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Protein

Chloride intracellular channel protein

Gene

CLIC4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChloride channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processIon transport, Transport
LigandChloride

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride intracellular channel proteinUniRule annotation
Gene namesi
Name:CLIC4Imported
ORF Names:hCG_24047Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000169504.14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26591

PTM / Processingi

Proteomic databases

PRIDEiQ6FIC5

Expressioni

Gene expression databases

BgeeiENSG00000169504
ExpressionAtlasiQ6FIC5 baseline and differential

Structurei

3D structure databases

SMRiQ6FIC5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini81 – 244GST C-terminalInterPro annotationAdd BLAST164

Domaini

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.UniRule annotation

Sequence similaritiesi

Belongs to the chloride channel CLIC family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1422 Eukaryota
ENOG410ZRK6 LUCA
HOVERGENiHBG050994
KOiK05024
OMAiIDHNSIE
OrthoDBiEOG091G0IHT

Family and domain databases

InterProiView protein in InterPro
IPR002946 CLIC
IPR030257 CLIC-4
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR43920:SF7 PTHR43920:SF7, 1 hit
PRINTSiPR01263 INTCLCHANNEL
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR00862 O-ClC, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q6FIC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSMPLNGL KEEDKEPLIE LFVKAGSDGE SIGNCPFSQR LFMILWLKGV
60 70 80 90 100
VFSVTTVDLK RKPADLQNLA PGTHPPFITF NSEVKTDVNK IEEFLEEVLC
110 120 130 140 150
PPKYLKLSPK HPESNTAGMD IFAKFSAYIK NSRPEANEAL ERGLLKTLQK
160 170 180 190 200
LDEYLNSPLP DEIDENSMED IKFSTRKFLD GNEMTLADCN LLPKLHIVKV
210 220 230 240 250
VAKKYRNFDI PKEMTGIWRY LTNAYSRDEF TNTCPSDKEV EIAYSDVAKR

LTK
Length:253
Mass (Da):28,772
Last modified:February 5, 2008 - v1
Checksum:i3DD21A33C66626A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315051 mRNA Translation: BAG37528.1
CR533501 mRNA Translation: CAG38532.1
CH471134 Genomic DNA Translation: EAW95143.1
CH471134 Genomic DNA Translation: EAW95144.1
CH471134 Genomic DNA Translation: EAW95145.1
CH471134 Genomic DNA Translation: EAW95146.1
RefSeqiNP_039234.1, NM_013943.2
UniGeneiHs.440544

Genome annotation databases

GeneIDi25932
KEGGihsa:25932

Similar proteinsi

Entry informationi

Entry nameiQ6FIC5_HUMAN
AccessioniPrimary (citable) accession number: Q6FIC5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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