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Q6FKJ1 (NTE1_CANGA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophospholipase NTE1

EC=3.1.1.5
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene names
Name:NTE1
Ordered Locus Names:CAGL0L11154g
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier284593 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces

Protein attributes

Sequence length1728 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulation

Inhibited by organophosphorus esters By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the NTE family.

Contains 2 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 17281728Lysophospholipase NTE1
PRO_0000295315

Regions

Topological domain1 – 4444Cytoplasmic By similarity
Transmembrane45 – 6521Helical; Potential
Topological domain66 – 9732Lumenal By similarity
Transmembrane98 – 11821Helical; Potential
Topological domain119 – 17281610Cytoplasmic By similarity
Domain1422 – 1586165Patatin
Nucleotide binding854 – 987134cNMP 1
Nucleotide binding983 – 1121139cNMP 2
Motif1453 – 14575GXSXG
Compositional bias284 – 2896Poly-Lys
Compositional bias315 – 3217Poly-Asp

Sites

Active site14551 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6FKJ1 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 88C134F24072720A

FASTA1,728193,367
        10         20         30         40         50         60 
MDSSSIAHES DIVSTERNIL PERFISNKQQ GNYLEDGSGD GNGKAAEHWL LAAIFNFFWV 

        70         80         90        100        110        120 
ISYFISGSTH IAFRSSWYIV SLLLLKFPKW IIVEANHIHL TIPFSVLVVT LAIIFYVSYE 

       130        140        150        160        170        180 
FLKGRLLSEY KNLTSDLNTD SLNSKNSKSS RLLHHDSKDS NTTRRRRYSS GKLLSSALHE 

       190        200        210        220        230        240 
SHSGINGGDD GDDTFLSSYL DQFLSAIRIF GYLEKPVFHD LTKNMKTQKL DEGEILLLDN 

       250        260        270        280        290        300 
SVGFAIVVEG TLDIYHEVEE KGNMNDIDGD FMVDDNQSIY SILKRKKKKY STSRHGQYNN 

       310        320        330        340        350        360 
NSDPGHYNGH NVNGDDEDDD DGILQMRSSS RNQNIPSFDA IESSSSDEES DINDGDSESQ 

       370        380        390        400        410        420 
SESDDESTGF IRLKDGLGKF QLLNTVKAGN PVSSLVNILN LFTSANDNVT SPSRTGRMDS 

       430        440        450        460        470        480 
NYTNPVERPT SKLSTSIEES AMRLELGKYS LSPTEASYRS TSNPSNNFSK DNDPLSKSIS 

       490        500        510        520        530        540 
GPDAVTTPSL PPLNNRAFVI PKVVARAATD CTIAIIPPQA FAKLKAKYPR SASHIIQMIL 

       550        560        570        580        590        600 
TKLYHVTFQT AHKYLGLTQE IAYTELLLNR TVSYDLPNYL KEIVIDRFKD KGKDMNLQKG 

       610        620        630        640        650        660 
FQSPTSSRLT SNFNGNSNNQ RTNSRNSQAL MSTRDLRKTR PELSQQSSMI HSPTPITGSR 

       670        680        690        700        710        720 
HVVLESRDKY NPGDLLSNVP LSRINLASPS SRGFDYSSMK KESSPQSSVN SRKRSTTGER 

       730        740        750        760        770        780 
PRLLKRPSIY NNQSSSRSDA LKGNNSNNKD INFTSFSAQE ETEDSVVRMA LVEAMLTYLG 

       790        800        810        820        830        840 
VNKTNMSILP GIYDGAPSEP HSHRASEISL VSSYTSSAAP QTTIRILPKE YAIVSTRKQK 

       850        860        870        880        890        900 
QSSKKRRKYK EEISPTLDYE YAKNEFAQAI ELQYFKQGTV IVEQDTRGKG LYYVVSGKID 

       910        920        930        940        950        960 
VTTSTVSDHE IFNSTRDKKK KKSKTLFTIE SGGIAGYLSS LVSYKSFVTL IAKTDVYVGF 

       970        980        990       1000       1010       1020 
LPYQTLEKLC DKYFLIYLRI AESLTSLLTP RMLKLDHALE WLHLNASDTL FNQGDPANGI 

      1030       1040       1050       1060       1070       1080 
YVILNGRLRQ LRNPELEENS TDYPNDGEEK DSSRDSTIVM GELGQGESFG EVEVLTAMDR 

      1090       1100       1110       1120       1130       1140 
ISSMVAVRDT ELARIPRSLF ELLAIEHPSI MIRVSRLVAK KILGQGQANM ALPKIGSGSN 

      1150       1160       1170       1180       1190       1200 
LRHDLNLTIP PSSSSSIHTH SYGNDNSNQM NNANFRTITI LPITSGLPVE SFAMKLVHAF 

      1210       1220       1230       1240       1250       1260 
KQVGRTTIGL NQRTTLSHLG RHAFDKLAKL KESGYFAELE ELYQTVVYIA DTPVKSSWTK 

      1270       1280       1290       1300       1310       1320 
TCIAQADCVI LLARADDSPE IGEYERLLLK SKTTSRTELV LLHNERSVEP GMTQRWLRSR 

      1330       1340       1350       1360       1370       1380 
SWVHNHYHIQ FAMDSLVNSS NVKDTGGNIG ALNLVDKFIQ TELGRKTQYN ISKLLPESIK 

      1390       1400       1410       1420       1430       1440 
MTVENFSSRF MKRKRQYYTP VHRHKDDFLR LARILSGQAI GLVLGGGGAR GLSHLGILQA 

      1450       1460       1470       1480       1490       1500 
LEERGIPIDM IGGTSIGSFV GGLYAKDYDL VPIFGRIKKF AGRISSIWRM LSDFTWPVTS 

      1510       1520       1530       1540       1550       1560 
YTTGHEFNRG IWKSFGDTRI EDFWVQYFCN STNITESVQE IHSYGYAWRY VRASMSLAGL 

      1570       1580       1590       1600       1610       1620 
LPPIEDNGSM LLDGGYVDNL PVLEMKARGC NTIFAVDVGS VDDRTPMKYG DSLNGFWIIL 

      1630       1640       1650       1660       1670       1680 
NRWNPFSKHP NIPTMAEIQV RLGYVSSVNA LEKAKRTPGV IYVRPPIENY ATLDFGKFEE 

      1690       1700       1710       1720 
IYKVGADFGK VFLQALAEEG KMPYIPGSNA DLVGDVETGF FLHRRNSI 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR380958 Genomic DNA. Translation: CAG62227.1.
RefSeqXP_449253.1. XM_449253.1.

3D structure databases

ProteinModelPortalQ6FKJ1.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2891028.
KEGGcgr:CAGL0L11154g.

Phylogenomic databases

KOK14676.
OMASPWTQTC.
OrthoDBEOG70W3NS.

Family and domain databases

Gene3D2.60.120.10. 5 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMSSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNTE1_CANGA
AccessionPrimary (citable) accession number: Q6FKJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 19, 2004
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families