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Protein

Iron-sulfur clusters transporter ATM1, mitochondrial

Gene

ATM1

Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei421Glutathione; via amide nitrogenBy similarity1
Binding sitei474ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi498 – 509ATPPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Iron transport, Transport
LigandATP-binding, Iron, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Iron-sulfur clusters transporter ATM1, mitochondrial
Gene namesi
Name:ATM1
Ordered Locus Names:CAGL0M13739g
OrganismiCandida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)
Taxonomic identifieri284593 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeNakaseomycesNakaseomyces/Candida clade
Proteomesi
  • UP000002428 Componenti: Chromosome M

Organism-specific databases

CGDiCAL0136911. ATM1.
EuPathDBiFungiDB:CAGL0M13739g.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 138Mitochondrial matrixBy similarityAdd BLAST113
Transmembranei139 – 160HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini161 – 183Mitochondrial intermembraneBy similarityAdd BLAST23
Transmembranei184 – 207HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini208 – 256Mitochondrial matrixBy similarityAdd BLAST49
Transmembranei257 – 280HelicalPROSITE-ProRule annotationAdd BLAST24
Topological domaini281Mitochondrial intermembraneBy similarity1
Transmembranei282 – 302HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini303 – 368Mitochondrial matrixBy similarityAdd BLAST66
Transmembranei369 – 387HelicalPROSITE-ProRule annotationAdd BLAST19
Topological domaini388 – 402Mitochondrial intermembraneBy similarityAdd BLAST15
Transmembranei403 – 424HelicalPROSITE-ProRule annotationAdd BLAST22
Topological domaini425 – 727Mitochondrial matrixBy similarityAdd BLAST303

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 25MitochondrionSequence analysisAdd BLAST25
ChainiPRO_000025544126 – 727Iron-sulfur clusters transporter ATM1, mitochondrialAdd BLAST702

Proteomic databases

PRIDEiQ6FIK3.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi284593.XP_449941.1.

Structurei

3D structure databases

ProteinModelPortaliQ6FIK3.
SMRiQ6FIK3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini139 – 429ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST291
Domaini465 – 701ABC transporterPROSITE-ProRule annotationAdd BLAST237

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni308 – 312Glutathione bindingBy similarity5
Regioni371 – 374Glutathione bindingBy similarity4

Sequence similaritiesi

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0057. Eukaryota.
COG5265. LUCA.
InParanoidiQ6FIK3.
KOiK05663.
OMAiYEAQRYD.
OrthoDBiEOG092C3H79.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6FIK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIGGAQNRL YQLRTSNILG LLRTRSALRV GSKVELRCPY NNWTNLGRSH
60 70 80 90 100
FSSTSIPPTF KSKTFGREKG LLAHNINVKR LSSTVSKSKL PNEDTAHNAS
110 120 130 140 150
EKNSKKTDTK AVNISELKIL KDLFKYIWPR GNTKVKVRVL LALALLIGAK
160 170 180 190 200
VLNVQVPFFF KQIIDGMNVD WSDATVALPA ALGLTIMCYG LARFGAVLFG
210 220 230 240 250
ELRNAIFARV AQNAIRNVSL QTFEHLMKLD LGWHLSRQTG GLTRAMDRGT
260 270 280 290 300
KGISYVLSAM VFHIIPITFE ISVVCGILTY QFGASFAGIT FTTMLLYSIF
310 320 330 340 350
TIRTTAWRTR FRKEANKADN KGASVALDSL INFEAVKYFN NESYLANKYH
360 370 380 390 400
NSLIKYRDSQ VKVAQSLAFL NSGQSLIFTT ALTGMMYMGC TGVIGGDLTV
410 420 430 440 450
GDLVLINQLV FQLSVPLNFL GSVYRELKQS LIDMESLFKL RKNQVKIQNC
460 470 480 490 500
SQPKSISKSD GPFEIKFENV TFGYDGQRKI LKNASFTIPA GMKTAIAGPS
510 520 530 540 550
GSGKSTVLKL VFRFYDPEEG RVLVNGVDVR EYDIDQLRKA IGVVPQDTPL
560 570 580 590 600
FNDTIWENVK FGRIEASDEE ITRVIDKAQL SDLIAKLPQG SSTIVGERGL
610 620 630 640 650
MISGGEKQRL AIARVLLKDA DIMFFDEATS ALDTHTEQSL LRTIRRNFNS
660 670 680 690 700
GEKTSVYIAH RLRTIADADK IIVLEEGTVR EEGTHQELLA RENSLYKELW
710 720
RIQEDLDLLE DEINHEKETL EKLNKSI
Length:727
Mass (Da):81,305
Last modified:July 19, 2004 - v1
Checksum:i7105D40D1174FBA3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CR380959 Genomic DNA. Translation: CAG62921.1.
RefSeqiXP_449941.1. XM_449941.1.

Genome annotation databases

EnsemblFungiiCAG62921; CAG62921; CAGL0M13739g.
KEGGicgr:CAGL0M13739g.

Similar proteinsi

Entry informationi

Entry nameiATM1_CANGA
AccessioniPrimary (citable) accession number: Q6FIK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 19, 2004
Last modified: August 30, 2017
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families