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Protein

Chloride intracellular channel protein

Gene

CLIC4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chloride channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Chloride intracellular channel proteinUniRule annotation
Gene namesi
Name:CLIC4Imported
ORF Names:hCG_24047Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Membrane UniRule annotation; Single-pass membrane protein UniRule annotation
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26591.

Expressioni

Gene expression databases

BgeeiENSG00000169504.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000363500.

Structurei

3D structure databases

SMRiQ6FIC5. Positions 6-253.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini81 – 244164GST C-terminalInterPro annotationAdd
BLAST

Domaini

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.UniRule annotation

Sequence similaritiesi

Belongs to the chloride channel CLIC family.UniRule annotation
Contains 1 GST C-terminal domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG1422. Eukaryota.
ENOG410ZRK6. LUCA.
HOVERGENiHBG050994.
KOiK05024.
OMAiIWKYLNN.
OrthoDBiEOG091G0IHT.
PhylomeDBiQ6FIC5.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR002946. CLIC.
IPR030257. CLIC-4.
IPR010987. Glutathione-S-Trfase_C-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11260:SF185. PTHR11260:SF185. 2 hits.
PRINTSiPR01263. INTCLCHANNEL.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00862. O-ClC. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FIC5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSMPLNGL KEEDKEPLIE LFVKAGSDGE SIGNCPFSQR LFMILWLKGV
60 70 80 90 100
VFSVTTVDLK RKPADLQNLA PGTHPPFITF NSEVKTDVNK IEEFLEEVLC
110 120 130 140 150
PPKYLKLSPK HPESNTAGMD IFAKFSAYIK NSRPEANEAL ERGLLKTLQK
160 170 180 190 200
LDEYLNSPLP DEIDENSMED IKFSTRKFLD GNEMTLADCN LLPKLHIVKV
210 220 230 240 250
VAKKYRNFDI PKEMTGIWRY LTNAYSRDEF TNTCPSDKEV EIAYSDVAKR

LTK
Length:253
Mass (Da):28,772
Last modified:February 5, 2008 - v1
Checksum:i3DD21A33C66626A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315051 mRNA. Translation: BAG37528.1.
CR533501 mRNA. Translation: CAG38532.1.
CH471134 Genomic DNA. Translation: EAW95143.1.
CH471134 Genomic DNA. Translation: EAW95144.1.
CH471134 Genomic DNA. Translation: EAW95145.1.
CH471134 Genomic DNA. Translation: EAW95146.1.
RefSeqiNP_039234.1. NM_013943.2.
UniGeneiHs.440544.

Genome annotation databases

GeneIDi25932.
KEGGihsa:25932.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK315051 mRNA. Translation: BAG37528.1.
CR533501 mRNA. Translation: CAG38532.1.
CH471134 Genomic DNA. Translation: EAW95143.1.
CH471134 Genomic DNA. Translation: EAW95144.1.
CH471134 Genomic DNA. Translation: EAW95145.1.
CH471134 Genomic DNA. Translation: EAW95146.1.
RefSeqiNP_039234.1. NM_013943.2.
UniGeneiHs.440544.

3D structure databases

SMRiQ6FIC5. Positions 6-253.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000363500.

Protocols and materials databases

DNASUi25932.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25932.
KEGGihsa:25932.

Organism-specific databases

CTDi25932.
PharmGKBiPA26591.

Phylogenomic databases

eggNOGiKOG1422. Eukaryota.
ENOG410ZRK6. LUCA.
HOVERGENiHBG050994.
KOiK05024.
OMAiIWKYLNN.
OrthoDBiEOG091G0IHT.
PhylomeDBiQ6FIC5.

Miscellaneous databases

ChiTaRSiCLIC4. human.
GenomeRNAii25932.

Gene expression databases

BgeeiENSG00000169504.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR002946. CLIC.
IPR030257. CLIC-4.
IPR010987. Glutathione-S-Trfase_C-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11260:SF185. PTHR11260:SF185. 2 hits.
PRINTSiPR01263. INTCLCHANNEL.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00862. O-ClC. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6FIC5_HUMAN
AccessioniPrimary (citable) accession number: Q6FIC5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 7, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.