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Protein
Submitted name:

TOLLIP protein

Gene

TOLLIP

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
TOLLIP proteinImported
Submitted name:
Toll interacting proteinImported
Submitted name:
Toll interacting protein, isoform CRA_aImported
Submitted name:
cDNA, FLJ96670, Homo sapiens toll interacting protein (TOLLIP), mRNAImported
Gene namesi
Name:TOLLIPImported
ORF Names:hCG_40380Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134876213.

Expressioni

Gene expression databases

BgeeiENSG00000078902.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CPSF6Q166303EBI-10249783,EBI-358410
DAB1O755533EBI-10249783,EBI-7875264
DAZAP2Q150383EBI-10249783,EBI-724310
PRR20CP864793EBI-10249783,EBI-10172814
RBPMSQ930623EBI-10249783,EBI-740322
SIAH1Q8IUQ43EBI-10249783,EBI-747107
TOM1O607843EBI-10249783,EBI-74634

Protein-protein interaction databases

STRINGi9606.ENSP00000314733.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini229 – 272CUEInterPro annotationAdd BLAST44

Phylogenomic databases

eggNOGiENOG410IE45. Eukaryota.
ENOG410XQPY. LUCA.
HOVERGENiHBG054213.
KOiK05402.
OMAiHVTIPES.
OrthoDBiEOG091G0JE1.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR003892. CUE.
IPR009060. UBA-like.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF02845. CUE. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00546. CUE. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEiPS51140. CUE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FIE9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATTVSTQRG PVYIGELPQD FLRITPTQQQ RQVQLDAQAA QQLQYGGAVG
60 70 80 90 100
TVGRLNITVV QAKLAKNYGM TRMDPYCRLR LGYAVYETPT AHNGAKNPRW
110 120 130 140 150
NKVIHCTVPP GVDSFYLEIF DERAFSMDDR IAWTHITIPE SLRQGKVEDK
160 170 180 190 200
WYSLSGRQGD DKEGMINLVM SYALLPAAMV MPPQPVVLMP TVYQQGVGYV
210 220 230 240 250
PITGMPAVCS PGMVPVALPP AAVNAQPRCS EEDLKAIQDM FPNMDQEVIR
260 270
SVLEAQRGNK DAAINSLLQM GEEP
Length:274
Mass (Da):30,282
Last modified:May 10, 2005 - v1
Checksum:i386E0F284D3837DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY730683 mRNA. Translation: AAX22229.1.
AK315592 mRNA. Translation: BAG37964.1.
CR533477 mRNA. Translation: CAG38508.1.
CH471158 Genomic DNA. Translation: EAX02433.1.
CH471158 Genomic DNA. Translation: EAX02434.1.
RefSeqiNP_061882.2. NM_019009.3.
UniGeneiHs.368527.

Genome annotation databases

GeneIDi54472.
KEGGihsa:54472.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY730683 mRNA. Translation: AAX22229.1.
AK315592 mRNA. Translation: BAG37964.1.
CR533477 mRNA. Translation: CAG38508.1.
CH471158 Genomic DNA. Translation: EAX02433.1.
CH471158 Genomic DNA. Translation: EAX02434.1.
RefSeqiNP_061882.2. NM_019009.3.
UniGeneiHs.368527.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000314733.

Protocols and materials databases

DNASUi54472.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi54472.
KEGGihsa:54472.

Organism-specific databases

CTDi54472.
PharmGKBiPA134876213.

Phylogenomic databases

eggNOGiENOG410IE45. Eukaryota.
ENOG410XQPY. LUCA.
HOVERGENiHBG054213.
KOiK05402.
OMAiHVTIPES.
OrthoDBiEOG091G0JE1.

Miscellaneous databases

ChiTaRSiTOLLIP. human.
GenomeRNAii54472.

Gene expression databases

BgeeiENSG00000078902.

Family and domain databases

Gene3Di2.60.40.150. 1 hit.
InterProiIPR000008. C2_dom.
IPR003892. CUE.
IPR009060. UBA-like.
[Graphical view]
PfamiPF00168. C2. 1 hit.
PF02845. CUE. 1 hit.
[Graphical view]
SMARTiSM00239. C2. 1 hit.
SM00546. CUE. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF49562. SSF49562. 1 hit.
PROSITEiPS51140. CUE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6FIE9_HUMAN
AccessioniPrimary (citable) accession number: Q6FIE9
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 30, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.