CLIC4

Functionⁱ

GO - Molecular functionⁱ

chloride channel activity Source: UniProtKB-KW
voltage-gated ion channel activity Source: UniProtKB-KW

GO - Biological processⁱ

angiogenesis Source: Ensembl
branching morphogenesis of an epithelial tube Source: Ensembl
endothelial cell morphogenesis Source: Ensembl
fertilization Source: Ensembl
keratinocyte differentiation Source: Ensembl
multicellular organism growth Source: Ensembl
retina vasculature morphogenesis in camera-type eye Source: Ensembl
vacuolar acidification Source: Ensembl

Keywordsⁱ

Molecular function	Chloride channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological process	Ion transport, Transport
Ligand	Chloride

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Chloride intracellular channel proteinUniRule annotation
Gene namesⁱ	Name:CLIC4Imported ORF Names:hCG_24047Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Subcellular locationⁱ

GO - Cellular componentⁱ

chloride channel complex Source: UniProtKB-KW
mitochondrion Source: Ensembl

Complete GO annotation...

Keywords - Cellular componentⁱ

CytoplasmUniRule annotation

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA26591.

PharmGKBⁱ

PA26591.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000169504.
ExpressionAtlasⁱ	Q6FIC5. baseline and differential.

Structureⁱ

3D structure databases

SMRⁱ	Q6FIC5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	81 – 244	GST C-terminalInterPro annotationAdd BLAST		164

Domainⁱ

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.UniRule annotation

Sequence similaritiesⁱ

Belongs to the chloride channel CLIC family.UniRule annotation

Phylogenomic databases

eggNOGⁱ	KOG1422. Eukaryota. ENOG410ZRK6. LUCA.
HOVERGENⁱ	HBG050994.
KEGG Orthology (KO) More...KOⁱ	K05024.
OMAⁱ	IDHNSIE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IHT.

Family and domain databases

InterProⁱ	View protein in InterPro IPR002946. CLIC. IPR010987. Glutathione-S-Trfase_C-like. IPR012336. Thioredoxin-like_fold.
PRINTSⁱ	PR01263. INTCLCHANNEL.
SFLDⁱ	SFLDG01175. Main.10_. 1 hit.
SUPFAMⁱ	SSF47616. SSF47616. 1 hit. SSF52833. SSF52833. 1 hit.
TIGRFAMsⁱ	TIGR00862. O-ClC. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50405. GST_CTER. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6FIC5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALSMPLNGL KEEDKEPLIE LFVKAGSDGE SIGNCPFSQR LFMILWLKGV 
        60         70         80         90        100
VFSVTTVDLK RKPADLQNLA PGTHPPFITF NSEVKTDVNK IEEFLEEVLC 
       110        120        130        140        150
PPKYLKLSPK HPESNTAGMD IFAKFSAYIK NSRPEANEAL ERGLLKTLQK 
       160        170        180        190        200
LDEYLNSPLP DEIDENSMED IKFSTRKFLD GNEMTLADCN LLPKLHIVKV 
       210        220        230        240        250
VAKKYRNFDI PKEMTGIWRY LTNAYSRDEF TNTCPSDKEV EIAYSDVAKR 

LTK

Length:253

Mass (Da):28,772

Last modified:February 5, 2008 - v1

Checksum:ⁱ3DD21A33C66626A5

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK315051 mRNA. Translation: BAG37528.1. CR533501 mRNA. Translation: CAG38532.1. CH471134 Genomic DNA. Translation: EAW95143.1. CH471134 Genomic DNA. Translation: EAW95144.1. CH471134 Genomic DNA. Translation: EAW95145.1. CH471134 Genomic DNA. Translation: EAW95146.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_039234.1. NM_013943.2.
UniGeneⁱ	Hs.440544.

Genome annotation databases

GeneIDⁱ	25932.
KEGGⁱ	hsa:25932.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK315051 mRNA. Translation: BAG37528.1. CR533501 mRNA. Translation: CAG38532.1. CH471134 Genomic DNA. Translation: EAW95143.1. CH471134 Genomic DNA. Translation: EAW95144.1. CH471134 Genomic DNA. Translation: EAW95145.1. CH471134 Genomic DNA. Translation: EAW95146.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_039234.1. NM_013943.2.
UniGeneⁱ	Hs.440544.

3D structure databases

SMRⁱ	Q6FIC5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	25932.
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	25932.
KEGGⁱ	hsa:25932.

Organism-specific databases

CTDⁱ	25932.
PharmGKBⁱ	PA26591.

Phylogenomic databases

eggNOGⁱ	KOG1422. Eukaryota. ENOG410ZRK6. LUCA.
HOVERGENⁱ	HBG050994.
KEGG Orthology (KO) More...KOⁱ	K05024.
OMAⁱ	IDHNSIE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0IHT.

Miscellaneous databases

ChiTaRSⁱ	CLIC4. human.
GenomeRNAiⁱ	25932.

Gene expression databases

Bgeeⁱ	ENSG00000169504.
ExpressionAtlasⁱ	Q6FIC5. baseline and differential.

Family and domain databases

InterProⁱ	View protein in InterPro IPR002946. CLIC. IPR010987. Glutathione-S-Trfase_C-like. IPR012336. Thioredoxin-like_fold.
PRINTSⁱ	PR01263. INTCLCHANNEL.
SFLDⁱ	SFLDG01175. Main.10_. 1 hit.
SUPFAMⁱ	SSF47616. SSF47616. 1 hit. SSF52833. SSF52833. 1 hit.
TIGRFAMsⁱ	TIGR00862. O-ClC. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50405. GST_CTER. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q6FIC5_HUMAN
Accessionⁱ	Q6FIC5Primary (citable) accession number: Q6FIC5
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 5, 2008
	Last sequence update:	February 5, 2008
	Last modified:	July 5, 2017
	This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

UniProtKB - Q6FIC5 (Q6FIC5_HUMAN)

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Chloride intracellular channel protein

Select a section on the left to see content.

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Organism-specific databases

Expressionⁱ

Gene expression databases

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Domainⁱ

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6FIC5 (Q6FIC5_HUMAN)

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Chloride intracellular channel protein

CLIC4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

Expressionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ