Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

AN1-type zinc finger protein 6

Gene

ZFAND6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in regulation of TNF-alpha induced NF-kappa-B activation and apoptosis. Involved in modulation of 'Lys-48'-linked polyubiquitination status of TRAF2 and decreases association of TRAF2 with RIPK1. Required for PTS1 target sequence-dependent protein import into peroxisomes and PEX5 stability; may cooperate with PEX6. In vitro involved in PEX5 export from the cytosol to peroxisomes (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri8 – 42A20-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri146 – 189AN1-typePROSITE-ProRule annotationAdd BLAST44

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • cellular response to tumor necrosis factor Source: UniProtKB
  • negative regulation of apoptotic process Source: UniProtKB
  • protein targeting to peroxisome Source: UniProtKB
  • regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB

Keywordsi

Biological processApoptosis, Protein transport, Transport
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
AN1-type zinc finger protein 6
Alternative name(s):
Associated with PRK1 protein
Zinc finger A20 domain-containing protein 3
Gene namesi
Name:ZFAND6
Synonyms:AWP1, ZA20D3
ORF Names:HT032
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000086666.18
HGNCiHGNC:30164 ZFAND6
MIMi610183 gene
neXtProtiNX_Q6FIF0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi54469
OpenTargetsiENSG00000086666
PharmGKBiPA134883256

Polymorphism and mutation databases

BioMutaiZFAND6
DMDMi110288083

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002452351 – 208AN1-type zinc finger protein 6Add BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineCombined sources1
Modified residuei204N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6FIF0
MaxQBiQ6FIF0
PaxDbiQ6FIF0
PeptideAtlasiQ6FIF0
PRIDEiQ6FIF0
TopDownProteomicsiQ6FIF0-1 [Q6FIF0-1]

PTM databases

iPTMnetiQ6FIF0
PhosphoSitePlusiQ6FIF0

Expressioni

Tissue specificityi

Widely expressed with high level in heart, skeletal muscle, liver, kidney and placenta.1 Publication

Gene expression databases

BgeeiENSG00000086666
CleanExiHS_ZFAND6
ExpressionAtlasiQ6FIF0 baseline and differential
GenevisibleiQ6FIF0 HS

Organism-specific databases

HPAiHPA034845

Interactioni

Subunit structurei

Interacts with PKN1 (By similarity). Interacts with TRAF2. Interacts with mono- and polyubiquitin. Interacts with PEX6. Interacts with PEX5 (Cys-linked ubiquitinated) (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119975, 14 interactors
IntActiQ6FIF0, 4 interactors
STRINGi9606.ENSP00000261749

Structurei

3D structure databases

ProteinModelPortaliQ6FIF0
SMRiQ6FIF0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi43 – 109Ser-richAdd BLAST67

Domaini

The A20-type zinc finger domain mediates regulation of NF-kappa-B activity.
The AN1-type zinc finger domain mediates association with TRAF2.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri8 – 42A20-typePROSITE-ProRule annotationAdd BLAST35
Zinc fingeri146 – 189AN1-typePROSITE-ProRule annotationAdd BLAST44

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3173 Eukaryota
ENOG4111UWC LUCA
GeneTreeiENSGT00510000046525
HOGENOMiHOG000238229
HOVERGENiHBG053349
InParanoidiQ6FIF0
OMAiEPIIAGH
OrthoDBiEOG091G0M53
PhylomeDBiQ6FIF0
TreeFamiTF313612

Family and domain databases

Gene3Di4.10.1110.10, 1 hit
InterProiView protein in InterPro
IPR035896 AN1-like_Znf
IPR002653 Znf_A20
IPR000058 Znf_AN1
PfamiView protein in Pfam
PF01754 zf-A20, 1 hit
PF01428 zf-AN1, 1 hit
SMARTiView protein in SMART
SM00259 ZnF_A20, 1 hit
SM00154 ZnF_AN1, 1 hit
SUPFAMiSSF118310 SSF118310, 1 hit
PROSITEiView protein in PROSITE
PS51036 ZF_A20, 1 hit
PS51039 ZF_AN1, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6FIF0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQETNHSQV PMLCSTGCGF YGNPRTNGMC SVCYKEHLQR QNSSNGRISP
60 70 80 90 100
PATSVSSLSE SLPVQCTDGS VPEAQSALDS TSSSMQPSPV SNQSLLSESV
110 120 130 140 150
ASSQLDSTSV DKAVPETEDV QASVSDTAQQ PSEEQSKSLE KPKQKKNRCF
160 170 180 190 200
MCRKKVGLTG FECRCGNVYC GVHRYSDVHN CSYNYKADAA EKIRKENPVV

VGEKIQKI
Length:208
Mass (Da):22,555
Last modified:July 11, 2006 - v2
Checksum:i28B443F2E6D84493
GO
Isoform 2 (identifier: Q6FIF0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-63: Missing.

Note: No experimental confirmation available.
Show »
Length:196
Mass (Da):21,396
Checksum:i030B4F52C8324630
GO

Sequence cautioni

The sequence AAD17528 differs from that shown. Reason: Frameshift at position 141.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138S → P in CAB66533 (Ref. 3) Curated1
Sequence conflicti138S → P in CAG38507 (Ref. 5) Curated1
Sequence conflicti140E → D in AAD17528 (Ref. 2) Curated1
Sequence conflicti179H → L in CAB66533 (Ref. 3) Curated1
Sequence conflicti179H → L in CAG38507 (Ref. 5) Curated1
Sequence conflicti197N → D in CAG38507 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01965252 – 63Missing in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ251095 mRNA Translation: CAC14876.1
AF061739 mRNA Translation: AAD17528.1 Frameshift.
AF261138 mRNA Translation: AAG44674.1
AL136598 mRNA Translation: CAB66533.1
CR533476 mRNA Translation: CAG38507.1
CH471136 Genomic DNA Translation: EAW99122.1
CH471136 Genomic DNA Translation: EAW99123.1
CH471136 Genomic DNA Translation: EAW99124.1
CH471136 Genomic DNA Translation: EAW99125.1
CH471136 Genomic DNA Translation: EAW99127.1
BC005283 mRNA Translation: AAH05283.1
CCDSiCCDS10313.1 [Q6FIF0-1]
CCDS58395.1 [Q6FIF0-2]
RefSeqiNP_001229840.1, NM_001242911.1 [Q6FIF0-1]
NP_001229841.1, NM_001242912.1 [Q6FIF0-1]
NP_001229842.1, NM_001242913.1 [Q6FIF0-1]
NP_001229843.1, NM_001242914.1 [Q6FIF0-1]
NP_001229844.1, NM_001242915.1 [Q6FIF0-1]
NP_001229845.1, NM_001242916.1 [Q6FIF0-1]
NP_001229846.1, NM_001242917.1 [Q6FIF0-2]
NP_061879.2, NM_019006.3 [Q6FIF0-1]
XP_011519986.1, XM_011521684.2 [Q6FIF0-1]
UniGeneiHs.596679
Hs.744030

Genome annotation databases

EnsembliENST00000261749; ENSP00000261749; ENSG00000086666 [Q6FIF0-1]
ENST00000558087; ENSP00000453888; ENSG00000086666 [Q6FIF0-1]
ENST00000558494; ENSP00000454137; ENSG00000086666 [Q6FIF0-1]
ENST00000559157; ENSP00000454152; ENSG00000086666 [Q6FIF0-2]
ENST00000559775; ENSP00000453709; ENSG00000086666 [Q6FIF0-1]
ENST00000559835; ENSP00000453291; ENSG00000086666 [Q6FIF0-1]
ENST00000561060; ENSP00000452735; ENSG00000086666 [Q6FIF0-1]
ENST00000613266; ENSP00000479071; ENSG00000086666 [Q6FIF0-1]
ENST00000616533; ENSP00000478129; ENSG00000086666 [Q6FIF0-1]
ENST00000618205; ENSP00000484971; ENSG00000086666 [Q6FIF0-1]
GeneIDi54469
KEGGihsa:54469
UCSCiuc002bfe.2 human [Q6FIF0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZFAN6_HUMAN
AccessioniPrimary (citable) accession number: Q6FIF0
Secondary accession number(s): D3DW92
, D3DW94, O95792, Q9BQF7, Q9GZY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: May 23, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health