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Protein

Phosphoglycerate kinase

Gene

PGK1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391SubstrateBy similarity
Binding sitei122 – 1221SubstrateBy similarity
Binding sitei169 – 1691SubstrateBy similarity
Binding sitei218 – 2181ATPBy similarity
Binding sitei311 – 3111ATP; via carbonyl oxygenBy similarity
Binding sitei342 – 3421ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi371 – 3744ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:PGK1
Ordered Locus Names:CAGL0L07722g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428: Chromosome L

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: CGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Phosphoglycerate kinasePRO_0000145877Add
BLAST

Proteomic databases

PRIDEiQ6FKY1.

Interactioni

Subunit structurei

Monomer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6FKY1.
SMRiQ6FKY1. Positions 2-415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni24 – 263Substrate bindingBy similarity
Regioni63 – 664Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

InParanoidiQ6FKY1.
KOiK00927.
OMAiFPVDYVT.
OrthoDBiEOG71K6D7.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FKY1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLSSKLTVQ DLELKDKRVF IRVDFNVPLD GKKITSNQRI VAALPTIKYV
60 70 80 90 100
LEHNPRYVVL ASHLGRPNGE RNEKYSLAPV AEELQSLLGK PVTFLNDCVG
110 120 130 140 150
SEVDSAVKAS APGSVILLEN LRYHIEEEGS RKVDGQKVKA SAEDVAKFRK
160 170 180 190 200
ELCSLADVYI NDAFGTAHRA HSSMVGFDLP QRAAGFLLTK ELQYFGKALE
210 220 230 240 250
NPTRPFLAIL GGAKVADKIQ LIDNLLDKVD SIIIGGGMAF TFKKVLENAE
260 270 280 290 300
IGDSIFDKAG AEIVPKLMEK AKAKGVEVVL PVDFVIADAF SADANTKIVS
310 320 330 340 350
DKEGIPAGWQ GLDNGPESRK LFAATIAKAK TIVWNGPPGV FEFEKFASGT
360 370 380 390 400
KAMLDEVVKS STSGNTVIIG GGDTATVAKK YGVTDKISHV STGGGASLEL
410
LEGKELPGVA FLSEKN
Length:416
Mass (Da):44,617
Last modified:July 19, 2004 - v1
Checksum:i1510C01064D0574A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380958 Genomic DNA. Translation: CAG62083.1.
RefSeqiXP_449113.1. XM_449113.1.

Genome annotation databases

GeneIDi2891002.
KEGGicgr:CAGL0L07722g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380958 Genomic DNA. Translation: CAG62083.1.
RefSeqiXP_449113.1. XM_449113.1.

3D structure databases

ProteinModelPortaliQ6FKY1.
SMRiQ6FKY1. Positions 2-415.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6FKY1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2891002.
KEGGicgr:CAGL0L07722g.

Phylogenomic databases

InParanoidiQ6FKY1.
KOiK00927.
OMAiFPVDYVT.
OrthoDBiEOG71K6D7.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGK_CANGA
AccessioniPrimary (citable) accession number: Q6FKY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 19, 2004
Last modified: January 7, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.