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Protein

Alpha-1,3/1,6-mannosyltransferase ALG2

Gene

ALG2

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Mannosylates Man2GlcNAc2-dolichol diphosphate and Man1GlcNAc2-dolichol diphosphate to form Man3GlcNAc2-dolichol diphosphate.By similarity

Catalytic activityi

GDP-D-mannose + D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-GlcNAc-diphosphodolichol.
GDP-D-mannose + D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = GDP + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol.

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT4. Glycosyltransferase Family 4.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1,3/1,6-mannosyltransferase ALG2 (EC:2.4.1.132, EC:2.4.1.257)
Alternative name(s):
Asparagine-linked glycosylation protein 2
GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase
GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase
GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
Gene namesi
Name:ALG2
Ordered Locus Names:CAGL0M05731g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome M

Organism-specific databases

CGDiCAL0137195. CAGL0M05731g.
EuPathDBiFungiDB:CAGL0M05731g.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000802641 – 458Alpha-1,3/1,6-mannosyltransferase ALG2Add BLAST458

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi284593.XP_449595.1.

Structurei

3D structure databases

ProteinModelPortaliQ6FJJ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase group 1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0853. Eukaryota.
COG0438. LUCA.
HOGENOMiHOG000177048.
InParanoidiQ6FJJ9.
KOiK03843.
OMAiYMQCPVI.
OrthoDBiEOG092C1IJD.

Family and domain databases

InterProiView protein in InterPro
IPR001296. Glyco_trans_1.
IPR028098. Glyco_trans_4-like_N.
PfamiView protein in Pfam
PF13439. Glyco_transf_4. 1 hit.
PF00534. Glycos_transf_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6FJJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPAKKLKIA FVHPDLGIGG AERLVVDAAL GLQEAGHEVI IYTSHCDKTH
60 70 80 90 100
CFEEVKNGTL KVEVFGDFLP TDLGKRFFIV FANLRQLYLT AKVVLSGRSK
110 120 130 140 150
DKDVFIIDQL STCVPFFKLA NNKVLFYCHF PDQLLAIRTN WIKSLYRIPF
160 170 180 190 200
DLLEQFTMYC SDEVVVNSNF TKSMYKKTFK YLQKNPNVIY PCVDTDTETL
210 220 230 240 250
INDRDMQIGN LLVGKCPNFY LSINRYERKK NIELAIQAFA KASVENTNLV
260 270 280 290 300
VCGGYDPRIH ENVQYLQELT CLCKELDLSY TVNHYSDFIE DSYSVNEIEK
310 320 330 340 350
LFGAKVIFLT SISSSLKEFL IQNMQLLLYT PSYEHFGIVP LEAMKYGKPV
360 370 380 390 400
LAVNNGGPVE TVVSYQKEDN EKSTTGWLRS ADADEWASAL IESKEVLNQN
410 420 430 440 450
PELFKNNGPK RVIELFSRKA MTQEFETNIK LALRHTSNIS IIYVVSIIFA

VLLKVFVF
Length:458
Mass (Da):52,255
Last modified:July 19, 2004 - v1
Checksum:iC6AC3B19E3ACDEC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380959 Genomic DNA. Translation: CAG62571.1.
RefSeqiXP_449595.1. XM_449595.1.

Genome annotation databases

EnsemblFungiiCAG62571; CAG62571; CAGL0M05731g.
GeneIDi2891643.
KEGGicgr:CAGL0M05731g.

Similar proteinsi

Entry informationi

Entry nameiALG2_CANGA
AccessioniPrimary (citable) accession number: Q6FJJ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: July 19, 2004
Last modified: September 27, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families