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Q6FIM1 (Q6FIM1_CANGA) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
6-phosphogluconate dehydrogenase, decarboxylating PIRNR PIRNR000109 RuleBase RU000485
EC=1.1.1.44 PIRNR PIRNR000109 RuleBase RU000485
Gene names
Ordered Locus Names:CAGL0M13343g
OrganismCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata) [Complete proteome]
Taxonomic identifier284593 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Nakaseomyces › mitosporic Nakaseomyces

Protein attributes

Sequence length489 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH By similarity. PIRNR PIRNR000109

Catalytic activity

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH. PIRNR PIRNR000109 RuleBase RU000485

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3. PIRNR PIRNR000109 RuleBase RU004281

Subunit structure

Homodimer By similarity. PIRNR PIRNR000109

Sequence similarities

Belongs to the 6-phosphogluconate dehydrogenase family. PIRNR PIRNR000109 RuleBase RU000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding9 – 146NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding32 – 343NADP By similarity PIRSR PIRSR000109-3
Nucleotide binding74 – 763NADP By similarity PIRSR PIRSR000109-3
Region128 – 1303Substrate binding By similarity PIRSR PIRSR000109-2
Region185 – 1862Substrate binding By similarity PIRSR PIRSR000109-2

Sites

Active site1821Proton acceptor By similarity PIRSR PIRSR000109-1
Active site1891Proton donor By similarity PIRSR PIRSR000109-1
Binding site1021NADP By similarity PIRSR PIRSR000109-3
Binding site1021Substrate By similarity PIRSR PIRSR000109-2
Binding site1901Substrate By similarity PIRSR PIRSR000109-2
Binding site2591Substrate; via amide nitrogen By similarity PIRSR PIRSR000109-2
Binding site2861Substrate By similarity PIRSR PIRSR000109-2
Binding site4461Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2
Binding site4521Substrate; shared with dimeric partner By similarity PIRSR PIRSR000109-2

Sequences

Sequence LengthMass (Da)Tools
Q6FIM1 [UniParc].

Last modified July 19, 2004. Version 1.
Checksum: 14D49CAC80E76AFE

FASTA48953,513
        10         20         30         40         50         60 
MSADFGLIGL AVMGQNLILN IADHGYTVVA YNRSVDKVHQ FLDNEAKGKS IIGAESIEDL 

        70         80         90        100        110        120 
VAKLKRPRKI MMLVKAGAPV DGLIAQLVPH LEKGDIIIDG GNSHFPDSNR RYEELKAKGI 

       130        140        150        160        170        180 
LFVGSGVSGG EDGARYGPSL MPGGAEEAWP HIKEIFQSIS AKSDGEPCCD WVGPAGSGHY 

       190        200        210        220        230        240 
VKMVHNGIEY GDMQLICEAY DIMKRIGGFT DKEISEVFGK WDTGVLDSFL VEITTNILKK 

       250        260        270        280        290        300 
DDVDGKPLVE KIMDSAGQKG TGKWTAINAL DLGMPVSLIG EAVFARCLSA LKCERVKASK 

       310        320        330        340        350        360 
TLPGPEIPKD LIKDRQQFID DLEQALYASK IISYAQGFML IREAAKTYGW KLNNPAIALM 

       370        380        390        400        410        420 
WRGGCIIRSV FLGEITKAYR ENPDLENLLF HKFFKDAVTK AQGGWRRSLA LAATYGIPSP 

       430        440        450        460        470        480 
AFATALSFYD GYRSERLPAN LLQAQRDYFG AHTFRVLPEC ASDSLPKDKD IHINWTGHGG 


NVSSTTYDA

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CR380959 Genomic DNA. Translation: CAG62903.1.
RefSeqXP_449923.1. XM_449923.1.

3D structure databases

ProteinModelPortalQ6FIM1.
SMRQ6FIM1. Positions 1-476.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2891214.
GenomeReviewsGene locus CAGL0M13343g in contig CR380959_GR.
KEGGcgr:CAGL0M13343g.

Phylogenomic databases

eggNOGfuNOG05795.
HOGENOMHBG286913.
OMAITKAYRE.
OrthoDBEOG4VDT6Z.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:1.20.5.320. Fibritin/6PGD_C-extension. 1 hit.
G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00033.
PfamPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFPIRSF000109. 6PGD. 1 hit.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00873. Gnd. 1 hit.
PROSITEPS00461. 6PGD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ6FIM1_CANGA
AccessionPrimary (citable) accession number: Q6FIM1
Entry history
Integrated into UniProtKB/TrEMBL: July 19, 2004
Last sequence update: July 19, 2004
Last modified: December 14, 2011
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info