ID   Q6FID7_HUMAN            Unreviewed;       127 AA.
AC   Q6FID7;
DT   10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2005, sequence version 1.
DT   27-MAR-2024, entry version 54.
DE   RecName: Full=Polyadenylate-binding protein-interacting protein 2 {ECO:0000256|ARBA:ARBA00040702};
GN   Name=PAIP2 {ECO:0000313|EMBL:CAG38520.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:CAG38520.1};
RN   [1] {ECO:0000313|EMBL:CAG38520.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT   "Cloning of human full open reading frames in Gateway(TM) system entry
RT   vector (pDONR201).";
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a repressor in the regulation of translation
CC       initiation of poly(A)-containing mRNAs. Its inhibitory activity on
CC       translation is mediated via its action on PABPC1. Displaces the
CC       interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for
CC       binding to PABPC1. Its association with PABPC1 results in disruption of
CC       the cytoplasmic poly(A) RNP structure organization.
CC       {ECO:0000256|ARBA:ARBA00037448}.
CC   -!- SUBUNIT: Interacts with the second and third RRM domains and C-terminus
CC       regions of PABPC1 in a 2:1 stoichiometry.
CC       {ECO:0000256|ARBA:ARBA00038779}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the PAIP2 family.
CC       {ECO:0000256|ARBA:ARBA00006858}.
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DR   EMBL; CR533489; CAG38520.1; -; mRNA.
DR   AlphaFoldDB; Q6FID7; -.
DR   PeptideAtlas; Q6FID7; -.
DR   ChiTaRS; PAIP2; human.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000900; F:mRNA regulatory element binding translation repressor activity; IEA:InterPro.
DR   GO; GO:0045947; P:negative regulation of translational initiation; IEA:InterPro.
DR   InterPro; IPR009818; Ataxin-2_C.
DR   InterPro; IPR040396; PAIP2-like.
DR   PANTHER; PTHR13154; POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 2; 1.
DR   PANTHER; PTHR13154:SF2; POLYADENYLATE-BINDING PROTEIN-INTERACTING PROTEIN 2; 1.
DR   Pfam; PF07145; PAM2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490}.
FT   DOMAIN          108..123
FT                   /note="Ataxin-2 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF07145"
SQ   SEQUENCE   127 AA;  14998 MW;  CAC27C537E5D7E33 CRC64;
     MKDPSRSSTS PSIINEDVII NGHSHEDDNP FAEYMWMENE EEFNRQIEEE LWEEEFIERC
     FQEMLEEEEE HEWFIPARDL PQTMDQIQDQ FNDLVISEGS SLEDLVVKSN LNPNAKEFVP
     GVKYGNI
//