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Protein

Lysophospholipase NTE1

Gene

NTE1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.

Enzyme regulationi

Inhibited by organophosphorus esters.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1455 – 14551By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi854 – 987134cNMP 1Add
BLAST
Nucleotide bindingi983 – 1121139cNMP 2Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid catabolic process Source: UniProtKB-KW
  2. phosphatidylcholine metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophospholipase NTE1 (EC:3.1.1.5)
Alternative name(s):
Intracellular phospholipase B
Neuropathy target esterase homolog
Gene namesi
Name:NTE1
Ordered Locus Names:CAGL0L11154g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
ProteomesiUP000002428 Componenti: Chromosome L

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444CytoplasmicBy similarityAdd
BLAST
Transmembranei45 – 6521HelicalSequence AnalysisAdd
BLAST
Topological domaini66 – 9732LumenalBy similarityAdd
BLAST
Transmembranei98 – 11821HelicalSequence AnalysisAdd
BLAST
Topological domaini119 – 17281610CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 17281728Lysophospholipase NTE1PRO_0000295315Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6FKJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1422 – 1586165PatatinAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi1453 – 14575GXSXG

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi284 – 2896Poly-Lys
Compositional biasi315 – 3217Poly-Asp

Sequence similaritiesi

Belongs to the NTE family.Curated
Contains 2 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ6FKJ1.
KOiK14676.
OMAiSPWTQTC.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FKJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSSIAHES DIVSTERNIL PERFISNKQQ GNYLEDGSGD GNGKAAEHWL
60 70 80 90 100
LAAIFNFFWV ISYFISGSTH IAFRSSWYIV SLLLLKFPKW IIVEANHIHL
110 120 130 140 150
TIPFSVLVVT LAIIFYVSYE FLKGRLLSEY KNLTSDLNTD SLNSKNSKSS
160 170 180 190 200
RLLHHDSKDS NTTRRRRYSS GKLLSSALHE SHSGINGGDD GDDTFLSSYL
210 220 230 240 250
DQFLSAIRIF GYLEKPVFHD LTKNMKTQKL DEGEILLLDN SVGFAIVVEG
260 270 280 290 300
TLDIYHEVEE KGNMNDIDGD FMVDDNQSIY SILKRKKKKY STSRHGQYNN
310 320 330 340 350
NSDPGHYNGH NVNGDDEDDD DGILQMRSSS RNQNIPSFDA IESSSSDEES
360 370 380 390 400
DINDGDSESQ SESDDESTGF IRLKDGLGKF QLLNTVKAGN PVSSLVNILN
410 420 430 440 450
LFTSANDNVT SPSRTGRMDS NYTNPVERPT SKLSTSIEES AMRLELGKYS
460 470 480 490 500
LSPTEASYRS TSNPSNNFSK DNDPLSKSIS GPDAVTTPSL PPLNNRAFVI
510 520 530 540 550
PKVVARAATD CTIAIIPPQA FAKLKAKYPR SASHIIQMIL TKLYHVTFQT
560 570 580 590 600
AHKYLGLTQE IAYTELLLNR TVSYDLPNYL KEIVIDRFKD KGKDMNLQKG
610 620 630 640 650
FQSPTSSRLT SNFNGNSNNQ RTNSRNSQAL MSTRDLRKTR PELSQQSSMI
660 670 680 690 700
HSPTPITGSR HVVLESRDKY NPGDLLSNVP LSRINLASPS SRGFDYSSMK
710 720 730 740 750
KESSPQSSVN SRKRSTTGER PRLLKRPSIY NNQSSSRSDA LKGNNSNNKD
760 770 780 790 800
INFTSFSAQE ETEDSVVRMA LVEAMLTYLG VNKTNMSILP GIYDGAPSEP
810 820 830 840 850
HSHRASEISL VSSYTSSAAP QTTIRILPKE YAIVSTRKQK QSSKKRRKYK
860 870 880 890 900
EEISPTLDYE YAKNEFAQAI ELQYFKQGTV IVEQDTRGKG LYYVVSGKID
910 920 930 940 950
VTTSTVSDHE IFNSTRDKKK KKSKTLFTIE SGGIAGYLSS LVSYKSFVTL
960 970 980 990 1000
IAKTDVYVGF LPYQTLEKLC DKYFLIYLRI AESLTSLLTP RMLKLDHALE
1010 1020 1030 1040 1050
WLHLNASDTL FNQGDPANGI YVILNGRLRQ LRNPELEENS TDYPNDGEEK
1060 1070 1080 1090 1100
DSSRDSTIVM GELGQGESFG EVEVLTAMDR ISSMVAVRDT ELARIPRSLF
1110 1120 1130 1140 1150
ELLAIEHPSI MIRVSRLVAK KILGQGQANM ALPKIGSGSN LRHDLNLTIP
1160 1170 1180 1190 1200
PSSSSSIHTH SYGNDNSNQM NNANFRTITI LPITSGLPVE SFAMKLVHAF
1210 1220 1230 1240 1250
KQVGRTTIGL NQRTTLSHLG RHAFDKLAKL KESGYFAELE ELYQTVVYIA
1260 1270 1280 1290 1300
DTPVKSSWTK TCIAQADCVI LLARADDSPE IGEYERLLLK SKTTSRTELV
1310 1320 1330 1340 1350
LLHNERSVEP GMTQRWLRSR SWVHNHYHIQ FAMDSLVNSS NVKDTGGNIG
1360 1370 1380 1390 1400
ALNLVDKFIQ TELGRKTQYN ISKLLPESIK MTVENFSSRF MKRKRQYYTP
1410 1420 1430 1440 1450
VHRHKDDFLR LARILSGQAI GLVLGGGGAR GLSHLGILQA LEERGIPIDM
1460 1470 1480 1490 1500
IGGTSIGSFV GGLYAKDYDL VPIFGRIKKF AGRISSIWRM LSDFTWPVTS
1510 1520 1530 1540 1550
YTTGHEFNRG IWKSFGDTRI EDFWVQYFCN STNITESVQE IHSYGYAWRY
1560 1570 1580 1590 1600
VRASMSLAGL LPPIEDNGSM LLDGGYVDNL PVLEMKARGC NTIFAVDVGS
1610 1620 1630 1640 1650
VDDRTPMKYG DSLNGFWIIL NRWNPFSKHP NIPTMAEIQV RLGYVSSVNA
1660 1670 1680 1690 1700
LEKAKRTPGV IYVRPPIENY ATLDFGKFEE IYKVGADFGK VFLQALAEEG
1710 1720
KMPYIPGSNA DLVGDVETGF FLHRRNSI
Length:1,728
Mass (Da):193,367
Last modified:July 19, 2004 - v1
Checksum:i88C134F24072720A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380958 Genomic DNA. Translation: CAG62227.1.
RefSeqiXP_449253.1. XM_449253.1.

Genome annotation databases

GeneIDi2891028.
KEGGicgr:CAGL0L11154g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380958 Genomic DNA. Translation: CAG62227.1.
RefSeqiXP_449253.1. XM_449253.1.

3D structure databases

ProteinModelPortaliQ6FKJ1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2891028.
KEGGicgr:CAGL0L11154g.

Phylogenomic databases

InParanoidiQ6FKJ1.
KOiK14676.
OMAiSPWTQTC.
OrthoDBiEOG70W3NS.

Family and domain databases

Gene3Di2.60.120.10. 5 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 2 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 4 hits.
SSF52151. SSF52151. 1 hit.
PROSITEiPS50042. CNMP_BINDING_3. 2 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNTE1_CANGA
AccessioniPrimary (citable) accession number: Q6FKJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 19, 2004
Last modified: January 7, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.