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Q6FKD4

- PHO85_CANGA

UniProt

Q6FKD4 - PHO85_CANGA

Protein

Negative regulator of the PHO system

Gene

PHO85

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (19 Jul 2004)
      Previous versions | rss
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    • Comment

    Functioni

    When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei35 – 351ATPPROSITE-ProRule annotation
    Active sitei132 – 1321Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 209ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. mRNA catabolic process Source: CGD
    2. pathogenesis Source: CGD
    3. response to endoplasmic reticulum stress Source: CGD
    4. single-species biofilm formation on inanimate substrate Source: CGD

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Negative regulator of the PHO system (EC:2.7.11.22)
    Alternative name(s):
    Serine/threonine-protein kinase PHO85
    Gene namesi
    Name:PHO85
    Ordered Locus Names:CAGL0L12474g
    OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
    Taxonomic identifieri284593 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
    ProteomesiUP000002428: Chromosome L

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 302302Negative regulator of the PHO systemPRO_0000086517Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with a number of cyclins.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6FKD4.
    SMRiQ6FKD4. Positions 18-300.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini6 – 296291Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    KOiK06655.
    OMAiQVPQNAY.
    OrthoDBiEOG7K3TWD.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6FKD4-1 [UniParc]FASTAAdd to Basket

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    MSSSQFKQLE KLGNGTYATV YKGLNKSTGV YVALKEVKLD SEEGTPSTAI    50
    REISLMKELK HDNIVRLYDV IHTENKLTLV FEYMDNDLKK YMDSRTVGNA 100
    PRGLEMNLVK YFQWQLLEGL AFCHENKILH RDLKPQNLLI TKRGQLKLGD 150
    FGLARAFGIP VNTFSSEVVT LWYRAPDVLM GSRTYSTSID IWSCGCILAE 200
    MITGKPLFPG TNDEEQLKLI FDKMGTPNET TWPGVTSLPK YNPNFQQRLP 250
    KDLKAELQPY VKEPLDDNVI DLLHGLLQLN PDMRLSAKQA LLHPWFSEYY 300
    ES 302
    Length:302
    Mass (Da):34,488
    Last modified:July 19, 2004 - v1
    Checksum:i79706E049D13B7B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380958 Genomic DNA. Translation: CAG62284.1.
    RefSeqiXP_449310.1. XM_449310.1.

    Genome annotation databases

    GeneIDi2890701.
    KEGGicgr:CAGL0L12474g.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CR380958 Genomic DNA. Translation: CAG62284.1 .
    RefSeqi XP_449310.1. XM_449310.1.

    3D structure databases

    ProteinModelPortali Q6FKD4.
    SMRi Q6FKD4. Positions 18-300.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2890701.
    KEGGi cgr:CAGL0L12474g.

    Phylogenomic databases

    KOi K06655.
    OMAi QVPQNAY.
    OrthoDBi EOG7K3TWD.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Entry informationi

    Entry nameiPHO85_CANGA
    AccessioniPrimary (citable) accession number: Q6FKD4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3