SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6FKD4

- PHO85_CANGA

UniProt

Q6FKD4 - PHO85_CANGA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Negative regulator of the PHO system
Gene
PHO85, CAGL0L12474g
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression By similarity.

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei35 – 351ATP By similarity
Active sitei132 – 1321Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 209ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. mRNA catabolic process Source: CGD
  2. pathogenesis Source: CGD
  3. response to endoplasmic reticulum stress Source: CGD
  4. single-species biofilm formation on inanimate substrate Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Negative regulator of the PHO system (EC:2.7.11.22)
Alternative name(s):
Serine/threonine-protein kinase PHO85
Gene namesi
Name:PHO85
Ordered Locus Names:CAGL0L12474g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
ProteomesiUP000002428: Chromosome L

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Negative regulator of the PHO system
PRO_0000086517Add
BLAST

Interactioni

Subunit structurei

Interacts with a number of cyclins By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6FKD4.
SMRiQ6FKD4. Positions 18-300.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 296291Protein kinase
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

KOiK06655.
OMAiQVPQNAY.
OrthoDBiEOG7K3TWD.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FKD4-1 [UniParc]FASTAAdd to Basket

« Hide

MSSSQFKQLE KLGNGTYATV YKGLNKSTGV YVALKEVKLD SEEGTPSTAI    50
REISLMKELK HDNIVRLYDV IHTENKLTLV FEYMDNDLKK YMDSRTVGNA 100
PRGLEMNLVK YFQWQLLEGL AFCHENKILH RDLKPQNLLI TKRGQLKLGD 150
FGLARAFGIP VNTFSSEVVT LWYRAPDVLM GSRTYSTSID IWSCGCILAE 200
MITGKPLFPG TNDEEQLKLI FDKMGTPNET TWPGVTSLPK YNPNFQQRLP 250
KDLKAELQPY VKEPLDDNVI DLLHGLLQLN PDMRLSAKQA LLHPWFSEYY 300
ES 302
Length:302
Mass (Da):34,488
Last modified:July 19, 2004 - v1
Checksum:i79706E049D13B7B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380958 Genomic DNA. Translation: CAG62284.1.
RefSeqiXP_449310.1. XM_449310.1.

Genome annotation databases

GeneIDi2890701.
KEGGicgr:CAGL0L12474g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380958 Genomic DNA. Translation: CAG62284.1 .
RefSeqi XP_449310.1. XM_449310.1.

3D structure databases

ProteinModelPortali Q6FKD4.
SMRi Q6FKD4. Positions 18-300.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2890701.
KEGGi cgr:CAGL0L12474g.

Phylogenomic databases

KOi K06655.
OMAi QVPQNAY.
OrthoDBi EOG7K3TWD.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiPHO85_CANGA
AccessioniPrimary (citable) accession number: Q6FKD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: July 19, 2004
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi