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Q6FM81 (PP4C_CANGA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase 4 catalytic subunit

Short name=PP4C
EC=3.1.3.16
Gene names
Name:PPH3
Ordered Locus Names:CAGL0K10208g
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier284593 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces

Protein attributes

Sequence length309 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Forms the histone H2A phosphatase complex in association with the regulatory subunits PSY2 and PSY4, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint By similarity.

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 1 iron ion per subunit By similarity.

Binds 1 manganese ion per subunit By similarity.

Subunit structure

Catalytic subunit of the histone H2A phosphatase complex (HTP-C) containing PPH3, PSY2 and PSY4 By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 309309Serine/threonine-protein phosphatase 4 catalytic subunit
PRO_0000223650

Sites

Active site1131Proton donor By similarity
Metal binding521Iron By similarity
Metal binding541Iron By similarity
Metal binding801Iron By similarity
Metal binding801Manganese By similarity
Metal binding1121Manganese By similarity
Metal binding1621Manganese By similarity
Metal binding2361Manganese By similarity

Amino acid modifications

Modified residue3091Leucine methyl ester By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6FM81 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 18E0E819D03D0EBD

FASTA30935,186
        10         20         30         40         50         60 
MLVDLDEILV SLKEGRHIPE ETVYALCMDS QELLMNESNV ARVDTPVTIC GDIHGQLHDL 

        70         80         90        100        110        120 
LTLFEKSGGV EKTRYVFLGD FVDRGFYSLE SFLLLLVYKL RYPDRITLIR GNHETRQITK 

       130        140        150        160        170        180 
VYGFYDEVMR KYGNSNVWRY CCEVFDYLSL GAIINDSIFC VHGGLSPDIT TLNEIRAIDR 

       190        200        210        220        230        240 
KQEVPHEGGM CDLLWSDPDE VDTWSMSPRG AGFLFGKGEV DEFLHVNNVD LIARAHQLVM 

       250        260        270        280        290        300 
EGYKEMFDGG LVTVWSAPNY CYRCGNVAAV LKIEDNLERK YTIFEAVQAQ NGVGNTIIPT 


KKAQMDYFL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR380957 Genomic DNA. Translation: CAG61626.1.
RefSeqXP_448663.1. XM_448663.1.

3D structure databases

ProteinModelPortalQ6FM81.
SMRQ6FM81. Positions 3-308.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2890113.
KEGGcgr:CAGL0K10208g.

Phylogenomic databases

HOGENOMHOG000172696.
KOK15423.
OMAINDSIFC.
OrthoDBEOG7FFN29.

Family and domain databases

InterProIPR004843. Calcineurin-like_PHP_apaH.
IPR006186. Ser/Thr-sp_prot-phosphatase.
[Graphical view]
PfamPF00149. Metallophos. 1 hit.
[Graphical view]
PRINTSPR00114. STPHPHTASE.
SMARTSM00156. PP2Ac. 1 hit.
[Graphical view]
PROSITEPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePP4C_CANGA
AccessionPrimary (citable) accession number: Q6FM81
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: July 19, 2004
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families