Reviewed, UniProtKB/Swiss-Prot Q6FLU2 (ACS1_CANGA)

Names and origin

Protein names

Recommended name:
    Acetyl-coenzyme A synthetase 1
    EC=6.2.1.1
Alternative name(s):
    Acetate--CoA ligase 1
    Acyl-activating enzyme 1

Gene names

Name:	ACS1
Ordered Locus Names:	CAGL0L00649g

Organism

Candida glabrata (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

5478 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces

Protein attributes

Sequence length	704 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.
Subcellular location	Microsome Potential. Endoplasmic reticulum Potential.
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Microsome
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	AMP binding Inferred from electronic annotation. Source: InterPro ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate-CoA ligase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 704	704	Acetyl-coenzyme A synthetase 1		PRO_0000208407
Regions
	Motif	702 – 704	3	Microbody targeting signal Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6FLU2-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: 9E3D72E57E80536A	FASTA	704	79,263
	10 20 30 40 50 60 MSPSAIAEKK QVDNIQEIKD KNQEPAHHEY EHLTNVGVVK QKPIDHRLKD NIKTHYSPHL 70 80 90 100 110 120 DGLQEYKRQY QESIENPEKF FSEKARSFMN WFRDFDRVFV PDVDNPTKPS FENNAWFLNG 130 140 150 160 170 180 QLNTCYNCVD RHALKTPNKT AIIYEADEPG EGYSMSYKEL LEKVCQVAQI LKYSMNVKKG 190 200 210 220 230 240 DTVAVYMPMI PEALITLLAI SRIGAIHSVV FAGFSSNSLR DRINDAGSRV VITADESNRG 250 260 270 280 290 300 GKIIETKRIV DDALRETPQV EHVLVYRRTN NPQVNFQAPR DLDWETERKK YKTYFPCEPV 310 320 330 340 350 360 DSEHPLFLLY TSGSTGTPKG VQHSTAGYLL GALLTMRYTF DVHQEDVFFT AGDIGWITGH 370 380 390 400 410 420 TYCVYGPLLY GCTTLVFEGT PAYPNFSRYW EIIDKHQVTQ FYVAPTALRL LKRAGDSFID 430 440 450 460 470 480 GFSLKSLRCL GSVGEPIAAE VWEWYSDKIG KNEIPIVDTY WQTESGSHLV TPLAGGVTPM 490 500 510 520 530 540 KPGSASLPFF GIETVILDPT TGEEINDSHA EGVLAIKRPW PSFARTIWKN HDRFLDTYLN 550 560 570 580 590 600 PYKGYYFTGD GAARDKDGYI WILGRVDDVV NVSGHRLSTA EIEAAIIEDR MVAECAVVGF 610 620 630 640 650 660 NDDLTGQAVA AFVVLKDKST WASASEEELQ DIKKHLILTV RKDIGPFAAP KLIVLVDDLP 670 680 690 700 KTRSGKIMRR ILRKILAGES DQLGDVSTLS NPGVVKHLID SVKL

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / IFO 0622 / NRRL Y-65.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR380958 Genomic DNA. Translation: CAG61772.1.
RefSeq	XP_448802.1.
3D structure databases
SMR	Q6FLU2. Positions 64-691.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6FLU2.
Genome annotation databases
GeneID	2891117.
GenomeReviews	Gene locus CAGL0L00649g in contig CR380958_GR.
KEGG	cgr:CAGL0L00649g.
Phylogenomic databases
HOGENOM	Q6FLU2.
OMA	IVIAPIP.
Enzyme and pathway databases
BRENDA	6.2.1.1. 189220.
Family and domain databases
InterPro	IPR011904. Ac_CoA_lig_AcsA. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
TIGRFAMs	TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACS1_CANGA

Accession

Primary (citable) accession number: Q6FLU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
Last sequence update:	July 19, 2004
Last modified:	November 3, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)