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Q6FI81

- CPIN1_HUMAN

UniProt

Q6FI81 - CPIN1_HUMAN

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Protein
Anamorsin
Gene
CIAPIN1, CUA001, PRO0915
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells By similarity. Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis. Electrons are transferred to the Fe-S cluster from NADPH via the FAD- and FMN-containing protein NDOR1.1 Publication

Cofactori

Binds 1 2Fe-2S cluster per subunit.2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi237 – 2371Iron-sulfur (2Fe-2S)
Metal bindingi246 – 2461Iron-sulfur (2Fe-2S)
Metal bindingi249 – 2491Iron-sulfur (2Fe-2S)
Metal bindingi251 – 2511Iron-sulfur (2Fe-2S)

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-HAMAP
  2. electron carrier activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW
  4. protein binding Source: IntAct

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. hemopoiesis Source: UniProtKB-HAMAP
  3. iron-sulfur cluster assembly Source: UniProtKB-HAMAP
  4. negative regulation of apoptotic process Source: UniProtKB
  5. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

2Fe-2S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_160176. Cytosolic iron-sulfur cluster assembly.

Names & Taxonomyi

Protein namesi
Recommended name:
Anamorsin
Alternative name(s):
Cytokine-induced apoptosis inhibitor 1
Fe-S cluster assembly protein DRE2 homolog
Gene namesi
Name:CIAPIN1
ORF Names:CUA001, PRO0915
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 16

Organism-specific databases

HGNCiHGNC:28050. CIAPIN1.

Subcellular locationi

Cytoplasm. Nucleus. Mitochondrion. Mitochondrion intermembrane space Inferred
Note: Imported into mitochondria (in vitro).2 Publications

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. mitochondrial intermembrane space Source: UniProtKB-SubCell
  3. nucleolus Source: UniProtKB
  4. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134978864.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312AnamorsinUniRule annotation
PRO_0000079288Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei182 – 1821Phosphoserine1 Publication
Modified residuei183 – 1831Phosphoserine1 Publication
Modified residuei305 – 3051Phosphoserine2 Publications
Modified residuei307 – 3071Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6FI81.
PaxDbiQ6FI81.
PRIDEiQ6FI81.

PTM databases

PhosphoSiteiQ6FI81.

Expressioni

Tissue specificityi

Ubiquitously expressed. Highly expressed in heart, liver and pancreas.1 Publication

Gene expression databases

ArrayExpressiQ6FI81.
BgeeiQ6FI81.
CleanExiHS_CIAPIN1.
GenevestigatoriQ6FI81.

Organism-specific databases

HPAiHPA041350.
HPA042182.

Interactioni

Subunit structurei

Monomer. Interacts with NDOR1; its oxidized form can be reduced by NDOR1. Interacts with CHCHD4 and may be a substrate for CHCHD4 chaperone activity.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GLRX3O760033EBI-750511,EBI-374781

Protein-protein interaction databases

BioGridi121328. 17 interactions.
IntActiQ6FI81. 4 interactions.
MINTiMINT-1469842.
STRINGi9606.ENSP00000377914.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi2 – 43
Beta strandi11 – 166
Helixi22 – 3615
Turni37 – 393
Beta strandi40 – 467
Helixi47 – 493
Helixi50 – 534
Beta strandi60 – 667
Beta strandi68 – 703
Helixi77 – 8610
Beta strandi87 – 10216
Beta strandi105 – 1095
Helixi112 – 12110
Beta strandi125 – 13410
Helixi137 – 14711
Beta strandi154 – 1629

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LD4NMR-A1-172[»]
2YUINMR-A1-170[»]
4M7RX-ray1.80A/B1-172[»]
ProteinModelPortaliQ6FI81.
SMRiQ6FI81. Positions 1-172.

Miscellaneous databases

EvolutionaryTraceiQ6FI81.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 172172N-terminal domainUniRule annotation
Add
BLAST
Regioni173 – 22351LinkerUniRule annotation
Add
BLAST
Regioni224 – 31289Intrinsically disorderedUniRule annotation
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi274 – 2774Cx2C motif 1UniRule annotation
Motifi285 – 2884Cx2C motif 2UniRule annotation

Domaini

The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine (1 Publication).2 Publications
The C-terminal domain binds one 2Fe-2S iron-sulfur cluster but is otherwise mostly in an intrinsically disordered conformation.2 Publications
The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.2 Publications

Sequence similaritiesi

Belongs to the anamorsin family.

Phylogenomic databases

eggNOGiCOG5636.
HOGENOMiHOG000241118.
HOVERGENiHBG051104.
OMAiDSMDLID.
OrthoDBiEOG7WHHC3.
PhylomeDBiQ6FI81.
TreeFamiTF314449.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_03115. Anamorsin.
InterProiIPR007785. Anamorsin.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PANTHERiPTHR13273. PTHR13273. 1 hit.
PfamiPF05093. CIAPIN1. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6FI81-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MADFGISAGQ FVAVVWDKSS PVEALKGLVD KLQALTGNEG RVSVENIKQL    50
LQSAHKESSF DIILSGLVPG STTLHSAEIL AEIARILRPG GCLFLKEPVE 100
TAVDNNSKVK TASKLCSALT LSGLVEVKEL QREPLTPEEV QSVREHLGHE 150
SDNLLFVQIT GKKPNFEVGS SRQLKLSITK KSSPSVKPAV DPAAAKLWTL 200
SANDMEDDSM DLIDSDELLD PEDLKKPDPA SLRAASCGEG KKRKACKNCT 250
CGLAEELEKE KSREQMSSQP KSACGNCYLG DAFRCASCPY LGMPAFKPGE 300
KVLLSDSNLH DA 312
Length:312
Mass (Da):33,582
Last modified:January 4, 2005 - v2
Checksum:i70A71D44074ABFBA
GO
Isoform 2 (identifier: Q6FI81-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-204: Missing.

Note: No experimental confirmation available.

Show »
Length:108
Mass (Da):11,735
Checksum:iC9B53F80FA24398A
GO
Isoform 3 (identifier: Q6FI81-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     53-66: SAHKESSFDIILSG → C

Show »
Length:299
Mass (Da):32,213
Checksum:i29CA61B57C265FE7
GO

Sequence cautioni

The sequence AAC24312.1 differs from that shown. Reason: Erroneous gene model prediction.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti34 – 341A → E.
Corresponds to variant rs11557672 [ dbSNP | Ensembl ].
VAR_033747
Natural varianti52 – 521Q → E.
Corresponds to variant rs11557674 [ dbSNP | Ensembl ].
VAR_033748

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 204204Missing in isoform 2.
VSP_012360Add
BLAST
Alternative sequencei53 – 6614SAHKE…IILSG → C in isoform 3.
VSP_012361Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti142 – 1421S → F in CAB66548. 1 Publication
Sequence conflicti142 – 1421S → F in CAG38576. 1 Publication
Sequence conflicti278 – 2781Y → C in CAG38576. 1 Publication
Sequence conflicti289 – 2891P → T in CAB66548. 1 Publication
Sequence conflicti289 – 2891P → T in CAG38576. 1 Publication
Sequence conflicti310 – 3101H → N in CAB66548. 1 Publication
Sequence conflicti310 – 3101H → N in CAG38576. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF248964 mRNA. Translation: AAG44562.1.
AL136613 mRNA. Translation: CAB66548.1.
AF116609 mRNA. Translation: AAF71034.1.
CR533545 mRNA. Translation: CAG38576.1.
AK292281 mRNA. Translation: BAF84970.1.
AC004382 Genomic DNA. Translation: AAC24311.1.
AC004382 Genomic DNA. Translation: AAC24312.1. Sequence problems.
CH471092 Genomic DNA. Translation: EAW82923.1.
BC002568 mRNA. Translation: AAH02568.1.
BC024196 mRNA. Translation: AAH24196.1.
BC067303 mRNA. Translation: AAH67303.1.
BC071740 mRNA. Translation: AAH71740.1.
CCDSiCCDS10781.2. [Q6FI81-1]
RefSeqiNP_064709.2. NM_020313.2. [Q6FI81-1]
XP_005256118.1. XM_005256061.2. [Q6FI81-3]
UniGeneiHs.4900.

Genome annotation databases

EnsembliENST00000394391; ENSP00000377914; ENSG00000005194. [Q6FI81-1]
ENST00000567518; ENSP00000456114; ENSG00000005194. [Q6FI81-3]
GeneIDi57019.
KEGGihsa:57019.
UCSCiuc002ell.1. human. [Q6FI81-1]
uc002elm.1. human. [Q6FI81-3]

Polymorphism databases

DMDMi57012667.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF248964 mRNA. Translation: AAG44562.1 .
AL136613 mRNA. Translation: CAB66548.1 .
AF116609 mRNA. Translation: AAF71034.1 .
CR533545 mRNA. Translation: CAG38576.1 .
AK292281 mRNA. Translation: BAF84970.1 .
AC004382 Genomic DNA. Translation: AAC24311.1 .
AC004382 Genomic DNA. Translation: AAC24312.1 . Sequence problems.
CH471092 Genomic DNA. Translation: EAW82923.1 .
BC002568 mRNA. Translation: AAH02568.1 .
BC024196 mRNA. Translation: AAH24196.1 .
BC067303 mRNA. Translation: AAH67303.1 .
BC071740 mRNA. Translation: AAH71740.1 .
CCDSi CCDS10781.2. [Q6FI81-1 ]
RefSeqi NP_064709.2. NM_020313.2. [Q6FI81-1 ]
XP_005256118.1. XM_005256061.2. [Q6FI81-3 ]
UniGenei Hs.4900.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LD4 NMR - A 1-172 [» ]
2YUI NMR - A 1-170 [» ]
4M7R X-ray 1.80 A/B 1-172 [» ]
ProteinModelPortali Q6FI81.
SMRi Q6FI81. Positions 1-172.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121328. 17 interactions.
IntActi Q6FI81. 4 interactions.
MINTi MINT-1469842.
STRINGi 9606.ENSP00000377914.

PTM databases

PhosphoSitei Q6FI81.

Polymorphism databases

DMDMi 57012667.

Proteomic databases

MaxQBi Q6FI81.
PaxDbi Q6FI81.
PRIDEi Q6FI81.

Protocols and materials databases

DNASUi 57019.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000394391 ; ENSP00000377914 ; ENSG00000005194 . [Q6FI81-1 ]
ENST00000567518 ; ENSP00000456114 ; ENSG00000005194 . [Q6FI81-3 ]
GeneIDi 57019.
KEGGi hsa:57019.
UCSCi uc002ell.1. human. [Q6FI81-1 ]
uc002elm.1. human. [Q6FI81-3 ]

Organism-specific databases

CTDi 57019.
GeneCardsi GC16M057462.
HGNCi HGNC:28050. CIAPIN1.
HPAi HPA041350.
HPA042182.
MIMi 608943. gene.
neXtProti NX_Q6FI81.
PharmGKBi PA134978864.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5636.
HOGENOMi HOG000241118.
HOVERGENi HBG051104.
OMAi DSMDLID.
OrthoDBi EOG7WHHC3.
PhylomeDBi Q6FI81.
TreeFami TF314449.

Enzyme and pathway databases

Reactomei REACT_160176. Cytosolic iron-sulfur cluster assembly.

Miscellaneous databases

ChiTaRSi CIAPIN1. human.
EvolutionaryTracei Q6FI81.
GeneWikii CIAPIN1.
GenomeRNAii 57019.
NextBioi 62770.
PROi Q6FI81.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6FI81.
Bgeei Q6FI81.
CleanExi HS_CIAPIN1.
Genevestigatori Q6FI81.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_03115. Anamorsin.
InterProi IPR007785. Anamorsin.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PANTHERi PTHR13273. PTHR13273. 1 hit.
Pfami PF05093. CIAPIN1. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Yang Y., Xu X., Gao G., Xiao H., Chen Z., Han Z.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Adrenal tumor.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Brain.
  3. "Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs."
    Yu Y., Zhang C., Zhou G., Wu S., Qu X., Wei H., Xing G., Dong C., Zhai Y., Wan J., Ouyang S., Li L., Zhang S., Zhou K., Zhang Y., Wu C., He F.
    Genome Res. 11:1392-1403(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Fetal liver.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain, Placenta, Skin and Testis.
  9. "Identification of a cytokine-induced antiapoptotic molecule anamorsin essential for definitive hematopoiesis."
    Shibayama H., Takai E., Matsumura I., Kouno M., Morii E., Kitamura Y., Takeda J., Kanakura Y.
    J. Exp. Med. 199:581-592(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  10. Cited for: SUBCELLULAR LOCATION.
  11. "Successful expression and purification of human CIAPIN1 in baculovirus-insect cell system and application of this system to investigation of its potential methyltransferase activity."
    Hao Z., Li X., Qiao T., Fan D.
    Int. J. Biol. Macromol. 42:27-32(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: LACK OF METHYLTRANSFERASE ACTIVITY.
  12. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-307, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182 AND SER-183, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305 AND SER-307, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-305, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. Cited for: INTERACTION WITH NDOR1, DOMAIN, FUNCTION, COFACTOR.
  18. "Solution structure of the N-terminal domain in human cytokine-induced apoptosis inhibitor anamorsin."
    RIKEN structural genomics initiative (RSGI)
    Submitted (APR-2008) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 1-171.
  19. "Anamorsin is a [2Fe-2S] cluster-containing substrate of the Mia40-dependent mitochondrial protein trapping machinery."
    Banci L., Bertini I., Ciofi-Baffoni S., Boscaro F., Chatzi A., Mikolajczyk M., Tokatlidis K., Winkelmann J.
    Chem. Biol. 18:794-804(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1-172, COFACTOR, INTERACTION WITH CHCHD4, SUBUNIT, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, DOMAIN.

Entry informationi

Entry nameiCPIN1_HUMAN
AccessioniPrimary (citable) accession number: Q6FI81
Secondary accession number(s): A8K8B6
, O75206, O75207, Q9H0W1, Q9P1L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: September 3, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

'Ana-mors-in' means 'anti-death molecule' in Latin.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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