Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6FKS5

- HAT1_CANGA

UniProt

Q6FKS5 - HAT1_CANGA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Histone acetyltransferase type B catalytic subunit

Gene

HAT1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.By similarity

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei177 – 1771Interaction with histone H4 N-terminusBy similarity
Active sitei258 – 2581Proton donor/acceptorBy similarity

GO - Molecular functioni

  1. histone acetyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. chromatin silencing at telomere Source: InterPro
  2. DNA repair Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Chromatin regulator, Transferase

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
Histone acetyltransferase type B catalytic subunit (EC:2.3.1.48By similarity)
Gene namesi
Name:HAT1
Ordered Locus Names:CAGL0L09042g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428: Chromosome L

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. histone acetyltransferase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Histone acetyltransferase type B catalytic subunitPRO_0000227720Add
BLAST

Interactioni

Subunit structurei

Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6FKS5.
SMRiQ6FKS5. Positions 6-323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini142 – 306165N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni197 – 1993Interaction with histone H4 N-terminusBy similarity
Regioni223 – 2253Acetyl-CoA bindingBy similarity
Regioni230 – 2367Acetyl-CoA bindingBy similarity

Sequence similaritiesi

Belongs to the HAT1 family.Curated
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiQ6FKS5.
KOiK11303.
OMAiYINEDED.
OrthoDBiEOG7HTHSD.

Family and domain databases

Gene3Di1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view]
PANTHERiPTHR12046. PTHR12046. 1 hit.
PfamiPF00583. Acetyltransf_1. 1 hit.
PF10394. Hat1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF038084. HAT-B_cat. 1 hit.
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FKS5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIDDFKPEK WTISSNEALK LSLVSEDNAI QFSPTFTYPI FGTEEQIFGY
60 70 80 90 100
KDLVIHLAFD AITFKPFLNV KFSSKFEGSE EELVNIKEKL LEYLPIDDTI
110 120 130 140 150
YKDEEKWIDS FKKEQESIEA YKNDQNIDEY KIDNADFEIY KVNLQDPKMK
160 170 180 190 200
RFHRRIQIFS LLFIEAASYI DEDDPKWEIF IVQTKKDKKF VGYATAYNYW
210 220 230 240 250
YYPGANNFDS ESKYRYRGKI SQFLILPPYQ GRGHGSHLYN SIVKNWRNDS
260 270 280 290 300
SILEIVVEDP NESFDDLRDV NDLEMLYKDG FFNKLPQERP IPNAWIESTR
310 320 330 340 350
LKYKIEKRQF SRLLEMILLS TGSNNFEYQV KQRLLIKNKD GLEGMEVSDI
360 370 380
KDALNKSFES LREDYDRILG KCQFSNDADG PSKKKIKT
Length:388
Mass (Da):45,819
Last modified:July 19, 2004 - v1
Checksum:i7D26B0E7E97840D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380958 Genomic DNA. Translation: CAG62139.1.
RefSeqiXP_449169.1. XM_449169.1.

Genome annotation databases

GeneIDi2891100.
KEGGicgr:CAGL0L09042g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380958 Genomic DNA. Translation: CAG62139.1 .
RefSeqi XP_449169.1. XM_449169.1.

3D structure databases

ProteinModelPortali Q6FKS5.
SMRi Q6FKS5. Positions 6-323.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2891100.
KEGGi cgr:CAGL0L09042g.

Phylogenomic databases

InParanoidi Q6FKS5.
KOi K11303.
OMAi YINEDED.
OrthoDBi EOG7HTHSD.

Family and domain databases

Gene3Di 1.10.10.390. 1 hit.
3.40.630.30. 1 hit.
3.90.360.10. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
IPR019467. Hat1_N.
IPR017380. Hist_AcTrfase_B-typ_cat-su.
IPR013523. Hist_AcTrfase_HAT1_C.
[Graphical view ]
PANTHERi PTHR12046. PTHR12046. 1 hit.
Pfami PF00583. Acetyltransf_1. 1 hit.
PF10394. Hat1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF038084. HAT-B_cat. 1 hit.
SUPFAMi SSF55729. SSF55729. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiHAT1_CANGA
AccessioniPrimary (citable) accession number: Q6FKS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: July 19, 2004
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3