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Protein
Submitted name:

G protein-coupled receptor kinase-interactor 2 isoform 4

Gene

GIT2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, ReceptorImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
G protein-coupled receptor kinase-interactor 2 isoform 4Imported
Submitted name:
G protein-coupled receptor kinase-interactor 2 isoform 4 variantImported
Submitted name:
GIT2 proteinImported
Gene namesi
Name:GIT2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28684.

Expressioni

Gene expression databases

BgeeiENSG00000139436.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000347464.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini132 – 221ANK_REP_REGIONInterPro annotationAdd BLAST90

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili437 – 464Sequence analysisAdd BLAST28

Sequence similaritiesi

Contains 1 ANK repeat.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotation, Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0818. Eukaryota.
ENOG410XR8U. LUCA.
HOVERGENiHBG012506.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR032352. GIT1/2_CC.
IPR013724. GIT_SHD.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PF16559. GIT_CC. 1 hit.
PF08518. GIT_SHD. 2 hits.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00248. ANK. 3 hits.
SM00105. ArfGap. 1 hit.
SM00555. GIT. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6FI58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRLRSSEV CADCSGPDPS WASVNRGTFL CDECCSVHRS LGRHISQVRH
60 70 80 90 100
LKHTPWPPTL LQMVETLYNN GANSIWEHSL LDPASIMSGR RKANPQDKVH
110 120 130 140 150
PNKAEFIRAK YQMLAFVHRL PCRDDDSVTA KDLSKQLHSS VRTGNLETCL
160 170 180 190 200
RLLSLGAQAN FFHPEKGNTP LHVASKAGQI LQAELLAVYG ADPGTQDSSG
210 220 230 240 250
KTPVDYARQG GHHELAERLV EIQYELTDRL AFYLCGRKPD HKNGQHFIIP
260 270 280 290 300
QMADSSLDLS ELAKAAKKKL QSLSNHLFEE LAMDVYDEVD RRETDAVWLA
310 320 330 340 350
TQNHSALVTE TTVVPFLPVN PEYSSTRNQG RQKLARFNAH EFATLVIDIL
360 370 380 390 400
SDAKRRQQGS SLSGSKDNVE LILKTINNQH SVESQDNDQP DYDSVASDED
410 420 430 440 450
TDLETTASKT NRQKSLDSDL SDGPVTVQEF MEVKNALVAS EAKIQQLMKV
460 470
NNNLSDELRI MQKKLLGKDA N
Length:471
Mass (Da):52,577
Last modified:May 10, 2005 - v1
Checksum:i4C82BB94EA3634DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei471Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK222736 mRNA. Translation: BAD96456.1.
AB451428 mRNA. Translation: BAG70242.1.
CR533568 mRNA. Translation: CAG38599.1.
RefSeqiNP_001317083.1. NM_001330154.1.
NP_631940.2. NM_139201.2.
UniGeneiHs.434996.

Genome annotation databases

GeneIDi9815.
UCSCiuc001tpw.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK222736 mRNA. Translation: BAD96456.1.
AB451428 mRNA. Translation: BAG70242.1.
CR533568 mRNA. Translation: CAG38599.1.
RefSeqiNP_001317083.1. NM_001330154.1.
NP_631940.2. NM_139201.2.
UniGeneiHs.434996.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000347464.

Protocols and materials databases

DNASUi9815.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi9815.
UCSCiuc001tpw.4. human.

Organism-specific databases

CTDi9815.
PharmGKBiPA28684.

Phylogenomic databases

eggNOGiKOG0818. Eukaryota.
ENOG410XR8U. LUCA.
HOVERGENiHBG012506.

Miscellaneous databases

ChiTaRSiGIT2. human.
GenomeRNAii9815.

Gene expression databases

BgeeiENSG00000139436.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001164. ArfGAP.
IPR032352. GIT1/2_CC.
IPR013724. GIT_SHD.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF01412. ArfGap. 1 hit.
PF16559. GIT_CC. 1 hit.
PF08518. GIT_SHD. 2 hits.
[Graphical view]
PRINTSiPR00405. REVINTRACTNG.
SMARTiSM00248. ANK. 3 hits.
SM00105. ArfGap. 1 hit.
SM00555. GIT. 2 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 1 hit.
PS50115. ARFGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ6FI58_HUMAN
AccessioniPrimary (citable) accession number: Q6FI58
Entry historyi
Integrated into UniProtKB/TrEMBL: May 10, 2005
Last sequence update: May 10, 2005
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.