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Q6FIS9

- KPYK1_CANGA

UniProt

Q6FIS9 - KPYK1_CANGA

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Protein
Pyruvate kinase 1
Gene
PYK1, CAGL0M12034g
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Magnesium.
Potassium.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei50 – 501Substrate By similarity
Metal bindingi52 – 521Potassium By similarity
Metal bindingi54 – 541Potassium By similarity
Metal bindingi85 – 851Potassium By similarity
Metal bindingi86 – 861Potassium; via carbonyl oxygen By similarity
Sitei241 – 2411Transition state stabilizer By similarity
Metal bindingi243 – 2431Magnesium Reviewed prediction
Binding sitei266 – 2661Substrate; via amide nitrogen By similarity
Metal bindingi267 – 2671Magnesium By similarity
Binding sitei267 – 2671Substrate; via amide nitrogen By similarity
Binding sitei299 – 2991Substrate By similarity
Binding sitei338 – 3381ADP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase 1 (EC:2.7.1.40)
Short name:
PK 1
Gene namesi
Name:PYK1
Ordered Locus Names:CAGL0M12034g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesmitosporic Nakaseomyces
ProteomesiUP000002428: Chromosome M

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: CGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 501501Pyruvate kinase 1
PRO_0000112110Add
BLAST

Proteomic databases

PRIDEiQ6FIS9.

Interactioni

Subunit structurei

Homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6FIS9.
SMRiQ6FIS9. Positions 3-500.

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.

Phylogenomic databases

HOGENOMiHOG000021559.
KOiK00873.
OMAiTAMENTC.
OrthoDBiEOG7M6DJC.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FIS9-1 [UniParc]FASTAAdd to Basket

« Hide

MDSRLARLTT LQTSAGEELR RTSIIGTIGP KTNNPETLVA LRKAGLNIVR    50
MNFSHGSYEY HKSVIDNARK SEELYPGRPL AIALDTKGPE IRTGTTTNEV 100
DYPIPPNHEM IFTTDDKYAK ACDDKIMYLD YKNITKVISA GRIIYVDDGV 150
LSFEVLQVVD DKTLKVKSLN AGKICSHKGV NLPGTDVDLP ALSEKDKADL 200
RFGVENGVHM IFASFIRTAQ DVLTIREVLG EDGKDIKIVV KIENQQGVNN 250
FDEILKVTDA VMVARGDLGI EIPAPEVLAV QKKLIAKSNL AGKPVICATQ 300
MLESMTYNPR PTRAEVSDVG NAVLDGADCV MLSGETAKGN YPINAVTTMA 350
ETALIAEQAI AYLPNYDDIR NCTPKPTSTT ETVAASAVAA VFEQKAKAII 400
VLSTSGTTAR LVSKYRPNCP IILVTRNART ARFSHLYRGV FPFVYEKESV 450
SDWTEDVEAR LNFGIEQAIE FGILKKGDTY VSIQGFKAGV GHSNTLQVST 500
A 501
Length:501
Mass (Da):54,668
Last modified:July 19, 2004 - v1
Checksum:iD3F800A625D7FD4E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380959 Genomic DNA. Translation: CAG62845.1.
RefSeqiXP_449865.1. XM_449865.1.

Genome annotation databases

GeneIDi2891415.
KEGGicgr:CAGL0M12034g.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CR380959 Genomic DNA. Translation: CAG62845.1 .
RefSeqi XP_449865.1. XM_449865.1.

3D structure databases

ProteinModelPortali Q6FIS9.
SMRi Q6FIS9. Positions 3-500.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6FIS9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2891415.
KEGGi cgr:CAGL0M12034g.

Phylogenomic databases

HOGENOMi HOG000021559.
KOi K00873.
OMAi TAMENTC.
OrthoDBi EOG7M6DJC.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Entry informationi

Entry nameiKPYK1_CANGA
AccessioniPrimary (citable) accession number: Q6FIS9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 19, 2004
Last modified: June 11, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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