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Q6FM81

- PP4C_CANGA

UniProt

Q6FM81 - PP4C_CANGA

Protein

Serine/threonine-protein phosphatase 4 catalytic subunit

Gene

PPH3

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Forms the histone H2A phosphatase complex in association with the regulatory subunits PSY2 and PSY4, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi52 – 521Manganese 1By similarity
    Metal bindingi54 – 541Manganese 1By similarity
    Metal bindingi80 – 801Manganese 1By similarity
    Metal bindingi80 – 801Manganese 2By similarity
    Metal bindingi112 – 1121Manganese 2By similarity
    Active sitei113 – 1131Proton donorBy similarity
    Metal bindingi162 – 1621Manganese 2By similarity
    Metal bindingi236 – 2361Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. phosphoprotein phosphatase activity Source: UniProtKB-KW

    GO - Biological processi

    1. calcium ion homeostasis Source: CGD
    2. cellular heat acclimation Source: CGD
    3. cellular response to drug Source: CGD
    4. fungal-type cell wall organization Source: CGD
    5. pathogenesis Source: CGD

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Manganese, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase 4 catalytic subunit (EC:3.1.3.16)
    Short name:
    PP4C
    Gene namesi
    Name:PPH3
    Ordered Locus Names:CAGL0K10208g
    OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
    Taxonomic identifieri284593 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
    ProteomesiUP000002428: Chromosome K

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 309309Serine/threonine-protein phosphatase 4 catalytic subunitPRO_0000223650Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei309 – 3091Leucine methyl esterBy similarity

    Keywords - PTMi

    Methylation

    Interactioni

    Subunit structurei

    Catalytic subunit of the histone H2A phosphatase complex (HTP-C) containing PPH3, PSY2 and PSY4.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6FM81.
    SMRiQ6FM81. Positions 3-308.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000172696.
    KOiK15423.
    OMAiINDSIFC.
    OrthoDBiEOG7FFN29.

    Family and domain databases

    Gene3Di3.60.21.10. 1 hit.
    InterProiIPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view]
    PfamiPF00149. Metallophos. 1 hit.
    [Graphical view]
    PRINTSiPR00114. STPHPHTASE.
    SMARTiSM00156. PP2Ac. 1 hit.
    [Graphical view]
    SUPFAMiSSF56300. SSF56300. 1 hit.
    PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6FM81-1 [UniParc]FASTAAdd to Basket

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    MLVDLDEILV SLKEGRHIPE ETVYALCMDS QELLMNESNV ARVDTPVTIC    50
    GDIHGQLHDL LTLFEKSGGV EKTRYVFLGD FVDRGFYSLE SFLLLLVYKL 100
    RYPDRITLIR GNHETRQITK VYGFYDEVMR KYGNSNVWRY CCEVFDYLSL 150
    GAIINDSIFC VHGGLSPDIT TLNEIRAIDR KQEVPHEGGM CDLLWSDPDE 200
    VDTWSMSPRG AGFLFGKGEV DEFLHVNNVD LIARAHQLVM EGYKEMFDGG 250
    LVTVWSAPNY CYRCGNVAAV LKIEDNLERK YTIFEAVQAQ NGVGNTIIPT 300
    KKAQMDYFL 309
    Length:309
    Mass (Da):35,186
    Last modified:July 19, 2004 - v1
    Checksum:i18E0E819D03D0EBD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380957 Genomic DNA. Translation: CAG61626.1.
    RefSeqiXP_448663.1. XM_448663.1.

    Genome annotation databases

    GeneIDi2890113.
    KEGGicgr:CAGL0K10208g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380957 Genomic DNA. Translation: CAG61626.1 .
    RefSeqi XP_448663.1. XM_448663.1.

    3D structure databases

    ProteinModelPortali Q6FM81.
    SMRi Q6FM81. Positions 3-308.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2890113.
    KEGGi cgr:CAGL0K10208g.

    Phylogenomic databases

    HOGENOMi HOG000172696.
    KOi K15423.
    OMAi INDSIFC.
    OrthoDBi EOG7FFN29.

    Family and domain databases

    Gene3Di 3.60.21.10. 1 hit.
    InterProi IPR004843. Calcineurin-like_PHP_apaH.
    IPR029052. Metallo-depent_PP-like.
    IPR006186. Ser/Thr-sp_prot-phosphatase.
    [Graphical view ]
    Pfami PF00149. Metallophos. 1 hit.
    [Graphical view ]
    PRINTSi PR00114. STPHPHTASE.
    SMARTi SM00156. PP2Ac. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56300. SSF56300. 1 hit.
    PROSITEi PS00125. SER_THR_PHOSPHATASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiPP4C_CANGA
    AccessioniPrimary (citable) accession number: Q6FM81
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3