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Q6FKJ1

- NTE1_CANGA

UniProt

Q6FKJ1 - NTE1_CANGA

Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

    Enzyme regulationi

    Inhibited by organophosphorus esters.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1455 – 14551By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi854 – 987134cNMP 1Add
    BLAST
    Nucleotide bindingi983 – 1121139cNMP 2Add
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid catabolic process Source: UniProtKB-KW
    2. phosphatidylcholine metabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophospholipase NTE1 (EC:3.1.1.5)
    Alternative name(s):
    Intracellular phospholipase B
    Neuropathy target esterase homolog
    Gene namesi
    Name:NTE1
    Ordered Locus Names:CAGL0L11154g
    OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
    Taxonomic identifieri284593 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
    ProteomesiUP000002428: Chromosome L

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 17281728Lysophospholipase NTE1PRO_0000295315Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6FKJ1.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4444CytoplasmicBy similarityAdd
    BLAST
    Topological domaini66 – 9732LumenalBy similarityAdd
    BLAST
    Topological domaini119 – 17281610CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei45 – 6521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1422 – 1586165PatatinAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi1453 – 14575GXSXG

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi284 – 2896Poly-Lys
    Compositional biasi315 – 3217Poly-Asp

    Sequence similaritiesi

    Belongs to the NTE family.Curated
    Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK14676.
    OMAiSPWTQTC.
    OrthoDBiEOG70W3NS.

    Family and domain databases

    Gene3Di2.60.120.10. 5 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 2 hits.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 4 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6FKJ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSSSIAHES DIVSTERNIL PERFISNKQQ GNYLEDGSGD GNGKAAEHWL     50
    LAAIFNFFWV ISYFISGSTH IAFRSSWYIV SLLLLKFPKW IIVEANHIHL 100
    TIPFSVLVVT LAIIFYVSYE FLKGRLLSEY KNLTSDLNTD SLNSKNSKSS 150
    RLLHHDSKDS NTTRRRRYSS GKLLSSALHE SHSGINGGDD GDDTFLSSYL 200
    DQFLSAIRIF GYLEKPVFHD LTKNMKTQKL DEGEILLLDN SVGFAIVVEG 250
    TLDIYHEVEE KGNMNDIDGD FMVDDNQSIY SILKRKKKKY STSRHGQYNN 300
    NSDPGHYNGH NVNGDDEDDD DGILQMRSSS RNQNIPSFDA IESSSSDEES 350
    DINDGDSESQ SESDDESTGF IRLKDGLGKF QLLNTVKAGN PVSSLVNILN 400
    LFTSANDNVT SPSRTGRMDS NYTNPVERPT SKLSTSIEES AMRLELGKYS 450
    LSPTEASYRS TSNPSNNFSK DNDPLSKSIS GPDAVTTPSL PPLNNRAFVI 500
    PKVVARAATD CTIAIIPPQA FAKLKAKYPR SASHIIQMIL TKLYHVTFQT 550
    AHKYLGLTQE IAYTELLLNR TVSYDLPNYL KEIVIDRFKD KGKDMNLQKG 600
    FQSPTSSRLT SNFNGNSNNQ RTNSRNSQAL MSTRDLRKTR PELSQQSSMI 650
    HSPTPITGSR HVVLESRDKY NPGDLLSNVP LSRINLASPS SRGFDYSSMK 700
    KESSPQSSVN SRKRSTTGER PRLLKRPSIY NNQSSSRSDA LKGNNSNNKD 750
    INFTSFSAQE ETEDSVVRMA LVEAMLTYLG VNKTNMSILP GIYDGAPSEP 800
    HSHRASEISL VSSYTSSAAP QTTIRILPKE YAIVSTRKQK QSSKKRRKYK 850
    EEISPTLDYE YAKNEFAQAI ELQYFKQGTV IVEQDTRGKG LYYVVSGKID 900
    VTTSTVSDHE IFNSTRDKKK KKSKTLFTIE SGGIAGYLSS LVSYKSFVTL 950
    IAKTDVYVGF LPYQTLEKLC DKYFLIYLRI AESLTSLLTP RMLKLDHALE 1000
    WLHLNASDTL FNQGDPANGI YVILNGRLRQ LRNPELEENS TDYPNDGEEK 1050
    DSSRDSTIVM GELGQGESFG EVEVLTAMDR ISSMVAVRDT ELARIPRSLF 1100
    ELLAIEHPSI MIRVSRLVAK KILGQGQANM ALPKIGSGSN LRHDLNLTIP 1150
    PSSSSSIHTH SYGNDNSNQM NNANFRTITI LPITSGLPVE SFAMKLVHAF 1200
    KQVGRTTIGL NQRTTLSHLG RHAFDKLAKL KESGYFAELE ELYQTVVYIA 1250
    DTPVKSSWTK TCIAQADCVI LLARADDSPE IGEYERLLLK SKTTSRTELV 1300
    LLHNERSVEP GMTQRWLRSR SWVHNHYHIQ FAMDSLVNSS NVKDTGGNIG 1350
    ALNLVDKFIQ TELGRKTQYN ISKLLPESIK MTVENFSSRF MKRKRQYYTP 1400
    VHRHKDDFLR LARILSGQAI GLVLGGGGAR GLSHLGILQA LEERGIPIDM 1450
    IGGTSIGSFV GGLYAKDYDL VPIFGRIKKF AGRISSIWRM LSDFTWPVTS 1500
    YTTGHEFNRG IWKSFGDTRI EDFWVQYFCN STNITESVQE IHSYGYAWRY 1550
    VRASMSLAGL LPPIEDNGSM LLDGGYVDNL PVLEMKARGC NTIFAVDVGS 1600
    VDDRTPMKYG DSLNGFWIIL NRWNPFSKHP NIPTMAEIQV RLGYVSSVNA 1650
    LEKAKRTPGV IYVRPPIENY ATLDFGKFEE IYKVGADFGK VFLQALAEEG 1700
    KMPYIPGSNA DLVGDVETGF FLHRRNSI 1728
    Length:1,728
    Mass (Da):193,367
    Last modified:July 19, 2004 - v1
    Checksum:i88C134F24072720A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380958 Genomic DNA. Translation: CAG62227.1.
    RefSeqiXP_449253.1. XM_449253.1.

    Genome annotation databases

    GeneIDi2891028.
    KEGGicgr:CAGL0L11154g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380958 Genomic DNA. Translation: CAG62227.1 .
    RefSeqi XP_449253.1. XM_449253.1.

    3D structure databases

    ProteinModelPortali Q6FKJ1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2891028.
    KEGGi cgr:CAGL0L11154g.

    Phylogenomic databases

    KOi K14676.
    OMAi SPWTQTC.
    OrthoDBi EOG70W3NS.

    Family and domain databases

    Gene3Di 2.60.120.10. 5 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 2 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 2 hits.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 4 hits.
    SSF52151. SSF52151. 1 hit.
    PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiNTE1_CANGA
    AccessioniPrimary (citable) accession number: Q6FKJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 24, 2007
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3