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Q6FKJ1

- NTE1_CANGA

UniProt

Q6FKJ1 - NTE1_CANGA

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Protein
Lysophospholipase NTE1
Gene
NTE1, CAGL0L11154g
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium By similarity.

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1455 – 14551 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi854 – 987134cNMP 1
Add
BLAST
Nucleotide bindingi983 – 1121139cNMP 2
Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. phosphatidylcholine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
Ordered Locus Names:CAGL0L11154g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
ProteomesiUP000002428: Chromosome L

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444Cytoplasmic By similarity
Add
BLAST
Transmembranei45 – 6521Helical; Reviewed prediction
Add
BLAST
Topological domaini66 – 9732Lumenal By similarity
Add
BLAST
Transmembranei98 – 11821Helical; Reviewed prediction
Add
BLAST
Topological domaini119 – 17281610Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17281728Lysophospholipase NTE1
PRO_0000295315Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6FKJ1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1422 – 1586165Patatin
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1453 – 14575GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi284 – 2896Poly-Lys
Compositional biasi315 – 3217Poly-Asp

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK14676.
OMAiSPWTQTC.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FKJ1-1 [UniParc]FASTAAdd to Basket

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MDSSSIAHES DIVSTERNIL PERFISNKQQ GNYLEDGSGD GNGKAAEHWL     50
LAAIFNFFWV ISYFISGSTH IAFRSSWYIV SLLLLKFPKW IIVEANHIHL 100
TIPFSVLVVT LAIIFYVSYE FLKGRLLSEY KNLTSDLNTD SLNSKNSKSS 150
RLLHHDSKDS NTTRRRRYSS GKLLSSALHE SHSGINGGDD GDDTFLSSYL 200
DQFLSAIRIF GYLEKPVFHD LTKNMKTQKL DEGEILLLDN SVGFAIVVEG 250
TLDIYHEVEE KGNMNDIDGD FMVDDNQSIY SILKRKKKKY STSRHGQYNN 300
NSDPGHYNGH NVNGDDEDDD DGILQMRSSS RNQNIPSFDA IESSSSDEES 350
DINDGDSESQ SESDDESTGF IRLKDGLGKF QLLNTVKAGN PVSSLVNILN 400
LFTSANDNVT SPSRTGRMDS NYTNPVERPT SKLSTSIEES AMRLELGKYS 450
LSPTEASYRS TSNPSNNFSK DNDPLSKSIS GPDAVTTPSL PPLNNRAFVI 500
PKVVARAATD CTIAIIPPQA FAKLKAKYPR SASHIIQMIL TKLYHVTFQT 550
AHKYLGLTQE IAYTELLLNR TVSYDLPNYL KEIVIDRFKD KGKDMNLQKG 600
FQSPTSSRLT SNFNGNSNNQ RTNSRNSQAL MSTRDLRKTR PELSQQSSMI 650
HSPTPITGSR HVVLESRDKY NPGDLLSNVP LSRINLASPS SRGFDYSSMK 700
KESSPQSSVN SRKRSTTGER PRLLKRPSIY NNQSSSRSDA LKGNNSNNKD 750
INFTSFSAQE ETEDSVVRMA LVEAMLTYLG VNKTNMSILP GIYDGAPSEP 800
HSHRASEISL VSSYTSSAAP QTTIRILPKE YAIVSTRKQK QSSKKRRKYK 850
EEISPTLDYE YAKNEFAQAI ELQYFKQGTV IVEQDTRGKG LYYVVSGKID 900
VTTSTVSDHE IFNSTRDKKK KKSKTLFTIE SGGIAGYLSS LVSYKSFVTL 950
IAKTDVYVGF LPYQTLEKLC DKYFLIYLRI AESLTSLLTP RMLKLDHALE 1000
WLHLNASDTL FNQGDPANGI YVILNGRLRQ LRNPELEENS TDYPNDGEEK 1050
DSSRDSTIVM GELGQGESFG EVEVLTAMDR ISSMVAVRDT ELARIPRSLF 1100
ELLAIEHPSI MIRVSRLVAK KILGQGQANM ALPKIGSGSN LRHDLNLTIP 1150
PSSSSSIHTH SYGNDNSNQM NNANFRTITI LPITSGLPVE SFAMKLVHAF 1200
KQVGRTTIGL NQRTTLSHLG RHAFDKLAKL KESGYFAELE ELYQTVVYIA 1250
DTPVKSSWTK TCIAQADCVI LLARADDSPE IGEYERLLLK SKTTSRTELV 1300
LLHNERSVEP GMTQRWLRSR SWVHNHYHIQ FAMDSLVNSS NVKDTGGNIG 1350
ALNLVDKFIQ TELGRKTQYN ISKLLPESIK MTVENFSSRF MKRKRQYYTP 1400
VHRHKDDFLR LARILSGQAI GLVLGGGGAR GLSHLGILQA LEERGIPIDM 1450
IGGTSIGSFV GGLYAKDYDL VPIFGRIKKF AGRISSIWRM LSDFTWPVTS 1500
YTTGHEFNRG IWKSFGDTRI EDFWVQYFCN STNITESVQE IHSYGYAWRY 1550
VRASMSLAGL LPPIEDNGSM LLDGGYVDNL PVLEMKARGC NTIFAVDVGS 1600
VDDRTPMKYG DSLNGFWIIL NRWNPFSKHP NIPTMAEIQV RLGYVSSVNA 1650
LEKAKRTPGV IYVRPPIENY ATLDFGKFEE IYKVGADFGK VFLQALAEEG 1700
KMPYIPGSNA DLVGDVETGF FLHRRNSI 1728
Length:1,728
Mass (Da):193,367
Last modified:July 19, 2004 - v1
Checksum:i88C134F24072720A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380958 Genomic DNA. Translation: CAG62227.1.
RefSeqiXP_449253.1. XM_449253.1.

Genome annotation databases

GeneIDi2891028.
KEGGicgr:CAGL0L11154g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380958 Genomic DNA. Translation: CAG62227.1 .
RefSeqi XP_449253.1. XM_449253.1.

3D structure databases

ProteinModelPortali Q6FKJ1.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2891028.
KEGGi cgr:CAGL0L11154g.

Phylogenomic databases

KOi K14676.
OMAi SPWTQTC.
OrthoDBi EOG70W3NS.

Family and domain databases

Gene3Di 2.60.120.10. 5 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 2 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEi PS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiNTE1_CANGA
AccessioniPrimary (citable) accession number: Q6FKJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 19, 2004
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi