ID   GLGB_CANGA              Reviewed;         706 AA.
AC   Q6FJV0;
DT   10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 120.
DE   RecName: Full=1,4-alpha-glucan-branching enzyme;
DE            EC=2.4.1.18;
DE   AltName: Full=Glycogen-branching enzyme;
GN   Name=GLC3; OrderedLocusNames=CAGL0M03377g;
OS   Candida glabrata (strain ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 /
OS   NRRL Y-65 / CBS 138) (Yeast) (Nakaseomyces glabratus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / BCRC 20586 / JCM 3761 / NBRC 0622 / NRRL Y-65 / CBS
RC   138;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Transfers a segment of a (1->4)-alpha-D-glucan chain to a
CC         primary hydroxy group in a similar glucan chain.; EC=2.4.1.18;
CC   -!- PATHWAY: Glycan biosynthesis; glycogen biosynthesis.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 13 family. GlgB
CC       subfamily. {ECO:0000305}.
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DR   EMBL; CR380959; CAG62470.1; -; Genomic_DNA.
DR   RefSeq; XP_449494.1; XM_449494.1.
DR   PDB; 7P43; X-ray; 1.93 A; A/B=1-706.
DR   PDB; 7P44; X-ray; 2.40 A; A/B=1-706.
DR   PDB; 7P45; X-ray; 2.09 A; A=1-706.
DR   PDBsum; 7P43; -.
DR   PDBsum; 7P44; -.
DR   PDBsum; 7P45; -.
DR   AlphaFoldDB; Q6FJV0; -.
DR   SMR; Q6FJV0; -.
DR   STRING; 284593.Q6FJV0; -.
DR   CAZy; CBM48; Carbohydrate-Binding Module Family 48.
DR   CAZy; GH13; Glycoside Hydrolase Family 13.
DR   EnsemblFungi; CAGL0M03377g-T; CAGL0M03377g-T-p1; CAGL0M03377g.
DR   GeneID; 2891502; -.
DR   KEGG; cgr:CAGL0M03377g; -.
DR   CGD; CAL0136349; CAGL0M03377g.
DR   VEuPathDB; FungiDB:B1J91_M03377g; -.
DR   VEuPathDB; FungiDB:CAGL0M03377g; -.
DR   eggNOG; KOG0470; Eukaryota.
DR   HOGENOM; CLU_011131_2_2_1; -.
DR   InParanoid; Q6FJV0; -.
DR   OMA; YEMHLGS; -.
DR   UniPathway; UPA00164; -.
DR   Proteomes; UP000002428; Chromosome M.
DR   GO; GO:0062040; C:fungal biofilm matrix; IDA:CGD.
DR   GO; GO:0003844; F:1,4-alpha-glucan branching enzyme activity; IEA:UniProtKB-EC.
DR   GO; GO:0102752; F:1,4-alpha-glucan branching enzyme activity (using a glucosylated glycogenin as primer for glycogen synthesis); IEA:UniProtKB-EC.
DR   GO; GO:0043169; F:cation binding; IEA:InterPro.
DR   GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR   GO; GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-UniPathway.
DR   CDD; cd11321; AmyAc_bac_euk_BE; 1.
DR   CDD; cd02854; E_set_GBE_euk_N; 1.
DR   Gene3D; 3.20.20.80; Glycosidases; 1.
DR   Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR006048; A-amylase/branching_C.
DR   InterPro; IPR037439; Branching_enzy.
DR   InterPro; IPR006047; Glyco_hydro_13_cat_dom.
DR   InterPro; IPR004193; Glyco_hydro_13_N.
DR   InterPro; IPR013780; Glyco_hydro_b.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   PANTHER; PTHR43651; 1,4-ALPHA-GLUCAN-BRANCHING ENZYME; 1.
DR   PANTHER; PTHR43651:SF3; 1,4-ALPHA-GLUCAN-BRANCHING ENZYME; 1.
DR   Pfam; PF00128; Alpha-amylase; 1.
DR   Pfam; PF02806; Alpha-amylase_C; 1.
DR   Pfam; PF02922; CBM_48; 1.
DR   PIRSF; PIRSF000463; GlgB; 1.
DR   SMART; SM00642; Aamy; 1.
DR   SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Glycogen biosynthesis; Glycosyltransferase;
KW   Reference proteome; Transferase.
FT   CHAIN           1..706
FT                   /note="1,4-alpha-glucan-branching enzyme"
FT                   /id="PRO_0000188779"
FT   ACT_SITE        358
FT                   /note="Nucleophile"
FT                   /evidence="ECO:0000250"
FT   ACT_SITE        419
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   HELIX           8..10
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           11..16
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           18..23
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           24..42
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           53..63
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          64..68
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   TURN            70..72
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          75..80
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          85..91
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           92..94
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          98..100
FT                   /evidence="ECO:0007829|PDB:7P45"
FT   STRAND          110..116
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          131..137
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          143..146
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           159..165
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          170..172
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   TURN            191..193
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          197..203
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          207..211
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           215..221
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           223..229
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          232..238
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           245..247
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          253..258
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           260..262
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           265..277
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          281..286
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          295..299
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   TURN            300..303
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          304..310
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           313..315
FT                   /evidence="ECO:0007829|PDB:7P45"
FT   TURN            321..323
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           333..349
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          354..357
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           360..364
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   TURN            366..369
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          371..374
FT                   /evidence="ECO:0007829|PDB:7P44"
FT   HELIX           380..384
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   TURN            386..388
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           393..409
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   TURN            411..413
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          415..418
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   TURN            425..428
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           431..433
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          439..442
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           446..456
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           459..461
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           464..472
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          480..482
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           487..490
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           497..502
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   TURN            507..509
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          511..514
FT                   /evidence="ECO:0007829|PDB:7P45"
FT   HELIX           518..537
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          540..545
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           548..550
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           561..563
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           575..578
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           584..600
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          604..606
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          610..615
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   TURN            616..619
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          620..625
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          628..633
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          640..649
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          651..658
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   HELIX           662..664
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          679..681
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          686..694
FT                   /evidence="ECO:0007829|PDB:7P43"
FT   STRAND          698..704
FT                   /evidence="ECO:0007829|PDB:7P43"
SQ   SEQUENCE   706 AA;  81044 MW;  18872CAADBCD2A87 CRC64;
     MSLTKIPENV QGAVSIDPWL EPFADVLSER RYLADKWLYD IKHATPDGSE QSLVDFARNA
     YKTYGLHANQ QTKEIVYREW APNAQRAFLV GEFNNWNEES HEMKHKDEFG VFSITLAPLE
     NGDFAIPHDS KIKVMFVLPD GSKVYRIPAW ITRATQPSKE TAQKYGPTYE GRFWNPPNSY
     QFKHQRPKFN LANDSIKIYE AHIGISSPEP KVASYKEFTQ NVLPRIKHLG YDAIQLMAIM
     EHAYYASFGY QVTNFFAISS RYGTPEDLKE LIDTAHSMGI LVLLDVIHSH ASKNSEDGLN
     MFDGSDHQYF HSLTSGRGEH PLWDSRLFNY GSFEVQRFLL ANLAYYIDVY QFDGFRFDGV
     TSMLYLHHGV GAGGAFSGDY NEYLSRDRSG VDHEALAYLM LANDLVHDLL PESAVTIAED
     VSGYPTLCLP RTAGGGGFDY RLAMALPDMW IKLLKTKQDD DWDMGHIVHT LTNRRHGEKV
     VAYCESHDQA LVGDKTLAFW LMDAAMYTDM TVLKEPTLVI DRGIALHKMI RLITHSLGGE
     AYLNFEGNEF GHPEWLDFPR VGNNDSYHYA RRQFNLVDDD LLRYRHLNEF DAAMQNCESK
     HQWLNTPQAY VSLKHEVDKV IAFERNGHLF VFNFHPTQSF TDYRIGVDVA GTYKIVLNTD
     RAEFGGHNRI DEAQEFFTTD LEWNNRRNFI QVYIPSRTAI VLTRQM
//