Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphoglycerate kinase

Gene

PGK1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase 1 (GPD1), Glyceraldehyde-3-phosphate dehydrogenase 2 (GPD2)
  2. Phosphoglycerate kinase (PGK1)
  3. Phosphoglycerate mutase (GPM1), Phosphoglycerate mutase (CAGL0K01705g)
  4. Enolase 1 (ENO1), Enolase 2 (ENO2)
  5. Pyruvate kinase 2 (PYK2), Pyruvate kinase 1 (PYK1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39SubstrateBy similarity1
Binding sitei122SubstrateBy similarity1
Binding sitei169SubstrateBy similarity1
Binding sitei218ATPBy similarity1
Binding sitei311ATP; via carbonyl oxygenBy similarity1
Binding sitei342ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi371 – 374ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:PGK1
Ordered Locus Names:CAGL0L07722g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome L

Organism-specific databases

CGDiCAL0135168. PGK1.
EuPathDBiFungiDB:CAGL0L07722g.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: CGD
  • mitochondrion Source: EnsemblFungi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001458771 – 416Phosphoglycerate kinaseAdd BLAST416

Proteomic databases

PRIDEiQ6FKY1.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi284593.XP_449113.1.

Structurei

3D structure databases

ProteinModelPortaliQ6FKY1.
SMRiQ6FKY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingBy similarity3
Regioni63 – 66Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiKOG1367. Eukaryota.
COG0126. LUCA.
InParanoidiQ6FKY1.
KOiK00927.
OMAiDMIFDIG.
OrthoDBiEOG092C2GKC.

Family and domain databases

CDDicd00318. Phosphoglycerate_kinase. 1 hit.
Gene3Di3.40.50.1260. 2 hits.
HAMAPiMF_00145. Phosphoglyc_kinase. 1 hit.
InterProiView protein in InterPro
IPR001576. Phosphoglycerate_kinase.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiView protein in Pfam
PF00162. PGK. 1 hit.
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiView protein in PROSITE
PS00111. PGLYCERATE_KINASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FKY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSSKLTVQ DLELKDKRVF IRVDFNVPLD GKKITSNQRI VAALPTIKYV
60 70 80 90 100
LEHNPRYVVL ASHLGRPNGE RNEKYSLAPV AEELQSLLGK PVTFLNDCVG
110 120 130 140 150
SEVDSAVKAS APGSVILLEN LRYHIEEEGS RKVDGQKVKA SAEDVAKFRK
160 170 180 190 200
ELCSLADVYI NDAFGTAHRA HSSMVGFDLP QRAAGFLLTK ELQYFGKALE
210 220 230 240 250
NPTRPFLAIL GGAKVADKIQ LIDNLLDKVD SIIIGGGMAF TFKKVLENAE
260 270 280 290 300
IGDSIFDKAG AEIVPKLMEK AKAKGVEVVL PVDFVIADAF SADANTKIVS
310 320 330 340 350
DKEGIPAGWQ GLDNGPESRK LFAATIAKAK TIVWNGPPGV FEFEKFASGT
360 370 380 390 400
KAMLDEVVKS STSGNTVIIG GGDTATVAKK YGVTDKISHV STGGGASLEL
410
LEGKELPGVA FLSEKN
Length:416
Mass (Da):44,617
Last modified:July 19, 2004 - v1
Checksum:i1510C01064D0574A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380958 Genomic DNA. Translation: CAG62083.1.
RefSeqiXP_449113.1. XM_449113.1.

Genome annotation databases

EnsemblFungiiCAG62083; CAG62083; CAGL0L07722g.
KEGGicgr:CAGL0L07722g.

Similar proteinsi

Entry informationi

Entry nameiPGK_CANGA
AccessioniPrimary (citable) accession number: Q6FKY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 19, 2004
Last modified: August 30, 2017
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families