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Protein

Alpha-1,3/1,6-mannosyltransferase ALG2

Gene

ALG2

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mannosylates Man2GlcNAc(2)-dolichol diphosphate and Man1GlcNAc(2)-dolichol diphosphate to form Man3GlcNAc(2)-dolichol diphosphate.By similarity

Catalytic activityi

GDP-D-mannose + D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-GlcNAc-diphosphodolichol.
GDP-D-mannose + D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1,3/1,6-mannosyltransferase ALG2 (EC:2.4.1.132, EC:2.4.1.257)
Alternative name(s):
Asparagine-linked glycosylation protein 2
GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase
GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
Gene namesi
Name:ALG2
Ordered Locus Names:CAGL0M05731g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome M

Organism-specific databases

CGDiCAL0137195. CAGL0M05731g.
EuPathDBiFungiDB:CAGL0M05731g.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei438 – 45821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 458458Alpha-1,3/1,6-mannosyltransferase ALG2PRO_0000080264Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_449595.1.

Structurei

3D structure databases

ProteinModelPortaliQ6FJJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0853. Eukaryota.
COG0438. LUCA.
HOGENOMiHOG000177048.
InParanoidiQ6FJJ9.
KOiK03843.
OMAiGETGWLR.
OrthoDBiEOG7G4QQG.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FJJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPAKKLKIA FVHPDLGIGG AERLVVDAAL GLQEAGHEVI IYTSHCDKTH
60 70 80 90 100
CFEEVKNGTL KVEVFGDFLP TDLGKRFFIV FANLRQLYLT AKVVLSGRSK
110 120 130 140 150
DKDVFIIDQL STCVPFFKLA NNKVLFYCHF PDQLLAIRTN WIKSLYRIPF
160 170 180 190 200
DLLEQFTMYC SDEVVVNSNF TKSMYKKTFK YLQKNPNVIY PCVDTDTETL
210 220 230 240 250
INDRDMQIGN LLVGKCPNFY LSINRYERKK NIELAIQAFA KASVENTNLV
260 270 280 290 300
VCGGYDPRIH ENVQYLQELT CLCKELDLSY TVNHYSDFIE DSYSVNEIEK
310 320 330 340 350
LFGAKVIFLT SISSSLKEFL IQNMQLLLYT PSYEHFGIVP LEAMKYGKPV
360 370 380 390 400
LAVNNGGPVE TVVSYQKEDN EKSTTGWLRS ADADEWASAL IESKEVLNQN
410 420 430 440 450
PELFKNNGPK RVIELFSRKA MTQEFETNIK LALRHTSNIS IIYVVSIIFA

VLLKVFVF
Length:458
Mass (Da):52,255
Last modified:July 19, 2004 - v1
Checksum:iC6AC3B19E3ACDEC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380959 Genomic DNA. Translation: CAG62571.1.
RefSeqiXP_449595.1. XM_449595.1.

Genome annotation databases

EnsemblFungiiCAG62571; CAG62571; CAGL0M05731g.
GeneIDi2891643.
KEGGicgr:CAGL0M05731g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380959 Genomic DNA. Translation: CAG62571.1.
RefSeqiXP_449595.1. XM_449595.1.

3D structure databases

ProteinModelPortaliQ6FJJ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi284593.XP_449595.1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAG62571; CAG62571; CAGL0M05731g.
GeneIDi2891643.
KEGGicgr:CAGL0M05731g.

Organism-specific databases

CGDiCAL0137195. CAGL0M05731g.
EuPathDBiFungiDB:CAGL0M05731g.

Phylogenomic databases

eggNOGiKOG0853. Eukaryota.
COG0438. LUCA.
HOGENOMiHOG000177048.
InParanoidiQ6FJJ9.
KOiK03843.
OMAiGETGWLR.
OrthoDBiEOG7G4QQG.

Enzyme and pathway databases

UniPathwayiUPA00378.

Family and domain databases

InterProiIPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
[Graphical view]
PfamiPF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALG2_CANGA
AccessioniPrimary (citable) accession number: Q6FJJ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: July 19, 2004
Last modified: June 8, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.