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Q6FKC6 (SSN3_CANGA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase SSN3

EC=2.7.11.22
EC=2.7.11.23
Alternative name(s):
Cyclin-dependent kinase 8
Gene names
Name:SSN3
Synonyms:CDK8
Ordered Locus Names:CAGL0L12650g
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier284593 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces

Protein attributes

Sequence length567 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II By similarity.

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Component of the SRB8-11 complex, a regulatory module of the Mediator complex By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 567567Serine/threonine-protein kinase SSN3
PRO_0000312939

Regions

Domain68 – 470403Protein kinase
Nucleotide binding74 – 829ATP By similarity
Compositional bias538 – 5469Poly-Ala

Sites

Active site2931Proton acceptor By similarity
Binding site1901ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6FKC6 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 4CED3A8B663AC2EF

FASTA56763,532
        10         20         30         40         50         60 
MQNSGRDLWQ NQSGYMSSLQ QGLNKSNMVG ASTSHGKTPM LMANNDVFTI APYRTRKDNA 

        70         80         90        100        110        120 
RVSVLDKYEI IGYIAAGTYG KVYKAKSRQS SKSSSSTGSD SLAQDTKPTT EFSNTSSLQN 

       130        140        150        160        170        180 
AGTYGDMMGA HGPNSNNISA GGNTNPELST RNNPNNPRVP TSTIISGDKR NSENTDNRRK 

       190        200        210        220        230        240 
AETTMYYAIK KFKTEKDGIE QLHYTGISQS ACREMALCRE LDNNHLTKLV EIFLQKKSIY 

       250        260        270        280        290        300 
MVYEFAEHDL LQIIHFHSHP EKRMIPPRMI RSIMWQILDG VSYLHQNWVL HRDLKPANIM 

       310        320        330        340        350        360 
VTMDGVVKIG DLGLARKFSN MLQTMYTGDK VVVTIWYRAP ELLLGARHYT PAIDLWAVGC 

       370        380        390        400        410        420 
IFAELIGLQP IFKGEEAKMD SKKTVPFQAN QLQRILKILG TPTPKSWPHL QKYPEYEQLS 

       430        440        450        460        470        480 
KFPKYRDNLP GWFHSAGGRD KHALSLLYHL LNYNPIERID AINALDHSYF THGDMPVCEN 

       490        500        510        520        530        540 
VFEGLNYKYP ARRIHTNDND ILNLGLHKPK VPAKVVQPTM NNSTATLGGL GVNKRILAAA 

       550        560 
AAAAAAVSGN SSSQSSRNME PMKKKRK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CR380958 Genomic DNA. Translation: CAG62292.1.
RefSeqXP_449318.1. XM_449318.1.

3D structure databases

ProteinModelPortalQ6FKC6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2890604.
KEGGcgr:CAGL0L12650g.

Phylogenomic databases

KOK02208.
OMAFHSHPEK.
OrthoDBEOG7K3TWD.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSSN3_CANGA
AccessionPrimary (citable) accession number: Q6FKC6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 19, 2004
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families