UniProtKB - Q6FIC5 (Q6FIC5_HUMAN)
(max 400 entries)x
Your basket is currently empty. i
Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)
Protein
Chloride intracellular channel protein
Gene
CLIC4
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- chloride channel activity Source: UniProtKB-KW
- voltage-gated ion channel activity Source: UniProtKB-KW
GO - Biological processi
- angiogenesis Source: Ensembl
- branching morphogenesis of an epithelial tube Source: Ensembl
- endothelial cell morphogenesis Source: Ensembl
- fertilization Source: Ensembl
- keratinocyte differentiation Source: Ensembl
- multicellular organism growth Source: Ensembl
- regulation of ion transmembrane transport Source: UniProtKB-KW
- retina vasculature morphogenesis in camera-type eye Source: Ensembl
- vacuolar acidification Source: Ensembl
Keywordsi
Molecular function | Chloride channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation |
Biological process | Ion transport, Transport |
Ligand | Chloride |
Names & Taxonomyi
Protein namesi | Recommended name: Chloride intracellular channel proteinUniRule annotation |
Gene namesi | Name:CLIC4Imported ORF Names:hCG_24047Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000169504.14. |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 81 – 244 | GST C-terminalInterPro annotationAdd BLAST | 164 |
Domaini
Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.UniRule annotation
Sequence similaritiesi
Belongs to the chloride channel CLIC family.UniRule annotation
Phylogenomic databases
eggNOGi | KOG1422. Eukaryota. ENOG410ZRK6. LUCA. |
HOVERGENi | HBG050994. |
KOi | K05024. |
OMAi | IDHNSIE. |
OrthoDBi | EOG091G0IHT. |
Family and domain databases
InterProi | View protein in InterPro IPR002946. CLIC. IPR030257. CLIC-4. IPR010987. Glutathione-S-Trfase_C-like. IPR036282. Glutathione-S-Trfase_C_sf. IPR036249. Thioredoxin-like_sf. |
PANTHERi | PTHR43920:SF7. PTHR43920:SF7. 1 hit. |
PRINTSi | PR01263. INTCLCHANNEL. |
SUPFAMi | SSF47616. SSF47616. 1 hit. SSF52833. SSF52833. 1 hit. |
TIGRFAMsi | TIGR00862. O-ClC. 1 hit. |
PROSITEi | View protein in PROSITE PS50405. GST_CTER. 1 hit. |
i Sequence
Sequence statusi: Complete.
Q6FIC5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALSMPLNGL KEEDKEPLIE LFVKAGSDGE SIGNCPFSQR LFMILWLKGV
60 70 80 90 100
VFSVTTVDLK RKPADLQNLA PGTHPPFITF NSEVKTDVNK IEEFLEEVLC
110 120 130 140 150
PPKYLKLSPK HPESNTAGMD IFAKFSAYIK NSRPEANEAL ERGLLKTLQK
160 170 180 190 200
LDEYLNSPLP DEIDENSMED IKFSTRKFLD GNEMTLADCN LLPKLHIVKV
210 220 230 240 250
VAKKYRNFDI PKEMTGIWRY LTNAYSRDEF TNTCPSDKEV EIAYSDVAKR
LTK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK315051 mRNA. Translation: BAG37528.1. CR533501 mRNA. Translation: CAG38532.1. CH471134 Genomic DNA. Translation: EAW95143.1. CH471134 Genomic DNA. Translation: EAW95144.1. CH471134 Genomic DNA. Translation: EAW95145.1. CH471134 Genomic DNA. Translation: EAW95146.1. |
RefSeqi | NP_039234.1. NM_013943.2. |
UniGenei | Hs.440544. |
Genome annotation databases
GeneIDi | 25932. |
KEGGi | hsa:25932. |
Similar proteinsi
Entry informationi
Entry namei | Q6FIC5_HUMAN | |
Accessioni | Q6FIC5Primary (citable) accession number: Q6FIC5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | February 5, 2008 |
Last sequence update: | February 5, 2008 | |
Last modified: | March 28, 2018 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |