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Protein

Serine/threonine-protein kinase SSN3

Gene

SSN3

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei190ATPPROSITE-ProRule annotation1
Active sitei293Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 82ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase
Biological processTranscription, Transcription regulation
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SSN3 (EC:2.7.11.22, EC:2.7.11.23)
Alternative name(s):
Cyclin-dependent kinase 8
Gene namesi
Name:SSN3
Synonyms:CDK8
Ordered Locus Names:CAGL0L12650g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome L

Organism-specific databases

CGDiCAL0135266. CAGL0L12650g.
EuPathDBiFungiDB:CAGL0L12650g.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003129391 – 567Serine/threonine-protein kinase SSN3Add BLAST567

Interactioni

Subunit structurei

Component of the SRB8-11 complex, a regulatory module of the Mediator complex.By similarity

Protein-protein interaction databases

STRINGi284593.XP_449318.1.

Structurei

3D structure databases

ProteinModelPortaliQ6FKC6.
SMRiQ6FKC6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 470Protein kinasePROSITE-ProRule annotationAdd BLAST403

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi538 – 546Poly-Ala9

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0666. Eukaryota.
ENOG410XPPA. LUCA.
InParanoidiQ6FKC6.
KOiK02208.
OMAiIMWQILD.
OrthoDBiEOG092C2FL8.

Family and domain databases

InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
PfamiView protein in Pfam
PF00069. Pkinase. 1 hit.
SMARTiView protein in SMART
SM00220. S_TKc. 1 hit.
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FKC6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQNSGRDLWQ NQSGYMSSLQ QGLNKSNMVG ASTSHGKTPM LMANNDVFTI
60 70 80 90 100
APYRTRKDNA RVSVLDKYEI IGYIAAGTYG KVYKAKSRQS SKSSSSTGSD
110 120 130 140 150
SLAQDTKPTT EFSNTSSLQN AGTYGDMMGA HGPNSNNISA GGNTNPELST
160 170 180 190 200
RNNPNNPRVP TSTIISGDKR NSENTDNRRK AETTMYYAIK KFKTEKDGIE
210 220 230 240 250
QLHYTGISQS ACREMALCRE LDNNHLTKLV EIFLQKKSIY MVYEFAEHDL
260 270 280 290 300
LQIIHFHSHP EKRMIPPRMI RSIMWQILDG VSYLHQNWVL HRDLKPANIM
310 320 330 340 350
VTMDGVVKIG DLGLARKFSN MLQTMYTGDK VVVTIWYRAP ELLLGARHYT
360 370 380 390 400
PAIDLWAVGC IFAELIGLQP IFKGEEAKMD SKKTVPFQAN QLQRILKILG
410 420 430 440 450
TPTPKSWPHL QKYPEYEQLS KFPKYRDNLP GWFHSAGGRD KHALSLLYHL
460 470 480 490 500
LNYNPIERID AINALDHSYF THGDMPVCEN VFEGLNYKYP ARRIHTNDND
510 520 530 540 550
ILNLGLHKPK VPAKVVQPTM NNSTATLGGL GVNKRILAAA AAAAAAVSGN
560
SSSQSSRNME PMKKKRK
Length:567
Mass (Da):63,532
Last modified:July 19, 2004 - v1
Checksum:i4CED3A8B663AC2EF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380958 Genomic DNA. Translation: CAG62292.1.
RefSeqiXP_449318.1. XM_449318.1.

Genome annotation databases

EnsemblFungiiCAG62292; CAG62292; CAGL0L12650g.
GeneIDi2890604.
KEGGicgr:CAGL0L12650g.

Similar proteinsi

Entry informationi

Entry nameiSSN3_CANGA
AccessioniPrimary (citable) accession number: Q6FKC6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 19, 2004
Last modified: November 22, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families