Reviewed, UniProtKB/Swiss-Prot Q6FL58 (ATG1_CANGA)

Names and origin

Protein names

Recommended name:
    Serine/threonine-protein kinase ATG1
    EC=2.7.11.1
Alternative name(s):
    Autophagy-related protein 1

Gene names

Name:	ATG1
Ordered Locus Names:	CAGL0L06006g

Organism

Candida glabrata (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

5478 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	942 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	CytoplasmBy similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 942	942	Serine/threonine-protein kinase ATG1		PRO_0000085642
Regions
	Domain	11 – 312	302	Protein kinase
	Nucleotide binding	17 – 25	9	ATP By similarity
Sites
	Active site	159	1	Proton acceptor By similarity
	Binding site	41	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6FL58-1 [UniParc]. Last modified July 19, 2004. Version 1. Checksum: DF4CE767B5F9D8B7	FASTA	942	107,095
	10 20 30 40 50 60 MDRFRIQDGK YVVEKEIGKG SFATVYRGHV TTDPKSHIAV KAVARSKLKN KKLLENLEIE 70 80 90 100 110 120 IAILKKIKHP HIVGLIDCER TTTDFYLVMD YCALGDLTFL IKKRKELENN HPLLQTVFNK 130 140 150 160 170 180 YPPPSKEHNG LNRAFVVCYL QQLASALKFL RSKNLVHRDI KPQNLLLATP LTNYRDSKTF 190 200 210 220 230 240 HELGYVGIYN LPILKIADFG FARFLPSTSL AETLCGSPLY MAPEILNYQK YNAKADLWSV 250 260 270 280 290 300 GTVLFEMCCG VPPFTASNHL ELFKKIKRAH DEINFPEVCE VEDGLKELIC SLLTFDPAKR 310 320 330 340 350 360 IGFEEFFNNK IVTEDLSHYE VDENTELESK SKDLQESNMF VSEFLIKKRN QKGVSSRKDT 370 380 390 400 410 420 EFIPKSKQEP MLDQAYKDET EMETGVKYGV NIAPEVYQNE MIDPEKLAAK LIAAKQLGSD 430 440 450 460 470 480 EKLTNKNISH LLSSNSSRVN KLDKSNLSGK SDSSLDRDYV VVEKKAVEVN SLADDLAQAN 490 500 510 520 530 540 VGNNDEAVKD QNIKTLEQPH IQVHQPHNDI QNLQRAPSTT SGGTSSRRAS LVERRLSISS 550 560 570 580 590 600 LNPSNALSRA LGLASTRIFG SSAQTNKNQT SNSTSPNYTQ PLLNSQIFYD LTENLILHTE 610 620 630 640 650 660 TLNQPALINV DHAKGINEVI RILESLSAKA FVVYSYAEVK YAQIIPLPQA VIRASPALQF 670 680 690 700 710 720 EKRLSDDSNP VIDEDSDEEL DVQKNLSNTL LSETVNTRYR LRNDSSRNSY NKRNSFNKER 730 740 750 760 770 780 FSFSSQGSNN SKRTNSYSST LLPAEIISIS KEAIVLYMKA LQILAQSMKI TSKWWYSCQE 790 800 810 820 830 840 KICSLRLNIL VQWIREKFNE CLDKTDFLRM KLEEYENSKP GTHNQSPKSK ISNDSNEDNV 850 860 870 880 890 900 AEKVYLEKLL YDRALEISKY AANLELQGQN LHICELAYAT SLWMLTISLE NSPYTDQGED 910 920 930 940 EYDEFLKDTN DVLDSEDKII IGKYIKSISH RLKMLRQKMA KY

References

[1]

"Genome evolution in yeasts." Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S. , Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J., Wincker P., Souciet J.-L. Nature 430:35-44(2004) [PubMed: 15229592] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 2001 / CBS 138 / IFO 0622 / NRRL Y-65.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CR380958 Genomic DNA. Translation: CAG62006.1.
RefSeq	XP_449036.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2890744.
KEGG	cgr:CAGL0L06006g.
Phylogenomic databases
HOGENOM	Q6FL58.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG1_CANGA

Accession

Primary (citable) accession number: Q6FL58

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	July 19, 2004
Last modified:	November 25, 2008
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)