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Q6FI81

- CPIN1_HUMAN

UniProt

Q6FI81 - CPIN1_HUMAN

Protein

Anamorsin

Gene

CIAPIN1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (04 Jan 2005)
      Previous versions | rss
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    Functioni

    Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells By similarity. Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein NDOR1.By similarity1 Publication

    Cofactori

    Binds 1 2Fe-2S cluster per subunit.2 PublicationsUniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi237 – 2371Iron-sulfur (2Fe-2S)
    Metal bindingi246 – 2461Iron-sulfur (2Fe-2S)
    Metal bindingi249 – 2491Iron-sulfur (2Fe-2S)
    Metal bindingi251 – 2511Iron-sulfur (2Fe-2S)

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-HAMAP
    2. electron carrier activity Source: UniProtKB-HAMAP
    3. metal ion binding Source: UniProtKB-KW
    4. protein binding Source: IntAct

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. hemopoiesis Source: UniProtKB-HAMAP
    3. iron-sulfur cluster assembly Source: UniProtKB-HAMAP
    4. negative regulation of apoptotic process Source: UniProtKB
    5. small molecule metabolic process Source: Reactome

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    2Fe-2S, Iron, Iron-sulfur, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_160176. Cytosolic iron-sulfur cluster assembly.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AnamorsinUniRule annotation
    Alternative name(s):
    Cytokine-induced apoptosis inhibitor 1UniRule annotation
    Fe-S cluster assembly protein DRE2 homologUniRule annotation
    Gene namesi
    Name:CIAPIN1UniRule annotation
    ORF Names:CUA001, PRO0915
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 16

    Organism-specific databases

    HGNCiHGNC:28050. CIAPIN1.

    Subcellular locationi

    Cytoplasm. Nucleus. Mitochondrion. Mitochondrion intermembrane space Curated
    Note: Imported into mitochondria (in vitro).

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. mitochondrial intermembrane space Source: UniProtKB-SubCell
    3. nucleolus Source: UniProtKB
    4. nucleus Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Mitochondrion, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134978864.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 312312AnamorsinPRO_0000079288Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei182 – 1821Phosphoserine1 Publication
    Modified residuei183 – 1831Phosphoserine1 Publication
    Modified residuei305 – 3051Phosphoserine2 Publications
    Modified residuei307 – 3071Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6FI81.
    PaxDbiQ6FI81.
    PRIDEiQ6FI81.

    PTM databases

    PhosphoSiteiQ6FI81.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed. Highly expressed in heart, liver and pancreas.1 Publication

    Gene expression databases

    ArrayExpressiQ6FI81.
    BgeeiQ6FI81.
    CleanExiHS_CIAPIN1.
    GenevestigatoriQ6FI81.

    Organism-specific databases

    HPAiHPA041350.
    HPA042182.

    Interactioni

    Subunit structurei

    Monomer. Interacts with NDOR1; its oxidized form can be reduced by NDOR1. Interacts with CHCHD4 and may be a substrate for CHCHD4 chaperone activity.2 PublicationsUniRule annotation

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GLRX3O760033EBI-750511,EBI-374781

    Protein-protein interaction databases

    BioGridi121328. 17 interactions.
    IntActiQ6FI81. 4 interactions.
    MINTiMINT-1469842.
    STRINGi9606.ENSP00000377914.

    Structurei

    Secondary structure

    1
    312
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi2 – 43
    Beta strandi11 – 166
    Helixi22 – 3615
    Turni37 – 393
    Beta strandi40 – 467
    Helixi47 – 493
    Helixi50 – 534
    Beta strandi60 – 667
    Beta strandi68 – 703
    Helixi77 – 8610
    Beta strandi87 – 10216
    Beta strandi105 – 1095
    Helixi112 – 12110
    Beta strandi125 – 13410
    Helixi137 – 14711
    Beta strandi154 – 1629

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LD4NMR-A1-172[»]
    2YUINMR-A1-170[»]
    4M7RX-ray1.80A/B1-172[»]
    ProteinModelPortaliQ6FI81.
    SMRiQ6FI81. Positions 1-172.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ6FI81.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 172172N-terminal domainAdd
    BLAST
    Regioni173 – 22351LinkerAdd
    BLAST
    Regioni224 – 31289Intrinsically disorderedAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi274 – 2774Cx2C motif 1
    Motifi285 – 2884Cx2C motif 2

    Domaini

    The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine.1 Publication
    The C-terminal domain binds one 2Fe-2S iron-sulfur cluster but is otherwise mostly in an intrinsically disordered conformation.
    The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.

    Sequence similaritiesi

    Belongs to the anamorsin family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG5636.
    HOGENOMiHOG000241118.
    HOVERGENiHBG051104.
    OMAiDSMDLID.
    OrthoDBiEOG7WHHC3.
    PhylomeDBiQ6FI81.
    TreeFamiTF314449.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_03115. Anamorsin.
    InterProiIPR007785. Anamorsin.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PANTHERiPTHR13273. PTHR13273. 1 hit.
    PfamiPF05093. CIAPIN1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6FI81-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MADFGISAGQ FVAVVWDKSS PVEALKGLVD KLQALTGNEG RVSVENIKQL    50
    LQSAHKESSF DIILSGLVPG STTLHSAEIL AEIARILRPG GCLFLKEPVE 100
    TAVDNNSKVK TASKLCSALT LSGLVEVKEL QREPLTPEEV QSVREHLGHE 150
    SDNLLFVQIT GKKPNFEVGS SRQLKLSITK KSSPSVKPAV DPAAAKLWTL 200
    SANDMEDDSM DLIDSDELLD PEDLKKPDPA SLRAASCGEG KKRKACKNCT 250
    CGLAEELEKE KSREQMSSQP KSACGNCYLG DAFRCASCPY LGMPAFKPGE 300
    KVLLSDSNLH DA 312
    Length:312
    Mass (Da):33,582
    Last modified:January 4, 2005 - v2
    Checksum:i70A71D44074ABFBA
    GO
    Isoform 2 (identifier: Q6FI81-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-204: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:108
    Mass (Da):11,735
    Checksum:iC9B53F80FA24398A
    GO
    Isoform 3 (identifier: Q6FI81-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         53-66: SAHKESSFDIILSG → C

    Show »
    Length:299
    Mass (Da):32,213
    Checksum:i29CA61B57C265FE7
    GO

    Sequence cautioni

    The sequence AAC24312.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti142 – 1421S → F in CAB66548. (PubMed:11230166)Curated
    Sequence conflicti142 – 1421S → F in CAG38576. 1 PublicationCurated
    Sequence conflicti278 – 2781Y → C in CAG38576. 1 PublicationCurated
    Sequence conflicti289 – 2891P → T in CAB66548. (PubMed:11230166)Curated
    Sequence conflicti289 – 2891P → T in CAG38576. 1 PublicationCurated
    Sequence conflicti310 – 3101H → N in CAB66548. (PubMed:11230166)Curated
    Sequence conflicti310 – 3101H → N in CAG38576. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti34 – 341A → E.
    Corresponds to variant rs11557672 [ dbSNP | Ensembl ].
    VAR_033747
    Natural varianti52 – 521Q → E.
    Corresponds to variant rs11557674 [ dbSNP | Ensembl ].
    VAR_033748

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 204204Missing in isoform 2. 1 PublicationVSP_012360Add
    BLAST
    Alternative sequencei53 – 6614SAHKE…IILSG → C in isoform 3. 3 PublicationsVSP_012361Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF248964 mRNA. Translation: AAG44562.1.
    AL136613 mRNA. Translation: CAB66548.1.
    AF116609 mRNA. Translation: AAF71034.1.
    CR533545 mRNA. Translation: CAG38576.1.
    AK292281 mRNA. Translation: BAF84970.1.
    AC004382 Genomic DNA. Translation: AAC24311.1.
    AC004382 Genomic DNA. Translation: AAC24312.1. Sequence problems.
    CH471092 Genomic DNA. Translation: EAW82923.1.
    BC002568 mRNA. Translation: AAH02568.1.
    BC024196 mRNA. Translation: AAH24196.1.
    BC067303 mRNA. Translation: AAH67303.1.
    BC071740 mRNA. Translation: AAH71740.1.
    CCDSiCCDS10781.2. [Q6FI81-1]
    RefSeqiNP_064709.2. NM_020313.2. [Q6FI81-1]
    XP_005256118.1. XM_005256061.2. [Q6FI81-3]
    UniGeneiHs.4900.

    Genome annotation databases

    EnsembliENST00000394391; ENSP00000377914; ENSG00000005194. [Q6FI81-1]
    ENST00000567518; ENSP00000456114; ENSG00000005194. [Q6FI81-3]
    GeneIDi57019.
    KEGGihsa:57019.
    UCSCiuc002ell.1. human. [Q6FI81-1]
    uc002elm.1. human. [Q6FI81-3]

    Polymorphism databases

    DMDMi57012667.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF248964 mRNA. Translation: AAG44562.1 .
    AL136613 mRNA. Translation: CAB66548.1 .
    AF116609 mRNA. Translation: AAF71034.1 .
    CR533545 mRNA. Translation: CAG38576.1 .
    AK292281 mRNA. Translation: BAF84970.1 .
    AC004382 Genomic DNA. Translation: AAC24311.1 .
    AC004382 Genomic DNA. Translation: AAC24312.1 . Sequence problems.
    CH471092 Genomic DNA. Translation: EAW82923.1 .
    BC002568 mRNA. Translation: AAH02568.1 .
    BC024196 mRNA. Translation: AAH24196.1 .
    BC067303 mRNA. Translation: AAH67303.1 .
    BC071740 mRNA. Translation: AAH71740.1 .
    CCDSi CCDS10781.2. [Q6FI81-1 ]
    RefSeqi NP_064709.2. NM_020313.2. [Q6FI81-1 ]
    XP_005256118.1. XM_005256061.2. [Q6FI81-3 ]
    UniGenei Hs.4900.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LD4 NMR - A 1-172 [» ]
    2YUI NMR - A 1-170 [» ]
    4M7R X-ray 1.80 A/B 1-172 [» ]
    ProteinModelPortali Q6FI81.
    SMRi Q6FI81. Positions 1-172.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121328. 17 interactions.
    IntActi Q6FI81. 4 interactions.
    MINTi MINT-1469842.
    STRINGi 9606.ENSP00000377914.

    PTM databases

    PhosphoSitei Q6FI81.

    Polymorphism databases

    DMDMi 57012667.

    Proteomic databases

    MaxQBi Q6FI81.
    PaxDbi Q6FI81.
    PRIDEi Q6FI81.

    Protocols and materials databases

    DNASUi 57019.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000394391 ; ENSP00000377914 ; ENSG00000005194 . [Q6FI81-1 ]
    ENST00000567518 ; ENSP00000456114 ; ENSG00000005194 . [Q6FI81-3 ]
    GeneIDi 57019.
    KEGGi hsa:57019.
    UCSCi uc002ell.1. human. [Q6FI81-1 ]
    uc002elm.1. human. [Q6FI81-3 ]

    Organism-specific databases

    CTDi 57019.
    GeneCardsi GC16M057462.
    HGNCi HGNC:28050. CIAPIN1.
    HPAi HPA041350.
    HPA042182.
    MIMi 608943. gene.
    neXtProti NX_Q6FI81.
    PharmGKBi PA134978864.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5636.
    HOGENOMi HOG000241118.
    HOVERGENi HBG051104.
    OMAi DSMDLID.
    OrthoDBi EOG7WHHC3.
    PhylomeDBi Q6FI81.
    TreeFami TF314449.

    Enzyme and pathway databases

    Reactomei REACT_160176. Cytosolic iron-sulfur cluster assembly.

    Miscellaneous databases

    ChiTaRSi CIAPIN1. human.
    EvolutionaryTracei Q6FI81.
    GeneWikii CIAPIN1.
    GenomeRNAii 57019.
    NextBioi 62770.
    PROi Q6FI81.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6FI81.
    Bgeei Q6FI81.
    CleanExi HS_CIAPIN1.
    Genevestigatori Q6FI81.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_03115. Anamorsin.
    InterProi IPR007785. Anamorsin.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PANTHERi PTHR13273. PTHR13273. 1 hit.
    Pfami PF05093. CIAPIN1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Yang Y., Xu X., Gao G., Xiao H., Chen Z., Han Z.
      Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Adrenal tumor.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Brain.
    3. "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs."
      Yu Y., Zhang C., Zhou G., Wu S., Qu X., Wei H., Xing G., Dong C., Zhai Y., Wan J., Ouyang S., Li L., Zhang S., Zhou K., Zhang Y., Wu C., He F.
      Genome Res. 11:1392-1403(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Fetal liver.
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
      Tissue: Testis.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain, Placenta, Skin and Testis.
    9. "Identification of a cytokine-induced antiapoptotic molecule anamorsin essential for definitive hematopoiesis."
      Shibayama H., Takai E., Matsumura I., Kouno M., Morii E., Kitamura Y., Takeda J., Kanakura Y.
      J. Exp. Med. 199:581-592(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    10. Cited for: SUBCELLULAR LOCATION.
    11. "Successful expression and purification of human CIAPIN1 in baculovirus-insect cell system and application of this system to investigation of its potential methyltransferase activity."
      Hao Z., Li X., Qiao T., Fan D.
      Int. J. Biol. Macromol. 42:27-32(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: LACK OF METHYLTRANSFERASE ACTIVITY.
    12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182 AND SER-183, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305 AND SER-307, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. Cited for: INTERACTION WITH NDOR1, DOMAIN, FUNCTION, COFACTOR.
    18. "Solution structure of the N-terminal domain in human cytokine-induced apoptosis inhibitor anamorsin."
      RIKEN structural genomics initiative (RSGI)
      Submitted (APR-2008) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 1-171.
    19. "Anamorsin is a [2Fe-2S] cluster-containing substrate of the Mia40-dependent mitochondrial protein trapping machinery."
      Banci L., Bertini I., Ciofi-Baffoni S., Boscaro F., Chatzi A., Mikolajczyk M., Tokatlidis K., Winkelmann J.
      Chem. Biol. 18:794-804(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 1-172, COFACTOR, INTERACTION WITH CHCHD4, SUBUNIT, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, DOMAIN.

    Entry informationi

    Entry nameiCPIN1_HUMAN
    AccessioniPrimary (citable) accession number: Q6FI81
    Secondary accession number(s): A8K8B6
    , O75206, O75207, Q9H0W1, Q9P1L7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: January 4, 2005
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    'Ana-mors-in' means 'anti-death molecule' in Latin.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 16
      Human chromosome 16: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3