Palmitoyltransferase AKR1 - Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast)

Preferred order of sections

Names and origin

Protein names

Recommended name:
Palmitoyltransferase AKR1
EC=2.3.1.-

Alternative name(s):
Ankyrin repeat-containing protein AKR1

Gene names

Name:	AKR1
Ordered Locus Names:	CAGL0M08712g

Organism

Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]

Taxonomic identifier

284593 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces ›

Protein attributes

Sequence length	763 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Palmitoyltransferase specific for casein kinase 1 By similarity.
Catalytic activity	Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA.
Subcellular location	Early endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein By similarity.
Domain	The DHHC domain is required for palmitoyltransferase activity By similarity.
Sequence similarities	Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily. Contains 7 ANK repeats. Contains 1 DHHC-type zinc finger.

Ontologies

Keywords
Cellular component	Endosome Golgi apparatus Membrane
Domain	ANK repeat Repeat Transmembrane Transmembrane helix Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular_component	Golgi membrane Inferred from electronic annotation. Source: UniProtKB-SubCell early endosome membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	transferase activity, transferring acyl groups Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 763

763

Palmitoyltransferase AKR1

PRO_0000212920

Regions

Topological domain

1 – 307

307

Cytoplasmic Potential

Transmembrane

308 – 325

18

Helical; Potential

Topological domain

326 – 330

5

Lumenal Potential

Transmembrane

331 – 348

18

Helical; Potential

Topological domain

349 – 368

20

Cytoplasmic Potential

Transmembrane

369 – 389

21

Helical; Potential

Topological domain

390 – 401

12

Lumenal Potential

Transmembrane

402 – 422

21

Helical; Potential

Topological domain

423 – 497

75

Cytoplasmic Potential

Transmembrane

498 – 518

21

Helical; Potential

Topological domain

519 – 546

28

Lumenal Potential

Transmembrane

547 – 567

21

Helical; Potential

Topological domain

568 – 763

196

Cytoplasmic Potential

Repeat

57 – 87

31

ANK 1

Repeat

92 – 121

30

ANK 2

Repeat

126 – 155

30

ANK 3

Repeat

159 – 188

30

ANK 4

Repeat

197 – 226

30

ANK 5

Repeat

230 – 259

30

ANK 6

Repeat

292 – 322

31

ANK 7

Zinc finger

454 – 504

51

DHHC-type

Sites

Active site

484

1

S-palmitoyl cysteine intermediate By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q6FJ70 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: E5A42F43026BEA59
Show »

FASTA

763

85,540

        10         20         30         40         50         60 
MEDNSEQASV SSQASMRPLV SDNGDREAGA GVEVNIANDN DTSVGVDGEN GNEDDDPILS 

        70         80         90        100        110        120 
KYHNACQRGD LEVVREMIHG GQVNVSSDAD REGVTGLHWA AINNRLNVVD FLVREGANVE 

       130        140        150        160        170        180 
SKAGALEATP LHWAARYGFV YVVDYLLQHG ASATTTDKQG FNLLHLSVNS SNIMLVVYVL 

       190        200        210        220        230        240 
FFVVSKGIID IDYVDPKGRT ALLWAAYQGD SLTVAALIKF NASVKIADEG GFTPLHWGTV 

       250        260        270        280        290        300 
KGQPHVLKYL IQDGADFFQK TNDNKDCFVI AEEMSNTHSF QEALRHNNFD KNGYPINKLV 

       310        320        330        340        350        360 
KRDDHAKIIT FLIPLLVLGF AFFGFSHLHI LFALPVIILL LLASNKFIKS FLLPSYETKG 

       370        380        390        400        410        420 
TNSASLLKSP LIAGILFGSI FWLAFVWILR ILPYTFTKRP LGNLTFCAIL CFVCYSLFLL 

       430        440        450        460        470        480 
AFSDPGHIGS ENDHEKIRET ISNLLKEGKF DTRSFCLETW VRKPLRSKYS YLNDALILRF 

       490        500        510        520        530        540 
DHYCPWIYND VGLKNHKLFI FFILALELGI FSFVKVCLKY FDELDMDGDC FILGDDDLCS 

       550        560        570        580        590        600 
GLIGDRFTFL IMTWACIQAV WIFSLVIVQL FQITKGLTNS ELNALIREGR RVDIDSQTHN 

       610        620        630        640        650        660 
EFFNTVPEGF INNKDTEEEA APPVRNNTNE RISTTFSGNL PKPRTCMGMI CAVTGLHQCV 

       670        680        690        700        710        720 
AIIKDTFGIA RHGSSRSTNT RSLLSSISTD YGWRRNWCDF WLLSDTNTPL WKRIFFSPPS 

       730        740        750        760 
TKALLNGKEA DYATLYEVPN KNHGSVSQLQ ELQDPLSEID DMV

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References

[1]

"Genome evolution in yeasts."
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.

Souciet J.-L.
Nature 430:35-44(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CR380959 Genomic DNA. Translation: CAG62700.1.
RefSeq	XP_449724.1. XM_449724.1.
3D structure databases
ProteinModelPortal	Q6FJ70.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2891285.
KEGG	cgr:CAGL0M08712g.
Phylogenomic databases
HOGENOM	HOG000033883.
OMA	HANIDIV.
OrthoDB	EOG4K3Q4F.
Family and domain databases
Gene3D	1.25.40.20. 1 hit.
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR001594. Znf_DHHC_palmitoyltrfase. [Graphical view]
Pfam	PF12796. Ank_2. 2 hits. PF01529. zf-DHHC. 1 hit. [Graphical view]
SMART	SM00248. ANK. 6 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 1 hit.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 4 hits. PS50216. ZF_DHHC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AKR1_CANGA

Accession

Primary (citable) accession number: Q6FJ70

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	July 19, 2004
Last modified:	May 1, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry information

Relevant documents