chromosome K

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 309309Serine/threonine-protein phosphatase 4 catalytic subunitPRO_0000223650Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei309 – 3091Leucine methyl esterBy similarity

Keywords - PTMi

Methylation

Interactioni

Subunit structurei

Catalytic subunit of the histone H2A phosphatase complex (HTP-C) containing PPH3, PSY2 and PSY4.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6FM81.
SMRiQ6FM81. Positions 3-308.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000172696.
InParanoidiQ6FM81.
KOiK15423.
OMAiINDSIFC.
OrthoDBiEOG7FFN29.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FM81-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLVDLDEILV SLKEGRHIPE ETVYALCMDS QELLMNESNV ARVDTPVTIC
60 70 80 90 100
GDIHGQLHDL LTLFEKSGGV EKTRYVFLGD FVDRGFYSLE SFLLLLVYKL
110 120 130 140 150
RYPDRITLIR GNHETRQITK VYGFYDEVMR KYGNSNVWRY CCEVFDYLSL
160 170 180 190 200
GAIINDSIFC VHGGLSPDIT TLNEIRAIDR KQEVPHEGGM CDLLWSDPDE
210 220 230 240 250
VDTWSMSPRG AGFLFGKGEV DEFLHVNNVD LIARAHQLVM EGYKEMFDGG
260 270 280 290 300
LVTVWSAPNY CYRCGNVAAV LKIEDNLERK YTIFEAVQAQ NGVGNTIIPT

KKAQMDYFL
Length:309
Mass (Da):35,186
Last modified:July 19, 2004 - v1
Checksum:i18E0E819D03D0EBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380957 Genomic DNA. Translation: CAG61626.1.
RefSeqiXP_448663.1. XM_448663.1.

Genome annotation databases

GeneIDi2890113.
KEGGicgr:CAGL0K10208g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380957 Genomic DNA. Translation: CAG61626.1 .
RefSeqi XP_448663.1. XM_448663.1.

3D structure databases

ProteinModelPortali Q6FM81.
SMRi Q6FM81. Positions 3-308.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2890113.
KEGGi cgr:CAGL0K10208g.

Phylogenomic databases

HOGENOMi HOG000172696.
InParanoidi Q6FM81.
KOi K15423.
OMAi INDSIFC.
OrthoDBi EOG7FFN29.

Family and domain databases

Gene3Di 3.60.21.10. 1 hit.
InterProi IPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view ]
Pfami PF00149. Metallophos. 1 hit.
[Graphical view ]
PRINTSi PR00114. STPHPHTASE.
SMARTi SM00156. PP2Ac. 1 hit.
[Graphical view ]
SUPFAMi SSF56300. SSF56300. 1 hit.
PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiPP4C_CANGA
AccessioniPrimary (citable) accession number: Q6FM81
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: July 19, 2004
Last modified: November 26, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3